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Mudasir Mudasir

Chemistry Department, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta

Author-ID : 3959548

Chemical Engineering, Chemistry & Bioengineering Chemistry

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INTERACTION OF IRON(II) MIXED-LIGAND COMPLEXES WITH DNA: BASE-PAIR SPECIFICITY AND THERMAL DENATURATION STUDIES Mudasir Mudasir; Karna Wijaya; Endang Tri Wahyuni; Hidenari Inoue
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

A research about base-pair specificity of the DNA binding of [Fe(phen)3]2+, [Fe(phen)2(dip)]2+ and [Fe(phen)(dip)2]2+ complexes and the effect of calf-thymus DNA (ct-DNA) binding of these metal complexes on thermal denaturation of ct-DNA has been carried out. This research is intended to evaluate the preferential binding of the complexes to the sequence of DNA (A-T or G-C sequence) and to investigate the binding strength and mode upon their interaction with DNA. Base-pair specificity of the DNA binding of the complexes was determined by comparing the equilibrium binding constant (Kb) of each complex to polysynthetic DNA that contain only A-T or G-C sequence. The Kb value of the interaction was determined by spectrophotometric titration and thermal denaturation temperature (Tm) was determined by monitoring the absorbance of the mixture solution of each complex and ct-DNA at λ =260 nm as temperature was elevated in the range of 25 - 100 oC. Results of the study show that in general all iron(II) complexes studied exhibit a base-pair specificity in their DNA binding to prefer the relatively facile A-T sequence as compared to the G-C one. The thermal denaturation experiments have demonstrated that Fe(phen)3]2+ and [Fe(phen)2(dip)]2+ interact weakly with double helical DNA via electrostatic interaction as indicated by insignificant changes in melting temperature, whereas [Fe(phen)2(dip)]2+ most probably binds to DNA in mixed modes of interaction, i.e.: intercalation and electrostatic interaction. This conclusion is based on the fact that the binding of [Fe(phen)2(dip)]2+ to ct-DNA moderately increase the Tm value of ct- DNA

MULTIPLE REGRESSION ANALYSIS OF THE INFLUENCE OF CATALYST CHARACTERS SUPPORTED ON γ-Al2O3 TOWARDS THEIR HYDROCRACKING CONVERSION OF ASPHALTENE Wega Trisunaryanti; Triyono Triyono; Mudasir Mudasir; Akhmad Syoufian
Indonesian Journal of Chemistry Vol 4, No 1 (2004)
Publisher : Universitas Gadjah Mada

Multiple regression study of the influence of catalyst's characters with γ-Al2O3 as a support, including acidity, specific area, average pore volume, average pore radius, Ni content, and Mo content the hydrocracking conversion of asphaltene has been conducted.A multivariable regression analysis method, including regression analysis and correlation analysis, was applied on this study. Using multivariable regression, the characters of catalyst was correlated together with the data of the asphaltene conversions. Furthermore, using this method, the characters of catalyst, which have the greatest influence on conversion, may be evaluated. The results showed that there was a high correlation between catalyst characters and hydrocracking conversion of asphalten (r = 0.983). It means that the conversion was 98.3% correlated with the catalyst characters. The value of the multivariable determination coefficient was 0.966, indicating that at least 96.6% variation on the conversions was determined by combination of catalyst characters on this research. From the parameter value of regression equation, it could also be known that average pore radius and specific surface area were the two characters that have the greatest influence on the hydrocracking conversion of asphalten.

SYNTHESIS OF IRON OXIDE-MONTMORILLONITE COMPOSITE AND STUDY OF ITS STRUCTURAL STABILITY AGAINTS SULFURIC ACID Karna Wijaya; Eko Sugiharto; Mudasir Mudasir; Iqmal Tahir; Ika Liawati
Indonesian Journal of Chemistry Vol 4, No 1 (2004)
Publisher : Universitas Gadjah Mada

The synthesis and characterization of iron oxide-montmorillonite and its structural stability test with various concentration of sulfuric acid were conducted. Synthesis was performed by treating Na-montmorillonite clay with oligocations of iron, followed by calcinating the intercalation compound of oligocations-montmorillonite at 200oC for 24 hours. Calcined product was then characterized to determine the iron content, basal spacing and its porosities distribution. To test structural stability againts strong acid (i.e. sulfuric acid), the composites were dispersed into solution of sulfuric acid with various concentration, i.e: 1, 2 and 3M for 24 hours.The characterization result, especially from x-ray-diffractometry analysis, demonstrated that modification of montmorillonite using iron (III)oxide produced so called house of card structure as indicated by its broad, low intensity reflection at 2θ = 5-6o. The addition of sulphuric acid into composite resulted in probably the formation of face to face arrangements indicated by the appearance of 001 plane reflection. The acid treatment also caused the decrease in the iron content of the iron oxide-montmorillonite as shown by its neutron activated analysis result. The iron content of iron oxide-montmorillonite before the acid treatment was 32,01% w/w, and after the acid treatment was 14.08% w/w (with sulfuric acid of 1M), 6.05% w/w (sulfuric acid of 2M) and 5,98% w/w (with sulfuric acid of 3M), respectively.In general, the sulphuric acid treatment to the composite did not distore the 001 planes of the montmorillonite.

STUDIES ON LEWIS ACID REACTION OF ISOEUGENOL AND ISOEUGENYL ACETATE Bambang Purwono; Retno Dwi Soelistyowati; Mudasir Mudasir
Indonesian Journal of Chemistry Vol 3, No 1 (2003)
Publisher : Universitas Gadjah Mada

Studies of the Lewis Acid (AlCl3 and BF3-methanol) to isoeugenol and isoeugenyl acetate have been conducted. Reactions were carried out by stirring of isoeugenol and isoeugenyl acetate for 4 days at room temperature.Structure analysis of the products using IR, MS, 1H NMR and 13C NMR spectrophotometer showed that cyclic dimer product has been obtained white crystal, 175 oC, as a 1-ethyl-5-hydroxy-3-(4-hydroxy-3-methyl phenyl)-6-methoxy-2-methyl indane.

QUANTITATIVE STRUCTURE AND ACTIVITY RELATIONSHIP ANALYSIS OF 1,2,4-THIADIAZOLINE FUNGICIDES BASED ON MOLECULAR STRUCTURE CALCULATED BY AM1 METHOD Mudasir Mudasir; Iqmal Tahir; Ida Puji Astuti Maryono Putri
Indonesian Journal of Chemistry Vol 3, No 1 (2003)
Publisher : Universitas Gadjah Mada

Quantitative structure-Activity relationship (QSAR) analysis of fungicides having 1,2,4-thiadiazoline structure based on theoretical molecular properties have been done. Calculation of the properties was conducted by semiempirical method AM1 and the activity of the compounds was taken from literature. Relationship analysis between fungicides activity (pEC50) and molecular properties was done using SPSS program. The QSAR analysis gave the best model as follows: pEC50 = 3.842 + (1.807x10-4) ET + (5.841x10-3) Eb - (5.689x10-2) DHf -0.770 log P + 1.144 a - 0.671 m + 9.568 GLOB - (5.54x10-2) MR. n=19 r=0.917 SE=0.216 Fcal/Ftable=2.459 PRESS=0.469. The best model obtained was then used to design and predict the fungicides activity of new compounds derived from 1,2,4-thiadiazoline.

Co-Authors Akhmad Syoufian Bambang Purwono Eko Sugiharto Endang Tri Wahyuni Hidenari Inoue Ida Puji Astuti Maryono Putri Ika Liawati Iqmal Tahir Karna Wijaya Retno Dwi Soelistyowati Triyono Triyono Wega Trisunaryanti

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