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Dislipidemia dan Oval Fat Bodies Dalam Urin Indranila Indranila
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
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Dyslipidemia and oval fat bodies in urineBackground: Lipid profiles such as cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol screening are expensive. Oval fat bodies (OFB) an epithelial tubulus cell within lipid degenerated/macrophag contains fat granule, is a marker of lipiduria will be expected as a feature of serum lipids and may be performed as a simple non invasive, inexpensive laboratory test. The aim of the study was to analyze the correlation between dyslipidemia and OFB.Methods: This study was performed in 66 male and female subjects of hypercholesterolemia and hypertriglyceridemia of 20-83 years old, which come to a private laboratory in Semarang within 3 months. Sample were taken purposively. The method used in detecting lipids serum was enzymatics (CHOD-PAP for cholesterol and GPO enzymatic for triglyceride) and OFB examination in urine using Sternheimer–Malbin staining.Results: Triglyceride and cholesterol mean value were 210.8 mg/dl (±131.74) and 230.6 mg/dl (±36.4). OFB were found in the urine of on 15 subjects (75%) with hyperlipidemia, 26 subjects (72.2%) with hypercholesterolemia and 6 subjects (70%) with hypertriglyceridemia. There were corellations between hypercholesterolemia and hypertriglyceridemia and OFB (r1=0.82, p1=0.01; r2=0.84, p2=0.05; r3=0.75, p3=0.05).Conclusions: There are positive correlation between dyslipidemia and the presence of OFB in urine.Keywords: Dyslipidemia, oval fat bodies.ABSTRAKLatar belakang: Profil lipid sebagai uji saring umumnya adalah kolesterol, trigliserid, kolesterol-HDL, kolesterol-LDL dimana biaya pemeriksaan ini masih cukup mahal, sementara pola makan cenderung tinggi lemak. Oval fat bodies (OFB) merupakan salah satu petanda lipiduria diharapkan dapat menggambarkan keadaan lemak darah pada uji saring laboratorium secara sederhana, non invasif dan murah. Penelitian ini bertujuan untuk mengetahui hubungan antara dislipidemi dengan OFB.Metode: Pengamatan dilakukan pada 66 subyek usia dewasa baik laki-laki dan wanita dengan hiperkolesterolemia dan atau hipertrigliseridemia yang memeriksakan diri di laboratorium klinik swasta di Semarang selama kurun waktu 3 bulan secara purposivesampling. Metode pemeriksaan yang digunakan adalah ensimatik (CHOD–PAP untuk kolesterol dan GPO ensimatik untuk trigliserida) dan mikroskopik sedimen urin menggunakan pengecatan Sternheimer-Malbin untuk OFB.Hasil: Didapatkan rerata trigliserid dan kolesterol 210,8 mg/dl (±131,7) dan 230,6 mg/dl (±36,4) OFB ditemukan dalam urin 15 subyek (75%) dengan hiperlipidemia, 26 subyek (72,2%) dengan hiperkolesterolemia dan 6 subyek (70%) dengan hipertrigliseridemia. Ada korelasi antara hiperlipidemia, hiperkolesterolemia dan hipertrigliseridemia dengan keberadaan OFB di urin (r1=0,82, p1=0,01; r2=0,84, p2=0,05; r3=0,75, p3=0,05).Simpulan: Ada korelasi positif antara dislipidemia dengan ditemukannya OFB di urin.
Pengaruh Media Kontras Iopamidol Dosis Tinggi Intravaskuler Terhadap Kadar Kreatinin Serum dan Gambaran Histopatologi Tubulus Ginjal pada Tikus Sprague-Dawley: Upaya Proteksi dengan L-arginin Hermina Sukmaningtyas; Djoko Untung Trihadi
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
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High dose intravascular iopamidol influence on serum creatinine level and histopatologic feature of kidney tubules in Sprague-Dawley rats: using L-arginine as protectionBackground: Iopamidol, a Low Osmolar Contrast Media (LOCM), has relatively less nephrotoxicity, but contrast media (CM) volume has role to develop acute renal failure even in healthy person. L-arginine as a natural precursor of nitric oxide might prevent contrast nephropathy. Objectives: To investigate effects of iopamidol on acute renal damage by observing serum creatinine level and acute renal necrosis and to assses the role of L-arginine to protect acute renal failure.Methods: This was a post test only control group design experimental study using 35 male, twelve weeks old Sprague-Dawley rats, weighing 200-350 g, allocated into seven groups. The control group (K), P1, P2, P3 were group given 1.8 ml iopamidol and P4, P5, P6 groups were given 8.4% (W/V) L-arginine personde twice a day, 5 ml each for 7 days before 1.8 ml iopamidol injection. Serum creatinine and histological examination were done to assess acute tubular necrosis with H&E staining observed on 24, 48, and 72 hour accordingly. Dose of iopamidol used was equal to 100 ml human dose. The difference of serum creatinine and acute tubular necrosis were analyzed by using ANOVA test.Results: There were no significant differences among groups on serum creatinine level (p=0.261). Acute tubular necrosis increased following iopamidol administration in 72 hour (P3) p=0.007, and pretreatment with L-arginin reduced necrosis in group P6 (p=0.008).Conclusions: Serum creatinine level was not different after administration of iopamidol and L-arginine. Iopamidol induce acute tubular necrosis, while L-arginine can prevent CM-induced nephropathy. Keywords: Iopamidol, serum creatinine, acute tubular necrosis, L-arginine ABSTRAK Latar belakang: Iopamidol, media kontras osmolalitas rendah mempunyai efek nefrotoksik relatif rendah, tetapi pemakaian dosis tinggi merupakan faktor resiko nekrosis tubuler akut. L-arginin, asam amino prekursor NO dan sebagai antioksidan dapat mencegah contrast-induced nephropaty.Tujuan: Mengetahui pengaruh iopamidol terhadap perubahan kadar kreatinin serum dan gambaran nekrosis tubuler akut, serta melihat pengaruh L-arginin terhadap penurunan kejadian contrast-induced nephropaty.Metode: Penelitian eksperimental sesungguhnya dengan rancangan post test only control group design pada tikus Sprague-Dawley jantan, sehat, umur 12 minggu, berat badan 200-350 g. Sebanyak 35 ekor tikus dibagi secara acak menjadi 7 kelompok. Kelompok K, tidak mendapatkan perlakuan, P1, P2, P3 diberi iopamidol 1,8 cc intravena. Kelompok P4, P5, P6 diberi L-arginin 8,4 w/v 2x sehari masing-masing 5 ml selama 7 hari, sebelum disuntik iopamidol 1,8 ml intravena. Kadar kreatinin serum dan pemeriksaan nekrosis tubuler akut diperiksa secara histopatologi dengan pengecatan H&E pada jam ke-24, jam ke-48, jam ke-72 sesuai dengan kelompok perlakuan. Dosis iopamidol setara dengan 100 ml pada dosis manusia. Perubahan kadar kreatinin serum dan nekrosis tubuler akut diuji dengan uji ANOVA.Hasil: Kadar kreatinin serum tidak berbeda di antara kelompok (p=0,261). Pemberian iopamidol menyebabkan nekrosis tubuler akut pada jam ke-72 (p=0,007), dan pemberian L-arginin menurunkan nekrosis tubuler akut pada jam ke-72 (p=0,008). Simpulan: Iopamidol dosis tinggi dapat menginduksi nekrosis tubuler akut pada keadaan tanpa resiko, dan pemberian L-arginin dapat mencegah contrast-induced nephropathy. Kadar kreatinin serum tidak berbeda setelah pemberian iopamidol maupun L-arginin.
Nyeri Yang Diprovokasi Electric Foot Shock, Daya Bunuh Makrofag dan Penggunaan Imunomodulator BCG pada Mencit Balb/C Dwi Pudjonarko; M. Naharuddin Jenie; Edi Dharmana
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
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Provocated pain by electric foot shock, macrophage killing ability and the use of BCG as immunomodulator in Balb/C miceBackground: Pain affects immune system through Hypothalamic-Pituitary-Adrenal (HPA) and Symphatetic-adrenal-medullary (SAM) axis. Immunostimulator BCG increase immune system via type I response. The aim of this study is to prove that the decrease of immune response due to pain can be improved by introducing BCG vaccine assessed by macrophage activity.Methods: The study adapts Laboratory Experimental and Post-Test Only Control Group Design. Samples were 24 female Balb/C mice average weight 21.88(SD=1.75) grams and divided into four groups. The control group (C) received no other additional treatment. The BCG group (B) received intra-peritoneal injection of 0.1 ml BCG at day 1st and 11th. The EFS (E) received Electric foot shock 1-3 mA at day 12th to 21st and the BCG+ EFS group (BE) received BCG and EFS as mentioned before. All groups wereintravenously injected with 104 live L. monocytogenes at day 21st and sacrificed at day 26th by chloroform anaesthesia. Then, Macrophages Nitrit Oxyde (NO) concentration and liver bacterial count were measured. Data were analyzed by One Way ANOVA, Post Hoc Test Bonferroni and Pearson’s product moment supported by computer software SPSS 13.0 (significant if p<0.05).Results: There were significant differences in the macrophages NO production and the liver bacterial count (p<0.05) among the groups. The highest number of bacterial count and the lowest number of NO production was found in the E group. In contrast, there were significant differences on the number of bacterial count and NO production between BE group and E group (p>0.05).Conclusions: Pain provocation causes low NO concentration in macrophages and the introduction of BCG could improve the condition.Keywords: Pain, macrophages, NO, bacterial count ABSTRAKLatar belakang: Nyeri dapat mempengaruhi imunitas tubuh melalui aksis Hypothalamic-Pituitary-Adrenal (HPA) dan Symphateticadrenal- medullary (SAM) dengan menurunkan produksi sitokin tipe 1. Penggunaan imunostimulator BCG terbukti dapat meningkatkan respon imunitas seluler melalui respon tipe I. Penelitian ini bertujuan untuk membuktikan penurunan imunitas seluler yang diakibatkan nyeri dapat diperbaiki dengan pemberian vaksin BCG dengan melihat aktivitas makrofag.Metode: Penelitian ini merupakan penelitian eksperimental laboratorik, dengan pendekatan The Post Test – Only Control Group Design yang menggunakan 24 ekor mencit betina strain Balb/C, umur 6-8 minggu. Sampel dibagi menjadi 4 kelompok dan mendapatkan makanan standar. Pada Kelompok Kontrol (K), mencit tidak mendapatkan perlakuan, sedangkan kelompok BCG (B) divaksinasi secara intra peritoneal dengan 0,1cc BCG pada hari ke-1 dan ke-11. Kelompok Nyeri (N), mendapat sensasi nyerimenggunakan Electric Foot Shock mulai hari ke-12 sampai 21 dan kelompok Nyeri + BCG (NB) mendapat kombinasi perlakuan N+B. Pada hari ke-21, semua mencit disuntik 104 Listeria monocytogenes hidup secara intravena. Dilakukan terminasi mencit pada hari ke-26 untuk dilakukan pemeriksaan konsentrasi produksi NO makrofag serta hitung kuman organ hepar. Dilakukan uji beda dengan Oneway ANOVA dan korelasi Pearson’s product moment dengan menggunakan software SPSS 13.0.Hasil: Didapatkan adanya perbedaan yang bermakna pada produksi NO makrofag dan hasil hitung kuman organ hepar antar kelompok perlakuan (p<0,05). Pada kelompok Nyeri (N) didapatkan produksi NO makrofag terendah dan jumlah hitung kuman tertinggi. Pada kelompok Nyeri yang mendapat BCG (NB) didapatkan hasil yang berlawanan dan perbedaannya bermakna dalam variabel yang diteliti dibandingkan dengan kelompok Nyeri yang tidak mendapat BCG (N) (p<0,05).Simpulan: Provokasi nyeri menyebabkan rendahnya konsentrasi NO makrofag dan penggunaan BCG dapat memperbaiki keadaan tersebut.
Penyuluhan Model Pendampingan dan Perubahan Status Gizi Anak Usia 6 – 24 Bulan Aswita Amir; S. Fatimah Muis; Suyatno Suyatno
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
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The outreach counseling model and nutritional status change in 6–24 months old childrenBackground: Insufficient knowledge on food and health of mothers will lead to inadequate food intake and high infection risk, especially diarrhea and acute respiratory tract infection (ARTI). Improvement of knowledge can be achieved by counseling. There are several model of counseling, one of them is the outreach model. This study aimed was to analyze the influence of outreach counseling model toward the change of nutritional status of 6–24 months old children. Methods: Research design was a quasi experiment with non randomized pre post test control group. Intervention group recieved outreach counseling model by outreach nutritionists (Tenaga Gizi Pendamping) and control group recieved conventional counseling from nutritionists of primary health care center (Tenaga Gizi Puskesmas). The study was done in Makassar City, South Sulawesi Province with the working area of Sudiang Raya’s Primary Health Care chosen as intervention area and Bira’s Primary Health Care as control site. Subjects were children aged 6–24 months with WAZ between -3 until 0 SD. The number of subjects in intervention group were 32 and control were 37 children. The observation variables were changes of mother’s knowledge, energy adequacy level, protein adequacy level, diarrhea and ARTI duration and nutritional status (WAZ, HAZ and WHZ) of the children. Data were analyzed using t-test and multivariate analysis by linear regression.Results: After 3 months of intervention, there were increase in mother’s knowledge, energy adequacy level, and the decrease of duration diarrhea was higher in the outreach counseling group than the control group. The WAZ and HAZ in outreach counseling group were better than control group, and there was an increase in WHZ in outreach counseling group with a decrease in the control group.Conclusions: Outreach counseling model is more effective than conventional counseling in lowering the decrease of nutritional status on 6–24 months old children.Key words: Outreached counseling, nutritional status, 6–24 months old children. ABSTRAK Latar Belakang: Pengetahuan ibu yang kurang tentang gizi dan kesehatan akan menyebabkan asupan makanan yang tidak cukup serta meningkatnya risiko penyakit infeksi diantaranya diare dan ISPA pada anak. Peningkatan pengetahuan dapat dilakukan dengan penyuluhan. Penyuluhan terdiri dari beberapa model, salah satu diantaranya adalah model pendampingan. Penelitian ini bertujuan untuk menganalisis pengaruh penyuluhan model pendampingan terhadap ibu selama 3 bulan terhadap perubahan status gizi anak usia 6-24 bulan.Metode: Desain penelitian adalah quasi experiment berupa non randomized pre post test control group. Kelompok intervensi mendapat penyuluhan model pendampingan oleh Tenaga Gizi Pendamping (TGP) dan kelompok kontrol mendapat penyuluhan konvensional oleh Tenaga Gizi Puskesmas. Penelitian dilakukan di wilayah kerja Puskesmas Sudiang Raya Kota Makassar sebagai lokasi intervensi dan Puskesmas Bira sebagai lokasi kontrol. Subyek penelitian adalah anak usia 6–24 bulan dengan skor Z BB/U -3 s.d. 0 SB. Jumlah subyek untuk kelompok intervensi 32 dan kontrol 37 anak. Variabel yang diamati meliputi perubahan pengetahuan ibu, Tingkat Kecukupan Energi (TKE), Tingkat Kecukupan Protein (TKP), hari sakit (Diare dan ISPA) dan status gizi (skor Z BB/U, PB/U dan BB/PB). Analisis data dilakukan dengan menggunakan uji beda dan analisis multivariat dengan regresi linier.Hasil: Setelah 3 bulan intervensi, terjadi peningkatan rerata skor pengetahuan ibu dan TKE, dan penurunan jumlah hari sakit diare lebih tinggi pada kelompok intervensi dibandingkan kontrol. Status gizi (skor Z BB/U dan PB/U) pada kelompok intervensi lebih baik dibandingkan kontrol (p<0,05), terjadi peningkatan skor Z BB/PB pada kelompok intervensi dan penurunan skor tersebut pada kelompok kontrol (p<0,05).Simpulan: Penyuluhan model pendampingan lebih efektif daripada penyuluhan konvensional dalam menekan penurunan status gizi anak usia 6–24 bulan.
Inspeksi Visual Asam Asetat (IVA) untuk Deteksi Dini Lesi Prakanker Serviks Sapto Wiyono; T. Mirza Iskandar; Suprijono Suprijono
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
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Visual acetic acid inspection (IVA) for early cervix pre cancer lesion detectionBackground: In 1985 WHO and had recommended an alternative approach, the down staging concept of cervical malignancy with visual inspection with acetic acid (VIA) for developing countries. Displastic cervical epithelial cells will make an acethowhite appearance with VIA. It is important to know the sensitivity and specificity of VIA for early detection of cervical precancer lesion.Methods: A hundred and twenty subjects who fullfilled inclution criteria had Pap test, VIA and four quadrant biopsy. Fortyfive subjects came from Gynecology and fertility clinic at Dr. Kariadi hospital and seventy five subjects came from Indonesian Cancer Foundation Semarang. From all of these examination the sensitivity, specificity, positive predictive value and negative predictive value were calculated by 2x2 tabel. Biopsy result was considered as gold standard.Results: Based on biopsy result there were 32 cases (26.7%) with normal finding, 31 cases (25.81%) with chronic cervicitis, 50 cases (41.6%) with chronic cervicitis with mild dysplasia, 3 cases (2.5%) with chronic cervicitis and moderate dysplasia, 2 cases (1.7%) with non specific inflammation, 2 cases (1.7%) with chronic cervicitis and mild dysplasia, 1 cases (0.8%) with malignancy. The sensitivity of Pap test was 55%, specificity 90%, PPV 84% and NPV 69% whether VIA had sensitivity 84%, specificity 89%, PPV87% and NPV 86%.Conclusions: Visual inspection with acetic acid has high sensitivity for early detection of cervical precancer lesion.Keywords: VIA, acetowhite, early detection, cervical precancer lesion.ABSTRAKLatar belakang: Tahun 1985 WHO merekomendasikan suatu pendekatan alternatif bagi negara yang sedang berkembang dengan konsep down staging terhadap kanker serviks dengan pemeriksaan IVA. Epitel serviks yang mengalami displasia akan memberikan gambaran acethowhile dengan pemeriksaan IVA. Untuk itu perlu diketahui seberapa besar sensitivitas dan spesifisitas dari pemeriksaan VIA dalam mendeteksi dini lesi prakanker serviks.Metode: Seratus dua puluh peserta penelitian, 45 berasal dari poliklinik ginekologi dan FER RSUP Dr. Kariadi dan 75 berasal dari YKI Cabang Semarang yang memenuhi kriteria penerimaan sampel dilakukan pemeriksaan tes Pap, IVA dan biopsi empat kuadran. Terhadap hasil pemeriksaan ini dilakukan perhitungan sensitivitas, spesifisitas, nilai duga positif maupun nilai duga negatifHasil: Berdasarkan hasil pemeriksaan biopsi didapatkan 32 subyek (26,7%) dengan hasil normal, 31 (25,8%) dengan servisitis kronis, 50 (41,6%) dengan servisitis kronis dengan displasia ringan, 3 (2,5%) servisitis kronis dengan displasia sedang, 2 (1,7%) dengan radang tidak spesifik dengan displasia ringan, 2 (1,7%) dengan radang tidak spesifik dan 1 (0,8%) dengan keganasan serviks. Sensitivitas untuk tes Pap 55%, spesifisitas 90%, nilai duga positif 84%, nilai duga negatif 69%, sedang sensitivitaspemeriksaan IVA 84%, spesifisitas 89%, nilai duga positif 87% dan nilai duga negatif 86%.Simpulan: Pemeriksaan IVA mempunyai sensitivitas yang tinggi untuk deteksi dini lesi prakanker serviks.
Pola Asuh Ibu, Kejadian Diare dan Pertumbuhan Sampai 4 Bulan pada Bayi yang Mengalami Hambatan Pertumbuhan Dalam Rahim Thresia Dewi Kartini Berek; Zinatul Faizah; Endang Purwaningsih
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
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ABSTRACTMother caring pattern, diarrhea occurrence and growth in the first four months of infants with intra uterine growth retardationBackground: Infants with Intra Uterine Growth Retardation (IUGR) are very sensitive toward infection especially diarrhea. Diarrhea may disrupt growth, while good quality of mother caring pattern improve growth. This study aimed to see the association between mother caring pattern, diarrhea occurrence and the growth of infants with IUGR.Methods: This prospective cohort study was conducted in 44 IUGR infants with from birth to 4 months old. Data were collected by interviews to the mother, using a structured questionnaire and observation. The variables measured were mother caring pattern, diarrhea occurrences, environmental sanitation, health service utility and growth. Data were analyzed using Pearson and Rank-Spearman correlation tests, as well as multiple linear regressions.Results: Eighty-eight point six percents of the respondents had good quality of caring pattern. The mean diarrhea episode per child was 0.84 (±1.1), with duration of 1.8 days/episode. Cummulative incidence of diarrhea was 84.1% and incidence density of diarrhea was 3.1 person-years. Diarrhea occurrences in subjects who were partially breastfed were higher than the subjects who wereexclusively breastfed. There was a correlation between mother’s feeding practice and growth (WAZ: p<0.004, BMI: p<0.039). There was no correlation between mother’s caring pattern, diarrhea occurrences, environmental sanitation, health service utility and growth. Environmental sanitation, health service utility, diarrhea occurrences, mother’s caring pattern of feeding, nursing andhygiene, were all contributed to 31.7% of WAZ scores.Conclusions: Among the mother caring pattern, only feeding practice was correlated to the growth of infants with IUGR, while diarrhea occurrences was not correlated. It is recommended that mothers of infants with IUGR should be given counseling with regard to infant feeding practice.Keywords: Pola Asuh Ibu, Kejadian Diare dan Pertumbuhan Sampai 4 Bulanpada Bayi yang Mengalami Hambatan Pertumbuhan Dalam RahimABSTRAKLatar Belakang: Bayi dengan hambatan pertumbuhan dalam rahim (IUGR) sangat rentan terhadap infeksi terutama diare yang dapat mengganggu pertumbuhannya. Pola asuh ibu diharapkan dapat memperbaiki dan menunjang pertumbuhan optimal bayi yang lahir dengan IUGR. Penelitian ini bertujuan untuk mengetahui hubungan pola asuh ibu dan kejadian diare dengan pertumbuhan bayi dengan IUGR.Metode: Penelitian kohort prospektif pada 44 bayi IUGR sampai umur 4 bulan. Variabel yang diamati: pola asuh ibu, kejadian diare, sanitasi lingkungan, pemanfaatan pelayanan kesehatan dan pertumbuhan. Analisis data dengan korelasi Pearson, Rank- Spearman dan analisis regresi linier ganda.Hasil: Pola asuh ibu 88,6% baik. Rerata episode diare 0,84(±1,16) dengan lama diare 1,8 hari/episode. Insidensi kumulatif diare 84,1% dan densitas insiden diare 3,1 orang-tahun. Kejadian diare subyek ASI parsial lebih banyak dibandingkan subyek ASI eksklusif. Ada hubungan antara praktik ibu memberi makan bayi dengan pertumbuhan bayi (BB/U p<0,004 dan BMI p<0,039). Tidak ada hubungan pola asuh ibu, kejadian diare, sanitasi lingkungan dan pemanfaatan pelayanan kesehatan dengan pertumbuhan bayi. Secara bersama-sama sanitasi lingkungan, pemanfaatan pelayanan kesehatan, kejadian diare, praktik ibu memberi makan,merawat, menjaga kebersihan diri dan bayi berpengaruh terhadap pertumbuhan bayi dengan kontribusi terbesar dari skor-Z BB/U(31,7%).Simpulan: Pada pola asuh ibu hanya praktik ibu memberi makan bayi berhubungan dengan pertumbuhan bayi yang lahir IUGRsampai umur 4 bulan.
Lingkar Pinggang, Kadar Glukosa Darah, Trigliserida dan Tekanan Darah pada Etnis Minang di Kabupaten Padang Pariaman, Sumatera Barat Fasli Jalal; Nur Indrawaty Liputo; Novia Susanti; Fadil Oenzil
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
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Waist circumference, plasma glucose, serum triglyceride and blood pressure amongst the Minangkabau in Padang Pariaman, West SumateraBackground: The abnormality of waist circumference together with serum triglyceride blood sugar and blood pressure are associated with metabolic syndrome. The increasing incidence of metabolic syndrome is in line with the increasing of central obesity. This study was done to investigate the incidence of metabolic syndrome and the relationship between waist circumference with other components of metabolic syndrome which are serum triglyceride, HDL-cholesterol, plasma glucose and blood pressure.Methods: The study was done amongst the Minangkabau in Padang Pariaman. Design of the study was cross sectional study. The study subjects were 92 chosen by multistage random sampling. Characteristic of the samples and food consumption were collected by interviewing. Waist circumference was measured using method that is recommended by WHO (1995). Blood samples were taken to measure lipid profile and plasma glucose. Blood pressure was measured using sphygmomanometer.Results: The result of the study showed 22.8% of the subjects had metabolic syndrome with high intake of energy, carbohydrateand cholesterol, and low intake of fiber and omega 3. Eighty seven percent and 12.5% of women and men had high waist circumference. A positive association were found between waist circumference and serum triglyceride, blood glucose and blood pressure, however no correlation was found with HDL-cholesterol.Conclusions: Waist circumference is an important indicator for metabolic syndrome. Keywords: Metabolic syndrome, waist circumference, triglyceride, blood sugar and blood pressureABSTRAK Latar Belakang: Lingkar pinggang yang berlebihan adalah salah satu komponen dalam Sindroma Metabolik (SM) bersama dengan tingginya kadar serum trigliserida, glukosa darah, dan tekanan darah. Peningkatan kejadian SM sejalan dengan peningkatan obesitas sentral. Penelitian ini bertujuan memperoleh gambaran kejadian SM dan hubungan lingkar pinggang dengan komponen SM lainnya, yaitu kadar trigliserida, HDL-kolesterol, glukosa darah, dan tekanan darah.Metode: Penelitian dilakukan pada masyarakat Minang di Padang Pariaman dengan desain cross sectional. Pengambilan sampel dilakukan multistage random sampling dengan jumlah sampel 92 orang. Pengumpulan data karakteristik dan konsumsi dilakukan dengan wawancara, pengukuran lingkar pinggang dilakukan dengan cara yang direkomendasikan WHO tahun 1995, juga dilakukan pengambilan sampel darah guna pengukuran profil lipid dan glukosa plasma, sedangkan pengukuran tekanan darah sistolik-diastolik menggunakan sphygmomanometer.Hasil: Hasil penelitian menemukan 22,8% responden ternyata menderita SM, dengan asupan energi tinggi, karbohidrat tinggi, serat rendah, kolesterol tinggi dan asupan omega 3 rendah. Delapan puluh tujuh persen responden wanita dan 12,5% pria memiliki lingkar pinggang besar dari normal. Ditemukan korelasi positif antara lingkar pinggang dengan kadar trigliserida, kadar glukosa plasma dan tekanan darah, namun tidak terhadap kadar HDL-kolesterol.Simpulan: Lingkar pinggang merupakan satu indikator penting penanda Sindroma Metabolik.

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