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INDONESIA
MEDIA MEDIKA INDONESIANA
Published by Universitas Diponegoro
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
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Articles 3 Documents
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Search results for , issue "2009:MMI VOLUME 43 ISSUE 6 YEAR 2009" : 3 Documents clear
Antioksidan Vitamin dan Kerusakan Otot pada Aktivitas Fisik Studi Eksperimen pada Mahasiswa JPOK-FKIP UNS Surakarta Kiyatno Kiyatno
MEDIA MEDIKA INDONESIANA 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

Vitamin antioxidants administration toward muscle damage on exercise. An experimental study in students of FKIP–JPOK Sebelas Maret UniversityBackground: Exercise has dual effects, which not only enhance health status and performance but also results in muscular damage. The aim of this study is to determine when the administration of vitamin antioxidants is more effective in reducing the muscular damage.Methods: An experimental quantitative study with a 2x2 factorial research design was used in this study. Forty of total students in third semester of JPOK-FKIP Sebelas Maret University were randomly selected to become the experimental subjects and divided equally into four groups. First and second groups performed exercise with strenuous sub maximal intensity (SSI, running 2x800 m) and took the vitamin antioxidants (30 mg vitamin A, 200 mg vitamin C, 50 mg vitamin E, 15 mg Zn and 25 mcg Se) before runningfor first group and after running for second group respectively. Prior to perform prolonged sub maximal intensity (PSI, running 1500 m) third group took the same antioxidants while fourth group took the antioxidant after doing PSI. 48 hours later, MDA plasma levels were determined by using TBARS in order to measure the muscular damage. T-test was use for analyzing all collected data.Results: There is different effect on muscle damage when vitamin antioxidants were taken before and after exercise (obs.T 3.70> tb.T 1.68), which vitamin antioxidants were taken after exercise has a better muscle damage (MDA 200.60><222.38).Conclusions: The administration of vitamin antioxidants after exercise has a better muscle damage.Keywords: Exercise, vitamin antioxidants, muscle damageABSTRAK Latar belakang: Aktivitas fisik selain membuat tubuh menjadi lebih sehat dan lebih bugar, juga dapat menimbulkan kerusakan otot. Tujuan penelitian untuk mengetahui waktu pemberian antioksidan vitamin yang paling efektif untuk mengurangi kerusakan otot.Metode: Jenis penelitian adalah kuantitatif–eksperimental menggunakan rancangan penelitian faktorial 2x2. Subyek penelitian diambil secara acak sederhana (n=40) mahasiswa JPOK-FKIP UNS semester III, dibagi menjadi 4 kelompok: (1) minum antioksidan vitamin lalu lari 2x800 m (2) lari 2x800 m lalu 20 jam kemudian minum antioksidan vitamin (3) minum antioksidan vitamin lalu lari 1500 m (4) lari 1500 m lalu 20 jam kemudian minum antioksidan vitamin. Kerusakan otot diukur berdasarkankadar MDA plasma dengan metode TBARS 48 jam setelah perlakuan. Antioksidan vitamin terdiri vitamin C 200 mg, vitamin E 50 mg, vitamin A 30 mg, Zn 15 mg, Se 25 mcg. Analisis data menggunakan t-test dengan tingkat kepercayaan 95%, dengan komputer minitab for Window release 13.Hasil: Terjadi perbedaan pengaruh yang bermakna terhadap kerusakan otot antara pemberian antioksidan vitamin sebelum dengan sesudah aktivitas fisik (thit 3,70>ttab 1,68). Pemberian antioksidan vitamin sesudah aktivitas fisik kerusakan otot lebih kecil dibanding sebelum aktivitas fisik. (MDA 200,60><222,38).Simpulan: Pemberian antioksidan vitamin sesudah aktivitas fisik kerusakan otot lebih kecil dibanding sebelum aktivitas fisik.
Pemberian Diet Tambahan pada Anak dengan Penyakit Jantung Bawaan Asianotik M. Wishnuwardhana; M. Mexitalia; JC. Susanto
MEDIA MEDIKA INDONESIANA 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

Food supplementation for children with acyanotic congenital heart diseaseBackground: Children with Congenital Heart Disease (CHD) have a high risk for growth faltering. The prevalence of undernutrition in children with acyanotic CHD on the Pediatric Cardiology Clinic Dr. Kariadi Hospital Semarang is 80.4%. The purpose of the study is to define the benefit of food supplementation to children with acyanotic CHD to improve their growth.Methods: Clinical trial with one group pre and post test design study were conducted in children with CHD in the Pediatric Cardiology Clinic Dr. Kariadi Hospital Semarang during 2005-2006. Twenty-two children aged 6-57 months were involved in this study. Besides their daily intake, they had been given biscuit as food supplementation for 3 months, 20% above their Requirement Daily Allowance (RDA). Their weight and length/height were measured every months. The data was analyzed using Wilcoxon test.Results: The mean of Weight of Age z score (WAZ), Height of Age z score (HAZ), and Weight of Height z score (WHZ) before the supplementation were -1.570.9; -0.751.97; and -0.891.7 respectively. After 3 months there were an increased on WAZ 0.16 and HAZ 0.33 significantly but the improvement of WHZ is 0.01 (not significant). During the supplementation the calorie and protein intake were increased 14.6% and 8.4% respectively.Conclusion: Food supplementation with biscuit 14.6% above the RDA for 3 months improve the growth of children with acyanotic CHD.Keywords: Food supplementation, growth, acyanotic CHDABSTRAKLatar belakang: Anak dengan penyakit jantung bawaan (PJB) merupakan anak yang rawan mengalami gangguan pertumbuhan. Di Klinik Kardiologi Anak RSUP Dr. Kariadi Semarang, didapatkan 80,4% anak dengan PJB asianotik mengalami gizi kurang. Pemberian diet tambahan diharapkan memperbaiki status gizi dan pertumbuhan. Tujuan penelitian ini untuk mengetahui manfaat diet tambahan pada anak dengan PJB asianotik terhadap pertumbuhan.Metode: Uji klinis one group dengan pre and post test design, dilakukan pada anak dengan PJB asianotik di Klinik Kardiologi Anak RSUP Dr. Kariadi Semarang tahun 2005-2006. Dua puluh dua anak berumur 6-57 bulan diberikan perlakuan dengan pemberian biskuit sampai dengan 20% di atas Angka Kecukupan Gizi (AKG) selama 3 bulan selain tetap diberikan diet sehari-hari. Setiap bulan berat badan, panjang/tinggi badan diukur. Data dianalisis dengan uji Wilcoxon dengan batas kemaknaan p<0,05.Hasil: Sebelum perlakuan rerata z skor BB/U (WAZ) -1,570,9, z skor TB/U (HAZ) -0,751,97, z skor BB/TB (WHZ) rerata -0,891,7 dan sesudah perlakuan WAZ BB/U -1,411, HAZ -0,421,8, WHZ -0,881,6. Peningkatan rerata pertumbuhan sebelum dan sesudah perlakuan WAZ 0,16, HAZ 0,33 dan WHZ 0,01. Didapatkan perbedaan bermakna pada WAZ dan HAZ sedangkan WHZ tidak bermakna. Akseptabilitas meningkat setiap bulan dan terjadi peningkatan bermakna rerata asupan energi dan protein yang bersumber dari biskuit masing-masing sebesar 14,6% dan 8,4% dalam waktu 3 bulan.Simpulan: Pemberian biskuit minimal 14,6% di atas AKG selama 3 bulan pada anak PJB asianotik meningkatkan pertumbuhan.
Determination of L-Type Calcium Current in the Primary Hypertrophied Left Ventricular Cardiomyocytes of Hypertrophy Heart Rats/HHR Vennetia R. Danes
MEDIA MEDIKA INDONESIANA 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

Background: The molecular mechanisms responsible for electromechanical derangements found in primary left ventricular (LV) hypertrophy have not been clearly elucidated. Of particular interest is the voltage gated L-type Ca current (ICa L) which plays crucial role in the EC-coupling. This study aimed to investigate cardiomyocyte ICa(L) in newly developed line of rats namely HHR (hypertrophy heart rat) and NHR (normal heart rat).Methods: A pure experimental study has been conducted using male HHR (n=7 rats) and NHR (n=9 rats), aged 19-25 week. Cardiomyocytes were isolated enzymatically. By using whole cell patch clamp techniques, ICa were measured and normalized (pA/pF) for cell size determined by capacitance (Cm). In Na-free superfusate, the ICa(L) of HHR (n=18 cells) and NHR (n=12 cells) obtained at holding potential (HP) -50 mV were analyzed using Student’s t-test and one-way ANOVA (repeated measures). p<0.05values were considered significance.Results: Myocyte mean Cm of HHR slightly increased but not significantly greater than that of NHR (364.3±22.33 pF vs 300.2±27.78 pF, p=0.08). In HHR, peak Ca current density was significantly increase, i.e, at HP -50 mV, the ICa(L) evoked at test potential (TP) -10 mV were -7.74±0.86 (HHR) vs -4.68±1.09 (NHR) pA/pF, p<0.02.Conclusions: Peak Ca current density of HHR increases approximately 1.6 times that of the NHR (-7.74±0.86 vs -4.68±1.09 pA/pF). This increase is attributed primarily to L-type Ca current, best known to peak at around TP -10 mV. The dramatic increase in sarcolemmal calcium influx in the HHR provides evidence of altered EC coupling processes in primary LV hypertrophy.Keywords: HHR rats, LV hypertrophy, cardiomyocyte, L-type calcium currentABSTRACT Penentuan arus kalsium tipe L pada kardiomiosit tikus yang mengalami hipertrofi primer ventrikel kiri (Hypertrophy Heart Rats/HHR)Latar belakang: Mekanisme molekuler yang bertanggung jawab pada munculnya kelainan elektro-mekanik pada hipertrofi primer ventrikel kiri masih belum jelas, khususnya arus kasium tipe L, ICa(L), yang berperan penting pada ‘EC-coupling’. Tujuan penelitian ini untuk mengukur dan menganalisis ICa(L) kardiomiosit dari tikus jenis baru bernama HHR (hypertrophy heart rat) dan NHR (normal heart rat).Metode: Eksperimen murni laboratorik dilakukan pada tikus jantan NHR (n=9) dan HHR (n=7) berusia 19-25 minggu. Kardiomiosit diisolasi menggunakan teknik enzimatika. Dengan teknik ‘whole cell patch clamp’; arus kalsium ICa(L) diukur dan dinormalisasi sesuai ukuran selnya (pA/pF), yang ditentukan melalui pengukuran kapasitans membran (Cm). Pada kondisi bebas Na, ICa(L) dari kedua kelompok sel HHR (n=18) dan NHR (n=12), yang didapat dari ‘holding potential’ (HP) -50mV dianalisis dengan Student’st-test dan one-way ANOVA (repeated measures). Nilai p<0,05 dianggap bermakna.Hasil: Rerata kapasitans membran (Cm) dari HHR dan NHR secara statistik tidak beda secara bermakna (364,3±22,33 pF vs 300,2±27,78 pF, p=0,08). Pada HP -50 mV, densitas arus kalsium ICa(L) yang dihasilkan dari ‘test potential’ (TP)-10 mV  meningkat secara bermakna pada HHR dibanding NHR -7,74±0,86 vs -4,68±1,09 pA/pF (p<0,02).Simpulan: Terjadi peningkatan densitas arus kalsium pada HHR yaitu 1,6 kali NHR (-7,74±0,86 vs -4,68±1,09 pA/pF). Peningkatan ini seluruhnya disebabkan oleh ICa(L), karena tipe ini biasanya memuncak pada TP sekitar -10 mV. Peningkatan influx kalsium sarkolemma HHR yang sangat besar ini, merupakan bukti adanya perubahan proses ‘EC coupling’ pada ventrikel kiri yang mengalami hipertrofi primer.

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