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ACI (Acta Cardiologia Indonesiana)
Published by Universitas Gadjah Mada
ISSN : 24605700     EISSN : 25794345     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ACI (Acta Cardiologia Indonesiana) is published twice a year (biannually) by the Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Arjuna Subject : -
Articles 8 Documents
 1 
Search results for , issue "Vol 2, No 2 (2016)" : 8 Documents clear
Bisoprolol Therapy and The Risk of Erectile Dysfunction in Stable Coronary Artery Disease Patients Firman Fauzan; Bambang Irawan; Hariadi Hariawan
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22603

Abstract

Background :Bisoprolol is an anti angina and ischemic therapy in patient with stable coronary artery disease (CAD). Moreover it can decrease mortality and rehospitalization rate up to 34 % and 28 %. However it is also known to increase erectile dysfunction risk. Leydig cells has beta receptor which contribute in testosterone release. The blockade of beta receptor by bisoprolol can inhibit testosterone release and cause erectile dysfunction (ED) Method :This retrospective case control study was done by age matched paired method. Men with CAD as diagnosed by angiography were evaluated for ED. Erectile function was assessed by a 5-item version of the International Index of Erectile Function (IIEF-5). History of disease and medical record were evaluated to check history of bisoprolol therapy for the last 6 month. Depression was screened using Indonesian version of Hospital Anxiety and Depression Scale (HADS). Result : From 157 total subject, patients were divided into 105 patients in case group and 52 patients in control group. Ninety patients (85.7%) had history of bisoprolol therapy. The odd ratio of bisoprolol to have ED risk was 2, but there was not significant statistically (95% CI 0.85- 2.93; p= 0.262). From sub analysis result 5 mg bisoprolol therapy have significant statistic result to ED risk (OR 2.65, 95% CI 1.12-6.25; p=0.026). Diabetes was another confounding factor which have significant risk to ED from multivariate analysis result (OR 3.8, 95 % CI 1.65-8.88, p=0.002). Conclussion : Stable CAD patients with bisoprolol therapy have a higher risk of ED compare with stable CAD patient without bisoprolol, however it was not statistically significant.Keywords : Bisoprolol; erectile dysfunction; stable coronary artery disease
The Dynamic Electrocardiogram Pattern of T Wave Inversion Following ST Segment Elevation in Acute Coronary Syndrome with Non Significant Coronary Artery Disease Anggoro Budi Hartopo; Hariadi Hariawan; Nahar Taufiq
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22608

Abstract

ST segment elevation acute myocardial infarction (STEMI) is sometime indicated by typical electrocardiogram pattern, and rarely by atypical pattern. The definite diagnosis of STEMI is important to be determined rapidly and timely and becoming the key management success. The 12 lead electrocardiogram is the main diagnostic tool which should be completed and interpreted as soon as possible on patient admission. In the case, a female patient with anginal chest pain and initial ST segment elevation in electrocardiogram with non significant coronary artery disease. The subsequent electrocardiogram shows T wave inversion evolution pattern.Keywords: STEMI; T wave inversion; variant angina; evolution
The Prevalence and Impact of Body Mass Index Category in Patients with Acute Myocardial Infarction Anggoro Budi Hartopo; Vina Yanti Susanti; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22604

Abstract

Background: Body mass index is widely recognized as a tool to classify obesity and adiposity. In Asian population, body mass index category can be divided as underweight, normal, overweight and obese. The prevalence of this categorisation is varied among patients with acute myocardial infarction. Furthermore, there is a J and U curve relationship between body mass index category with outcome in acute myocardial infarction. This research aims to investigate the prevalence of body mass index category and its impact on patients with acute myocardial infarction.Methods: The research design is a cross sectional study. The subjects of this research are patients hospitalised with acute myocardial infarction. Subjects are categorised as underweight, normal, overweight and obese, based on Asian body mass index categorisation. The demography, clinical and laboratory data is compared among categories and statistically analysed. The major adverse cardiac events occuring during hospitalisation are recorded and its incidence is compared among group. A p value < 0.05 is statistics limit for significance.Results: We analyse 375 subjects hospitalised with acute myocardial infarction. The most prevalence BMI category is overweight (47.7 %), the second most common category is normal (33.1 %), followed by obese (15.5 %) and the least common category is underweight (3.7 %). No significant difference is observed in respect of gender and cardiovascular risk factors. The underweight subject is significantly older as compared to other categories. The glucose level and atherogenic lipid tend to be higher in underweight subject as compared with normal subject. There is no difference in the incidence of major adverse cardiac events among body mass index categorisation.Conclusion: The overweight is the most common body mass index category in acute myocardial infarction. The underweight subject is significantly older and tend to have worse biochemical parameters as compared to other categories. The incidence of MACE is not associated with the body mass index category.Keywords: body mass index; overweight; underweight; acute myocardial infarction 
Current Diagnosis and Management of Myocarditis Windhi Dwijanarko; Hasanah Mumpuni; Bambang Irawan
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22605

Abstract

Myocarditis is an inflammation of the myocardium. The clinical presentations of myocarditis range from nonspecific systemic symptom such as fever, myalgias, palpitations, or exertional dyspnea, to severe hemodynamic derangement and sudden death. The wide variation of clinical manifestations has made the exact incidence of myocarditis difficult to determine. The prevalence of myocarditis based on autopsy data is ranging from 2 to 42%. Myocarditis has heterogeneous clinical presentation, ranging from mild chest pain or palpitations to cardiogenic shock and life-threatening ventricular arrhythmias. The diagnosis of myocarditis requires a high initial suspicion. Non-invasive techniques, such as cardiac magnetic resonance imaging, can be useful to diagnose and monitor of disease. The endomyocardial biopsy is the gold standard for definitive diagnosis of myocarditis and can identify the etiology of myocarditis. By endomyocardial biopsy, it can direct patients who can be managed by conventional therapy or who require specific treatment based on underlying etiology, such as antiviral or intravenous immunoglobulin infusion.Keywords: myocarditis; diagnosis; management
Prediction of Failed Fibrinolytic Using Scoring System in ST Elevation Myocardial Infarction Patients Satria Mahendra; Budi Yuli Setianto; Hariadi Hariawan
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22601

Abstract

Background: ST elevation myocardial infarction (STEMI) is the most common acute coronary syndrome in adults, and requiring immediate reperfusion. Primary percutaneous coronary intervention (PCI) is the main reperfusion therapy, but because of many limitations, fibrinolytic is often chosen. Fibrinolytic have high failure risk, so it is important to be able to predict whether this therapy will fail or not. This research aim to create a scoring system to predict failed fibrinolytic in STEMI patients. Methods: This is retrospective cohort study using medical records data from Dr. Sardjito General Hospital in Yogyakarta, recorded in June 2014-December 2015. The population was STEMI patients that reperfused with streptokinase regiment. Determination of failed fibrinolytic was using the difference in the ST segment elevation of the pre and post fibrinolytic electrocardiogram (ECG). The clinical variables of subjects were recorded. The statistical analysis was done and scoring system was constructed. Results: A total of 105 patients with mean age of 57.82±9.59 years were included in this study. Subjects with failed fibrinolytic was 53 patients (50.5%). Several variables were independently associated with failed fibrinolytis, i.e. the onset of ≥ 6 hours, hyperglycemia, and the location of anterior infarction (OR = 11.3, p = 0.000; OR = 6.11, p = 0.003 and OR = 10.5, p = 0.001, respectively). After scoring system was constructed, it was found that score ≥ 2 predict failed fibinolytic, with 53% sensitivity and 94% specificity. Conclusions : Scoring system consisting of onset ≥ 6 hours, hyperglycemia in arrival, and anterior infarct location, can be used to predict failed fibrinolytic in STEMI patients using streptokinase with 53% sensitivity and 94% specificity. Keywords: failed fibrinolytic scoring; fibrinolytic; STEMI; streptokinase
Brain Abscess in Young Adult with Double Outlet Right Ventricle (DORV): A Case Report Hendry Purnasidha Bagaswoto; Rendi Asmara; Hasanah Mumpuni
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22606

Abstract

Intracranial lesions frequently occur in association with congenital malformation of the heart. Intracranial abscess and cerebral thrombosisare the two most serious complications of the brain due to congenital cyanotic heart disease. We reported a case of brain abscess occurring in patients with double outlet right ventricle (DORV). The identification of focal infection and appropriate treatment with parenteral antibiotics,steroid, antiplatelet and anticonvulsant improved patients clinically.Keywords: brain abscess; congenital; double outlet right ventricle
Association Between Mean Platelet Volume (MPV) with Major Adverse Cardiovascular Events in Acute Coronary Syndrome during Hospitalization Hasanah Mumpuni; Hariadi Hariawan; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22602

Abstract

Background: Platelets play a central role in the pathogenesis of acute coronary syndrome with various clinical manifestations of unstable angina pectoris, myocardial infarction with ST segment elevation, and myocardial infarction without ST segment elevation. Mean platelet volume (MPV), the average size of platelets in blood obtained from routine blood tests, reflects the activation of platelets. Previous study revealed that higher MPV showed a higher thrombotic potential, by increasing the platelet activation, secretion of tromboxan A2 and the expression of glycoprotein Ib and IIb/IIIa receptors. This study aims to determine whether the MPV may predict the major cardiovascular events in patients with acute coronary syndrome.Metode: We perform a retrospective cohort study involving 372 patients with acute coroanry syndrome who admitted to Intensive Cardiac Care Unit Dr. Sardjito Hospital Yogyakarta. The research is conducted between January 2009 to January 2011, comprising 180 (48.3%) STEMI patients, 87 (23.3%)NSTEMI patients and 105 (28.4%) unastable angina patients. Subjects are further grouped as those with high MPV and low MPV. MPV measurement is obtained on routine blood tests of those patients.The major adverse cardiovascular events are cardiovascular death, non fatal reinfarction, stroke, acute heart failure and cardiogenic shock.Result: Cut-off value of MPV in this study is 8.85 fL determined with ROC curve analysis. The major adverse cardiovascular events is significantly higher in those with MPV >8.85 fL compared with those with the MPV ≤8.85 fL (incidence: 28.4% vs. 18.9%, p = 0.034), with the relative risk (RR) 1.65, 95% CI 1.037-2.783. The mean MPV in patients with major adverse cardiovascular events was significantly higher as compared to those without major adverse cardiovascular events (9.506 ± 1.76 fl vs.8.96 ± 1.45 fl, p = 0.001).Conclusion: Mean platelet volume (MPV) are associated with major adverse cardiovascular events in acute coronary syndrome. The high MPV may be considered as a predictor of major cardiovascular events in patients with acute coronary syndrome.Keywords: acute coronary syndrome, mean platelet volume, major adverse cardiovascular events.
Isolated Persistent Left Superior Vena Cava, Role of Echocardiography Screening and CT angiography Putrika Prastutu Ratna Gharini; Erika Maharani; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22607

Abstract

Background: An isolated persistent left SVC with concomittant agenesis of right SVC in adult patients is a very rare abnormality. Physician should consider it particularly in patients, in which venous acces will be performed. Our rare case deals with the importance of detailed echocardiographic examination with screening of coronary sinus dilatation before the electrophysiology study.Case: A 65-year-old woman came to outpatient clinic for a chief complaint of palpitations. Her ECG showed paroxysmal SVT with WPW syndrome. She underwent echocardiography examination before electrophysiology study and it was found that she had a dilated coronary sinus. Therefore we performed cardiac CT. It was found that she had a persistent left superior vena cava (SVC) and an absence of a right SVC with no other congenital anomaly.Conclusion: A comprehensive echocardiography examination to look for a dilation of coronary sinus is a first suggestion to screen this anomaly, eventually followed by echocardiography with agitated saline injection and/or computed tomography can help physician to anticipate the anomaly before the invasive procedure involving the thoracic vein.Keywords: echocardiography, cardiac CT angiography, vascular malformation, superiorvena cava

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