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Acute Coronary Syndrome in Young Patients at Dr. Sardjito General Hospital Setianto, Budi Yuli; Sari, Julia; Hartopo, Anggoro Budi; Gharini, Putrika Prastuti Ra
Acta Interna The JOurnal of Internal Medicine Vol 4, No 1 (2014): Acta Interna The Journal Of Internal Medicine
Publisher : Acta Interna The JOurnal of Internal Medicine

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Abstract

ABSTRACTBackground: The incidence of acute coronary syndrome in the young patients is increased recently.Several studies reported that young patients have distinct clinical characteristics as compare with olderpatients.Objective: To assess the prevalence, risk factors and clinical presentation of acute coronarysyndrome(ACS) in young patients at Dr. Sardjito Hospital, Yogyakarta.Methods: We conducted a cross sectional study between September 2008-May 2009 at intensivecardiovascular care unit (ICCU) of Dr. Sardjito Hospital. We enrolled consecutive patients admittedwith acute coronary syndrome. We divided the patients as young ACS (age ≤ 45 years) and older ACS(age >45 years). We compared cardiovascular risk factors, clinical presentation and clinical spectrumsfrom both groups. Statistics analysis was performing using chi-square test, p value < 0.05 was consideredsignifi cantly different.Results: In our study there were 20 (13.5%) young ACS and 128 (86.5%) older ACS patients. Mostyoung ACS patients are male (90%). Proportion of diabetes mellitus in young ACS was not differentfrom that in older ACS patients (20% vs. 18.8%; p=0.55). Hypertension was not different either (50%vs. 53.1%; p=0.49). Sixty percent of young ACS patients were smoker, however its proportion did notdiffer from older ACS patients (p=0.84). There were no signifi cant differences of dyslipidemia. Theyoung ACS patients mostly experienced STEMI than NSTEMI and unstable angina (55% vs. 15%vs. 30%), but there were no signifi cant differences when compared to older ACS patients (p=0.65).Thirty percent of young ACS patients presented with Killip class II or higher, however there were nosignifi cant differences between groups (p=0.40).Conclusion: In this study we found that there were no signifi cant differences in risk factors, clinicalpresentation and spectrums between young ACS and older ACS patients. The need for preventionprogram in both groups should not be difference.Keywords: ACS– young– older– clinical presentation.
Acute Coronary Syndrome in Young Patients at Dr. Sardjito General Hospital Setianto, Budi Yuli; Sari, Julia; Hartopo, Anggoro Budi; Ra Gharini, Putrika Prastuti
Acta Interna The Journal of Internal Medicine Vol 4, No 1 (2014): Acta Interna The Journal Of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.819 KB)

Abstract

ABSTRACTBackground: The incidence of acute coronary syndrome in the young patients is increased recently. Several studies reported that young patients have distinct clinical characteristics as compare with older patients.Objective: To assess the prevalence, risk factors and clinical presentation of acute coronary syndrome(ACS) in young patients at Dr. Sardjito Hospital, Yogyakarta.Methods: We conducted a cross sectional study between September 2008-May 2009 at intensive cardiovascular care unit (ICCU) of Dr. Sardjito Hospital. We enrolled consecutive patients admitted with acute coronary syndrome. We divided the patients as young ACS (age ≤ 45 years) and older ACS (age >45 years). We compared cardiovascular risk factors, clinical presentation and clinical spectrums from both groups. Statistics analysis was performing using chi-square test, p value < 0.05 was considered significantly different.Results: In our study there were 20 (13.5%) young ACS and 128 (86.5%) older ACS patients. Most young ACS patients are male (90%). Proportion of diabetes mellitus in young ACS was not different from that in older ACS patients (20% vs. 18.8%; p=0.55). Hypertension was not different either (50% vs. 53.1%; p=0.49). Sixty percent of young ACS patients were smoker, however its proportion did not differ from older ACS patients (p=0.84). There were no signifi cant differences of dyslipidemia. The young ACS patients mostly experienced STEMI than NSTEMI and unstable angina (55% vs. 15% vs. 30%), but there were no signifi cant differences when compared to older ACS patients (p=0.65). Thirty percent of young ACS patients presented with Killip class II or higher, however there were no significant differences between groups (p=0.40).Conclusion: In this study we found that there were no signifi cant differences in risk factors, clinical presentation and spectrums between young ACS and older ACS patients. The need for prevention program in both groups should not be difference.Keywords: ACS– young– older– clinical presentation.
Acute Coronary Syndrome in Young Patients at Dr. Sardjito General Hospital Budi Yuli Setianto; Julia Sari; Anggoro Budi Hartopo; Putrika Prastuti Ra Gharini
Acta Interna The Journal of Internal Medicine Vol 4, No 1 (2014): Acta Interna The Journal Of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.819 KB) | DOI: 10.22146/acta interna.5728

Abstract

ABSTRACTBackground: The incidence of acute coronary syndrome in the young patients is increased recently. Several studies reported that young patients have distinct clinical characteristics as compare with older patients.Objective: To assess the prevalence, risk factors and clinical presentation of acute coronary syndrome(ACS) in young patients at Dr. Sardjito Hospital, Yogyakarta.Methods: We conducted a cross sectional study between September 2008-May 2009 at intensive cardiovascular care unit (ICCU) of Dr. Sardjito Hospital. We enrolled consecutive patients admitted with acute coronary syndrome. We divided the patients as young ACS (age ≤ 45 years) and older ACS (age >45 years). We compared cardiovascular risk factors, clinical presentation and clinical spectrums from both groups. Statistics analysis was performing using chi-square test, p value < 0.05 was considered significantly different.Results: In our study there were 20 (13.5%) young ACS and 128 (86.5%) older ACS patients. Most young ACS patients are male (90%). Proportion of diabetes mellitus in young ACS was not different from that in older ACS patients (20% vs. 18.8%; p=0.55). Hypertension was not different either (50% vs. 53.1%; p=0.49). Sixty percent of young ACS patients were smoker, however its proportion did not differ from older ACS patients (p=0.84). There were no signifi cant differences of dyslipidemia. The young ACS patients mostly experienced STEMI than NSTEMI and unstable angina (55% vs. 15% vs. 30%), but there were no signifi cant differences when compared to older ACS patients (p=0.65). Thirty percent of young ACS patients presented with Killip class II or higher, however there were no significant differences between groups (p=0.40).Conclusion: In this study we found that there were no signifi cant differences in risk factors, clinical presentation and spectrums between young ACS and older ACS patients. The need for prevention program in both groups should not be difference.Keywords: ACS– young– older– clinical presentation.
The Prevalence and Impact of Body Mass Index Category in Patients with Acute Myocardial Infarction Anggoro Budi Hartopo; Vina Yanti Susanti; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22604

Abstract

Background: Body mass index is widely recognized as a tool to classify obesity and adiposity. In Asian population, body mass index category can be divided as underweight, normal, overweight and obese. The prevalence of this categorisation is varied among patients with acute myocardial infarction. Furthermore, there is a J and U curve relationship between body mass index category with outcome in acute myocardial infarction. This research aims to investigate the prevalence of body mass index category and its impact on patients with acute myocardial infarction.Methods: The research design is a cross sectional study. The subjects of this research are patients hospitalised with acute myocardial infarction. Subjects are categorised as underweight, normal, overweight and obese, based on Asian body mass index categorisation. The demography, clinical and laboratory data is compared among categories and statistically analysed. The major adverse cardiac events occuring during hospitalisation are recorded and its incidence is compared among group. A p value < 0.05 is statistics limit for significance.Results: We analyse 375 subjects hospitalised with acute myocardial infarction. The most prevalence BMI category is overweight (47.7 %), the second most common category is normal (33.1 %), followed by obese (15.5 %) and the least common category is underweight (3.7 %). No significant difference is observed in respect of gender and cardiovascular risk factors. The underweight subject is significantly older as compared to other categories. The glucose level and atherogenic lipid tend to be higher in underweight subject as compared with normal subject. There is no difference in the incidence of major adverse cardiac events among body mass index categorisation.Conclusion: The overweight is the most common body mass index category in acute myocardial infarction. The underweight subject is significantly older and tend to have worse biochemical parameters as compared to other categories. The incidence of MACE is not associated with the body mass index category.Keywords: body mass index; overweight; underweight; acute myocardial infarction 
The Dynamic Electrocardiogram Pattern of T Wave Inversion Following ST Segment Elevation in Acute Coronary Syndrome with Non Significant Coronary Artery Disease Anggoro Budi Hartopo; Hariadi Hariawan; Nahar Taufiq
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22608

Abstract

ST segment elevation acute myocardial infarction (STEMI) is sometime indicated by typical electrocardiogram pattern, and rarely by atypical pattern. The definite diagnosis of STEMI is important to be determined rapidly and timely and becoming the key management success. The 12 lead electrocardiogram is the main diagnostic tool which should be completed and interpreted as soon as possible on patient admission. In the case, a female patient with anginal chest pain and initial ST segment elevation in electrocardiogram with non significant coronary artery disease. The subsequent electrocardiogram shows T wave inversion evolution pattern.Keywords: STEMI; T wave inversion; variant angina; evolution
Manajemen Pasien Infark Miokardium Akut Dengan Elevasi Segmen ST (IMA-EST) Anterior Onset Lebih dari 48 Jam Tanpa Tindakan Reperfusi di Bangsal Perawatan Jantung Iswandi Darwis; Anggoro Budi Hartopo; Muhammad Gahan Sarwiko
Jurnal Kedokteran Universitas Lampung Vol 7, No 1 (2023): JURNAL KEDOKTERAN UNIVERSITAS LAMPUNG
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila7125-36

Abstract

Latar Belakang. Sindrom koroner akut merupakan penyakit utama penyebab kematian di dunia. Infark miokardium akut dengan elevasi segmen ST merupakan salah satu SKA yang banyak menimbulkan kematian. Tatalaksana reperfusidengan IKP primer sesuai dengan onset nyeri dada menjadi tatalaksana utama untuk menurunkan morbiditas danmortalitas. Kasus. Pasien laki-laki 62 tahun dengan diagnosis IMA-EST anterior onset lebih dari 48 jam berdasarkan keluhan nyeri dada khas angina dan sesak nafas. Pada pemeriksaan EKG didapatkan irama sinus, frekuensi 120 x/menit, dengan aksisnormal, terdapat elevasi segmen ST pada lead V1-V4 dan Q patologis pada lead V1-V3 serta terdapat peningkatan enzim hs-Troponin I. Pasien didapatkan kondisi infeksi paru dan terjadi perbaikan selama perawatan di bangsal. Pasien tidakdilakukan reperfusi karena menurut rekomendasi pada pasien IMA-EST onset lebih dari 48 jam rekomendasi III untuk dilakukan reperfusi. Pasien diterapi dengan pemberian vasodilator, penyekat beta, statin, heparinisasi dan kontrolkomorbid infeksi pada pasien merupakan tatalaksana lanjutan pada pasien di bangsal perawatan jantung. Pasien dirawat selama 7 hari di RS dan didapatkan perbaikan klinis. Pasien dilakukan 6MWT sebagai dasar penilaian untukaktivitas fisik pasien di rumah. Aktivitas fisik pasca SKA sangat diperlukan untuk memperbaiki luaran klinis, menurunkan angka mortalitas dan rehospitalisasi dan mencegah kejadian reinfark pada pasien di kemudian hari. Tes viabilitasjantung diperlukan untuk mengetahui apakah didapatkan perbaikan fungsi mikardium bila dilakukan reperfusi. Pada pasien direncanakan untuk tes viabilitas dengan menggunakan DSE.Kesimpulan.  Pasien dengan diagnosis IMA-EST onset lebih dari 48 jam tanpa ada keluhan nyeri dada, hemodinamik stabil dan tidak ada kelainan irama jantung yang mengancam jiwa tidak direkomendasikan untuk dilakukan reperfusi. Kata kunci: Infark miokardium akut dengan elevasi segmen ST, onset 48 jam, Repefusi
Plateletcrit as Risk Factor of Major Adverse Cardiac Event in Elderly Patient with Acute Coronary Syndrome Kathrine, Anita Septiana Maria; Pramantara, I Dewa Putu; Hartopo, Anggoro Budi
Acta Interna The Journal of Internal Medicine Vol 12, No 1 (2023): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.98161

Abstract

Background. The morbidity and mortality of patients with acute coronary syndrome (ACS) are very high so it is important to do risk factor stratification. Several studies found that plateletcrit plays an important role in predicting mortality in STEMI patients and that it had a significant correlation as a predictor of a coronary slow flow phenomenon correlated with a worse cardiovascular outcome. The aging process is associated with altered platelet activity and a higher rate of vascular disease. The effect of aging on thrombotic function is not fully understood yet, so further research is needed. It is hypothesized that high plateletcrit increases the risk of major cardiovascular events (MACE) in elderly acute coronary syndrome (ACS) patients treated in intensive cardiac care unit (ICCU).Objective. To determine the role of plateletcrit as a risk factor for major cardiovascular events in elderly acute coronary syndrome patients.Method. We collected samples of elderly patients who experienced ACS in the period January 2016 - December 2019, recorded plateletcrit data and whether there were MACE incidents or not. The data were processed in SPSS to find a cut off of plateletcrit values which are a risk factor for the occurrence of MACE in elderly patients at Dr. Sardjito Hospital.Result. A total of 174 study subjects consisted of 58 MACE and 116 non-MACE groups, the results showed that platelecrit ≥0.35 increased the risk of MACE with a p value of 0.046 and OR 5.49.Conclusion. Plateletcrit is statistically significant to the incidence of MACE in elderly coronary syndrome patients who are treated in intensive cardiac are units.
The Role of Neutrophil-Lymphocyte Ratio (NLR) as a Predictor of Successful Thrombolysis in Patients with STEMI at RSUP Dr. Sardjito Rahadiyani, IDA Swasty; Dinarti, Lucia Kris; Hartopo, Anggoro Budi
Acta Interna The Journal of Internal Medicine Vol 12, No 2 (2023): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.98238

Abstract

Background. Coronary atherosclerosis is a major cause of ST-elevation acute myocardial infarction (STEMI). Many factors influence the pathophysiology of atherosclerosis formation, and one of the most important is inflammation. Neutrophils have an important role in the progression and instability of atherosclerotic plaques that lead to acute coronary syndromes, while lymphopenia is caused by an increase in endogenous cortisol that occurs during acute stress in acute coronary syndromes. The neutrophil-lymphocyte ratio (NLR) is a combination of inflammatory markers, integrating the two roles of leukocyte subtypes with their respective pathways into one predictor factor that can be applied to the outcome stratification of patients with STEMI undergoing thrombolytic therapy.Objectives. To identify the role of NLR as a predictor of successful thrombolysis in patients with STEMI and knowing the NLR cut-off point that can act as a predictor of successful thrombolysis in patients with STEMI.Method. This study was a retrospective cohort study. The research subjects were patients who were first diagnosed with STEMI in the ER/ICCU Dr. Sardjito Hospital and who met the inclusion and exclusion criteria, from January 1, 2016, to November 30, 2020. The independent variable in this study was the NLR at admission. The dependent variable in this study was the success of thrombolysis. Characteristic data in this study are presented in the form of categorical data. Bivariate statistical analysis with Chi-Square test. The prognostic value for success of thrombolysis was analyzed using the Receiver Operating Characteristic curve to determine the NLR limit value, followed by calculating the Relative Risk (RR). Variables having p<0.25 were continued in multivariate analysis.Result. A total of 162 subjects met the inclusion and exclusion criteria. Overall, the success of thrombolysis was 81.5%. NLR values are in the range of 6 to 13 with a median value of 6.38. ROC NLR analysis on the success of thrombolysis obtained a cut-off of 10.16 fL. From the bivariate analysis for all possible predictors, 6 predictors had logistical significance (p<0.25) namely NLR, gender, age, BMI, onset, and Killip. From multivariate analysis, statistically significant independent predictors of thrombolysis success were NLR (p=0.007, OR 3.44), onset (p=0.003, OR 4.13), and Killip (p=0.009, OR 6.76).Conclusion. A low NLR can be used as a predictor of successful thrombolysis in STEMI patients at RSUP Dr. Sardjito, with 3.44 times higher compared to the high NLR.
Simplified Selvester QRS Score as an Infarct Size Parameter in STEMI Patients Undergoing Pharmacoinvasive or Primary Percutaneous Coronary Intervention Prasetia, Arif Eka; Hartopo, Anggoro Budi; Taufiq, Nahar; Bagaswoto, Hendry Purnasidha; Setianto, Budi Yuli
Jurnal Kardiologi Indonesia Vol 43 No 4 (2022): Indonesian Journal of Cardiology: October - December 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1186

Abstract

Background:Cardiovascular disease especially acute myocardial infarct (AMI) is one of the highest cause of mortality worldwide. Majority of AMI comes in the form of ST elevation myocardial infarct (STEMI) that requires timely diagnosis and revascularization management to restore myocardial circulation. The simple method to estimate infarct size is by using simplified Selvester QRS Score to electrocardiogram records, which is a tested method that have good correlation with gold standard, namely cardiac magnetic resonance imaging. Objectives : To investigate difference of infarct size with simplified Selvester QRS score parameter between STEMI patients undergoing pharmacoinvasive compared to primary PCI. Methods: Eighty-two STEMI patients, 41 of pharmacoinvasive and 41 of primary PCI was scored with simplified Selvester QRS score from electrocardiogram recording. Patient data are retroactively taken form Sardjito Cardiovascular Intensive Care (SCIENCE) registry. Scoring of simplified Selvester QRS Score was done by two experienced cardiologist blinded to patient procedure, and results then measured for interobserver agreement with Bland-Altman test. Comparison of QRS Score in pharmacoinvasive and primary PCI group was done with independent sample T test followed with multivariable linear regression test. Results: The means of simplified Selvester QRS score in pharmacoinvasive and primary PCI group is 7.240±3.015 and 8.900±4.188, p=0.043, respectively. Independent sample T test shows significant difference in the simplified Selvester QRS score in pharmacoinvasive and primary PCI group. The multivariable analysis shows that variables other than revascularization method independently influences QRS score are onset, anterior segment ST elevation and ST segment elevation in more > 3 leads in electrocardiogram. Conclusion: There is significant difference in infarct size measured by simplified Selvester QRS score betweem STEMI patient undergoing pharmacoinvasive method compared to primary PCI procedure, which is lower in the pharmacoinvasive group
Kardioversi Listrik yang Berhasil pada Wanita Kehamilan Tahap Akhir dengan Takikardia Supraventrikular Setiaji, Dimas; Jati, Lintang Daru; Shiddiq, Achmad; Hartopo, Anggoro Budi; Arso, Irsad Andi
Jurnal Kardiologi Indonesia Vol 44 No 4 (2023): Indonesian Journal of Cardiology: October - December 2023
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1280

Abstract

Background: Pregnancy, precipitate cardiac arrhythmia, and supraventricular tachycardia (SVT) are some most frequent and sustained arrhythmias in pregnancy. In general, the pharmacological approach in pregnant patient is similar to that in the non-pregnant patient. However, fetal safety becomes a special consideration before administering the therapy. Case Presentation: We reported a 34-year-old female G3P2A0 with 35 weeks of gestation who came to the emergency department with sudden onset palpitations within 2 hours before admission. She had no prior history of any major medical illness. The clinical examination revealed that the patient had a regular pulse rate of 198/minute, and the blood pressure was 80/50 mmHg. The electrocardiogram showed the presence of SVT. Synchronized cardioversion with 50 joules was performed. The patient’s rhythm was converted to sinus tachycardia with a pulse rate of 120/minute and blood pressure was 90/60 mmHg. The patient was admitted to ICCU immediately after cardioversion and discharged from the hospital without any adverse effects after two days of monitoring. Conclusion: SVT is arrhythmia condition that is often found in pregnant women. In an unstable SVT condition, cardioversion is the first general action that is safe to be performed on the mother and the fetus. It must have strict observation before and after cardioversion to monitor whether there was a problem with the fetus or not.
Co-Authors Abdul Majid Halim Wiradhika Abdul S Wahab, Abdul S Ageng Brahmadhi Ambari, Ade Meidian Anandini, Hesti Andreasta Meliala Anggraeni, Vita Yanti Anggrahini, Dyah Wulan Anwar Santoso Anwar Santoso Arityanti, Dean Armalya Pritazahra Badai Bhatara Tiksnadi Baiq Gerisa Rahmi Faharani Budi Yuli Setianto Cholid Tri Tjahjono Desandri, Dwita Rian Deva Bachtiar Deva Bachtiar Dwiputra, Bambang Dyah Wulan Anggrahini Erwan, Nabila Erina Fajarwati, Prahesti Febrianora, Mega Fitra, Maha Gumilang, Rizki Amalia Hariadi Hariawan Hasan, Harris Hasanah Mumpuni Hendry Purnasidha Bagaswoto Hergaf, Indah Widyasari I Dewa Putu Pramantara Iri Kuswadi Irsad Andi Arso Irsad Andi Arso, Irsad Andi Iswandi Darwis Jarir At Thobari Jarir At Thobari Jati, Lintang Daru Julia Sari Kathrine, Anita Septiana Maria Krevani, Citra Kiki Likke Prawidya Putri Lucia Kris Dinarti Lucia Kris Dinarti Lucida Kris Dinarti, Lucida Kris Luhur Pribadi Luhur Pribadi Lukman Ade Chandra Lukman Ade Chandra Makes, Indira Kalyana Mardiah Suci Hardianti Metalia Puspitasari Muhammad Gahan Sarwiko Muhammad Gahan Satwiko Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Ridwan Nahar Taufiq Nahar Taufiq, Nahar Pompini Agustina Sitompul Pompini Agustina Sitompul Prasetia, Arif Eka Putri Ayudhia Trisnasari Putrika Prastuti Ra Gharini Putrika Prastuti Ra Gharini Qhabibi, Faqrizal Ria Raden Heru Prasanto Rahadiyani, IDA Swasty Rahayu, Dian Herlusiatri Raynaldo, Abdul Halim Rita Hamdani Rizki Amalia Gumilang Rochmat, Muflihatul Baroroh setiaji, dimas Shiddiq, Achmad Sjughiarto, M.Afies Susilowati, Eliana Syaoqi, Muhammad Tarsidin, Najmi Fauzan Togi Junice Hutadjulu Togi Junice Hutadjulu Tri Asti Isnariani Tri Asti Isnariani Umi Sa'adatun Nikmah Umi Sa'adatun Nikmah Vina Yanti Susanti Vita Yanti Anggraeni Wiradhika, Abdul Majid Halim Yasmine Fitrina Siregar Yulia Wardhani