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INDONESIA
ACI (Acta Cardiologia Indonesiana)
Published by Universitas Gadjah Mada
ISSN : 24605700     EISSN : 25794345     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ACI (Acta Cardiologia Indonesiana) is published twice a year (biannually) by the Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol 3, No 1 (2017)" : 6 Documents clear
Aspirin and Clopidogrel Resistance in Coronary Artery Disease Fera Hidayati; Bambang Irawan; Hasanah Mumpuni
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29683

Abstract

Dual antiplatelet therapy has been proven effective to reduce recurrent cardiovascular eventin patients with coronary artery disease and recommended as standard therapy for acute coronary syndrome and patients who underwent percutaneous coronary intervention. The adverse clinical occurrence in patients who taking aspirin and clopidogrel associates with antiplatelet non responsiveness, in addition to repetitive bleeding incident in such a way that platelet reactivity and genetic polymorphisms investigation rises intense interest. Resistance to antiplatelet or antiplatelet non responsiveness means a phenomenon in which antiplatelet drug fails to deliver pharmacological target and it is determined by platelet function measurement. Recent laboratorymethods have been developed to diagnose antiplatelet resistance, but none of them was considered as standard tool since its wide inter-individual variability and poor correlation between them. The mechanism of antiplatelet resistance is not fully understood, multifactorial, involving pharmaco dynamic and pharmacokinetic of the drugs. This review is aimed to comprehend theantiplatelet resistance mechanism and provide crucial information on managing patients who take dual antiplatelet treatment with adverse clinical events. 
Prognostic Factor of Soluble ST2 Serum on 90 Days-Major Cardiovascular Events in ST-Elevation Acute Myocardial Infarction Patients with Reperfusion Therapy Pamrayogi Hutomo; Anggoro Budi Hartopo; Indah Sukmasari; Ira Puspitawati; Putrika Prastuti Ratna Gharini; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29680

Abstract

Background: Soluble ST2 (sST2) is released by strained myocardial. High baseline sST2 levels have been shown to be a predictor of mortality and heart failure in STEMI patients within 30 days and within 1 year, but its effect on medium-term events has not been widely investigated. Aims: To assess the prognostic factor of sST2 levels during admission with major cardiovascular events in the form of cardiovascular death and heart failure due to left ventricular dysfunction within 90 days of observation. Methods: A retrospective cohort study was conducted on STEMI patients with an onset of ≤ 24 hours undergoing reperfusion therapy from April 2014 - June 2015 in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The sST2 sample of venous blood was performed at admission. Primary outcomes for this analysis included cardiovascular death and congestive heart failure (CHF) through 90 days of follow-up. Assessment of major cardiovascular events was based on medical record data. Bivariate analysis were conducted on demographic and clinical factors related to sST2 and major cardiovascular events. A multivariate analysis was then conducted to determine the independent factors that influenced the emergence of major cardiovascular events. Results: Of the 107 patients who met the subject criteria, there were 33 (30.8%) subjects withmajor cardiovascular events and 74 subjects (69.2%) without major cardiovascular events in 90 days of observation. Of the 33 subjects with major cardiovascular events, there were 10 subjects (9.3%) died and 23 subjects (21.5%) with heart failure. The sST2 levels did not have a significant relationship with the incidence of mortality (p=0.617), heart failure (p=1.000), orboth combined (p = 1.000) in 90 days of observation. Conclusion: High serum sST2 levels during admission in STEMI patients who had undergonereperfusion therapy were not associated with increased incidence of major cardiovascular events (either the incidence of mortality or heart failure alone or both combined) in 90 days observation. 
Rehabilitation Program in a Patient Undergoing Mitral and Aortic Valve Replacement Surgery Purwati Pole Rio; Muhamad Taufik Ismail; Irsad Andi Arso
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29759

Abstract

Heart disease due to valvular anomaly has increased prevalence along with increasing age. The operative management including reparation or substitution with prosthetic valve is the main therapy. Still becoming question mark either rehabilitation program is benefcience for patient undergoing valvular surgery. We report a patient with heart failure due to valvular heart disease and underwent double valve replacement surgery. Cardiac rehabilitation phase 1 and phase 2 was done. Patient feel physical condition is much better than before.  
T Peak–T End Interval Alteration as Parameter of Successful Fibrinolysis in Patients with ST Segment Elevation Acute Myocardial Infarction Windhi Dwijanarko; Erika Maharani; Dyah Wulan Anggrahini
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29681

Abstract

Background: In STEMI patients, the duration of action potential dispersion occurs between normal and ischemic tissue due to the lengthening of the refractory period, causing transmural dispersion of repolarization, which could be detected with Tp-Te interval prolongation on the electrocardiogram (ECG). Benefits of fibrinolytic therapy in patients with STEMI has been demonstrated, with reduced mortality significantly and improve coronary patency in order to increase myocardial perfusion. The goal of this study was to determine Tp-Te interval alteration in STEMI patients before and after the fibrinolytic therapy between successful fibrinolysis compared to failed fibrinolysis. Method: Cross-sectional study was conducted to collect ECG from medical records at Dr. Sardjito General Hospital in January–September 2016. STEMI patients with onset less than 12hours whom reperfused with fibrinolytic therapy were registered. Tp-Te interval was measured before, soon after (0 minute), and 30 minutes after fibrinolysis with successful and failed results. The unpaired t-test analysis was used to compare Tp-Te interval alteration after fibrinolysis. Then, ΔTp-Te cut-off value was determined to find sensitivity and specificity based on ROC. Result: Among 84 patients enrolled in this study, 46 patients with successful fibrinolysis and 38patients with failed fibrinolysis. Both of groups had Tp-Te interval prolongation before fibrinolysis, with mean value of 120.30 ± 13.02 ms in successful fibrinolysis group and 118.57 ± 15.24 ms in failed fibrinolysis group. In successful fibrinolysis group, Tp-Te interval reduced significantly with ΔTp-Te value of 17.55 ± 13.35 ms on 0 minute and 20.85 ± 15.62 ms on 30 minutes after fibrinolysis, while in failed fibrinolysis group there was not a decrease of Tp-Te interval with ΔTp-Te value of -0.77 ± 11.00 ms on 0 minute (p <0.001) and -1.53 ± 14.35 ms on 30 minutes after fibrinolysis (p <0.001). Cut-off value ΔTp-Te 20 ms had sensitivity 52.2% and specificity 94.7% based on ROC, with strong discriminator value of AUC (0.888). Conclusion: There was a greater reduction of Tp-Te interval in STEMI patients with successful fibrinolysis compared to failed fibrinolysis, so it may be used as a alternative parameter of successful fibrinolysisKeywords: STEMI; Tp-Te interval; fibrinolysis
Recurrent Hemoptysis in Patient with Primary Pulmonary Hypertension – A Case Report and Literature Review Indra Widya Nugraha; Bambang Irawan; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29703

Abstract

Pulmonary hypertension (PH) is defned as an increase in mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg at rest as assessed by right heart catheterization (RHC). The symptoms of PH are non-specifc and mainly related to progressive right ventricular (RV) dysfunction. In some patients the clinical presentation may be related to mechanical complications of PH andthe abnormal distribution of blood flow in the pulmonary vascular bed, include hemoptysis related to rupture of hypertrophied bronchial arteries. Hemoptysis is a serious complication that is rarely reported in patients with pulmonary arterial hypertension (PAH). Hemoptysis severity ranges from mild to very severe leading tosudden death. Hemoptysis are reported to be a terminal stage ofa complication due to PAH with prevalence is variable, from 1% to 6%. Although the incidence is quite rare, the presence of recurrent hemoptysis in patients with pulmonary hypertension is a sign of poor prognosis. Bronchial artery embolization is suggested as an acute emergency procedure in the case of severe hemoptysis or as elective intervention in cases of frequent mild or moderate episodes. 
Correlation between Blood Pressure and Severity of Atherosclerosis in The Left Main Coronary Artery with CT Coronary Angiography Examination Esis Prasasti Inda Chaula; Nurdopo Baskoro
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29682

Abstract

Background: Cardiovascular disease, especially hypertension, is the main cause of death in both developed and developing countries. Hypertensioncan lead to atherosclerosis, which is the most common cause of ischemic and coronary heart disease. Some countries have used Computed Tomography Coronary Angiography (CTCA), which is a noninvasive test, to observe the anatomy of coronary artery. Nevertheless, invasive angiography isstill the gold standardfor coronary artery visualization. Atherosclerotic plaques cancause left main coronary artery stenosis. Purpose: The purpose of this research is to analyze the correlation between blood pressure and severity of the atherosclerosis in the left main coronary artery. With CTCA examination, the presence of plaque, severity of stenosis and type of plaques were assessed. Methods: The study design was analytic observational with cross sectional design. Data was drawn from medical records. The sample included a total of 29 patients which were suspected of having coronary heart disease and examined with CTCA who meet inclusion and exclusion criteria in Dr. Kariadi Hospital, Semarang, Indonesia. Result: The correlation between systolic blood pressure and left main coronary artery stenosis was obtained by Spearman’s rho r = 0.0429, p-value of with of 0.020 (2-tailed). The correlation between diastolic blood pressure and left main coronary artery stenosis was obtained by Spearman’s rho r = 0.354 with p-value of 0.060(2 -tailed). Some types of plaques were found in left main coronary artery, and systolic blood pressure are significantly different analysed usingAnova (analysis of variance) which probability was significant with p value 0.041. Conclusion: There was a significant correlation between systolic blood pressure and left main coronary artery stenosis. Therewas no correlation between diastolic blood pressure and left main coronary artery stenosis. Furthermore, there was a significant difference between systolic blood pressure and the type of plaques in the left main coronary artery. 

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