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ACI (Acta Cardiologia Indonesiana)
Published by Universitas Gadjah Mada
ISSN : 24605700     EISSN : 25794345     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ACI (Acta Cardiologia Indonesiana) is published twice a year (biannually) by the Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol 4, No 1 (2018)" : 7 Documents clear
The Shared Pathogenesis of Pulmonary Artery Hypertension Anggoro Budi Hartopo; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36635

Abstract

Pulmonary artery hypertension is defined as an increased in pulmonary artery pressureexceeding 25 mmHg with normal pulmonary wedge pressure. The pathogenesis of pulmonaryartery hypertension involves interaction among vascular, cellular and biomarker componentsin the pulmonary tissue; with eventual result is elevated pulmonary artery pressure. Vascularcomponents are remodeling of intimal, medial and adventitial layers. Cellular components areplayed by apoptosis-resistant endothelial cells, proliferative-prone pulmonary artery smoothmuscle cells, fibroblasts and inflammatory cells. The functional biomarkers are produced andmediated by these cellular changes, mainly endothelin-1, thromboxane, serotonin, nitric oxide,and prostacyclin. The pulmonary vascular remodeling in pulmonary artery hypertension arediverse and may present in various severity based on underlying etiology. Understanding theshared pathogenesis in pulmonary artery hypertension is of paramount importance in order toimprove the disease management and treatment approach.
Obesity in Patient with Grown Up Congenital Heart Disease Ventricular Septal Defect with Pulmonary Hypertension in Sanglah Hospital, Bali, Indonesia Nabila Natasya; Maya Paramita Wijaya; Yosi Kusuma; I Made Putra Swi Antara
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36636

Abstract

Ventricular septal defect (VSD) is a congenital heart disease (CHD) which characterized bya hole in the wall that separate between the right and left ventricle. There are several typesof VSD based on its location, which are perimembranous/conoventricular, subpulmonary/conotruncal, supracristal/doubly commited, muscular and atrioventricular canal/inlet. AVSD is one of the most common CHD which occurs in approximately 2-6 of every 1,000live births and accounts for more than 20% of all CHDs. However, the population of VSDpatients with grown up congenital heart disease (GUCH) is still uncertain. We are presentinga rare case of a 19 year old patient with congestive heart failure NYHA functional class IVdue to uncorrected left-to-right shunt supracristal VSD with body mass index of 35.5 kg/m2. He presented in the emergency room with acute decompensated heart failure profileB. Echocardiography revealed decreased left ventricle (LV) systolic function, normal rightventricle (RV) systolic function, decreased LV diastolic function, and dilated left atriumand LV. We plan to perform right heart catheterisation and pulmonary artery oxygenresponsiveness test followed by VSD closure in this patient. Another explanation will bediscussed in this paper.
Comparison of Predicted Significant Coronary Lesion by Duke Treadmill Score among Coronary Heart Disease Risk Factors in Patients with Positive Ischemic Response Treadmill Test David Rubiyaktho; Cholid Tri Tjahjono
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36632

Abstract

Background: According to Framingham Study, independent risk factors for coronary heart disease (CHD) are diabetes, hypertension, smoking, dyslipidemia, family history of CHD and obesity. Previous study reported cut-off value of Duke Treadmill Score (DTS) < -0.5 represents a significant coronary lesion with positive predictive value 88.4%. Objective: To compare the incidence of predicted significant coronary lesions by DTS among various risk factors for coronary heart disease. Methods: A cross sectional study was done on 292 patients age 18 to 74 years old who had positive exercise testing for CAD screening during period of June 1st 2016 until May 30th 2017. DTS was calculated from treadmill test as: exercise time - (5 x ST deviation in mm) - (4 x exercise angina). A coronary lesion was predicted significant with DTS cut off value < -0.5. Results: Subjects mean age was 57 years old, male were 60.4%. The risk factors for CHD were found sequentially from the most frequent were hypertension 51.9%, smoking 35.3%, diabetes mellitus 23.1%, dyslipidemia 11.9%, obesity 4.2% and family history of CHD 6.3%. It was found that diabetes was significantly different from its effect on DTS value with p value = 0.021, while hypertension, obesity, dyslipidemia and family history CHD had no significant effect. Logistic regression found consistently that diabetes was significant (p=0.019). Conclusion: Predicted significant coronary lesions by DTS developed more frequent in diabetes compared to, hypertension, smoking, dyslipidemia, obesity and family history of coronary heart disease.
Atrial Fibrillation in Dengue Infection: A Self-limiting Phenomenon? (Two Case Reports) Raymond Pranata; Wendy Wiharja; Vito Damay
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36637

Abstract

Dengue fever (DF) is highly prevalent in Indonesia as evidenced by 129,650 cases in 2015.Atrial fibrillation (AF) in dengue is exceptionally rare and usually self-limiting with resolution after recovery of illness. The aim of this case report is to depict two patients with AF in DF which resolves spontaneously in one and persists after infection in the other. Case 1 was 50 years old male presented with fever since 4 days before admission. NS1 antigen and IgM anti-Dengue virus were positive. An electrocardiogram (ECG) showed AF with rapid ventricular response (AFRVR). Case 2 was 53 years old male presented with dyspnea and palpitations 1 hour before admission. Patient had fever since 5 days before admission. Laboratory exams showed leukopenia, thrombocytopenia and positive IgM anti-Dengue virus. An electrocardiogram showed AFRVR. Intravenous fluids (normal saline), paracetamol, and digoxin were administered in both patients. They were admitted for close monitoring. Pre-discharge ECG of Case 1 showed resolution of AF. However, in Case 2, AF persists in pre-discharge ECG. In conclusion, physicians should be aware that a potentially reversible atrial fibrillation might be caused by this infection. It should be ensured that in those persisting cases, they should not be dismissed as just an ‘irreversible’ AF and progress into full-blown heart failure.
The Characteristics and Distribution of Congenital Heart Disease in Outpatient Clinic and Inpatient Ward of RSUD Dr. Soedono Madiun East Java in Year 2015 Finariawan Finariawan; Syifa Mahmud S.A.
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36633

Abstract

Background: Congenital heart disease is a heart abnormality that presents at birth and fatal in the majority of the case. Congenital heart disease affecting up to 8-10 in every 1,000 newborn. Methods: This study was a descriptive research about the characteristics and distribution of congenital heart disease at ward and clinic of a government hospital in East Java for a year, by investigating medical record from 1 January 2015 – 31 December 2015. We classified and analyzed the patients based on the different groups of age, gender, type of congenital heart disease, the age of first diagnosed, nutritional status, co-morbidities of the disease, medical intervention, and the funding. Result: Total sample from this research was 49 subjects, consist of 53% male and 46% female. CHD was mostly diagnosed in the first year of life (75%), with acyanotic CHD as the most common type. Malnutrition was found in 51% of the subjects. Nonsurgical medical intervention was the most common management performed to treat the condition (97%). The funding with National Health Insurance (PBI or non-PBI) was used in more than half of the subjects (51%). Conclusion: As the conclusion, CHD was commonly found in the first year of life with noncyanotic type dominated the CHD patients. As the highly cost of this disease, it was surprising that only half of the subjects were covered by National Health Insurance. A good funding resource was really needed to make sure the treatment plan of the diseases was well executed.
Pulmonary Artery Hypertension Associated with HIV Infection in Nine Year-Old Child Baskoro Adi Prabowo; Abdus Samik Wahab; Hasanah Mumpuni
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36638

Abstract

Pulmonary arterial hypertension (PAH) is a serious life threatening and severe complication ofHIV infection. A PAH presentation in patient with HIV tends to non specific, result in recognizeddiagnosis at a later stage. A 9 year-old HIV patient came to Pediatric Clinic with a chief complaint of worsening dyspneu for 1 month, leg edema and difficulty lying on a flat bed. Patient showed signs and symptoms that lead to pulmonary hypertension. An ECG findings were sinus rhythm, right axis deviation, and right ventricular hypertrophy. Echocardiography findings showed rightventricular and atrial enlargement, and high probability of pulmonary hypertension. Blood examination showed CD 4 was 84 cells/μL. The patient was managed as pulmonary arteryhypertension associated with HIV (HIV-PAH) infection.The patient was admitted for 3 weeksand eventually discharged with relieve condition.
Correlation between Left Ventricular Eccentricity Index and Mean Pulmonary Arterial Pressure in Secundum Type Atrial Septal Defect Adult Patients Citra Dewi Wahyu Fitria; Azhafid Nashar; Dyah Wulan Anggrahini; Anggoro Budi Hartopo; Hasanah Mumpuni; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36634

Abstract

Background: Secundum type atrial septal defect (ASD) is the most common adult congenital heart disease. Hemodynamically, ASD result in a left-to-right shunt that causes right heart volume overload. This condition affects interventricular septal position and shape. Left ventricular (LV) eccentricity index (EI) suggests right ventricle (RV) overload when this ratio is >1.0. The aim of this study was to assess correlation between LV EI and mean pulmonary arterial pressure (mPAP) in secundum type ASD patients. Methods: We conducted a cross sectional study from ASD patients registry data. We enrolled subjects with secundum type ASD from the complete registry data. The LV EI was calculated from transthoracal echocardiography. The mPAP was measured by right heart catheterization as a gold standart. The correlation was performed by Spearman correlation test. Results: There were 40 adult secundum type ASD patients participated. The mean LV EI in enddiastolic was 1.55±0.39 and LV EI in end-systolic was 1.75±0.58. The median value of mPAP was 29 (12-99) mmHg. There was a moderate strength, positive and significant correlation between LV EI in end-diastolic and mPAP (r=0.37, p=0.018). The correlation was more significant and stronger between LV EI in end-systolic and mPAP (r=0.52, p=0.001). Conclusion: There was sufficiently strong and significant correlation between LV EI in both end-diastolic and end-systolic phase with mPAP in adult secundum type ASD.

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