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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,731 Documents
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Embryo Quality: The Most Critical Factor for Pregnancy Rates after day-2, day-3, and day-5 of Embryo Transfer Tono Djuwantono
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To determine the most critical factor on day-2, day-3, and day-5 of embryo transfer in correlation with pregnancy rates. Method: This research is a retrospective study in Aster Fertility Clinic, IVF program- Dr. Hasan Sadikin Hospital, Bandung, Indonesia. One hundred ninety five women enrolled in an IVF program conducted from March 2006 through November 2009 at the Aster Fertility Clinic. Effect of embryo-transfer day and any other factors (including quality of embryo, oocyte quantity, difficulty of embryo transfer technique, and blood or mucus contamination on the catheter) on pregnancy rate in IVF. Results: The mean age of the pregnant group was 34.65 (SD = 3.91), and the mean of the infertility period was 7.25 years (SD = 3.54). There were no siginificant differences in pregnancy rates in the day-2, day-3, and day-5 groups. The most critical factor influencing pregnancy was the total score for the quality of embryos [p = 0.001; OR (CI 95%) = 1.94 (0.91 - 4.08)]. Otherwise, the day of embryo transfer, oocyte quantity, and difficulties in embryo transfer did not affect the pregnancy rate (p > 0.05). Conclusion: Our study suggests that the total score for the quality of the embryos was the most critical factor for the success rate of pregnancy rather than the day of embryo transfer, oocyte quantity, difficulty of embryo transfer technique, or contamination of blood and mucus on the catheter. [Indones J Obstet Gynecol 2010; 34-4: 175-9] Keywords: day of embryo transfer, in vitro fertilization, quality of embryo total score, oocytes quantity, catheter contamination
Predictive Factors for Pregnancy in IVF: An Analysis of 348 Cycles Budi Wiweko
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To determine predictive factors for pregnancy after IVF. Method: The subject of this study were three hundred and forty eight IVF cycles in 266 couples who underwent controlled ovarian hyperstimulation in IVF cycles between January 2005 and March 2010. Categorical variables were compared using Chi Square test and continuous variables were analyzed using Independent t-test, p < 0.05 was considered statistically significant. Multivariate logistic regression analysis was done to test correlations between clinical variables and the occurrence of pregnancy. Results: The women’s age significantly influenced pregnancy rate since women under 35 years old has the best chance for pregnancy (56.4%). Endometrial thickness on the day of hCG administration also significantly influenced pregnancy in IVF (p < 0.001) because 64.1% of pregnancy occurred if endometrial thickness ≥ 10.95 mm. Serum FSH on 3rd day of period that can predict ovarian reserve also has significance on pregnancy. On the other hand, 61.5% pregnancy occurred if more than 6 mature oocytes were retrieved (p < 0.001). Among 92 patients of 348 cycles we found strong correlation between AMH level with number of mature oocytes retrieved (p < 0.001; r 0.659). Logistic regression done revealed the couple with best chance of pregnancy can be described as follows: women with endometrial thickness ≥ 10.95 mm, number of mature oocytes > 6 and age under 35 years old. Conclusion: This study enabled the characterization of many prognostic factors for pregnancy. [Indones J Obstet Gynecol 2010; 34-4: 180-4] Keywords: in vitro fertilization, clinical pregnancy, age, mature oocytes, endometrial thickness
The Influence of Low HLA-G Protein Expression on Hsp-70 and VCAM-1 Profile in Preeclampsia Sri Sulistyowati
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To analyze HLA-G, Hsp-70, and VCAM-1 proteins expression on trophoblast in women with preeclampsia and women with normal pregnancy, and to assess causality relationship between low HLA-G expression and the increased Hsp-70 and VCAM-1 expression in preeclampsia. Method: Observational analytic study with cross sectional design. Results: Trophoblastic HLA-G expression in pregnant women with preeclampsia is lower (p = 0.01) than its expression in women with normal pregnancy. The expressions of Hsp-70 (p = 0.02) and VCAM-1 (p = 0.00) in preeclampsia are higher, compared to normal pregnancy. Regression analysis showed that low HLA-G is a predictor for the increase of trophoblastic Hsp-70 and VCAM-1. Conclusion: Low trophoblastic HLA-G in is a predictor for endothelial dysfunction in women with preeclampsia. [Indones J Obstet Gynecol 2010; 34-4: 185-90] Keywords: preeclampsia, HLA-G, Hsp-70, VCAM-1, endothelial dysfunction
IL-10 Serum Concentration was Observed Higher in Threatened Preterm Labor Nurul Afriana
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To determine the serum concentration of Th-1 and Th-2 cytokine in threatened preterm labor compared to that in normal pregnancy. Method: The design was analytical cross-sectional, comparing the serum levels of TNF-α, IL-2, IL-10, TNF-α to IL-10 ratio and IL-2 to IL-10 ratio between 29 subjects with threatened preterm labor and 29 normal pregnant women. The cytokine concentration was measured with ELISA. T test and Mann-Whitney U test was used for statistical analysis. Results: The mean concentration of TNF-α and IL-2 in both groups did not reveal any difference (p = 0.188 and p = 0.493). Median of IL-10 serum concentration in the threatened preterm labor (PTL) group was observed higher than that observed in the normal pregnancy group (p = 0.001). Compared to normal pregnancy group, the TNF-α to IL-10 ratio in the PTL group was observed lower (p = 0.009). Both groups did not show any difference in the IL-2 to IL-10 ratio (p = 0.057). Conclusion: The IL-10 serum concentration was increased in threatened preterm labor. There was no difference observed in the Th-1 to Th-2 cytokines serum ratio in threatened preterm labor as compared to normal pregnancy. [Indones J Obstet Gynecol 2010; 34-4: 191-4] Keywords: IL-10, preterm labor, Th-1 and Th-2 cytokines
The use of B-Lynch Technique and Lasso-Budiman Technique to Control Postpartum Hemorrhage in Uterine Atony Muhammad Nurhadi Rahman
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To evaluate the use of B-Lynch Technique and Lasso Budiman Technique as conservative way to control post partum hemorrhage due to uterine atony. Method: The cross-sectional retrospective study in Department of Obstetrics and Gynecology, Tangerang General Hospital, Banten, year 2005 - 2008 and Department of Obstetrics and Gynecology, Wonosobo General Hospital, Central Java, year 2003 - 2008. Results: Total 38 post partum hemorrhage cases managed conservatively using B-Lynch technique and Lasso-Budiman technique. Twenty-six cases were done at Wonosobo General Hospital using B-Lynch technique, with 1 failure case and hysterectomy was done with good result. No complications has been reported for the rest 25 successful cases. Twelve cases were done at Tangerang General Hospital, using Lasso-Budiman technique, 1 failure reported, continue to hysterectomy. Among 11 successful cases, 2 complications were found. Ssecondary amenorrhea after performing Lasso-Budiman technique due to uterine sinechia were reported. Conclusion: The B-Lynch technique and Lasso-Budiman technique, both are simple, easy, and effective to control post partum hemorrhage due to uterine atony. If failed, hysterectomy is the last choice. These techniques are also effective methods to conserve uterus and fertility. [Indones J Obstet Gynecol 2010; 34-4: 195-8] Keywords: postpartum hemorrhage, conservative methode, BLynch technique, Lasso-Budiman technique
Management Therapy in Chronic Ectopic Pregnancy Aryando Pradana
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: Improving skill in making a diagnosis and management therapy in chronic ectopic pregnancy. Method: Case Report. Conclusion: Diagnosis of chronic EP is difficult to establish before surgery. Conservative treatment using medication (methotrexate) can not be applied to chronic EP because the β-hCG level is difficult to be detected. [Indones J Obstet Gynecol 2010; 34-4: 199-203] Keywords: ectopic pregnancy, chronic ectopic pregnancy
Adhesion Prevention in Operative Laparoscopy Wachyu Hadisaputra
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To know the modalities used for prevention of adhesion formation in operative laparoscopy. Method: Literature study. Results: Methods of prevention of adhesion in laparoscopy include: modification of surgical technique, anti-inflammatory agents, peritoneal instillates and barrier adjuvants. Modification of surgical techniques such as adherence to basic principles of microsurgery, the use of electrothermal bipolar vessel sealer, liberal irigation of the abdominal cavity and instillation of a large amount of Ringer’s lactate at the completion of the procedure. This technique alone, eventhough seems effective, is insufficient. The anti-inflammatory agents used are the NSAIDs, corticosteroids, antihistamines, progestogens, GnRH agonists and calcium channel blocker. But none of them demonstrated to be significantly effective. Barrier adjuvants consist of: oxidized regenerated cellulose (ORC) and expanded polytetrafluoroethylene (ePTFE) and peritoneal instillates are the crystalloids, icodextrin, hyaluronic acid (HA), solution of HA, viscoelastic gel, hydrogel, and fibrin sealent. There is insufficient evidence data regarding the methods above for the prevention of adhesiogenesis in laparoscopy. But one study evaluating the use of viscoelastic gel did significantly reduce adnexal adhesion in laparoscopy. Conclusion: Laparoscopy does not trully eliminate the adhesiogenesis problem. No single therapy is effective for prevention of adhesion formation. The multimodal methods shall be used to increase the successful rate in adhesion prevention. [Indones J Obstet Gynecol 2010; 34-4: 204-7] Keywords: laparoscopy, adhesion, microsurgery, anti-inflammatory, peritoneal instillates, barrier adjuvants
High Level of Tumor Necrosis Factor (TNF)-α is a Risk Factor for Preeclampsia I.G.N. Anom
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.779 KB) | DOI: 10.32771/inajog.v36i3.306

Abstract

Objective: To define that elevated TNF-α serum level was the risk factor of preeclampsia in pregnancy. Method: This research is a case-control study. From 56 pregnant women, there are 28 women with preeclampsia and the other 28 women with normal pregnancy. Then the serum level of TNF-α was obtained at Prodia’s clinical Laboratory Denpasar. Data’s normality test was done with Kolmogorov-Smirnov, then an analysis of data was done with Independent Sample Test, predictive value a = 0.05. To define the role of TNF-α level in preeclampsia, Chi-Square test was chosen. Result: From this research we found the average level of TNF-α in preeclampsia (6.64 ± 7.64 pg/ml) was higher than in normal pregnancy (2.42 ± 1.77 pg/ml). Analysis with t-independent test shows that the t-value was 2.85 and p-value was 0.006, which means that the average level of TNF-α between the two group was significantly different (with predictive value, p<0.05). Based on cut-off value 2.42 pg/ml, the relative risk for preeclampsia was six time (RO = 6.33, IK 95%=1.97-20.34, p = 0.001) in patient with TNF-α level greater than 2.42 pg/ml. Conclusion: TNF-α level in preeclampsia was significantly different with TNF-α level in normal pregnancy and the elevated serum level of TNF-α in pregnancy could be one of the risk for preeclampsia. [Indones J Obstet Gynecol 2012; 36-3: 107-11] Keywords: normal pregnancy, preeclampsia, TNF-α
Lower Glutathione Peroxidase Serum Level Compared to Normal Pregnancy Kadek Pramarta
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.928 KB) | DOI: 10.32771/inajog.v36i3.307

Abstract

Objective: To determine the difference of glutathione peroxidase (GPx) in threatened miscarriages and normal pregnancy. Method: This is an analytic cross sectional study with 42 samples divided into two groups. Group 1 consists of 21 cases of threatened miscarriages with < 20 gestational age and group 2 is divided into 21 normal pregnancies of < 20 weeks gestational age. We took 3 cc of blood samples from the cubiti veins and mixed it with EDTA. Its GPx quantities were than examined at the Pathology Lab at Sanglah General Hospital. Data was then analyzed using the Shapiro Wilk Test and the independent t-test with p < 0.05. Result: From this research, we obtained the mean GPx levels on the threatened miscarriages was 49.92 ± 14.17 U/g Hb lower than the mean of normal pregnancy levels, which was 88.94 ± 30.11 U/g Hb. Conclusion: The quantities of GPx between threatened miscarriages and normal pregnancies are statistically different, in which the quantity of GPx in threatened miscarriages is lower compared to normal pregnancy. [Indones J Obstet Gynecol 2012; 36-3: 112-5] Keywords: GPx, normal pregnancy, threatened miscarriages
High Expression of Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) is Highly Correlated with Eclampsia Efendi Lukas
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.534 KB) | DOI: 10.32771/inajog.v36i3.308

Abstract

Objectives: To understand the expression of placental vascular endothelial growth factor receptor (VEGFR-1) in severe preeclampsia with complication (eclampsia and HELLP syndrome). Methods: The study was an observational study with cross sectional design, performed at several hospitals of Department of Obstetrics and Gynecology Medical Faculty of University of Hasanuddin, Makassar. Subjects met to inclusion criteria were taken as samples. Placental tissue samples were taken from cord insertion site and fixated with formalin buffer solution. Immunohistochemical examination was performed at Center of Research University of Hasanuddin. Antibody used were primary antibody of Mouse monoclonal anti VEGFR-1 antibody (Santa Cruz) dissolved to 1:100 and link antibody (secondary antibody labeled with biotin) (Dakopatt). Placental tissues were examined in Streptavidin biotin peroxides and interpreted according to the intensity of trophoblast cytoplasmic dye. Results: High VEGFR-1 expression was found in 100% of the placenta from patients with eclampsia , 42.9&% in patients with HELLP syndrome and 37.8% in patients with severe preeclampsia. High VEGFR-1 expression was correlated to incidence of eclampsia (p=.000) and not correlated to severe preeclampsia and HELLP syndrome (p=0.734). Conclusion: High VEGFR-1 expression was correlated to eclampsia and not correlate to severe preeclampsia and HELLP syndrome. [Indones J Obstet Gynecol 2012; 36-3:116-20] Keywords: eclampsia, HELLP syndrome, severe preeclampsia, VEGFR-1 expression

Page 116 of 174 | Total Record : 1731

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