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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 5 Documents
 1 
Search results for , issue "Vol 5, No 1" : 5 Documents clear
Anti-inflammatory Activity of the Gel Containing a Combination of Neem Leaf Extract and Shallot Extract Sara Nurmala; Moerfiah Moerfiah; Restu T. Purnama
Pharmacology and Clinical Pharmacy Research Vol 5, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (351.124 KB) | DOI: 10.15416/pcpr.v5i1.26133

Abstract

Neem leaves (Azadirahcta indica A. Juss) and shallots (Allium cepa L) contain flavonoids that are effective as an antioxidant, antibacterial, and anti-inflammatory. The aim of this study was to determine the effective concentration and the duration of treatment of the anti-inflammatory activity of the gel containing a combination of neem leaf extract and shallot extract. These substances have a similar effect, and it is believed that these combinations may effective as an anti-inflammatory at small doses to reduce the side effects. The animals were randomly divided into 6 groups with 5 rats per group. The rats were wound-induced by incising its back (length 1.5 cm, depth 0.7 mm) and were observed for 8 days. Parameters measured were wound’s closure, color, and healing process. Statistical analysis showed that the most effective concentration as an anti-inflammatory was formula 1 (neem leaf extract 3.125%: shallots extract 4%) with the fastest healing time was 5 days. Thus, this formula is one of the effective treatment options for healing wounds.Keywords: neem leaves, shallots, anti-inflammatory, combination, gel
The Profile of Antihypertensive Drug Prescriptions and Interactions at Pindad General Hospital Yane S. Herliany; Siti R. Wahyuningsih
Pharmacology and Clinical Pharmacy Research Vol 5, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.483 KB) | DOI: 10.15416/pcpr.v5i1.26172

Abstract

Hypertension is a major problem in the world. World Health Organization (WHO) reported that 1.13 billion people in the world suffer from hypertension. This study aimed to determine antihypertensive prescription profile and drug interaction in outpatient installation at PINDAD General Hospital, Bandung in January 2019. This study was non-experimental observational studies with retrospective data collection. There were 381 patients with hypertension (50,13% female and 49,87% male). The most widely used antihypertensive drug is Amlodipine (33,28%) and Calcium Channel Blocker drug (34,20%). Moreover, we found 74,07% was moderate drug-drug interaction (DDI) with Amlodipine and Lisinopril as the most common cases (21,08%). We concluded that 15,7% prescription contain antihypertensive drugs and moderate DDI occurred in the use of amlodipine and lisinopril. DDI should get more attention due to the clinical manifestations that may occur in patients.
Assessment of Factors Influencing Adherence to Antidiabetic Drugs among Patients with Type 2 Diabetes Mellitus at a Tertiary Care Hospital in India Nandini H C; Akshay Gali; Sushma Muraraiah
Pharmacology and Clinical Pharmacy Research Vol 5, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i1.26507

Abstract

Diabetes mellitus is a chronic endocrine disorder that requires long-term treatment. Non-adherence to anti-diabetic drugs is common and associated with poor outcomes. Non-adherence leads to complications, higher incidence of hospital admissions and imposes economic burden. Hence, the present study was undertaken to measure adherence to anti-diabetic medication and factors contributing to it. This cross-sectional study was conducted among patients on anti-diabetic medication after taking their informed consent in a tertiary care hospital in India. Each patient’s demographic, clinical, and treatment data along with the adherence to treatment has been assessed during a personal interview with each patient using Medication Adherence Report Scale (MARS-5). Factors contributing to medication adherence was assessed using chi-square test. A total of 250 patients were recruited in the study. The mean age was 54 years and non-adherence to anti-diabetic medications was 21.6%.  Univariate Analysis showed that marital status, education status, good glycemic control, illness >5years had a statistically significant association (p=<0.05) with self-reported adherence to anti-diabetic medication.
Synthesis and Molecular Docking Study of 1-(3-Chloropropyl)-3,5-Bis((E)-4-Methoxybenzylidene)Piperidin-4-One as Dengue Virus Type 2 (DEN2) NS2B/NS3 Protease Inhibitor Candidate Romi Habibi; Noval Herfindo; Rudi Hendra; Hilwan Y. Teruna; Adel Zamri
Pharmacology and Clinical Pharmacy Research Vol 5, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i1.25624

Abstract

Curcumin is a secondary metabolite compound that has diverse biological activities. However, it is easily hydrolyzed at physiological pH due to the presence of the β-diketone group. Therefore, the replacement of the β-diketone group with mono ketone is expected to overcome this issue. We hereby report the synthesis of mono ketone curcumin derivatives from piperidone by two-steps reactions. The synthesis of curcumin derivate 3 was carried out by Claisen-Schmidt condensation between 4-piperidone and 4-methoxybenzaldehyde using alkaline catalyst. The synthesized curcumin derivate 3 was then reacted with the 1-bromo-3-chloropropane to produce curcumin derivate 5, 1-(3-chloropropyl)-3.5-bis((E)-4-methoxybenzylidene)piperidin-4-one, with 72% yield. The calculated docking scores, the curcumin derivate 5 possessed a better affinity for receptors than the standard panduratin A. The curcumin derivate 5 has a lower docking score of -6.40 kcal/mol compared to panduratin A with value of -5.18 kcal/mol and also had strong binding interactions to DEN2 NS2B/NS3 protease. Thus, this compound is promising candidate as a new anti-dengue agent.
Knowledge, Attitude and Practice of Insulin Use of Diabetic Patients in India Venkataraman A P; Laxminarayana Kamath; Samhita Shankar
Pharmacology and Clinical Pharmacy Research Vol 5, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.747 KB) | DOI: 10.15416/pcpr.v5i1.26564

Abstract

 Diabetes mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. India is emerging as the world diabetic capital. Insulin is a therapeutic option to treat either type 1 and type 2 DM. Inadequate awareness about the use of insulin is likely to influence its acceptance and adherence. The present study was done to assess the knowledge, attitude, and practice regarding insulin use among diabetic patients at Victoria Hospital, Bangalore, India. Knowledge, attitude, and practice of sixty diabetic patients (either inpatients or outpatients) were assessed by using a validated questionnaire consisting of 24 items. Scores were allotted to each question and evaluated after applying appropriate statistical tests. The mean age of the patients was 53.51±6.48 years (58.33% males). The mean knowledge score was 9.06±1.88 out of 22, attitude score was 4.78±1.37 out of 12 and practice score was 7.75±1.24 out of 11. The mean score of attitude was better in females compared to male patients (5.32±1.34 vs. 4.4±1.28). Male patients scored 38.57% compared to female patients (41.33%) for the question regarding symptoms of hypoglycemia. 57.14% of male patients and 72% of female patients carried simple carbohydrates when going out. Despite good practice scores, the knowledge and attitude scores regarding insulin use were inadequate. Potential adverse effects of insulin can be avoided and better knowledge, attitude, and practice can be achieved by providing proper education to patients. Keywords: knowledge, attitude, practice, diabetic, insulin 

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