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JURNAL KIMIA SAINS DAN APLIKASI
Published by Universitas Diponegoro
ISSN : 14108917     EISSN : 25979914     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering
urnal Kimia Sains dan Aplikasi (p-ISSN: 1410-8917) and e-ISSN: 2597-9914) is published by Department of Chemistry, Diponegoro University. This journal is published four times per year and publishes research, review and short communication in field of Chemistry.
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Articles 6 Documents
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Search results for , issue "Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024" : 6 Documents clear
Green Synthesis of 4-Nitro-4’-Methoxy Chalcone by Grinding Technique and its Antibacterial Activity Elfi Susanti V. H.; Sri Mulyani; Sri Retno Dwi Ariani; Suryadi Budi Utomo; Muhammad Hizbul Wathon; Widiastuti Agustina Eko Setyowati
Jurnal Kimia Sains dan Aplikasi Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.12.597-602

Abstract

This research aims to synthesize 4-nitro-4’-methoxy chalcone and determine the potential of 4-nitro-4’-methoxy chalcone as an antibacterial against Staphylococcus aureus and Escherichia coli bacteria. The synthesis of 4-nitro-4’-methoxy chalcone was carried out using the grinding technique, an environmentally friendly green synthesis approach—characterization of the synthesized chalcone using FTIR, 1H-NMR, and 13C-NMR. The research demonstrated that 4-nitro-4’-methoxy chalcone could be synthesized via grinding techniques using 4-methoxyacetophenone, 4-nitrobenzaldehyde, and NaOH as catalysts. The synthetic process achieved higher yields and was environmentally friendly due to the absence of organic solvents. The resulting product was yellow crystalline with a yield of 54.42% and a melting point of 172°C–173°C. Antibacterial activity tests revealed that the synthesized chalcone exhibited greater inhibition against E. coli than S. aureus. This was evidenced by the clear zones formed (9.57 mm for S. aureus and 12.46 mm for E. coli), indicating that 4-nitro-4’-methoxy chalcone possesses strong antibacterial activity.
Optimization of Zn/Al-Oxalate Hydrotalcite as an Environmentally Friendly Adsorbent for Dye Waste Processing Dian Windy Dwiasi; Ely Setiawan; Aisyah Nur Izah; Arikunto Tegar Rizqian
Jurnal Kimia Sains dan Aplikasi Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.12.603-610

Abstract

Methylene blue is a synthetic dye commonly used in the textile industry. Methylene blue waste that is discharged into water bodies without treatment causes environmental pollution. One method of waste treatment is adsorption. Hydrotalcite is an anionic clay consisting of stacked positively charged layers, usually divalent (+2) and trivalent (+3) metal cations, and has anions between the layers. This study aims to determine the synthesis method of Zn/Al-Oxalate hydrotalcite, and its characterization results are compared with Zn/Al-NO3 hydrotalcite to determine the optimum conditions of Zn/Al-Oxalate hydrotalcite in adsorbing methylene blue dye and to determine the kinetic and isotherm models of adsorption. Zn/Al-Oxalate hydrotalcite was successfully synthesized by the coprecipitation method and continued with the hydrothermal process at a temperature of 120°C for 20 hours. Hydrotalcite Zn/Al-Oxalate was characterized using FTIR and XRD. The optimum condition of hydrotalcite Zn/Al-Oxalate in adsorbing methylene blue dye was carried out by the batch method at optimum pH 7, contact time 60 minutes, adsorbent weight 80 mg, and methylene blue concentration 20 mg/L. The adsorption kinetics of hydrotalcite Zn/Al-Oxalate in adsorbing methylene blue followed the pseudo-second-order model. with a value of R2 = 0.9996 and k = 0.2047 mg/g.min and the adsorption isotherm follows the Langmuir adsorption isotherm model R2 = 0.9904, qm = 19.8413 mg/g and kL = 2.913 L/mg.
An Investigation into the Anti-Aggregation Potential of Swietenia macrophylla Triterpenoid on Bovine Serum Albumin: Docking and RMSF Bayu Fajriansyah Al-Khairi; Mukhammad Asy'ari; Agustina L. N. Aminin
Jurnal Kimia Sains dan Aplikasi Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.12.560-568

Abstract

Protein aggregation, caused by environmental factors, can lead to neurodegenerative diseases. Hydrophobic compounds like latrepirdine are used in medical treatments like anti-Parkinson’s and Huntington’s diseases. Swietenia macrophylla contains abundant hydrophobic compounds from the triterpenoid group, but their anti-aggregation potential has not been reported. This study investigates the hydrophobic interactions and anti-aggregation potential of triterpenoid compounds, including swietenine, swietenolide, khayasin T, beta-sitosterol, and stigmasterol, against bovine serum albumin (BSA). Latrepirdine is employed as the control compound. In silico methods, molecular docking and molecular dynamics showed potential in clusters 1 and 2, with swietenine having a more stable RMSF value than latrepirdine. The study found four clusters with all ligands, with cluster 1 being the earliest protein opening area. Mahogany seed triterpenoid compounds have potential in cluster 1 (51-67%), while cluster 2 has 37-46%. In cluster 2, they have an advantage over latrepirdine (2%). Stigmasterol and beta-sitosterol are spread across the clusters. The swietenine compound has a more stable RMSF value than latrepirdine. This suggests that mahogany seed triterpenoid compounds have potential as anti-aggregation agents.
Thermodynamic Study of Chitosan as a Corrosion Inhibitor for Carbon Steel in Chloride Solutions (NaCl and HCl) at Various Temperatures and Concentrations Khafid Ubay Ilyas; Eni Budiyati; Nur Hidayati; Tri Widayatno
Jurnal Kimia Sains dan Aplikasi Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.12.569-579

Abstract

This research investigates the thermodynamic characteristics of chitosan as a corrosion inhibitor for carbon steel in chloride electrolyte environments, specifically saturated sodium chloride and 1 M hydrochloric acid, across different temperatures and concentrations. The study aimed to evaluate the effectiveness of chitosan in preventing corrosion and to examine the thermodynamic characteristics of the adsorption process. The results revealed that chitosan achieved the highest inhibition efficiency of 90.07% in a 1 M hydrochloric acid solution with a concentration of 250 mg/L at 303.15 K. In contrast, the maximum inhibition efficiency in a saturated sodium chloride solution was 50.50% at the same concentration of 250 mg/L and 303.15 K. Thermodynamic analysis showed that the adsorption of chitosan is spontaneous and exothermic in both media. The standard free energy of adsorption was found to be -38.63 kJ/mol at 303.15 K, decreasing to -43.69 kJ/mol at 343.15 K in saturated NaCl, and -42.40 kJ/mol at 303.15 K, decreasing to -48.65 kJ/mol at 343.15 K in 1 M HCl. The enthalpy of adsorption was -0.24976 kJ/mol in NaCl and 4.93560 kJ/mol in HCl, while the entropy of adsorption was -0.12661 J/mol·K in NaCl and -0.15610 J/mol·K in HCl. Additionally, the activation energy for corrosion increased from 1.61 kJ/mol at 0 mg/L to 6.96 kJ/mol at 250 mg/L chitosan in NaCl and from 4.10 kJ/mol at 0 mg/L to 23.79 kJ/mol at 250 mg/L chitosan in HCl. SEM analysis confirms the formation of a protective chitosan film, significantly reducing corrosion damage compared to uninhibited conditions. These findings indicate that chitosan is a highly effective corrosion inhibitor with favorable thermodynamic characteristics for applications in chloride-containing environments.
Cigarette Filter-Based Membranes with Tannin and FeCl₃ Additives for Enhancing the Antifouling Properties of Oil Emulsion Filtration Anisa Luthfiana; Sri Mulyati; Nasrul Arahman; Aulia Cintia Ambarita; Muhammad Prayogie Aulia
Jurnal Kimia Sains dan Aplikasi Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.12.580-589

Abstract

Industries in Indonesia significantly contribute to the economy by increasing foreign exchange earnings and creating job opportunities. However, industrial activities also negatively impact the environment, particularly water pollution caused by liquid waste containing oil emulsions. This research aims to develop a membrane based on cigarette filters as an alternative to cellulose acetate for separating oil emulsions in water. Cigarette filters were processed into membranes with tannic acid (TA) and ferric chloride (FeCl3) as additives using a vacuum-filtration coating technique. The resulting membranes were tested for their characteristics and performance, including morphological analysis, functional group analysis, hydrophilicity, water uptake, porosity, pure water flux, selectivity toward oil emulsions (artificial emulsions from CPO and sodium dodecyl sulfate (SDS)) and antifouling properties. The results showed that membranes with additives exhibited more uniform pores, asymmetric structures, and improved surface characteristics. The addition of tannic acid 2.4 mmol and FeCl3 3.7 mmol also enhanced the antifouling properties of the membranes, although it decreased the pure water flux. Membranes without additives (M1) and with additives (M2) were compared for pure water flux, separation efficiency, and antifouling properties. M2 exhibited a lower flux (15.03 L/m2·h) than M1 (19.69 L/m2·h) due to reduced porosity. Although the oil emulsion selectivity of M2 (97.80%) showed no significant improvement compared to M1 (97.79%), the addition of additives notably enhanced the antifouling performance. M2 demonstrated a flux recovery ratio (FRR) of 71.22%, significantly higher than M1’s FRR of 46.01%, indicating the effectiveness of the additives in reducing fouling and improving membrane reusability. The membranes achieved high selectivity for oil emulsions with a separation efficiency of up to 97%. These findings suggest that using cigarette filters as the base material for membranes and adding additives can provide an efficient and environmentally friendly solution to reducing oil emulsion pollution.
Biodegradation of the Ciprofloxacin Antibiotic by White Rot Fungus Trametes hirsuta D7 Ananda Novita Hi Pattu; Charlena Charlena; Dede Heri Yuli Yanto; Irma Herawati Suparto; Maulida Oktaviani
Jurnal Kimia Sains dan Aplikasi Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.12.590-596

Abstract

This study highlights the potential of fungal microorganisms, particularly Trametes hirsuta D7, in addressing antibiotic contaminants, such as ciprofloxacin, in the environment. The degradation process was conducted at room temperature over 7 days, and the results demonstrated that laccase was predominant in the degradation capacity; this was evidenced by the laccase enzyme activity levels obtained, namely 93 U/L, 120 U/L, and 130 U/L, compared to manganese peroxide activity of 7 U/L, 16 U/L, and 13 U/L at concentrations of 100, 300, and 500 mg/L, respectively. Notably, the laccase enzyme of T. hirsuta D7 exhibited significant degradation of ciprofloxacin, with high degradation rates of 64% at 100 mg/L, 48% at 300 mg/L, and 26% at 300 mg/L. This indicates that laccase from T. hirsuta D7 effectively degraded ciprofloxacin at various concentrations. Furthermore, this study revealed that ciprofloxacin did not significantly affect the growth of T. hirsuta D7. This suggests that microorganisms can survive and function effectively in the presence of antibiotic contamination without being impaired by these compounds. In conclusion, this study presents a potential solution for environmental antibiotic contamination by utilizing fungal microorganisms, particularly T. hirsuta D7, and their laccase enzymes. The findings of this study provide valuable insights for developing more environmentally sustainable and efficient degradation methods for antibiotic contamination in the ecosystem.

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