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JPSCR : Journal of Pharmaceutical Science and Clinical Research
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 2503331x     DOI : -
Core Subject : Health, Social,
Environmental Science Public Health
Journal of Pharmaceutical Science And Clinical Research (e-ISSN 2503-331x) offers a forum for publishing the original research articles, review articles from contributors, and the novel technology news related to pharmaceutical science and clinical research. Scientific articles dealing with natural products, pharmaceutical science-industry and clinical research, etc. are particularly welcome. The journal encompasses research articles, original research report, reviews, short communications and scientific commentaries pharmaceutical science and clinical research including: bioactive products, chemotaxonomy, chemistry, ecological biochemistry, metabolism, pharmacy management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, pharmaceutical social and pharmaceutical industry.
Arjuna Subject : -
Articles 14 Documents
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Search results for , issue "Vol 9, No 1 (2024)" : 14 Documents clear
Potensi Daun Keji beling (Strobilanthus crispus) sebagai Antibakteri dan Antibiofilm terhadap Bakteri Cutibacterium acnes Sumi Wijaya; Inggar Dwi Kuncahyani; Lisa Soegianto
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.74341

Abstract

Cutibacterium acnes, merupakan salah satu mikroorganisme permanen pada permukaan stratum korneum, dimana populasinya mewakili 20-70% dari mikroorganisme yang banyak ditemukan pada kondisi muka berjerawat. Pembentukan biofilm dari mikroorganisme ini merupakan salah satu faktor yang mengakibatkan obat anti jerawat tidak efektif dalam bekerja. Strobilanthus crispus (keji beling) merupakan salah satu tanaman yang memiliki potensi cukup tinggi dalam pengobatan tradisional, khususnya sebagai antibakteri. Penelitian ini akan menguji kemampuan ekstrak etanol daun keji beling sebagai antibakteri dan antibiofilm terhadap bakteri Cutibacterium acnes. Ekstrak etanol daun keji beling di dapatkan dengan menggunakan metode maserasi dengan pelarut etanol 96%. Metode Difusi Sumuran dengan Diameter Hambat Pertumbuhan (DHP) sebagai parameter pengukuran digunakan sebagai metode pengujian untuk aktivitas antibakteri. Ekstrak etanol daun keji beling pada konsentrasi 50% memberikan DHP 7,21 ± 0,103 mm. Aktivitas antibiofilm diuji dengan menggunakan metode mikrodilusi pada rentang konsentrasi ekstrak 0,06 % - 30%. Hasil menunjukkan 1,88% ekstrak etanol daun keji beling telah mampu memberikan persentase penghambatan pembentukan biofilm sebesar 98,23 ± 0,230%, dimana hasil ini menunjukkan hasil yang tidak berbeda dengan klindamisin 10µg/100µL. Skrinning fitokimia yang dilakukan pada ekstrak etanol daun keji beling menunjukkan adanya flavonoid, alkaloid dan tanin, yang di duga menunjukkan potensi sebagai antibiofilm.
Sintesa Nanopartikel Senyawa Bioaktif Daun Pegagan (Centella asiatica) dan Uji Pengaruh Pemanasan dan Tekanan Terhadap Diameter dan Indeks Polidispersitasnya Horasdia Saragih
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.74982

Abstract

Senyawa bioaktif daun pegagan memiliki banyak manfaat. Senyawa ini memiliki sifat antioksidan, antimikroba dan antiinflamasi. Senyawa ini telah banyak digunakan untuk menyembuhkan beragam jenis penyakit. Oleh karena itu sangat berpotensi untuk dikembangkan sebagai bahan obat-obatan. Namun sifatnya sangat hidrofobik dan mudah terdegradasi. Untuk mengatasi masalah ini, pendekatan baru yaitu memperkecil ukuran partikelnya berorde nanometer, dapat dilakukan. Tujuan penelitian ini adalah mensintesa partikel senyawa bioaktif daun pegagan berukuran nanometer dan menguji pengaruh pemanasan dan tekanan terhadap diameter dan indeks polidispersitasnya. Senyawa bioaktif daun pegagan diekstrak menggunakan pelarut etanol. Nanopartikelnya disintesa menggunakan surfaktan tween 80. Pengaruh pemberian pemanasan dan tekanan terhadap diameter rata-rata dan indeks polidispersitasnya, diuji. Dari hasil yang diperoleh dengan menggunakan 6 ragam massa konsentrat hasil ekstrak: 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, dan 9 mg yang masing-masing dilarutkan ke dalam 100 mL etanol, diameter rata-rata nanopartikelnya (dan indeks polidispersitas) masing-masing adalah 10,7 nm (0,266); 11,1 nm (0,240); 11,8 nm (0,395); 12,7 nm (0,086); 12,8 nm (0,299); dan 13,2 nm (0,464). Ketika nanopartikel ini dipanaskan pada temperatur 121oC dan tekanan 2 bar selama 15 menit, diameter rata-ratanya menjadi lebih besar: 11,0 nm; 11,3 nm; 12,4 nm; 12,9 nm; 13,5 nm; 14,1 nm; dan indeks polidispersitasnya menjadi lebih kecil: 0,196; 0,202; 0,242; 0,058; 0,274; dan 0,303. Hasil ini menunjukkan bahwa semakin besar massa konsentrat yang digunakan, semakin besar diameter rata-rata nanopartikel yang dihasilkan. Pemberian pemanasan dan tekanan, memperbesar diameter rata-rata nanopartikel dan memperkecil indeks polidispersitasnya.
Formulasi Tea Tree Oil sebagai Pengawet dalam Masker Gel Peel-Off Ekstrak Etanol Beras Merah (Oryza rufipogon Griff.) Eka Wulansari; Agus Siswanto; Diniatik Diniatik
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.78349

Abstract

Bahan pengawet merupakan eksipien yang sangat dibutuhkan dalam sediaan cair seperti masker gel peel-off ekstrak etanol beras merah. Penggunaan paraben diyakini memiliki efek samping jangka panjang pada sistem endokrin dan reproduksi sehingga perlu dikembangkan pengawet alami seperti tea tree oil. Selain faktor kualitas sediaan, faktor harga produk juga seringkali menjadi pertimbangan konsumen dalam membeli produk. Tujuan penelitian ini adalah untuk mendapatkan komposisi optimum bahan pengawet metil paraben, propil paraben, dan tea tree oil dalam sediaan masker gel peel-off ekstrak etanol beras merah. Metode optimasi simplex lattice design (SLD) digunakan untuk optimasi kombinasi pengawet metilparaben, propilparaben, dan tea tree oil dalam 8 run formula. Formula optimum ditentukan dengan parameter pH, daya sebar, waktu mengering, Angka Lempeng Total (ALT), Angka Kapang Khamir (AKK), dan biaya produksi. Hasil penelitian menunjukkan kombinasi tea tree oil, metilparaben, dan propilparaben dapat menjaga stabilitas masker gel peel-off ekstrak etanol beras merah. Berdasarkan optimasi metode numerik diperoleh komposisi optimum pengawet dalam sediaan terdiri dari metilparaben 0,119%, propilparaben 0,151%, dan tea tree oil 0,13%.
Overview of Indonesian Community Pharmacy: Understanding Practice Changes Vinci Mizranita; Thellie Ponto; Beulah Sipana
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.80498

Abstract

Community pharmacy practice in Indonesia has shifted to a patient-centered model, offering a range of services that include treatment advice, chronic disease management, and public health promotion. This shift benefits consumers who visit community pharmacies as their initial healthcare point. The Indonesian healthcare system, a mix of public and private providers, is governed by a decentralized structure, fostering significant investment in private healthcare despite access limitations due to financial capacity. Medicines distribution, managed by the District Health Office, ensures supply to primary healthcare facilities, with community pharmacies regulated by the Ministry of Health and the Indonesian National Food and Drug Agency. Despite stringent regulations mandating comprehensive services, most pharmacists are not remunerated for their services. Pharmacy staff, including formally qualified pharmacists and pharmacy technicians, are registered professionals, with recent trends indicating a shift towards employing pharmacy technicians to enable pharmacists to focus on clinical roles. Economic factors and innovative service delivery modes, such as telepharmacy and online purchasing, are expected to influence future practices, enhancing the pharmacist's role in chronic disease management and other health conditions. The evolving community pharmacy practice in Indonesia reflects broader changes in the healthcare system and professional roles, with continued progression anticipated.
Formulasi dan Uji Iritasi Tabir Surya dengan Kandungan Aktif Pati Umbi Porang (Amorphophallus oncophyllus) Asti Rizki Saputri; Afifah Hasna Fauzia; Afifah Khoirunnisa; Mutiara Az-Zahra; Deasy Vanda Pertiwi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.79432

Abstract

Tabir surya dapat melindungi kulit manusia dari paparan radiasi ultraviolet penyebab kanker, tetapi beberapa tabir surya yang beredar di pasaran mengandung senyawa karsinogenik. Pemanfaatan pati umbi porang (Amorphophallus oncophyllus) sebagai zat aktif dalam formula tabir surya dapat menjadi alternatif sediaan tabir surya yang aman. Tujuan dari penelitian ini adalah mengetahui potensi pemanfaatan pati umbi porang sebagai tabir surya. Tahapan penelitian terdiri atas formulasi sediaan dengan konsentrasi pati umbi porang sebesar 5%, 10%, dan 15%, evaluasi sifat fisik, penentuan nilai SPF, dan uji iritasi terhadap hewan coba. Evaluasi sifat fisik terdiri atas uji organoleptis, uji pH, uji viskositas, uji daya sebar, dan uji daya lekat. Hasil penelitian menunjukkan tabir surya pati umbi porang memiliki penampakan fisik yang baik dan homogen. Nilai pH berada pada rentang 7,24±0,03-7,74±0,03, viskositas 2538,24±213,97-14356±4,3 cPs, daya lekat 0,69±0,23-1,32±0,09 detik, dan daya sebar 6,25±0,43-6,38±0,25 cm. Nilai SPF formula I, II, dan III berturut-turut adalah 5,143; 9,312; dan 17,231. Formula III merupakan formula terbaik dari segi sifat fisik dan tidak menimbulkan iritasi saat diuji pada hewan coba. Pati umbi porang disimpulkan dapat diformulasikan sebagai zat aktif dalam tabir surya.
Cost Effectiveness Analysis Jamu Saintifik Antihipertensi di Wisata Kesehatan Jamu Kalibakung dan Terapi Kombinasi Antihipertensi Konvensional di Puskesmas Kalibakung Galar Sigit Prasuma; Didik Setiawan; Dina Ratna Juwita
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.58389

Abstract

Hipertensi menjadi masalah utama bagi masyarakat di Indonesia dengan prevalensi mencapai 32,2%. Berbagai jenis terapi pengobatan sudah banyak direkomendasikan salah satu yang direkomendasikan dari JNC VIII adalah penggunaan kombinasi antihipertensi konvensional. Kementerian kesehatan melalui B2P2TOOT juga berhasil memproduksi jamu antihipertensi tersaintifikasi yang ditujukan sebagai terapi komplementer. Saat ini masalah efektivitas dalam mencapai target tekanan darah masih menjadi masalah untuk terapi antihipertensi konvensional maupun jamu saintifik. Selain itu besarnya biaya yang dikeluarkan untuk masing-masing terapi juga menjadi pertimbangan bagi pasien dalam menentukan jenis terapi yang akan dipilih. Berdasarkan permasalah tersebut, makan akan di teliti cost effectiveness analysis antara jamu saintifik antihipertensi dengan kombinasi antihipertensi konvensional. Rancangan penelitian yang digunakan yaitu observasional analitik dan analisis data menggunakan metode Incremental Cost Effectiveness Ratio (ICER) dan diinterpretasikan menggunakan Cost Effectiveness Plane (CEP). Pengambilan data biaya menggunkan perspektif provider sebagai penyedia layanan kesehatan. Responden sebanyak 44 pasien, terdiri dari 18 pasien dengan terapi kombinasi antihipertensi konvensional di Puskemas Kalibakung, dan 26 pasien dengan terapi jamu saintifik antihipertensi di Wisata Kesehatan Jamu Kalibakung. Hasil persentase efektivitas keberhasilan terapi kombinasi antihipertensi konvensional mencapai 47%, sedangkan persentase efektivitas keberhasilan terapi jamu saintifik antihipertensi mencapai 53,8%. Total biaya rata rata per pasien untuk terapi kombinasi antihipertensi konvensional sebanyak Rp 115.561, dan untuk terapi jamu saintifik antihipertensi sebanyak Rp 102.138. Data tersebut kemudian dianalsis dengan ICER dan didapatkan nilai ICER Rp -2.029/pasien. Interpretasi nilai ICER menggunakan CEP menyimpulkan bahwa terapi jamu saintifik antihipertensi lebih cost effective dibandingkan terapi kombinasi antihipertensi konvensional karena nilai ICER berada di area SouthEast.
The Influence of Release Modifier Differences in Formulations on the Pharmacokinetic Profile of Ketoprofen in Rats: A Scoping Review Adi Yugatama; Alyanis Mufid SWM; Rasmaya Niruri; Ya-Lin Huang; Nguyen Dang Khoa
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.80292

Abstract

The pharmacokinetic profile of drugs can be changed by genetic, environmental, and physiological variables such as age, sex, pregnancy, and different preparations and formulations. Ketoprofen is widely used in many different preparations and formulations. The various formulations can made by adding solubilizing and extending release agents. This study aimed to determine the influence of formulation differences on the pharmacokinetic profile of ketoprofen in rats. This research was a Literature Review. Articles were retrieved from the ScienceDirect and PubMed databases from 2011 to 2020. The inclusion criteria were the research article, the presence of ketoprofen was formulated with the addition of a solubilizing or extended-release agent, given orally and available in open access. The study resulted in differences in formulation, notably the addition of various dissolving agents or extended-release agents, which caused changes in the pharmacokinetic profile of ketoprofen. The highest increase in the pharmacokinetic parameters Cmax and AUC of ketoprofen was observed with poloxamer-188 as a release modifier agent. Therefore, the use of release modifier agents could have a significant effect on the drug's pharmacokinetic profile.
Antidiabetic Potential and Metabolite Profile of Leaf and Stem Extract of Castanopsis tungurrut (Blume) A.DC. Bilqis Zahra Nabila; Muhammad Imam Surya; Intani Quarta Lailaty; Frisca Damayanti; Tri Rini Nuringtyas
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.74955

Abstract

Diabetes mellitus is a metabolic disorder caused by high blood sugar levels. One species in the Castanopsis genus is proven with a hypoglycemic effect. Therefore, the study aimed to discover the potential of Castanopsis tungurrut as an antidiabetic. Sample extraction, α-amylase inhibition, glucose diffusion analysis, GC-MS analysis, and molecular docking were applied in this study. Maceration of the leaf ethanol extract showed the highest yield value of 21.08%, while the stem extract was 14.04%. Leaf ethanol extract and stem ethyl acetate extract showed the highest inhibiting α-amylase activity with an inhibition value of 33.74%±1.54 and 34.45%±1.08 at 1 mg/mL concentration. The glucose entrapment assay showed that these two extracts could inhibit the diffusion of glucose in the dialysis bag. The final result was glucose concentration in dialysate for the two extracts of 0.114±0.001 mg/mL and 0.116±0.001 mg/mL which was lower than acarbose in 0.120±0.004 mg/mL. GC-MS analysis showed 6 metabolites in leaf ethanol extract and 22 metabolites in stems ethyl acetate extract from an alkane, salicylic, cinnamic, terpene, steroid, and fatty acid. Molecular docking resulting between the compounds with α-amylase enzymes complex showed γ-sitosterol and ß-bisabolene from C. tungurrut extract have the potential to be developed as an antidiabetic drug due to its good inhibitory activity with binding affinity values of -9.1 and -6.9 that considered better and quite close to acarbose as control of -7.7.
Cholecalciferol Effects on Lipid Profile of Experimental Animals: A Scoping Review Dea Anenta Veonika; Budiyanti Wiboworini; Muthmainah Muthmainah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.73400

Abstract

Vitamin D is an essential nutrient that has various beneficial effects on the human body. The results of cholecalciferol supplementation are varied, and there has yet to be a comprehensive review regarding its effect on animal models. Therefore, this scoping review aims to summarize the evidence regarding the effect of cholecalciferol (vitamin D3) supplementation on the lipid profiles of animal subjects. PubMed, Scopus, and DOAJ were searched for original research articles published until 2022. Studies were included if they were experimental studies, cholecalciferol was used as a supplement, and the changes in the lipid profile were analyzed. A total of 260 articles were collected, of which 250 articles were excluded, and 10 articles were included for qualitative synthesis. All studies used oral routes to supplement cholecalciferol with various doses and duration ranging from several weeks to several months. Most studies reported reduced lipid parameters in serum or organ-specific animals supplemented with cholecalciferol. As conclusion, cholecalciferol reduces lipid content in animal subjects and may have a beneficial effect on populations with metabolic diseases such as diabetes and dyslipidemia. Further research is required to explore the mechanism of how cholecalciferol affects the lipid profiles of experimental animals.
Caesalpinia sappan Reduce Fever with An Anti-inflammatory and Antioxidant Mechanism: A Review Heru Sasongko; Delia Putri Hedianti; Listiyana Ika Safitri
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.79562

Abstract

Caesalpinia sappan L (Sappan wood) is an herbal plant that has long been trusted by the public as an herbal medicine for tuberculosis, diarrhea, dysentery, skin infections, anemia, and other diseases by utilizing the decoction of C.sappan. Sappan wood is an herbal plant widely used as a raw material for traditional medicinal products. Sappan wood has been reported to have substantial pharmacological effects in analgesic, antioxidant, antibacterial, anti-inflammatory, and anti-viral. Fever is a clinical manifestation of certain conditions or diseases characterized by increased body temperature above the normal range (36.5–37.5 °C). Many studies declare that antioxidant and anti-inflammatory activity in C.sappan reduces oxidative stress and pro-inflammatory cytokines. This literature review shows that the antioxidant and anti-inflammatory properties of C.sappan are linked to fever as a sign of illness. Literature review using the last ten years' Scopus, ScienceDirect, and Pubmed databases. There are as many as 20 journals regarding sappan wood's antioxidant and anti-inflammatory effects. Sappan wood has been shown to have an antioxidant effect by lowering reactive oxygen species levels via SOD, GPx, or CAT markers. It inhibits inflammation cytokines such as IL-1, IL-6, TNF-????, and INF produced during fever. Sappan wood also has an anti-inflammatory effect by inhibiting PGE2 production when someone has a fever. The findings of our review state that C.sappan can be used to treat fever for both of these reasons. The use of C.sappan as a component in producing traditional health beverages has potential.

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