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SCIENTIA JOURNAL
Published by Universitas Adiwangsa Jambi
ISSN : 23029862     EISSN : 27768562     DOI : -
Core Subject : Health,
Medicine & Pharmacology Nursing Public Health
SCIENTIA JOURNAL is a scientific journal in the field of health published twice a year by LPPM Adiwangsa Jambi University, especially in the public health, nursing and midwifery field.
Arjuna Subject : -
Articles 3 Documents
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Search results for , issue "Vol. 14 No. 1 (2025): SCIENTIA JOURNAL" : 3 Documents clear
Hubungan Antara Body Mass Index (Bmi) dan First Degree Dengan Fenotipe Molekul Her-2 pada Pasien Breast Cancer of No Special Type (NST) di RSUD Raden Mattaher Jambi Ismail Usman
SCIENTIA JOURNAL Vol. 14 No. 1 (2025): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Abstract

Breast cancer of No Special Type (NST) is the most common histological subtype of breast malignancy and demonstrates diverse molecular phenotypes, including the expression of Human Epidermal Growth Factor Receptor-2 (HER-2), a key marker associated with tumor aggressiveness and therapeutic response. Risk factors such as nutritional status measured through Body Mass Index (BMI) and the presence of a first-degree family history of breast cancer are suspected to be associated with molecular phenotypes; however, local evidence remains limited. This study aimed to analyze the association between BMI and first-degree family history with HER-2 molecular phenotype among patients diagnosed with breast cancer NST at RSUD Raden Mattaher Jambi.This analytic observational research employed a cross-sectional design. Data were collected from medical records, including BMI values, first-degree family history, and HER-2 expression determined through immunohistochemistry (IHC). Statistical analysis using the Chi-Square test was conducted to assess the relationship between the independent variables and the HER-2 phenotype. The results indicated that most patients were categorized as overweight or obese. There was a tendency for patients with higher BMI to show a greater proportion of HER-2–positive expression compared with those with normal BMI. Additionally, patients with a first-degree family history of breast cancer exhibited a higher proportion of HER-2–positive cases than those without such a history. Overall, this study found a significant association between BMI and first-degree family history with HER-2 molecular phenotype in patients with breast cancer NST. These findings underscore the importance of early detection, enhanced risk factor education, and close monitoring among individuals with elevated BMI and positive family history. The results are expected to support the development of clinical and preventive strategies for breast cancer management at RSUD Raden Mattaher Jambi.
Hubungan Antara Usia dan Tempat Tinggal dengan Fenotipe Molekular ER pada Pasien Invasive Carcinoma Mammae of No Special Type (Nst) di RSUD Raden Mattaher Melly Miranda
SCIENTIA JOURNAL Vol. 14 No. 1 (2025): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Abstract

Breast cancer of No Special Type (NST) is the most common histological subtype of breast malignancy and demonstrates diverse molecular phenotypes, including the expression of Human Epidermal Growth Factor Receptor-2 (HER-2), a key marker associated with tumor aggressiveness and therapeutic response. Risk factors such as nutritional status measured through Body Mass Index (BMI) and the presence of a first-degree family history of breast cancer are suspected to be associated with molecular phenotypes; however, local evidence remains limited. This study aimed to analyze the association between BMI and first-degree family history with HER-2 molecular phenotype among patients diagnosed with breast cancer NST at RSUD Raden Mattaher Jambi.This analytic observational research employed a cross-sectional design. Data were collected from medical records, including BMI values, first-degree family history, and HER-2 expression determined through immunohistochemistry (IHC). Statistical analysis using the Chi-Square test was conducted to assess the relationship between the independent variables and the HER-2 phenotype. The results indicated that most patients were categorized as overweight or obese. There was a tendency for patients with higher BMI to show a greater proportion of HER-2–positive expression compared with those with normal BMI. Additionally, patients with a first-degree family history of breast cancer exhibited a higher proportion of HER-2–positive cases than those without such a history. Overall, this study found a significant association between BMI and first-degree family history with HER-2 molecular phenotype in patients with breast cancer NST. These findings underscore the importance of early detection, enhanced risk factor education, and close monitoring among individuals with elevated BMI and positive family history. The results are expected to support the development of clinical and preventive strategies for breast cancer management at RSUD Raden Mattaher Jambi.
Hubungan Kadar Trombosit dan Hematokrit Terhadap Mortalitas Pasien Stroke Iskemik Fase Akut Pela Meyadsa
SCIENTIA JOURNAL Vol. 14 No. 1 (2025): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Abstract

Ischemic stroke is a major medical condition with a high mortality rate, particularly during the acute phase. Various factors influence the prognosis and mortality of ischemic stroke patients, including hematological factors such as platelet count and hematocrit levels. This study aims to analyze the relationship between platelet count and hematocrit levels with mortality in acute ischemic stroke patients in the hospital. This study used an observational analytic design with a cross-sectional approach. Data were collected from medical records of patients admitted to the intensive care unit (ICU) and inpatient ward with a diagnosis of acute ischemic stroke between January and December 2025. Platelet count and hematocrit levels were measured on the first day of hospital admission and correlated with 30-day mortality. Statistical analysis was performed using the Chi-Square test to assess the relationship between the independent variables (platelet count and hematocrit levels) and the dependent variable (mortality). The results of the study showed that patients with higher platelet counts and lower hematocrit levels had a significantly higher risk of mortality compared to other groups. These findings suggest that elevated platelet count and low hematocrit levels may serve as important prognostic indicators in predicting mortality in acute ischemic stroke patients. This study provides additional insights into the importance of monitoring hematological factors in the management of acute ischemic stroke patients and could serve as a foundation for developing more targeted therapeutic strategies.

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