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Indonesian Journal of Applied Sciences

ijas
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Published by Universitas Padjadjaran

ISSN : 20899203 EISSN : 25811991 DOI : -

Core Subject : Social,

Environmental Science

Indonesian Journal of Applied Sciences (IJAS) is a scientific journal published three times a year (April, August, December). Indonesian Journal of Applied Sciences publish original research results related to research in the field of natural science, covering a wide range of topics written in the field of knowledge: medicine, agriculture, animal husbandry, fisheries, pharmaceuticals, and other exact sciences

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Articles 8 Documents

Search results for , issue "Vol 1, No 1 (2011)" : 8 Documents clear

Pengaruh Jumlah Donor Hipofisis Ikan Mas (Cyprinus carpio Lin) terhadap Keragaan Reproduksi Ikan Lele Sangkuriang (Clarias sp) Hamdan Jamal
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijas.v1i1.1805

The objective of research is to identify the number of carp pituitary donors providing an effect on the quickest latency time of ovulation, the highest percentages of the egg hatching rate and survival rate larvae. In this research there were 6 treatments and 3 replications where A was 1 tail donor with the weight 600 gram, B was 2 tails donor with the individually weight 600 gram, C is 3 tails donor with the individually weight 200 gram, D is 1 tail donor with the individually weight 1200 gram, E is 2 tails donor with the individually weight 600 gram and F is 3 tails donor with the individually weight 400 gram, whereas the mother or tested fish’s weight is 600 gram. The result of research indicates that the number of fish donors in the pituitary gland injecting has had effects on the latency time of ovulation where in the treatment of F provided the quickest time of 8,30 hours, the next the treatment of E with the time of 9,40 hours, the treatment of D with the time of 9,64 hours, the treatment of B with the time of 9,70 hours, the treatment of A with the time of 9,76 hours, and the treatment of C with the time of 10,48 hours. At the observation to the egg hatching rate tested the number of eggs hatched is 500 eggs, the result of research shows that the highest percentage at the treatment of F with 94.66%, the next the treatment of E with 92.93%, the treatment of D with 92.26%, the treatment of A with 90.86%, the treatment of B with 90.53%, and the smallest at the treatment of C with 89.33%. The research to the number of fish donors has no real effects on the survival rate larvae.

Simulasi Doking Antibodi Monoklonal Chimeric dan Humanized dengan Reseptor HER-1 dan HER-2 Rustaman Rustaman; Abdul Mutalib; Rustam E. Siregar; Ukun M. Syukur S.
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

In the last decade, cancer treatment get into a new era called targeted therapy for cancer. Monoclonal antibody (mAb) is one of the targeted therapy agents and belongs to a part of passive immunotherapy. The aim of this study is to predict the relative strength of binding affinity for several monoclonal antibodies binding to HER-1 and HER-2 receptors by calculating dissociation constants, evaluating a dominant interaction of the complexes, and predict the reactivity of HER-1 and HER-2 according to potential electrostatic map. Structures of the complexes of mAB (cetuximab and nimotuzumab) with HER-1 and anti-HER-2 (trastuzumab and petuzumab) with HER-2 was generated by docking simulation which combine three docking protocols (ZDOCK, ZRANK, and RDOCK). Filtering the initial docked poses with CDR’s (Complementarity Determining Regions) residues of antibody and the binding site of residues was done to narrow the resulted poses. The result of this study show that generally, the interaction between chimeric and humanized monoclonal antibodies with HER-1 present polar-polar interaction from lysine, asparagin, serin, arginin, and glutamin amino acids, and both of mAb interacted with domain III of HER-1, whereas, interaction between humanized monoclonal antibodies with HER‑2 was dominated by polar-polar interaction from aspartic acid, glutamic acid, glutamin, and lysin amino acids with domain II and IV of HER-2.*****Pada dekade terakhir, pengobatan kanker memasuki era baru yang disebut terapi kanker terarah. Antibodi monoklonal (mAb) adalah salah satu jenis obat terapi terarah yang merupakan bentuk pasif dari imunoterapi. Tujuan dari penelitian ini adalah memprediksi kekuatan relatif afinitas pengikatan kompleks-kompleks yang terbentuk dari hasil simulasi doking dengan menghitung tetapan disosiasinya, menginventarisasi jenis-jenis interaksi yang dominan, dan memprediksi reaktifitas HER-1 dan HER-2 berdasarkan pemetaan potensial elektrostatik molekul. Struktur kompleks tiga dimensi kompleks antibodi monoklonal anti-HER-1 (cetuximab dan nimotuzumab) dengan reseptor HER-1 dan antibodi monoklonal anti-HER‑2 (trastuzumab dan pertuzumab) dengan reseptor HER-2 ditentukan menggunakan metode doking protein-protein yang mengkombinasikan antara protokol pencarian ZDOCK dan fungsi skor ZRANK, serta protokol perbaikan pose RDOCK. Penyaringan hasil pose dilakukan berdasarkan sekuen asam-amino di daerah CDR (Complementarity Determining regions) dari antibodi dan sisi binding dari reseptor. Hasil penelitian yang diperoleh menunjukkan bahwa secara umum interaksi antara antibodi monoklonal chimeric dan humanized dengan HER-1 digambarkan oleh interaksi polar-polar dari asam-asam amino lisin, asparagin, serin, arginin, dan glutamin serta keduanya berinteraksi di domain III HER-1, edangkan interaksi antara antibodi monoklonal humanized dengan HER‑2 didominasi oleh interaksi polar-polar dari asam-asam amino aspartat, glutamat, glutamin, dan lisin di domain II dan IV HER-2.

Peningkatan Imunitas Ikan Nila (Oreochromis niloticus) terhadap Serangan Streptococciasis Menggunakan Ekstrak Sargassum sp Ike Rustikawati
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

Tilapia farming might increase the level of prevalence of streptococciasi. Immunostimulants can be used to enable non specific immune response. In addition defense mechanisms. Sargassum sp. including brown algae, has not ben known effectiveness as immunostimulan of tilapia (Oreochromis niloticus). The aim of this work was to obtain effective concentration of Sargassum sp extract in increasing the body defense of tilapia (Oreochromis niloticus) against streptococciasis. Research carried out experimentally by using a complete randomized design. There were five treatments and each treatment was repeated three times. The result concluded that application of Sargassum extract by injection was effective in inreasing the immunity of Nila fish against streptococciasis caused by the bacteria of Streptococcus innane. Observing on leucocyte difference parameters, phagocytic index and antibody titer the best application of Sargassum extract was at a dosage of 75 ug/g, leading to the highest survival level of 82.22 percents.

Pengaruh Human Capital terhadap Positive Organizational Behavior Pegawai Divisi Marketing di BUMN Bidang Jasa Wilayah Jawa Barat Anissa L. Kadiyono
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

This study investigates the meaning of employee as human capital in organization. Drawing form positive psychology movements, the main purpose of the research is to analyze the influences of human capital to Positive Organizational Behavior. The value-added contribution that organizational member can achieve organizational effectiveness is Positive Organizational Behavior. What capacities should employees develop that will make them more productive and provide competitive advantages in today’s turbulent environment is human capital. Human Capital (Petterson & Spiker) is an individual asset as employee who has knowledge, experience, skills, attitude, value, and other personal attributes that have contribury value on organization. Positive Organizational Behavior based on Luthans is the study and application of positive oriented human resource strengths and psychological capacities that can be measured, developed, and effectively managed for performance improvement in today's workplace. Using Lisrel software, a confirmatory factor analysis was conducted using maximum likelihood techniques and replicated the second order factor structure. Specifically, this analysis conducted confirmatory factor analytic model comparisons to determine the statistically best performing measurement model. Sample size is 452 person, has been taken from marketing division in The State-Owned Enterprises of Services Industry in West Java. They are PT. Telekomunikasi Indonesia, Tbk., PT. Pos Indonesia (Persero), PT. PLN (Persero), and PT. Industri Telekomunikasi Indonesia (Persero). The hypothesis indicated that there is significant influences of Human Capital to Positive Organizational Behavior at Marketing Division Employees in The State Owned Enterprises of Services Industry in West Java.*****Penelitian ini dilakukan untuk mengungkapkan peran pegawai di perusahaan dalam konsep human capital. Berlandaskan gerakan psikologi positif, maka penelitian ini berupaya meneliti apakah Human Capital memegang peranan dalam mempengaruhi Positive Organizational Behavior pegawai yang merupakan cerminan upaya pegawai dalam mencapai tujuan organisasi. Konsep Human Capital yang digunakan menggunakan konsep yang dikemukakan oleh Petterson dan Spiker yang menyatakan bahwa human capital adalah aset individu selaku pegawai yang berisikan pengetahuan, pengalaman, keterampilan, sikap, nilai dan atribut personal lainnya yang memiliki nilai tambah bagi organisasi. Positive Organizational Behavior menggunakan konsep yang dikemukakan oleh Luthans, yaitu pengaplikasian potensi individu selaku sumber daya manusia yang memiliki potensi dan kapasitas psikologis yang dapat diukur, dikembangkan, dan dikelola untuk mengembangkan performansi kerja di tempat kerjanya. Pengujian hipotesis penelitian menggunakan Structural Equation Model dengan metode Second Order Confirmatory Factor Analysis dengan Maximum Likelihood Techniques. Metode penelitian yang digunakan bersifat deskriptif dan exsplanatory survey terhadap unit sampel sebesar 452 orang pegawai divisi marketing di BUMN bidang Jasa di wilayah Jawa Barat, yaitu PT. Telekomunikasi Indonesia, Tbk., PT. Pos Indonesia (Persero), PT. PLN (Persero), dan PT. Industri Telekomunikasi Indonesia (Persero). Hasil pengujian hipotesis menunjukkan bahwa terdapat pengaruh Human Capital terhadap Positive Organizational Behavior pada pegawai divisi marketing pada BUMN bidang jasa di wilayah Jawa Barat.

Fabrikasi dan Karakterisasi Kristal Fotonik Satu Dimensi untuk Aplikasi Divais Laser Planar Sahrul Hidayat
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

Fabrication of 1D photonic crystal using hybrid polymer for planar laser application has been carried out. The hybrid polymer material was synthesized by sol-gel route using 3-(Trimethoxysilyl) propyl methacrylate (TMSPMA) as monomer. Then, the hybrid polymer is modified with (4-dicyanmethylene-2-methyl-6-(p-dimethyl-aminostyryl)-4H-Pyran (DCM) by guest-host method. Fabrications of 1D photonic crystal have been conducted by Lloyd Mirror interference method. The results of characterization show that organic-dye (DCM) good incorporated with hybrid polymer in sub-micrometer scale. The hybrid polymer can change from gel into solid by irradiated using UV-light. The Lloyd Mirror interference method was used to make light patterns in sub-micrometer order for fabrication of 1D photonic crystal. We found it method is quite well for fabrication of 1D photonic crystal with various periods.******Telah dilakukan fabrikasi kristal fotonik satu dimensi (1D) dari bahan polimer hibrid, untuk diaplikasikan sebagai divais laser planar. Bahan polimer hibrid diperoleh secara sintesis dari 3-(Trimethoxysilyl)propyl methacrylate (TMSPMA) dengan metode sol-gel. Untuk mengaktifkan sifat lasingnya, prekursor polimer hibrid dimodifikasi dengan kromofor (4-dicyanmethylene-2-methyl-6-(p-dimethyl-aminostyryl)-4H-Pyran (DCM) melalui metode guest-host. Selanjutnya dilakukan fabrikasi kristal fotonik 1D dengan teknik interferensi Lloyd Mirror. Hasil pengujian menunjukkan bahwa polimer hibrid dapat bersatu secara homogen dengan kromofor DCM. Polimer hibrid dapat berubah fasa dari gel menjadi padat apabila disinari dengan cahaya UV. Fabrikasi kristal fotonik 1D dapat dilakukan dengan menggunakan berkas cahaya terpola, yang dihasilkan dari metode interferensi Lloyd Mirror. Metode tersebut telah diketahui cukup baik untuk memfabrikasi kristal fotonik 1D dengan beragam periode kisi.

Performansi Entog (Cairina moschata) Jantan yang Diberi Ransum Berbagai Imbangan Energi/Protein pada Sistem Kandang Berbeda Winwin Tanwiriah
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

The aim of this work was to study the effect of various energy/protein ransum ratios on the performance of 108 male Muscovy ducks (Cairina moschata) of 3 weeks of age which were treated under different housing systems, i.e., cage and ranch. Research method employed a Completely Randomized Design of Factorial Nested Patterns which were energy/protein ransum (E/P) ratio (B factor) at housing systems of cage and ranch (A factor). Each treatment consisted of three ducks at two replications each. Nine E/P ratio (R) given were: R1: 2400/13; R2: 2400/15; R3: 2400/17; R4: 2600/13; R5: 2600/15; R6: 2600/17; R7:2800/13; R8: 2800/15; and R9: 2800/17. Feeding trial variable observed were: feed, energy and protein consumption, body weight gain, feed conversion ratio, carcass weight and "income over feed cost". Results indicated that (1) Housing Muscovy ducks in cage gave a better value of income over feed cost than that of ranch system (Rp. 5076.08 over Rp. 3978.79 per duck); (2)The best performance and income over feed cost value obtained from R4:2600/13 (= 17.33 kcal/g protein) of cage housing systems.*****Penelitian untuk mengetahui pengaruh berbagai imbangan energi/protein terhadap 108 ekor entog jantan berumur 3 minggu yang dipelihara pada kandang cage dan ranch telah dilakukan. Metode percobaan yang digunakan adalah Rancangan Acak Lengkap Pola Dua Faktor Tersarang, yaitu Imbangan E/P Ransum (faktor B) yang tersarang pada sistem kandang cage dan ranch (faktor A). Setiap perlakuan diulang 2 kali dan setiap ulangan terdiri atas 3 ekor anak entog. Sembilan macam ransum energi/protein (R) yang diberikan adalah: R1:2400/13; R2:2400/15; R3:2400/17; R4:2600/13; R5:2600/15; R6:2600/17; R7:2800/13; R8:2800/15; dan R9:2800/17. Peubah yang diamati adalah konsumsi ransum, konsumsi energi, konsumsi protein, pertambahan bobot badan, konversi ransum, bobot karkas dan income over feed cost. Hasil penelitian menunjukkan bahwa: (1) Pemeliharaan entog jantan pada kandang sistem cage (Rp. 5076,08/ekor) menghasilkan income over feed cost yang lebih tinggi dibandingkan pemeliharaan pada kandang ranch (Rp. 3978,79/ekor). (2) Ransum dengan R4:2600/13 (= 17,33 kkal/g protein) menghasilkan performansi dan nilai income over feed cost terbaik pada kandang cage.

Aktivitas Antioksidan Minyak Atsiri dan Ekstrak Etanol Kulit Batang Sintok (Cinnamomum sintoc Bl.) terhadap 1,1-difenil-2-pikrilhidrazil (DPPH) Sri Adi Sumiwi; Anas Subarnas; Supriyatna Supriyatna; Marline Abdassah Bratadiredja
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

Sintoc (Cinnamomum sintoc Bl.) is a plant which is used as medicine. This plant has been known to have an analgesic antiinflamatory activity, therefore it is predicted to have an antioxidant activity. An investigation on antioxidant activity of sintoc essential oils and ethanolic extract of its cortex using ascorbic acid as standard has been carried out. Essential oils and ethanol extract of sintoc cortex was tested using DPPH (1,1-diphenyl-2-pikril-hidrazil) by measuring absorbance using visible spectrophotometer at 518 nm. The methods of this research were distillation of essential oils and extraction of sintoc cortex, determination of the essential oil and extract concentrations required for 50% inhibition of DPPH radical scavenging effect (IC50) with ascorbic acid as the possitive control. The variation concentration of essential oils are 15, 5, 1, 0.1, 0.5 ppm and 25, 20, 17, 15, 10 ppm for ethanolic extracts. The results showed that the essential oil showed antioxidant activity with IC50 value was 16.29 ppm (5 times lower than ascorbic acid) and then ethanolic extract showed IC50 value 38.89 ppm (11 times lower than ascorbic acid, IC50 of ascorbic acid was 3.35 ppm).

Pendugaan Parameter Genetik, Korelasi Antar Karakter Fenotipik serta Hubungan Kekerabatan Genetik Populasi Bibit Surian (Toona sinensis Roem) Yayat Hidayat; Murdaningsih Haeruman K.; Suseno Amien; Iskandar Zulkarnaen Siregar
Indonesian Journal of Applied Sciences Vol 1, No 1 (2011)
Publisher : Universitas Padjadjaran

An experiment to estimate genetic parameter, correlation among traits and genetic relationship of seedling population of Toona siensis Roem that progeny halfsib from 13 parent trees came from four sertified seed stands of surian in Java island was carried out in nursery et ex Faculty of Forestry Winayamukti University Jatinangor, from January until February 2010. The experment was arrenge in a randomized block design with four seed stand as treatments and five replications. The observation was performed on 17 phenotipic traits of surian seedling six month old after spin out. The data were analyzed using anova, correlation, pricipal component analysis, and cluster analysis. The results showed that the characters have a large genetic variance, high heritability and high genetic advance were character of the total height, clear leave hight, the robustness of the stem, leaf length and leaf lamina shape. Characters that have a positive phenotypic and genotypic correlation and significant to the total height were clear leave height, colar diameter, leaf length, shoot length, number of leaves, length of leaflets, width of leaflets, distance first leaflet to petiol, and distance widest point of laminae to petiol. Characters that have a positive phenotypic and genotypic correlation and significant to the colar diameter were total height, shoot length, number of levaes, shoot length, number of leaves, length of leaflets, width of leaflets, distance first leaflet to petiol, and distance widest point of laminae to petiol. Group of seedlings from TBI Kendal has a closer genetic relationship to the group of seedlings from TBS Jatinangor, whereas the group of seedlings from TBI Sumedang have a closer genetic relationship with TBI Tasikmalaya.*****Penelitian yang bertujuan untuk menduga parameter genetik, korelasi antar karakter dan hubungan kekerabatan genetik populasi bibit dari keturunan halfsib 13 genotip pohon induk surian yang berasal dari empat populasi tegakan benih surian bersertifikat di Pulau Jawa telah dilakukan di persemaian eks Fakultas Kehutanan Unwim Jatinangor pada Januari hingga Juni 2010. Penelitian menggunakan rancangan acak kelompok dengan empat populasi tegakan benih sebagai perlakuan yang diulang lima kali. Pengamatan dilakukan terhadap 17 karakter fenotipik pertumbuhan bibit surian umur enam bulan setelah sapih. Analisis data dilakukan melalui analisis ragam, analisis korelasi, analisis komponen utama dan analisis klaster. Hasil penelitian menunjukan bahwa karakter yang memiliki varians genetik luas, heritabilitas tinggi dan kemajuan genetik tinggi adalah karakter tinggi total, tinggi bebas daun, kekokohan batang, panjang daun dan bentuk lamina daun. Karakter yang memliki korelasi fenotipik dan genotipik searah dan nyata dengan karakter tinggi total adalah karakter tinggi bebas daun, diameter batang, panjang daun, panjang pucuk, jumlah daun, panjang anak daun, lebar anak daun, jarak anak daun pertama terhdap petiol, panjang petiol dan jarak titik lamina terlebar terhadap petiol. Karakter yang memiliki korelasi fenotipik dan genotipik searah dan nyata dengan karakter diameter batang bibit adalah karakter tinggi total, panjang pucuk, jumlah daun, panjang anak daun, lebar anak daun, jarak anak daun pertama terhadap petiol, dan jarak titik lamina terlebar terhadap petiol. Kelompok bibit asal TBI Kendal memiliki hubungan kekerabatan genetik yang lebh dekat dengan kelompok bibit asal TBS Jatinangor, sedangkan kelompok bibit asal TBI Sumedang memiliki hubungan kekerabatn genetik lebih dekat dengan TBI Tasikmalaya.

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