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Journal of Pharmaceutical and Medicinal Research Sekolah Tinggi Ilmu Farmasi Makassar Perintis Kemerdekaan Street KM 13.7 90242 Makassar-Indonesia
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Journal of Pharmaceutical and Medicinal Sciences
Published by Sekolah Tinggi Ilmu Farmasi Makassar
ISSN : 25282824     EISSN : 2580328X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical and Medicinal Sciences (JPMS) pISSN 2528-2824; eISSN 2580-328X dedicated to publish original research papers, original research notes, invited topical reviews, mini-reviews, editorial commentary and news. Medicinal resources about exchange of information and understandings about people's use of plants, fungi, animals, microorganisms, minerals, their biological and pharmacological effects based on the principles established through international conventions. Pharmaceutical including drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
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Articles 17 Documents
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Search results for , issue "Vol 1 No 2 (2016): JPMS" : 17 Documents clear
Penentuan Kadar Flavonoid Total dan Aktivitas Antioksidan Ekstrak Etanol Daun Bidara (Ziziphus spina-christi L.) Haeria, Hermawati, Andi Tenri Ugi Dg. Pine
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Research on determination of total flavonoid content and antioxidant activity of ethanol extract of bidara leaves (Ziziphus spina-christi L.) has been conducted. This study aimed to determine the total flavonoid content and antioxidant activity of ethanol extract of bidara leaves (Ziziphus spina-christi L.) by using a UV-Vis spectrophotometer. Total flavonoid content was determined at a wavelength of visible light 437.55 nm using a comparison of quercetin. Antioxidant activity was performed by measuring DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging by UV-Vis spectrophotometer at a wavelength of 516.94 nm. Free radical scavenging activities carried out by comparison with Troloks® radical. This study showed that total flavonoid content of ethanol extracts of bidara leaves (Ziziphus spina-christi L.) is equal to 1.5312%, and IC50 90.9584 ppm. This result indicates that the ethanol extract of bidara leaves (Ziziphus spina-christi L.) has potential as a powerful antioxidant.
Uji Iritasi Krim Hasil Fermentasi Bunga Rosella (Hibiscus sabdariffa L.) Dengan Variasi Konsentrasi Emulgator Novemer Pada Kulit Kelinci (Oryctalagus cuniculus) Aisyah Fatmawaty, Marianti A Manggau, Rosany Tayeb, Rabiah Al Adawiah
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

The research about irritation test of antioxidant cream from fermented Rosella’s flower infusion using emulgator Novemer has been conducted. This research was aimed to found emulgator Novemer’s concentration that using in the formula of antioxidant cream has the irritation effect on the rabbit’s skin. This research utilized 6 rabbits with the skin has been abraded at the back for a 1-square-inch, those for each irritant sample using 3 formulas of the antioxidant cream I, II, III, (have variation in concentration of emulgator Novemer) and its cream base. The test is measured by patch test by Draize. The results indicate to primary irritation index of the three formulas of antioxidant cream and the cream basics are middle irritating (irritation index 0.5 - 2)
Physical Stability Profile Of Curcuma xanthorrhiza Roxb Extract Gel With Various Carbomer® 940 Concentration Jainer Pasca Siampa, Abdul Halim Umar, Muhammad Afif
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Curcuminoid is a compound contained in turmeric (Curcuma xanthorrhiza Roxb) that act as antioxidants, anti-inflammatory, hepatoprotective and antibacterial. This research aimed to obtain a gel formula from ethanol extract of Curcuma xanthorrhiza Roxb that has good physical stability by using Carbomer® 940 as a gelling agent. Gel made in six formulas with extract and various concentration of Carbomer® 940 and evaluated physically such as organoleptic, homogeneity, viscosity, pH, spreading power, and adhesion before and after accelerated test. The data were analyzed using paired T-test. The result showed that formula 6 with 2% Carbomer is the best and physically stable before and after the stress condition. Formula 6 showed a homogeny gel with brownish yellow color, specific odor, texture soft and viscous. The value of viscosity, pH, spreading power, and adhesion respectively was 185,000 mPas; 6.8; 6.8 cm; and 44.16 seconds
Identifikasi dan Eksplorasi Etnomedisina pada Suku Samin di Kabupaten Bojonegoro, Jawa Timur Alifia Putri Febriyanti , Siti Jazimah, Praditya Widya Pariwara
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Indonesia merupakan negara yang kaya akan sumber daya alam, yang dapat digunakan sebagai obat tradisonal. Beberapa cara pengobatan hilang karena metode pengajarannya secara lisan dan empiris menyebabkan berkembangnya etnomedisin di Indonesia. Pengobatan tradisional identik dengan masyarakat asli (suku). Salah satu suku di Indonesia adalah suku Samin, yang masih menggunakan pengobatan tradisional seperti pengolahan bahan dari tanaman, hewan, dan bahan lain yang dapat dikembangkan untuk pengobatan modern. Tujuan dilakukan penelitian ini adalah mengidentifikasi dan mengeksplorasi cara penggunaan tumbuhan, hewan, dan bahan lain yang dimanfaatkan Suku Samin sebagai bahan obat tradisional. Pengambilan data dilakukan dengan menggunakan metode wawancara dengan alat kuisioner, dan didapat hasil berupa nama tanaman, hewan, dana bahan lain yang digunakan serta cara pakainya dalam pengobatan tradisional di Suku Samin. Dari hasil penelitian dapat disimpulkan penggunaan obat tradisional pada masyarakat Suku Samin Bojonegoro dari 40 narasumber telah diidentifikasi 19 jenis penyakit dengan 21 tumbuhan, 4 jenis hewan dan 4 bahan mineral alam. Bahan-bahan yang digunakan sebagai obat tradisional oleh Suku Samin sebagian besar sudah diteliti dan mempunyai khasiat obat, sehingga memiliki prospek untuk dikembangkan menjadi bahan baku industri obat tradisional. Cara penggunaan tumbuhan, hewan, dan bahan mineral pada Suku Samin sebagai obat tradisional sangat sederhana antara lain: campuran bahan atau bahan tunggal ditumbuk, diremas-remas, atau direbus kemudian diminum atau dioleskan pada bagian tubuh yang sakit.
Uji Aktivitas Antioksidan Ekstrak Etanol Daging Buah Asam (Tamarindus indica L.) Asal Kota Bima Nusa Tenggara Barat Dengan Metode DPPH Imrawati, Muzakkir Baitz, Mar’atun Jannah
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Antioxidant are compounds neutralizing free radicals. Based on the previous research, in the flesh of tamarind fruit contains flavonoids that act as antioxidant. This research aimed to determine the antioxidant activity on the extract of tamarind fruit flesh (Tamarindus indica L). Antioxidant activity was done using the reduction method of free radicals by DPPH (1,1- DiPhenyl-2-Picryl Hidrazil). Antioxidant assay of the tamarind fruit flesh extract was measured using UV-VIS Spectrophotometer at the maximum wavelength 0f 515,23 nm with various concentrations of 50, 100, 200, 250 and 300 ppm. The comparison used was quercetin with concentrations of 1, 2, 3 and 5 ppm. The calculation showed that the tamarind fruit flesh has antioxidant activity with IC50 values 740,833 µg/mL and the quercetin has IC50 values 1,045 µg/mL.
Formulasi Losio Emolien dari Ekstrak Etanol Sarang Semut (Myrmecodia pendens) dengan Menggunakan Emulgator Anionik dan Nonionik Astri Syamsuddin, Iskandar Zulkarnain, Nursiah Hasyim
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Myrmecodia (Myrmecodia pendens) is an epiphytic plant with several active chemical constituents as antioxidants including flavonoids, tocopherol, and tannins. This research aimed to obtain the formula of emolien lotion of the ethanol extract was obtained by soxhletation method using ethanol 96%. In the initial stage of formulation the emulsifier used was first optimized, then formulated and tested its physical stability, such as other organoleptic test, pH, homogeneity, emulsion type, creaming, dispersiibility, viscosity, and the determination of the type of flow before and after the stressed conditions. The data obtained were processed by anova two replication in Microsoft Excel worksheet 2010. The result of myrmecodia extraction were obtained the rendamen of 26,00078%, while the result of the optimization showed that TEA-Stearat 3-7% and Tween 80-Span 80 5% more stable. The results of stability test showed that the anionic emulsifier formula (TEA-Stearat 3-7%) and nonionic emulsifier (Tween 80-Span 80 5%) were physically stable.
Formulasi Emulgel Antiinflamasi dari Ekstrak Temulawak (Curcuma xanthorrhiza Roxb) Radhia Riski, Abdul Halim Umar, Rismadani
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Ginger extract are known to have antiinflamatory effect at a dose of 200 mg. In order to be applied to the skin, ginger extract must be formulated into stable emulgel. This study aims to formulate and evaluate the physical stability of emulgel from ginger extract using carbomer® 940 as gelling agent with concentration variation 0,5%, 1%, 1,5% and 2%. Physical stability evaluation was conducted including organoleptic test, pH, spreading test, adhesion test and viscosity test. From the research result it is obtained yellow and distinctive odor of emulgel. pH of all emulgel formula were 6. Adhesion test result of formula 5, 6, 7, 8 were 00.63, 19.03, 50.84 and 60.50 respectively. Spreading test result from formula 5, 6, 7, 8 were 5,725, 4,875, 4,325 and 3,85 respectively. Viscosity test result were 2.200, 3.720, 4.000 and 7.720 for formula 5, 6, 7 and 8 respectively. According to paired sample T-test there was not significant differences between formula on pH test, viscosity test, adhesion test (p>0,05), before and after accelerated storage condition. In spreading test result showed a significant difference 0,000 (0<0,05) before and after accelerated storage condition.

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