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All Journal Jurnal Kesehatan Program Kreativitas Mahasiswa - Penelitian Journal of Agromedicine and Medical Sciences Jurnal Fitofarmaka Indonesia CARADDE: Jurnal Pengabdian Kepada Masyarakat Aplikasia: Jurnal Aplikasi Ilmu-Ilmu Agama Journal of Pharmaceutical and Medicinal Sciences Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Farmasi Farmasyifa Jurnal farmasi UIN Alauddin Makassar Jurnal Ilmiah Medicamento Jurnal Midwifery International Journal on Health and Medical Sciences JURNAL PENGABDIAN MASYARAKAT YAMASI
Alifia Putri Febriyanti
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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PIPERANTHA:INOVASI TERAPI KOMBINASI EKSTRAK DAUN SALAM (EUGENIA POLYANTHA) DAN SIRIH MERAH (PIPER CROCATUM) TERHADAP PENINGKATAN AKTIVITAS FAS/FAS-L PADA REGRESI PERTUMBUHAN KANKER SERVIKS SECARA IN VITRO Wicaksono, Firman Mulyo; Sari, Desie Suci Permata; Sekti, Beta Herilla; Sari, Yitania; Natalia, Ellen; Lyrawati, Diana; Febriyanti, Alifia Putri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (898.977 KB)

Abstract

In this study, we evaluated Eugenia polyantha and Piper crocatum leaves alone and in combination for their anti-cancer properties on HeLa cells. The extraction method by using soxhlet and maceration. The phytochemical constituents of extract were evaluated by qualitative and quantitative analysis. The anti-cancer property and mechanism of the extract were evaluated by its effect on cell viability and apoptosis. Total flavonoids content was higher in maceration than soxhlet extracts. Single extracts of Eugenia polyantha alone or Piper crocatum showed better anti-cancer activity than their combination. However, Eugenia polyantha extracts showed better anti-cancer activity than Piper crocatum extracts. Keywords : HeLa cell, Eugenia polyantha, Piper crocatum, single, combination
Uji Aktivitas Antiplasmodium Dari Isolat Kulit Batang Kayu Tammate (Lannea coromandelica Houtt. Merr.) Secara In-Vitro Karlina Amir Tahir; Haeria Haeria; Alifia Putri Febriyanti; St. Chadijah; Nursalam Hamzah
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.203 KB) | DOI: 10.33096/jffi.v7i1.591

Abstract

One of the main causes of death and a major public health problem is malaria. Some drug resistance and the limited number of effective drugs have given the community a sense of worry. This makes the discovery of new antimalarial compounds very necessary. Based on the results of exploration of natural materials, Javanese wood is one of the plants that is efficacious as an antimicrobial and is thought to be efficacious as antiplasmodium. This study was then conducted to find hexan and ethyl acetate isolates from the Java wood fraction (Lannea coromandelica Houtt. Merr.) Which effectively inhibited the development of Plasmodium falciparum in vitro. This research is a follow-up study from previous studies in testing the fraction of Javanese bark against antioxidant activity. The procedure starts from hexan and ethyl acetate isolates with five concentrations of 10 (µg / ml), 1 (µg / ml), 0.1 (µg / ml), 0.01 (µg / ml) and 0.001 (µg / ml) 3D7 strain of Plasmodium falciparum was measured based on the average percent resistance. The results of this study indicate that etil asetat isolate have IC50 2,727 µg/ml, its mean moderate activity as antiplasmodium. While hexan isolate have IC50 >10 µg/ml its mean not have or low antiplasmodium activity.
EVALUASI PENGGUNAAN OBAT ANTIDIABETIK ORAL PADA PASIEN DIABETES MELITUS TIPE 2 MENGGUNAKAN METODE ATC/DDD DAN DU 90% Nurshalati Tahar; Alifia Putri Febriyanti; Munifah Wahyuddin; Syahifah Auliyah Hasti
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18380

Abstract

Diabetes mellitus is a chronic metabolic disease caused by the pancreas not producing enough insulin or not being able to use the required insulin effectively. Evaluate the use of oral antidiabetic drugs using ATC Diabetes mellitus is a chronic metabolic disease caused by the pancreas not producing enough insulin or not being able to use the required insulin effectively. Evaluate the use of oral antidiabetic drugs using ATC / DDD and DU 90% methods. Oral antidiabetic used in Makassar Hospita Hospital there are 3 types of metformin as many as 1020 units with a dose per unit that is 500 mg with a total use of 601000 mg 99.56%, more than 48 units with a perunit dose of 60 mg with a total dose of 2520 mg 0 , 41%, the last is 41 units of glimepiride with a perunit dose of 2 mg with a total use of 82 0.01%. Of the 3 types of oral antidiabetic, 3 usage patterns were obtained, namely 84% single metformin, 9% metformin + gliclazide combination pattern and 7% metformin + glimepirid combination. Included in the 90% DU segment or included in the list of incoming drugs is collected 90% of drug use after being sorted from the highest and highest percentage of drug use for compilation and low use is the use of metformin, using the correct use of drugs according to the choice, right dose, right delivery time, exact route and right information.
Identifikasi dan Eksplorasi Etnomedisina pada Suku Samin di Kabupaten Bojonegoro, Jawa Timur Alifia Putri Febriyanti , Siti Jazimah, Praditya Widya Pariwara
Jurnal Farmasi dan Ilmu Pengobatan Vol 1 No 2 (2016): JPMS
Publisher : STIFA Makassar

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Abstract

Indonesia merupakan negara yang kaya akan sumber daya alam, yang dapat digunakan sebagai obat tradisonal. Beberapa cara pengobatan hilang karena metode pengajarannya secara lisan dan empiris menyebabkan berkembangnya etnomedisin di Indonesia. Pengobatan tradisional identik dengan masyarakat asli (suku). Salah satu suku di Indonesia adalah suku Samin, yang masih menggunakan pengobatan tradisional seperti pengolahan bahan dari tanaman, hewan, dan bahan lain yang dapat dikembangkan untuk pengobatan modern. Tujuan dilakukan penelitian ini adalah mengidentifikasi dan mengeksplorasi cara penggunaan tumbuhan, hewan, dan bahan lain yang dimanfaatkan Suku Samin sebagai bahan obat tradisional. Pengambilan data dilakukan dengan menggunakan metode wawancara dengan alat kuisioner, dan didapat hasil berupa nama tanaman, hewan, dana bahan lain yang digunakan serta cara pakainya dalam pengobatan tradisional di Suku Samin. Dari hasil penelitian dapat disimpulkan penggunaan obat tradisional pada masyarakat Suku Samin Bojonegoro dari 40 narasumber telah diidentifikasi 19 jenis penyakit dengan 21 tumbuhan, 4 jenis hewan dan 4 bahan mineral alam. Bahan-bahan yang digunakan sebagai obat tradisional oleh Suku Samin sebagian besar sudah diteliti dan mempunyai khasiat obat, sehingga memiliki prospek untuk dikembangkan menjadi bahan baku industri obat tradisional. Cara penggunaan tumbuhan, hewan, dan bahan mineral pada Suku Samin sebagai obat tradisional sangat sederhana antara lain: campuran bahan atau bahan tunggal ditumbuk, diremas-remas, atau direbus kemudian diminum atau dioleskan pada bagian tubuh yang sakit.
PENETAPAN KADAR PIPERIN DALAM EKSTRAK BUAH LADA HITAM (Piper nigrum Linn.) MENGGUNAKAN LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC–MS/MS) Alifia Putri Febriyanti; Siti Jazimah Iswarin; Susanti Susanti
Jurnal Ilmiah Farmasi Farmasyifa Vol 1, No 2 (2018)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v1i2.3160

Abstract

The utilization of medicinal plants have started growing rapidly in the world, including in Indonesia, along with the thinking back to nature, one of the plants that are often used as a medicine is black pepper fruit (Piper nigrum Linn.). Piperine is a major compound and potent substances contained in black pepper fruit as antidiarrheal activity. The aim of this study was to determine levels of piperine in 96% ethanol extract of black pepper fruit. The extraction method used Soxhlet in 96% ethanol as solvent. Analysis of piperine using qualitative analysis by thin layer chromatography (TLC) produces yellow stain after being sprayed by dragendorf and dark blue on observation Uv-Vis 365 nm with Rf extract value 0.49 and Rf piperine value 0.5. Quantitative analysis using LC – MS produces piperine levels at 26%. Before quantitative analysis, validation method needs to be done with the parameters, among others: linearity have regression equation y = has 1,981,691.1333x + 561,445.0000 and correlation coefficient (R2) of 0.9973, LOD and LOQ at 0.14 and 0.44 ppm, accuracy value (% recovery) between 95.90 – 100.77%, precision value (% KV) between 0.02 – 1.84%, and selectivity (RT) between 2.47 – 2.49. The results of the validation parameters are eligible so that piperine levels were obtained by LC – MS declared accurate, specific, and precise.
PERBANDINGAN KADAR ASIATIKOSIDA DALAM EKSTRAK ETANOL 70% PEGAGAN (Centella asiatica (L)Urban) DENGAN METODE EKSTRAKSI MASERASI DAN SONIKASI SECARA LC-MS/MS Alifia Putri Febriyanti; Siti Jazimah Iswarin; Tristy Digjayanti
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 2 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i2.2246

Abstract

Currently, among the many new types of modern medicine in the market there is a global tendency for going back to nature. In Indonesia, for generations plants that have medicinal properties have been used based on the ancestors experience. One of the plants oftenly used as a medicine is pennywort (Centella asiatica (L) Urban). One of the major component of pennywort is asiatikoside which has activity to accelerate wound healing. The objective of this study was to compare the extraction method that produce the highest levels of asiatikoside in 70% ethanol extract of pennywort. The extraction method were maceration and sonication in ethanol 70%. Qualitative analysis of asiatikoside was performed by thin layer chromatography (TLC) producing purplish stains after being soaked in anisaldehid sulfuric acid solution and observed under UV lamp at 366 nm. The results showed at the Rf values 0.45 in maceration and 0.43 in sonication. Quantitative analysis for assay asiatikosida using LC-MS/MS. Before quantitative analysis, validation method needs to be done. Results of the validation are: the linearity have correlation coefficient (R2) of 0.9989, LOD and LOQ at 0.06 ppm and 0.19 ppm, accuracy value (% recovery) between 98.02%-107.49%, precision value (% Coefficient of Variation) between 0.32%-3.31%, and selectivity (Retention Time) between 3.44-3.49. Asiatikoside assay results in maceration extract at 7.19% and sonication at 7.43%. The results of the validation are eligible, so that asiatikoside level were obtained by LC-MS/MS declared accurate, specific, and precise.
HUBUNGAN TINGKAT PENDIDIKAN IBU TERHADAP PENGGUNAAN ZINC DALAM TERAPI DIARE PADA ANAK BALITA DI APOTEK PLATUK JAYA SURABAYA Alifia Putri Febriyanti; Miranti Nugrahini
Jurnal Farmasi UIN Alauddin Makassar Vol 5 No 2 (2017): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v5i2.3421

Abstract

Diare  adalah  suatu  kondisi  dimana  seseorang buang air besar dengan konsistensi lembek atau cair, bahkan dapat berupa air saja dan frekuensinya tiga kali atau lebih dalam satu hari. Di Indonesia, diare masih merupakan salah satu masalah kesehatan masyarakat utama. Pengetahuan yang dimiliki ibu dalam penanganan diare pada anak juga dipengaruhi oleh tingkat pendidikan yang kemudian akan berpengaruh terhadap penggunaan obat-obatan dalam penanganan diare pada anak. Tujuan penelitian ini untuk mengetahui hubungan tingkat pendidikan ibu terhadap penggunaan zinc dalam terapi diare pada anak balita. Jenis penelitian yang dilakukan adalah observasional prospektif dengan teknik pengambilan sampel secara purposive sampling dan responden didapatkan sebanyak 100 orang. Hasil penelitian dengan menggunakan chi-square diperoleh hasil signifikansi sebesar 0,528 (p > 0,05) dan nilai koefisien korelasi yang diperoleh sangat rendah yaitu sebesar 0,176, sehingga dapat disimpulkan bahwa tidak ada hubungan antara tingkat pendidikan dengan penggunaan zinc dalam terapi diare pada anak balita.
PERAN FARMASIS DALAM PENYELESAIAN PERMASALAHAN TERKAIT OBAT INFEKSI SALURAH KEMIH Alifia Putri Febriyanti; Amhar Jamil
Jurnal Farmasi UIN Alauddin Makassar Vol 5 No 4 (2017): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v5i4.4465

Abstract

Penggunaan antibiotik yang tidak tepat adalah bagian dari Permasalahan terkait Obat (PTO) yang menyebabkan resistensi antibiotika, sehingga sangat penting untuk mengatasi PTO. Penelitian ini bertujuan untuk mengetahui peran apoteker dalam mengatasi PTO dalam terapi Infeksi Saluran Kemih (ISK). Penelitian prospektif observasional dilakukan pada pasien rawat inap pada bulan Januari dan Februari 2016. PTO yang paling banyak berasal dari domain masalah efektivitas (n = 42, 64%), diikuti oleh masalah lainnya (n = 14; 22%) dan terakhir adalah masalah reaksi yang merugikan (n = 9; 14%). Analisis PTO menggunakan alat PCNE versi 7.0. Intervensi yang dilakukan oleh farmasis meliputi pemberian informasi kepada penulis resep sebesar 11%, permintaan konfirmasi dari penulis resep sebesar 21%, pemberian intervensi kepada penulis resep sebesar 68%, pemberian konseling obat pada pasien sebesar 100%, perubahan obat sebesar 6%, perubahan dosis sebesar 21%, perubahan formulasi sebesar 11%, perubahan petunjuk penggunaan sebesar 31%, penghentian obat sebesar 22% dan permulaan obat baru sebesar 9%. Semua PTO dapat diselesaikan. Intervensi apoteker sepenuhnya diterima dan diimplementasikan.
KARAKTERISASI FITOSOM EKSTRAK PEGAGAN (Centela asiatica) Alifia Putri Febriyanti; Pipit Sulistiyani
Jurnal Farmasi UIN Alauddin Makassar Vol 6 No 1 (2018): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v6i1.6743

Abstract

Pegagan (Centella asiatica) dapat digunakan untuk obat luka. Pemanfaatan pegagan secara modern dalam bentuk topikal membutuhkan sistem penghantaran yang baik untuk meningkatkan bioavailabilitas dan bioekivalensinya sehingga dikembangkan teknologi pengahantarannya melalui  Drug  Delivery  System  (DDS)  dengan  sistem  partikulat  seperti  fitosom. Penelitian ini bertujuan untuk       mengetahui karakteristik fitosom ekstrak pegagan (Centella asiatica). Penambahan kolesterol dapat meningkatkan ukuran partikel fitosom ekstrak pegagan secara signifikan, meningkatkan entrapment efficiency fitosom ekstrak pegagan, meningkatkan pH fitosom ekstrak pegagan namun menurunkan kadar asiatikosida didalam fitosom. Fitosom ekstrak pegagan yang dihasilkan dengan penambahan kolesetrol berbentuk sferik dengan ukuran partikel antara 1,13- 1,59 µm, entrapment efficiency sebesar ± 85%, pH sebesar ± 5,6  dan kadar asiatikosida sebesar 0,215%.
Studi Literatur Profil Farmakokinetik dan Penetrasi Antibiotik ke Jaringan Ulkus Diabetik Munifah Wahyuddin; Dwi Wahyuni Leboe; Khaerani Khaerani; Nurshalati Tahar; Alifia Putri Febriyanti; Nursyamsi Dhuha; Yuliani Yuliani
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.4153

Abstract

A diabetic foot ulcer is a complication of diabetes that causes open sores that can develop into an infection. The selection of the right antibiotics is based on the pharmacokinetic profile of antibiotics that can show antibiotic activity as bactericidal or bacteriostatic, the main bacteria found in diabetic ulcer disease are gram-positive bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSa). This study aims to determine the antibiotics acting on diabetic ulcer tissue and the pharmacokinetic profile and penetration of antibiotics into diabetic ulcer tissue based on a literature study using the PICO (patient/population, intervention, comparison, and outcomes) method. The results of the analysis of 8 articles that met the inclusion criteria showed that the pharmacokinetic profile (PK) of several antibiotics obtained showed bactericidal activity in the treatment of diabetic ulcers including the antibiotics ceftolozane/tazobactam, tedizolid, cefepime, daptomycin, trimethoprim/sulfamethoxazole. Several antibiotics have shown activity as bacteriostatic in the treatment of diabetic ulcers, including linezolid antibiotics and vancomycin antibiotics.
Co-Authors Ahmad Haikal Zamzami Zamzami Akiful Khoir Amhar Jamil Andi Arwini Puspitasari Anieq Mumthi’ah Al Kautsar Aulan nadiya Beta Herilla Sekti Binti Ni'matul Mufarrichah Desie Suci Permata Sari Dewi Nur Aini Dhani Wijaya Diana Lyrawati Dina Nur Afida Dirgantara, Aprillia Angely Putri Diva Libriyani Syauqi Ningrum Dwi Wahyuni Leboe Egi Dwi Sakti Parenta Ellen Natalia Firman Mulyo Wicaksono Haeria Haeria Helma Chika Oktaviani Inayatilah, Fidia Rizkiyah Karlina Amir Tahir Khaerani Khaerani Khaerani Laily Khasinatil Asror Lulu’ Choir Risalina M. Rusdi Miranti Nugrahini Mirsya Awulia Reski Mochammad Rif’al Maulana Ilham Mukhriani Munifah Wahyuddin Munifah Wahyuddin Nada Nafisati Zahrah Neni Haerani Nurfianti Indriana Nursalam Hamzah Nurshalati Tahar Nurshalati Tahar Nursyamsi Dhuha Nurul Afia Wardhani Pipit Sulistiyani Prida Ayudianti Putri Wulan Akbar Qoriah Nur Alfaizah Ratna Nabila Permataningrum Ria Ramadhani Dwi Atmaja Rio Martin Rosadian Maharani Siti Jazimah Iswarin Siti Jazimah Iswarin St. Chadijah Susanti Susanti Syahifah Auliyah Hasti Tristy Digjayanti Tsabitah Daffa' Aulia Akmal Ummu Khairunnisa Azzahra Wahyuddin, Munifah Yashinta Avrilia Rahma Yitania Sari Yuliani Yuliani Yustisia Sifaiyya Yuwan Ihzudin Sumitro