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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 13 Documents
 1   2 
Search results for , issue "Vol 10 No 1 (2012): JIFI" : 13 Documents clear
Sintesis dan Uji Aktivitas Antimalaria Senyawa Turunan 2,4-Difenil-1,10-Fenantrolin RUSLIN HADANU; MUSTAFA MUSTAFA; NAZUDIN NAZUDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Malaria is still the main health problems in subtropical and tropical countries. There are 105 countries in the world at malaria endemic and more than 500 million cases or more than 2.7 million deaths from malaria each year. The traditional remedies are no longer effective and the incidence of malarial by P. falciparum, the most dangerous species of parasite, continues to grow, while some traditional drugs such as chloroquine has been resistance. Synthesis of 2,4-diphenyl-1,10-phenanthroline [5] compounds with benzaldehyde [1], acetophenone [2], t-calcone [3], 8-aminoquinoline [4] as starting material through three steps has been carried out. The results of all steps of the reaction were obtained compounds of [5], (1)-N methyl-7,9-diphenyl-1,10-phenanthrolinium sulfate [6] and (1)-N-ethyl-7,9-diphenyl-1,10-phenanthrolinium sulfate [7]. The results of antiplasmodial activity in vitro testing of the derivatives on chloroquine resistant P. falciparum FCR3 indicated that compound [7] has higher antimalarial activity (IC5O = 0.06±0.05 µM) than the activity of [6] compound (ICSO = 1.27±O.97 µM) and [5] compound (1C50 = 1.66±0.70 µM). Results of similar in vitro testing on chloroquine resistant P. falciparum D10 strain indicated that [7] compound has higher antimalarial activity (IC50 = 0.04±0.04 uM) than the activity of [5] compound (IC50 = 1.13±0.30 µM) and [6] compound (ICSO = 0.81±0.06 µM).
Sintesis Artemeter dengan Katalis Bifungsional dalam Satu Sistem Reaksi dan Uji Aktivitas Sitotoksik Terhadap Sel Leukimia L1210 LIA NURLIANA; HARMITA HARMITA; SILVESTER S. TURSILOADI; L.B. S KARDONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Artemisinin has been known as herbal medicine from China, which was isolated from the Artemisia annua L. plant. Artemisinin was originally known as antipyretic and antimalarial drug. Artemisinin and its derivatives also have potential as anticancer, due to the sesquiterpene lactone containing a unique peroxide group. This study aimed to modify the structure of artemisinin into artemether using solid catalyst Ni/TiO2-SO4 through the hydrogenation and methylation of the alcohol group in one pot reaction system. The product was then investigated for its cytotoxic activity against L1210 leukemia cells. The solid catalyst in this study was composed of metalic Ni as the active center, TiO2 as a catalyst support and sulphate as the promoter. The modification of artemisinin produced 1.29% artemether white crystalls as a minor product, and 19% dihidroartemisinin as an intermediate compound. The synthesized artemether showed an anticancer activity against L1210 leukimia cells with IC50 value of 3.07 µg / mL. The result suggests that the synthesized artemether has a potency as an anticancer.
Pengaruh Pemberian Ekstrak Etanol Buah Makasar (Brucea javanica [L.] Merr) terhadap Aktivitas dan Kapasitas Fagositosis serta Produksi ROI Sel Fagosit Mencit secara In vivo ROS SUMARNY; SILVI RISDIYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

One way to prevent of disease through increased endurance by increasing the effectiveness of the immune system to light the causes of disease. Macassar fruit (Brucea javanica [L.] Merr) of Simambaceae is known containing quasinoid which has cytotoxic activity against cancer, antiplasmodium, and improving the effectiveness of humoral immun system. The work is to investigate the effect of Macassar fruit ethanol extract on the activity and phagocytic capacity, as well as phagocyte ROI production of mice phagocyte cells. Five groups consisted of 12 mice per group were prepared. Group I, a normal control was given distilled water, Group II was given orally with Macassar fruit ethanol extract dose of 100 mg/ kg, Group III a dose of 200 mg/kg, Group IV a dose of 300 mg/kg, and positive control group V was given Stimuno. Results showed that the phagocytic activity of phagocyte cells increased with increasing doses. The highest phagocytic activity was achieved by the 300 mg/kg dose, observed either at 8th and 15th days after the treatment, with an increase in phagocytic activity of 65 .60% and 70.5%. ROI production of phagocytic cells has different response after 7 days or 14 days treatment with Macassar fruit extract. The ROI production increased by 43% after 14 days treatment with Maccasar fruit ethanol extract with the dose of 300 mg/kg BW.

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