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All Journal ALCHEMY Jurnal Penelitian Kimia Syntax Literate: Jurnal Ilmiah Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Poltekita : Jurnal Ilmu Kesehatan Daengku: Journal of Humanities and Social Sciences Innovation Borneo Journal of Pharmacy

ROS SUMARNY

UNIVERSITAS PANCASILA

Author-ID : 3682607

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Peran Apoteker Terhadap Keberhasilan Pengobatan Tahap Intensif Pasien Tuberkulosis Katharina Aditya Candra Utukaman; Dian Ratih Laksmitawati; Ros Sumarny; Edwin Tomasoa
Poltekita : Jurnal Ilmu Kesehatan Vol. 15 No. 3 (2021): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v15i3.510

Penelitian ini bertujuan untuk mengetahui pengaruh edukasi dan monitoring pengobatan tuberkulosis pada PKM dengan intervensi Apoteker (PKM Saumlaki) dan PKM tanpa intervensi Apoteker (PKM Larat). Responden penelitian ini adalah pasien baru TB dan Pengawas Menelan Obat (PMO) di kedua PKM pada bulan September-November 2020. Penelitian ini merupakan jenis penelitian quasi experimental dengan rancangan two group pretest-posttest design. Peran apoteker berupa edukasi dan monitoring dilakukan pada responden PKM Saumlaki selama 8 minggu observasi. Data dikumpulkan dalam bentuk kuesioner dan data catatan pengobatan di PKM masing-masing. Hasil penelitian menunjukkan karakteristik demografi responden di kedua PKM tidak berbeda bermakna. Perbedaan bermakna antara kedua PKM terdapat pada data pengetahuan, kepatuhan, outcome klinis berdasarkan BTA negative pada akhir pengobatan tahap intensif, dan data kepuasan pasien terhadap PMO. Sedangkan efek samping dan berat badan pasien antara kedua PKM tidak berbeda bermakna. Hal ini menandakan ada pengaruh edukasi dan monitoring oleh apoteker terhadap peningkatan jumlah pasien yang berhasil menjalani pengobatan TB. Analisis mengenai faktor yang signifikan berhubungan dengan keberhasilan pengobatan memberikan hasil bahwa faktor yang signifikan berpengaruh adalah adanya intervensi apoteker pada tingkat kepatuhan pasien, tingkat pengetahuan pasien dan PMO. Kesimpulan yaitu edukasi dan monitoring pengobatan langsung oleh apoteker pada pasien TB di PKM Saumlaki di KKT berpengaruh meningkatkan keberhasilan pengobatan pasien tuberkulosis

PENGARUH ANTIBIOTIKA PROFILAKSIS TERHADAP KEJADIAN INFEKSI LUKA OPERASI Oktaviana Zunnita; Ros Sumarny; July Kumalawati
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 8, No 1 (2018): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Antibiotik profilaksis adalah antibiotik yang diberikan pada pasien yang akan menjalani pembedahan untuk mencegah terjadinya infeksi akibat tindakan operasi. Antibiotik profilaksis diberikan secara intravena agar dicapai konsentrasi maksimum di serum/jaringan pada saat operasi. Pemilihan antibiotika profilaksis yang sesuai pada tindakan pembedahan sangat menentukan keberhasilan dalam mencegah terjadinya infeksi luka operasi. Penelitian ini bertujuan untuk mengetahui besarnya angka kejadian infeksi luka operasi dan mengevaluasi penggunaan antibiotika profilaksis dalam pencegahan infeksi luka operasi di rumah sakit Premier Bintaro, Kota Tanggerang. Jenis penelitian ini adalah observasional dengan rancangan studi deskriptif analitik melalui penelusuran data yang dilakukan secara retrospektif pada pasien yang menjalani pembedahan di ruang operasi. Analisa dan evaluasi data berupa deskripsi pola penggunaan antibiotika profilaksis dan angka kejadian infeksi luka operasi serta hubungan antara penggunaan antibiotika profilaksis dengan kejadian infeksi luka operasi. Hasil yang diperoleh dalam penelitian ini menunjukan bahwa angka kejadian infeksi luka operasi pada tindakan pembedahan sebanyak 7 kasus (1,97%) dari jumlah total 355 kasus bedah pada periode penelitian. Antibiotika profilaksis yang paling banyak digunakan adalah sefalosporin generasi III (66,2%). Hasil analisa dengan Fisher exact menunjukkan bahwa sifat operasi, jenis antibiotika dan waktu pemberian antibiotika mempunyai hubungan bermakna dengan kejadian ILO (p 0,05). Dari penelitian terlihat pula bahwa semakin lama operasi berlangsung semakin tinggi risiko infeksi luka operasi. Antibiotik sefalosporin generasi III terbanyak yang digunakan adalah ceftriaxone injeksi.

Efek Stimulansia Infus Lada Hitam (Piperis nigri fructus) Pada Mencit ROS SUMARNY; LESTARI RAHAYU; NI MADE DWI SANDHIUTAMI; LIBERT MORY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.345 KB)

Black pepper (Piperis nigri fructus) has been empirically used to eliminate fatigue and to increase stamina or as stimulant. The aim of this study was to determine the efficacy of black pepper infuse as stimulant on 30 male DDY mice using swimming and rotarod methods. The mice were divided into five groups. First group was given distilled water as control, second group was given caffeine of 0.36 mg/20 g bw. The other three groups were given orally with black pepper infuse of 0.32 mg/20 g bw, 0.65 mg/20 g bw, or 1.3 mg/20 g bw. Observations on mice swimming endurance and mice endurance on a rotarod, were carried out 60 minutes after oral administration of the solutions. Analysis using Kruskal-Wallis showed that there was significant difference in the stimulant efficacy between the black pepper infuse and the negative control (p<0.05). There was no significant difference in stimulant effect between the 0.32 mg/20 g bw of black pepper infuse and the caffeine positive control, however, the infuse dose of 0.65 mg/20 g bw and 1.3 mg/20 g bw have demonstrated stronger stimulant effects (p>0.05) as compared to the caffeine positive control.

Pengaruh Pemberian Aspartam secara Oral terhadap Kadar AST dan ALT Serum serta Gambaran Histopatologi Hati Tikus Putih Ros Sumarny; Sondang Khairani; Mohamad Rega Satria Ramadhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Aspartame is low calorie sweetener metabolized into aspartic acid, phenylalanine and methanol, methanol cause damage to the liver. The purpose this study to determine the effect rats of oral aspartame administration for 90 days on biochemical parameters AST, ALT and liver histopathology. Rats were divided randomly into four groups: normal control, dose groups 126, 252, 504 mg/kgBW. Blood samples were taken on the 0th, 30th, 60th and 90th days to measure AST, ALT levels and 90th day to see liver histopathology. AST and ALT measurements using UV-VIS spectrophotometry with a wavelength of 340 nm. The levels of AST and ALT on the 90th day in the normal group 41,55 and 48,40 UI/L. Dose groups 126, 252, and 504 mg / kgBW were low doses 54,62 and 57,72 UI/L, 66,88 and 70,47 UI/L, 77,50 and 80,03 UI/L. Rats histopathology liver of aspartame showed hemorrhage. Concluded aspartame can increase of AST and ALT levels in rats blood serum and liver damage.

Pengaruh Pemberian Ekstrak Etanol Buah Makasar (Brucea javanica [L.] Merr) terhadap Aktivitas dan Kapasitas Fagositosis serta Produksi ROI Sel Fagosit Mencit secara In vivo ROS SUMARNY; SILVI RISDIYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1379.477 KB)

One way to prevent of disease through increased endurance by increasing the effectiveness of the immune system to light the causes of disease. Macassar fruit (Brucea javanica [L.] Merr) of Simambaceae is known containing quasinoid which has cytotoxic activity against cancer, antiplasmodium, and improving the effectiveness of humoral immun system. The work is to investigate the effect of Macassar fruit ethanol extract on the activity and phagocytic capacity, as well as phagocyte ROI production of mice phagocyte cells. Five groups consisted of 12 mice per group were prepared. Group I, a normal control was given distilled water, Group II was given orally with Macassar fruit ethanol extract dose of 100 mg/ kg, Group III a dose of 200 mg/kg, Group IV a dose of 300 mg/kg, and positive control group V was given Stimuno. Results showed that the phagocytic activity of phagocyte cells increased with increasing doses. The highest phagocytic activity was achieved by the 300 mg/kg dose, observed either at 8th and 15th days after the treatment, with an increase in phagocytic activity of 65 .60% and 70.5%. ROI production of phagocytic cells has different response after 7 days or 14 days treatment with Macassar fruit extract. The ROI production increased by 43% after 14 days treatment with Maccasar fruit ethanol extract with the dose of 300 mg/kg BW.

Analisis Urea-Kreatinin Tikus Putih pasca Pemberian Ekstrak Buah Mahkota Dewa dan Herba Pegagan WAHONO SUMARYONO; AGUNG ERU WIBOWO; SRI NINGSIH; KURNIA AGUSTINI; ROS SUMARNY; FITRIANIAR AMRI; HENDIG WINARNO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1432.686 KB)

The evaluation of toxicity of a mixed herbal extract containing mahkota dewa fruits (Phaleria macrocarpa Scheff. Boerl) and pegagan leaves (Centella asiatica L. Urban) on Wistar-strain rats had been carried out by the determination of the urea and creatinine content in urine and plasma after feeding. Oral doses of 100 mg, 500 mg, and 2500 mg of the mixed extract/kg body Weight were administered for 16 consecutive weeks to three groups of rats. Each treated group consisted of 15 males and 15 females, and the control group was represented by 10 males and 10 females. Samples of urine and plasma of the treated groups were taken at the time right before treatment (Week zero) and at Sm, 16th, 18th Week, while those of the control were taken at zero Week, 8th, and 16th Week, respectively. The result showed that theurea and creatinine contents among the treated and control groups were not signihcantly different. It could be concluded that oral administration ofthe mixed extract by a dose up to 2500 mg/kg body weight for 16 Weeks did not influence the urea and creatinine contents both in urine and plasma of the treated animals. Based on this result, it could be assumed that the use of the mixed extract is safe.

Efek Antioksidan Larutan Kosolven Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) pada Tikus dengan Parameter MDA dan SOD ROS SUMARNY; LILIEK NURHIDAYATI; SITI SOFIAH; YATI SUMIYATI; FRANSISKA DIANA SANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.637 KB)

Mangosteen (Garcinia mangostana L.) rinds extract in capsule form has been marketed. a-mangostin, the active compound of G. mangostana had been known has low solubility in water. This study was aimed to measure and compare antioxidant effect of a-mangostin as cosolvent solution to extracts suspentions. 25 rats were divided into 5 groups: negative (I) and positive (II) control, cosolvent solution (III), extract (IV) and extract® (V). Treatment were given for 14 days, free radicals were induced by CCl . MDA were analyzed using thiobarbituric acid method while SOD by using adenochrome assay. Results showed MDA level were: 1.0±0.19; 0.3±0.05; 0.4±0.04; 0.6±0.04 and 0.5±0.00 nmol/mL, whereas SOD activity were: 17±0.0; 123±25.3; 107±19.0; 73±18.9 and 97±27.0 U/mL for group I, II, III, IV and V, respectively. Kruskal Wallis test showed a significant difference in MDA between group III with IV and V (p>0.05), showing cosolvent has higher ability to decrease MDA than the extracts suspension. There were significant differences of SOD between group III and IV (p>0.05), meaning cosolvent has higher ability to increase SOD activity compare to the extracts. Research showed cosolvent has a higher antioxidant effect with potential to inhibit MDA formation by 70% and increase SOD activity by 623%.

High Performance Liquid Chromatography Method Validation Of α-Mangostin Assay in Mangosteen (Garcinia mangostana L.) Fruit Rind Extract Formulated in Oral Solution Liliek Nurhidayati; Siti Sofiah; Ros Sumarny; Kevin Caesar
ALCHEMY Jurnal Penelitian Kimia Vol 11, No 1 (2015): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.11.1.104.38-46

Mangosteen fruit rind extract contain a lot of antioxidants. α-Mangostin is a component in mangosteen fruit rind that has highest antioxidant effect. The oral solution containing mangosteen fruit rind extract is required an assay method for quality assessment. Determination of a very low concentration of analyte in sample with very complex matrix, such as α-mangostin in oral solution, needs a selective and sensitive method, such as high performance liquid chromatography (HPLC). In this study, α-mangostin assay was performed by reverse phase HPLC system using octadecylsilane (C18) as stationary phase, methanol-water (90:10) as mobile phase, the flow rate is 1.0 mL/min, and the UV detector at 316 nm. The retention time of α-mangostin was 9.622 minutes. Peak of α-mangostin was well separated with resolution of 1.725. Linearity was in the range of 1.67-5.01 ppm with correlation coefficient of 0.9986. The relative standard deviation (RSD) was 1.30 %, the recovery was in the range of 95.80-100.76

Analisis Efektivitas Penggunaan Antibiotik Profilaksis dan Faktor Risiko Infeksi Daerah Operasi pada Pasien Bedah Apendisitis Di RS X Adi Setiadi; Ros Sumarny; Delina Hasan; Alfina Rianti
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Infeksi daerah Operasi adalah merupakan salah satu komplikasi utama operasi yang meningkatkan morbiditas dan biaya perawatan penderita di rumah sakit, bahkan meningkatkan mortalitas penderita. IDO merupakan kejadian tersering infeksi nosokomial. Tujuan penelitian ini adalah untuk mengetahui efektifitas penggunaan antibiotic profilaksis dan faktor risiko terjadinya IDO pada pasien bedah apendisistis di RSUP Fatmawati periode Januari 2016 - Desember 2018. Penelitian ini menggunakan desain penelitian cross Sectional. Besarnya sampel sebanyak 112 pasien. Teknik pengambilan data dilakukan secara total sampling. Pengumpulan data dilakukan secara retrospektif pada rekam medis pasien. Hasilnya terdapat 11 pasien yang mengaami IDO dari 112 pasien. Berdasarkan hasil analisis bivariat dan multivariat, faktor yang paling dominan menyebabkan IDO adalah penyakit penyerta, skor ASA, lama rawat, suhu tubuh kadar leukosit, karena nilai P-Value semuanya 0, 000 yakni < 0,05. Kesimpulan penelitian yaitu faktor risiko yang mempengaruhi kejadian IDO pada pasien bedah apendisitis di RSUP Fatmawati diantaranya penyakit penyerta, skor ASA, lama rawat, suhu tubuh kadar leukosit.

EVALUASI PENGGUNAAN ANTIBIOTIK DEFINITIF PADA SEPSIS NEONATORUM AWITAN DINI DAN LAMBAT DI RSPAD GATOT SOEBROTO Marselina Marselina; Ros Sumarny; Wawaimuli Arozal; Marliana Sri Rejeki
Majalah Farmasi dan Farmakologi Vol. 24 No. 3 (2020): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v24i3.11181

Angka kejadian sepsis neonatorum yang tinggi karena sulitnya penegakan diagnosis disebabkan faktor klinis tidak spesifik. Pasien akan mendapatkan antibiotik setelah 1 jam yang diduga sepsis. Hal ini meningkatkan resistensi karena penggunaan antibiotik tidak rasional. Maka perlu ibu serta pasien sepsis dan penggunaan antibiotik. Penelitian deskriptif analitik dengan studi kohort retrospektif menggunakan data rekam medis yang memenuhi kriteria inklusi. Analisis data secara bivariat dengan uji chi square pada p≤0.05. Ada 98 pasien (SNAD 55 pasien; SNAL 43 pasien). Hubungan hubungan antara ibu hamil kehamilan kehamilan SNAD (p = 0,025), kehamilan kehamilan kehamilan (p = 0,020).Hubungan antara hubungan antara variabel pasien detak jantung terhadap SNAD (p = 0.010). Evaluasi metode DDD didapatkan antibiotik yang sering digunakan yaitu meropenem 20.147 DDD / 100 hari sabar . Analisis hubungan antara metode Kunin terhadap luaran klinis pasien SNAD (p = 0.175; RR = 2.316; 95% Cl = 0.677-7.919), lama rawat (p = 0.057; RR = 4.929; 95% Cl = 0.954-25.469). Analisis hubungan antara metode Kunin terhadap luaran klinis pasien SNAL (p = 0.811; RR = 1.167; 95% Cl = 0.331-4.116), lama rawat (p = 0.110; RR = 0.525; 95% Cl = 0.391-1.705). Hasil tersebut menunjukkan bahwa tidak ada hubungan antara kerasionalan penggunaan antibiotik definitif dengan luaran kinis serta lama rawat yang di nilai menggunakan metode Kunin.Kata kunci: sepsis neonatorum, baterai, antibiotik definitif

Co-Authors . Syamsudin Achmad Riviq Said Adi Setiadi AGUNG ERU WIBOWO Alfina Rianti Anisa Rachmita Arianti Annisa`'a Nurillah Moesthafa Delina Hasan Dian Ratih Laksmitawati Edwin Tomasoa FITRIANIAR AMRI FRANSISKA DIANA SANTI HENDIG WINARNO Hesty Utami Katharina Aditya Candra Utukaman KURNIA AGUSTINI Lestari Rahayu LIBERT MORY Liliek Nurhidayati Lusi Nursilawati Syamsi Manuppak Irianto Tampubolon Marliana Sri Rejeki Marselina Marselina Mohamad Rega Satria Ramadhan Ni Made Dwi Sandhiutami Nyayu Tri Yeni Aryani Ryan Saputra Saputra S.Farm., M.Farm., Apt, Sondang Khairani SILVI RISDIYANTI Siti Sofiah SRI NINGSIH Wahono Sumaryono Wawaimuli Arozal Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono YATI SUMIYATI Zunnita, Oktaviana

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