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Syafira Dwi Cahyani
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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol 7 No 1 (2009): JIFI" : 8 Documents clear
Synergistic Effect of Areca catechu L. Ethanolic Extract and Its Chloroform Fraction with Doxorubicin on MCF7 EDY MEIYANTO; SRI HANDAYANI; ENDAH PUJI SEPTISETYANI; RATNA ASMAH SUSIDARTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ekstrak etanol biji buah pinang (Areca catechu L.) menunjukkan efek sitotoksik pada sel kanker MCF7 dan WiDr. Penelitian ini bertujuan untuk mempelajari efek sinergisme antara ekstrak etanol biji buah pinang (AE) dan fraksi kioroforrnnya (ACF) dengan doxorubicin (Dox) dalam pemacuan apoptosis sel MCF7. Ekstrak etanol dipartisi dengan n-heksan dan kloroform untuk mendapatkan fraksi kloroforin. Efek sitotoksik.AE, ACF, dan Dox pada perlakuan tunggal dan kornbinasi ditentukan dengan metode MTT. Penganiatan apoptosis dilakukan dengan pengecatan DNA dengan akridin oranye-etidium bromida (double staining). Imunositokimia dilakukan untuk melihat ekspresi COX-2 dan Bax. Kombinasi Dox 100, 250, 334, dan 500 nM dengan AE 8 µg/ml; Dox 100 nM dengan AE 20 µg/ml; serta Dox 100 dan 250 nM dengan ACF 7 dan 18 µg/ml memperlihatkan efek sinergistis yang kuat (CI 0,1-0,3). Sernentara itu, kombinasi Dox 250, 334, dan 500 nM dengan AE 20, 27, dan 40 µg/ml; Dox 100 nM dengan AE 27 dan 40 µg/ml; Dox 100 nM dengan AE 20 µg/mi; Serta 500 nM dengan ACF 24 dan 35 µg/ml menunjukkan efek sinergistis (CI 0,3-0,7). Secara keseluruhan, kombinasi AE dan ACF dengan Dox memperiihatkan efek sinergistis pada MCF7 dengan indeks kombinasi (CI) kurang dari 0,9 (P<0,05). Periakuan kombinasi juga memacu apoptosis. Penekanan ekspresi Bcl-2 terjadi padaperlakuan kombinasi ACF-Dox. Hasil penelitian ini menunjulckan bahwa koinbinasi AE dan ACF dengan Dox memberikan efek sinergistis dalam pemacuan apoptosis dengan kemungkinan mekanisme meialui penekanan ekspresi Bcl-2.
Surveilens Epidemiologi HIV/AIDS di Rumah Sakit Pemerintah di Jakarta Selatan pada 2005 AGUS PURWANGGANA; ENDANG POEDJININGSIH; MUNIRO MUNIRO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

HIV/AIDS has become a pandemic disease Which hits the Whole World including Indonesia. Antiretroviral (ARV) drugs are drugs pursuing HIV replication. A Government Hospital in South Jakarta is among hospitals that accept training on Voluntary Counseling and Testing (VCT) by the Department of Health, Republic of Indonesia, and has been a reference hospital for the medication of HIV/AIDS and its associated opportunistic infection in people With HIV/AIDS. This epidemiologic surveillance was conducted to find out proportion number, Case Fatality Rate (CFR), incidence rate and prevalence rate of all incidents related to HIV/AIDS. Data collection for people with HIV/AIDS was done through drug counseling cards, medical records and the laboratory examination results, and data analysis Was performed using Stata 7.0 software. Antiretroviral diugs often used in the Government Hospital in South Jakarta were Duviral-Neviral, Duviral-Evafir and Hiviral-Stavudin-Evahr. The results of this study show that the goals of the surveilance conducted can be achieved except for the number of incidence. Among 397 patients suspected to have HIV/AIDS, 324 patients had risk factor of HIV/AIDS, 240 patients were diagnosed positive HIV 290 patients Were severed with opportunistic infections, and 104 patients died.
Uji Ketersediaan Hayati Tablet Parasetamol dan Tablet Teofilin pada Kelinci DJOKO WAHYONO; ARIEF RAHMAN HAKIM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The objective of this research is to evaluate the bioavailability of paracetamol tablet to Panadol and theophyllin tablet to Bronsolvan in rabbits. The study Was conducted employing a same subject design using male rabbits which were divided into 2 groups (5 rabbits for each group). The group I was given a single oral antipyretic tablet (paracetamol 500 mg) and the group H was given a single oral antiasthmatic tablet (theophyllin 130 mg). After Wash out period, the group I Was given asingle oral Panadol tablet (paracetamol 500 mg) and the group ll Was given a single oral Bronsolvan tablet (theophyllin 150 mg). Serial blood samples were taken at various interval time for HPLC analysis of unchanged form of paracetamol and theophyllin in blood. Based on the data of the concentration over the time, the pharmacokinetic parameters (Cmaks, tmaks, and AUC0- ̴ ) were determined and compared using statistic analysis paired t test with 95% degree of comidence. The results indicated that the bioavailability of antipyretic and antiasthmatic tablet is not significantly difference to the respective controls (P>0,05).
Radiolabelling Optimization of Cells with 51Cr(VI) for Measurement of Immune Responses after Anti-Rabies Vaccinations MARTALENA RAMLI; CICILIA WIDIYANINGSIH; AGUS ARYANTO; FITRIA YUNITA; RAHMAT MAHARIS; IDA LESTARI; DODO HERMAWAN; NENI NURYANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Telah dilakukan optimasi penandaan sel dengan 51Cr(VI) untuk penentuan respon imun setelah vaksinasi antirabies. Optimasi dilakukan karena, pada pengerjaan awal, penandaan yang didasarkan pada prosedur yang telah dipublikasi memberikan hasil penandaan dan cacah per menit per sel (CPM/ sel) yang rendah. Sangat kontras dengan yang pernah dilaporkan, penandaan dalam media lengkap (media + feral bovin serum, FBS) memberikan efisiensi penandaan hanya 3.7 ± 0,7% dan CPM/sel ≤ 0.02 (persyaratan untuk chromium release assay ≥ 0.2 CPM/sel). CPM/sel dari sel bertanda tetap rendah Walaupun diinkubasi selama lima jam. Penandaan kemudian dilakukan dalam media yang tidak mengandung FBS, atau tanpa media di mana 51Cr langsung ditambahkan pada sel, untuk mengamati apakah ada kompetisi antara sel dengan FBS dalam mengikat 51Cr Efisiensi penandaan dalam media OPTI, EMEM 10, PBS, dan air, atau tanpa media memperlihatkan peningkatan yang sangat berarti. Efisiensi penandaan paling tinggi (96,3 ± 3,9 %) dengan CPM/sel (1 ,7 ± 0,07) Serta kehidupan sel yang terjaga (2 80%) diperoleh dengan media OPTI. Eiisiensi penandaan dan CPM/sel dalam media lain relative lebih rendah, yaitu 12-26% dan 0,07-0,13. Sel Vero dan sel fetus ayam, yang juga dapat digunakan untuk penentuan respon imun setelah vaksinasi antirabies, ditandai pula dengan 51Cr dalam media OPTI. Penandaan dalam kondisi ini memberikan hasil yang memuaskan (efisiensi ~ 90%, dan CPM/sel > 1,5). Hasil penandaan di atas mengindikasikan adanya kompetisi antara FBS (albumin) dalam penandaan sel dengan 51Cr Sel yang ditandai dengan 51Cr dalam media OPTI telah berhasil digunakan untuk penentuan respon imun setelah vaksinasi antirabies secara intradermal dan intramuskular.
Penangkapan Radikal 2,2-Difenil-1-Pikril Hidrazil oleh Ekstrak Buah Psidium guajava. L dan Averrhoa carambola L. ABDUL ROHMAN; SUGENG RIYANTO; RIZKA DAHLIYANTI; DIMAS BAGUS PRATOMO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Two fruits, Guava (Psidium guajava L.) and Carambola (Averrhoa cammbola L.), Which are frequently consumed by Indonesian people, have been evaluated for its activities as 2,2-diphenyl-1-picrylhidrazyl (DPPH) radical scavenging. The fruits were macerated, evaporated, dissolved in Water, partitioned with chloroform and then with aethyl acetate to afford methanolic extract and fractions of chloroform, aethyl acetate, and Water respectively. Total phenolic and total flavonoid contents of each extract and fraction Were determined by spectrophotometric technique and used to evaluate the correlation between the natural chemical contents and their activities as DPPH radical scavengers. The results showed that extracts and fractions of R guajava L. fruit have more ability to scavenge 2,2-diphenyl- 1-picrylhidrazyl (DPPH) radical than those of A. carambola L. The total phenolic and total flavonoid contents of extracts and fractions of R guajava L. fruit are also higher than those of A. cammbola L.
Identification of a Triterpenoid Saponin from Seeds of Barringtonia asiatica (L.) Kurz HINDRA RAHMAWATI; BUSTANUSSALAM BUSTANUSSALAM; PARTOMUAN SIMANJUNTAK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Barringtonia asiatica (L.) Kurz (nama local: keben) termasuk ke dalam suku Lecythidaceae, dan biasanya digunakan sebagai racun ikan. Tanarnan ini banyak tumbuh di sekitar pantai, sepanjang sungai, atau di hutan bakau. Secara tradisional, keben digunakan untuk pengobatan yang pemakaiannya berbeda-beda di setiap daerah, seperti obat sakit perut, hernia, dan sakit kepala. Biji tanaman ini mengandung saponin yang diperkirakan berperan sebagai zat bioaktifnya. Ekstrak metanol dari biji ini dipartisi dengan etilasetat- air (1:1) dan ekstrak air yang diperoleh dimurnikan dengan kromatografi kolom (LH-20; MeOH; MeOH 50%; air) hingga memberikan suatu serbuk amorf yang berwarna coklat. Dari hasil identifikasi struktur kimia dengan FT-IR, RMI (protondan karbon), diperkirakan komponen ini adalah senyawa triterpenoidsaponin 3-0-{[ β -D-galaktopiranosi1(1→3)-β-D-glukopiranosil(1→2)]-β-D-glukuronopiranosiloksi}-22- O-(2-metilbutiroiloksiy-15,16,28-trihidroksi-(3β,15α,16 α,22 α)-olean-12-en.
Pemakaian Sel HeLa dalam Uji Sitotoksisitas Fraksi Kloroform dan Etanol Ekstrak Daun Annona squamosa IRA DJAJANEGARA; PRIO WAHYUDI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Custard apple (Annona squamosa) is a favorite fruit in Indonesia. The leave of this plant is used and known for long time as an astringent, antiinflammatory, birth control, and antitumor agents. Previous experiments on toxicity using brine shrimp lethality test (BSLT) method indicated that the chloroform fraction of custard apple leaves was toxic to the shrimp larvae with LC50 value at 1.77µg/ml. This experiment was carried out to investigate further the possible role of custard apple leaves as an anticancer agent using HeLa cell line. Experiment was initiated by extracting the leaves using 70% ethanol by means of maceration. The macerate was then fractionated further using chloroform as solvent. The ethanol fraction and chloroform fraction were used in cytotoxicity assay using (cervix cancer) HeLa cell line. Cytotoxicity assay Was done using direct counting method. The amount of living cells were observed and counted, death percentage Was then determined and probit analysis Was applied to determine the LC50 value. LC50 value for ethanol fraction from the leaves of custard apple (Annona squamosa) Was 7.695 µg/ml While for chloroform fraction was 4.547 µg/ml based on cytotoxicity analysis using HeLa cells. This experiment concluded that theleaves of custard apple (Annona squamosa) has cytotoxicity toward HeLa cell lines which confirmed the previous toxicity experiment using brine shrimp lethality test (BSLT) method. Overall, this experiment indicated that the leaves of custard apple (Annona squamosa) have anticancer activity.
Lauret-7-Sitrat sebagai Detergensia dan Peningkat Busa pada Sabun Cair Wajah Glysine soja (Sieb.) Zucc SITI UMRAH NOOR; DESY NURDYASTUTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Soya milk is an extraction product from soya bean that can be used as humectant due to its amino acids which are similar to those in our skin, such as glycine, serine, alanine, asparagine, ornithine, citruline, proline, and 17 other amino acids. ln this study, a liquid facial Wash containing soya milk using lauret-7-citrate (concentration 0, 1, 2, and 3%) was formulated that could affect the surface active characteristis, and the foam formation. The organoleptic characteristics, density, viscosity, rheology, surface tension, foam height and stability of foam height in pure and hard Water were determined at 25°C and 40°C for 8 Weeks. The results obtained showed that the best facial Wash was that contained 15% soya milk (2% lauret-7-citrate) of which had the following properties: a pseudoplastic rheology, a density of 1.076-l.079 g/cm3, a viscosity of 14,550-17,300 cPs, a surface tension of 25.41-27.18 dyne/ cm3, foam height in pure Water of 850-866.67 ml and in hard Water 466.67-600 ml, and stable at pH 4.99-5.00.

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