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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Articles 26 Documents
Search results for , issue "Vol 25, No 3 (2019)" : 26 Documents clear
THE PLATELET-TO-LYMPHOCYTE RATIO ON ACUTE COMPLICATION OF DIABETES MELLITUS Hariogie Putradi; Catur Suci Sutrisnani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1476

Abstract

Hariogie Putradi1, Catur Suci Sutrisnani21Resident of Clinical Pathology Department, Faculty of Medicine Brawijaya University Malang/ dr. Saiful Anwar General Hospital, Malang2Clinical Pathology Department, Faculty of Medicine Brawijaya University Malang/                    dr. Saiful Anwar General Hospital, MalangABSTRACTBackgroundHyperglycemia crisis can occur in Diabetes Mellitus (DM). The uncontrolled complications of DM are Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar State (HHS). Inflammatory response is potentially occur in these condition. Platelet-to-Lymphocyte Ratio (PLR) is a new marker of inflammation in which platelet counts tend to increase, while lymphocyte counts tend to decrease due to severe apoptosis. AimDescribe PLR on acute complication of DM and to know the difference of PLR between DKA and non-DKA (HHS and Mixed).MethodRetrospective study in patients with acute complication of DM in dr. Saiful Anwar General Hospital Malang in January 2017-May 2018. The platelet and lymphocyte count were obtained from the Laboratory Information System (LIS). The PLR was calculated by dividing the platelet count by the lymphocyte count.ResultA total of 71 patients were involved in the study, consisting of 21 DKA patients and 50 non-DKA patients. There was significant difference of platelet count between DKA and non-DKA patients (p=0,001). However, there were no significant differences of lymphocyte count (p=0,087) and PLR (p=0,762) between DKA and non-DKA patients.DiscussionIn DKA, there is a chronic inflammatory process that can affect PLR. As a result, platelet counts tend to increase, while lymphocyte counts tend to decrease due to severe apoptosis.  Conclusion and SuggestionThe study showed significant difference of platelet count between DKA and non-DKA groups, and no significant difference of PLR between DKA and non-DKA groups. It is recommended to conduct further research with larger sample size.
ANALYSIS OF IMMATURE PLATELET FRACTION AND MEAN PLATELET VOLUME IN ACUTE CORONARY SYNDROME PATIENT Pratia Paramita; Asvin Nurulita; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1390

Abstract

Platelets have a central role in the pathogenesis of ACS. Immature Platelet Fraction (IPF) considered as a potential marker of the platelet activation process and platelet turnover process. Immature platelets have greater prothrombotic potential and aggregate more rapidly with collagen that affects platelet hemostasis potential that may contribute to the formation of thrombus. Therefore IPF is associated with the progression of coronary heart disease. MPV values reflect platelet activation. A cross sectional study was held in the clinical pathology laboratory of Dr. WahidinSudirohusodo Hospital Makassar during September-November 2016. 67 samples underwent and declared ACS by the physician. 67 patients with ACS were involved with a distribution of 30 patients STEMI (44.8%), 30 patients NSTEMI (44.8%), and 7 patients UAP (10.4%). Subjects are mostly male (73.1%) and young adult age (82.1%). There was significant difference of IPF value especially in STEMI group with mean 3,1 (p = 0,004) and no significant difference of MPV value in ACS group.Pearson correlation test showed there was positive correlation with weak strength of IPF and MPV values in ACS patients (p = 0.02, r = 0.388). There was a significant difference between IPF scores according to GRACE score (p = 0.005).  Increased  IPF value in STEMI group. The IPF score can be considered as a risk stratification of ACS patients replacing GRACE score. There was a positive correlation with weak strength of IPF and MPV value in ACS patients.
D-DIMER IN HEMODIALYSIS PATIENTS RECEIVING CONTINUOUS AND INTERMITTENT HEPARIN Derry Heppy Fritiwi; Harun Rasyid Lubis; Adi Koesoema Aman; Herman Hariman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1461

Abstract

Haemodialysis is the most widely used kidney replacement therapy in Indonesia and in the world, but the procedure may trigger development on thrombogenesis. Doe to this reason, anticoagulant heparin is given during haemodialysis to prevent the development of thrombus. However, haemostasis monitoring is essential to predict the possibility of heparin induced bleeding. The use of heparin in general needs a machine to regulate continuous heparin administration, nonetheless not all hospitals have that instruments and for this reasons some centre use intermittent heparin injection. The aim of this study is to investigate whether  intermittent heparin is as effective as continuous heparin to prevent thrombus formation as well as to prevent bleeding and predict the survival outcome. Patient divided in to two grup from intermittent heparin and continuous heparin in total 50 patient were participated. Platelet count, PT, APTT, TT, fibrinogen, and D-dimer were investigated. The result demonstrates that platelet count, PT, APTT, TT, fibrinogen, and D-dimer were not significantly differed between the groups receiving intermittent and continuous heparin (p >0.05). When the test is compared between intermittent and continuous heparin in pre and post haemodialysis it is clear that there is significant increases in APTT and fibrinogen both in the intermittent and continuous heparin, but D-dimer is increased in continuous heparin only during post haemodialysis. There is no difference in the 1-year survival outcome between intermittent and continuous heparin. In conclusion, intermittent heparin produces less D-dimer increase compared to continuous heparin but it is as effective as continuous heparin. Intermittent heparin may be used as the alternative choice when continuous syringe driver machine is not available.
Subjects and Authors Index Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1569

Abstract

Author Guideline and Subcribes Form Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1781

Abstract

PLATELET LEUCOCYTE AGGREGATES ANALYSIS IN LEUCODEPLETED AND NON-LEUCODEPLETED PLATELET CONCENTRATES Teguh Triyono; Raehanul Bahraen
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1458

Abstract

Activated platelet could initiate aggregation and linkage with nearby leucocytes to form Platelet-Leucocyte Aggregates (PLA). Leucodepletion procedure could remove leucocyte and separate it from the other blood components therefore minimalizing the probability of PLA formation. We analyze percentage difference of PLA in leucodepleted and non-leucodepleted platelet concentrate. Dual expression of CD41 and CD45 was determined by flowcytometry method representing the value of PLA, PLA percentage of each group was calculated and analyzed with statistical software SPSS 22. Mean percentage value of PLA in leucodepleted group was 63.05 ±19.86, meanwhile in non-leucodepleted group was 64.61 ±17.27. We found that the percentage of PLA in nonleucodepleted group is higher than leucodepleted although the difference is not statistically significant.

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