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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 24 Documents
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Search results for , issue "Vol 28, No 2 (2022)" : 24 Documents clear
Relationship between High Sensitivity C-Reactive Protein and Total Testosterone Levels in Male Patients with Stage V Chronic Kidney Disease Metana Puspitasari; MI. Diah Pramudianti; Yuwono Hadisuparto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1833

Abstract

The incidence of decreased total testosterone level increases in stage V CKD patients. Decreased total testosterone levels is influenced by uremia and hemodialysis bioincompatibility through an increase in the inflammatory mediator hs-CRP. Obesity and age are risk factors of CKD incidence which can directly affect testosterone level. This study aimed to analyze the relationship between hs-CRP, serum urea, age, obesity, and hemodialysis duration with decreased total testosterone levels in stage V CKD patients. This observational study with cross-sectional approach was performed are 60 stage V CKD patients treated in Dr. Moewardi General Hospital, Surakarta on November 2020. The data were analyzed with 2x2 table test, followed by multivariate analysis using logistic regression. The examinations of total testosterone and hsRP used ECLIA and immunoturbidimetric assay, respectively. This study obtained 21 (37%) study who experienced a decreased total testosterone level (<3ng/mL). hs-CRP level [PR 3.656 (95% CI: 1.202-11,124; p=0.020)]; obesity [PR 4.156 (95% CI: 1.272-13.581; p=0.015)] and urea [PR 4.474 (95% CI: 1.273-15.728; p=0.015)] significantly associated with decreased total testosterone level of <3 ng/ml. Meanwhile age was not statistically significant (p=0.694) and hemodialysis duration obtained PR <1 and CI 95% < 1 (p=0.018). Therefore in patients with stage V, hs-CRP levels ≥ 0.65 mg/dl, serum urea ≥ 120 mg/dL, and obesity correlate with decreased total testosterone level while age is not associated with decreased total testosterone level. The hemodialysis duration is not a risk factor of decreased total testosterone.
Implementation of Six Sigma in Glucose POCT Quality Control at Dr. Soetomo General Academic Hospital Susi Oktaviani; M. Robiul Fuadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1848

Abstract

Point of Care Testing (POCT) is important for the examination of critically ill patients in the emergency room and intensive care unit. The evaluation of the analytic quality of POCT is needed to ensure the quality of patient care at Dr. Soetomo General Academic Hospital. The purpose of this study is to evaluate the analytical quality of POCT at Dr. Soetomo General Academic Hospital. This was an observational analytical study that was done at Dr. Soetomo General Academic Hospital Surabaya in July 2017. Point of care testing quality analysis was based on 20 within run Internal Quality Control (IQC). Internal quality control data was used to calculate the mean, SD, and CV%. CV% was calculated with the following equation "CV%=(SD × 100)/mean". Bias % = [ control mean – control true value]/control true value x 100. The sigma value was obtained from Total Error Allowance (TEa) – Bias/CV. TEa in this study was based on ISO 15197:2003. The results of the glucose examination (58 samples) from Dimension EXL 1, 2, 3 (hexokinase method) compared with 7 glucose POCT (glucose oxidase:i-STAT Nova Biomedical method). The correlation was calculated with Spearman statistical analysis using the SPSS version 23.0. the mean CV of seven POCTs=3.5% (1.7%-5%), mean bias of seven POCT=7.75% (4.8%-12.5%), the mean six sigma of 7 POCT=6.77 (4.0–11.6). The best POCT with a six sigma value of > 6 was glucometer K14_2, Palem 1 and GRIU. The glucometer with the lowest six sigma values but still had good quality control were K14_1 and ROI. All glucometers had a good correlation with r value > 0.8 (p=0.000). Glucose POCT in Dr. Soetomo General Academic Hospital all had good quality and met world-class standards. Further study using IQC 2 levels is recommended for a better POCT quality evaluation.
Procalcitonin and Troponin-I as Predictor of Mortality in Acute Myocardial Infarction Patients Novi Khila Firani; Jennifer Prisilla
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1817

Abstract

Acute Myocardial Infarction (AMI) is known as one of the leading causes of death in the world as well as in Indonesia. Procalcitonin is a marker of inflammation that has been recognized as a predictor of mortality in sepsis patients. The role of procalcitonin as a predictor of mortality in AMI patients has not been widely studied. Troponin-I has been recognized as a biomarker of AMI. It is unclear whether Troponin-I can also act as a biomarker to predict the death of AMI patients. This study aim is to determine the role of procalcitonin and troponin-I as predictors of mortality in AMI patients. A 5-month analytical observational study was performed on AMI patients who were admitted to Dr. Saiful Anwar, Malang. Patients with sepsis or infection were excluded. There were 51 study subjects, of whom median procalcitonin and troponin-I levels of patients who died were significantly different from survivors (p<0.05). Procalcitonin level with a cut-off of 2.16 ng/mL had a sensitivity of 77% and specificity of 87%. Troponin-I level with a cut-off of 3.1 ng/mL had a sensitivity of 61% and specificity of 84%. Odds ratio of procalcitonin to mortality was 17.78 (p=0.001), while troponin-I was not significant. Procalcitonin correlated with mortality (r= 0.519, p= 0.005). The conclusion of this research is procalcitonin acts as a predictor of in AMI patients.
Cover and Contents Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.2014

Abstract

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