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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 24 Documents
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Search results for , issue "Vol. 29 No. 3 (2023)" : 24 Documents clear
Beta-Catenin Plasma Test: Liver Fibrosis Degree Assessment in Chronic Hepatitis B Patients Anne Marrya; B. Rina A. Sidharta; Lusi Oka Wardhani; JB. Suparyatmo; MI. Diah Pramudianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2021

Abstract

Liver fibrosis caused by chronic hepatitis B infection leads to significant mortality and morbidity. Monitoring and evaluation of liver fibrosis progression depend on the ability to detect the fibrosis. Liver biopsy as a gold standard for liver fibrosis is an invasive technique, while Fibroscan ® with transient elastography as a non-invasive technique has a limitation. Therefore, a biomarker is needed to detect liver fibrosis. Beta-catenin is a multifunctional protein, which has a Wnt-regulated transcription factor and resides in hepatocytes. Hepatitis B virus infection activates Wnt/beta-catenin and affects the expression of target genes for liver fibrosis. This study aimed to analyze the diagnostic performance of plasma beta-catenin levels using transient elastography as a standard reference to assess the degree of liver fibrosis in patients with chronic hepatitis B infection. This was an observational analytic study with a cross-sectional design. The analysis was performed on 70 chronic Hepatitis B patients between December 2020 and January 2021 at Dr. Moewardi Hospital, Surakarta. This ROC analysis was used to determine the cut-off point. The best AUC point was chosen using a 2x2 diagnostic test table. The cut-off point for plasma beta-catenin was 73.132 pg/mL and AUC was 0.793 (CI 95%: 0.681-0.906; p<0.001), indicating that the results were statistically significant with p<0.05. Sensitivity of 74.3%; specificity of 71.4%; PPV of 72.2%; NPV of 73.5%; LR (+) 2.6; LR (-) 0.36 were obtained. The beta-catenin level was <73.132 pg/mL. A total of 26 subjects were at risk for liver fibrosis with transient elastography >8 kPa. Plasma beta-catenin levels had moderate performance as a liver fibrosis marker.
Diagnostic Performance of Mac 2–Binding Protein Glycosylation Isomer in Chronic Hepatitis B Wita Prominensa; B. Rina A. Sidharta; Lusi Oka Wardhani; JB. Suparyatmo; MI. Diah Pramudianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2022

Abstract

Chronic Hepatitis B (CHB) is a concern for Chronic Liver Disease (CLD) and causes a 74% mortality rate in Asia Pacific. World Health Organization (WHO) showed Indonesia is the highest second country of Hepatitis B (HB) in the South East Asian Region, Central Java is the highest in Java and Dr. Moewardi Hospital (RSDM) Surakarta in 2019 increased to 15%. Liver biopsy is fibrosis gold standard staging. It has limitations and requires invasive procedure pain in 40% of patients. This study aimed to determine M2BPGi diagnostic test against to transient elastography (TE) Fibroscan® (sensitivity 85.7%, specificity 81.6%) as a predictor of significant liver fibrosis of CHB in RSDM. Fibroscan® examination was performed on patients diagnosed with CHB by a clinician performed at the endoscopy department of RSDM, whereas laboratory tests were carried out from December 2020 to January 2021. Plasma M2BPG-I cut-off value was determined using Receiving Operating Characteristic (ROC) curve, M2BPGi levels were measured sandwich ELISA using spectrophotometry at a wavelength of 450 ± 2 nm. A total of 70 subjects was divided into 35 subjects with significant and 35 subjects with non-significant fibrosis. The results of the statistical calculation showed that plasma M2BPGi levels had a cut-off of 12.939 ng/mL (mean value of 17.841 ng/mL with significant fibrosis at 16.74 ng/mL and non-significant fibrosis at 10.14 ng/mL) had a moderate performance as a marker of liver fibrosis in CHB (71.4% sensitivity; 68.6% specificity; 69.4% PPV; 70.6% NPV and PLR 2.273), NR 0.417 with AUC of 0.727, CI 96% (0.681-0.0906). M2BPGi plasma levels at a cut-off of 12.939 ng/mL had a moderate performance as a predictor of significant liver fibrosis in chronic hepatitis B patients.
SAA as Inflammatory Marker in Rheumatoid Arthritis: Study on Standard Therapy and Moringa Extract Yan Ajie Nugroho; B. Rina A. Sidharta; Lusi Oka Wardhani; JB. Suparyatmo; MI. Diah Pramudianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2028

Abstract

Rheumatoid arthritis is a chronic systemic inflammatory autoimmune disorder characterized by persistent joint inflammation leading to cartilage and bone damage, disability, and systemic complications. The levels of APR such as SAA serum increase during synovitis. Previous studies have demonstrated the anti-inflammatory effect of M.oleifera leaf extract in the treatment of RA in animals; however, research data on humans remain limited. An experimental study on pre- and post-treatment of 40 RA patients was carried out by dividing subjects into 2 groups, including a standard therapy group and a standard therapy group added with M.oleifera leaf extract. The research was conducted at Dr. Moewardi Hospital, Surakarta from October 2020 to January 2021. The SAA levels were measured using ELISA. Paired T-test was used to analyze the differences in mean SAA levels before and after treatment. There was a significant difference between pre-treatment (346.57±54.40 ng/mL) and post-treatment (314.77±37.40 ng/mL) SAA levels in the standard therapy group added with M.oleifera leaf extract with p=0.01. Pre-treatment and post-treatment SAA levels in the standard therapy group were 322.68±87.01 ng/mL and 302.93±86.51 ng/mL, respectively with p=0.04. The mean of delta SAA in the standard therapy group added with M.oleifera leaf extract (-31.81±4.04 ng/mL) was greater than delta SAA in the standard therapy group (-19.75±4.07 ng/mL) with p=0.26. There was a significant decrease in SAA levels in RA patients on standard therapy and M. oleifera leaf extract.
Hematology Reference Values in Indonesian Children Ina S. Timan; Aryati Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2031

Abstract

Every clinical laboratory has to establish its reference ranges for every parameter analyzed. These reference values are intervals considered normal in a healthy person's physiological condition. It will be used by the clinician or other health professionals to interpret the laboratory test results of the patient for making diagnostic decisions, monitoring patient therapy, and predicting the prognosis and it is also used in epidemiology studies. A reference range is defined as an interval in which 95% of a reference population’s values fall. It is very crucial to establish reference intervals for the local population as it is sometimes affected by ethnicity, nutrition, food habits, and  economic and other local conditions. Hematology is the most common test performed in a clinical laboratory, and the most used parameter by the clinician including pediatricians. There up to now no well-established reference interval for hematological parameters in pediatrics and children in Indonesia. The reference interval used for hematology parameters in Indonesia is based on reference intervals from other countries or the manufacturer of the hematology analyzers used in a particular laboratory. Establishing a population-specific hematology reference interval is very difficult for pediatrics and children, so it is rarely performed. This study aims to compile the results of hematology parameters from Indonesian children to establish an Indonesian reference value for hematology. The method used was compiling data for the hematology parameter intervals based on studies performed in the Indonesian population and presented as 95% confidence intervals. A pediatric reference range for several hematology parameters has been established based on 3 groups of age in Indonesian children.
Correlation of sTfR, Hemoglobin, Serum Iron, and eGFR in Pre-dialysis CKD Patients at Sanglah Hospital I Nyoman Wande; Dewa Ayu Putu Rasmika Dewi; Ni Ketut Puspa Sari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2033

Abstract

Patients with CKD usually have chronic inflammation and impaired antioxidant systems, which worsen with the degree of renal impairment. Anemia is one of the major complications in pre-dialysis CKD patients Examination of iron status that is commonly done today such as serum iron parameters, ferritin, and transferrin saturation is still influenced by the inflammatory process. As an alternative to assessing iron status, the soluble transferrin receptor (sTfR) is not affected by chronic disease or inflammation. The purpose of this study was to determine the correlation of sTfR, hemoglobin, serum iron, and estimation of glomerular filtration rate (eGFR) in pre-dialysis CKD patients. This research was conducted from February to June 2022 at the Nephrology Outpatient Clinic and Clinical Pathology Laboratory of Sanglah Hospital, Denpasar. This research is an observational analytic study with a cross-sectional study design. The research subjects involved were 61 pre-dialysis CKD patients who met the inclusion and exclusion criteria. The results showed that the research subjects consisted of 54.1% male and 45.9% female. The results of the Spearman correlation test showed a weak significant negative correlation between sTfR levels and serum iron in pre-dialysis CKD patients (r = -0.264; p=0.040), but no significant correlation with hemoglobin (r = -0.116; p=0.372) and eGFR ((r = 0.134; p=0.302). This study showed a significant correlation indicating that an increase in serum sTfR levels would affect a decrease in serum iron, so it could be considered as a marker for the management of iron deficiency anemia in CKD.
Profile of Pulmonary Tuberculosis Patients in Dr. Soetomo General Academic Hospital Muhammad Dany Ramadhan; Aryati Aryati; Laksmi Wulandari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2040

Abstract

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis, which mainly attacks the lungs but can also infect other body organs. Tuberculosis is a global health problem that causes the highest death after Human Immunodeficiency Virus (HIV). Indonesia ranks third highest in the world, with 420,994 cases in 2017. This study aims to determine the profile of pulmonary tuberculosis patients at Dr. Soetomo General Academic Hospital, Surabaya from January 1st to December 31st, 2019. The research was conducted using a descriptive method by collecting secondary data, through medical records of pulmonary tuberculosis patients at the Inpatient Unit of Dr. Soetomo General Academic Hospital during January 1st - December 31st, 2019. The data obtained were processed according to gender, age, education, occupation, comorbidities, clinical symptoms, history of TB treatment, sputum examination results, and GeneXpert. This study uses total sampling presented in the form of pictures. The results showed that most of the patients were male (61.92%), aged 45-54 years old (25.13%), high school education level (56.48%), and private employees (34.45%). The most common comorbidities were diabetes mellitus (35.07%), the most clinical symptoms found were shortness of breath (29.56%), the complete history of TB treatment was first-line OAT (42.22%), as many as (77.97%) sputum examinations showed no data. Many (7.77%) GeneXpert results showed resistance to rifampicin after six months of therapy.
Analysis of Alfa-Fetoprotein as A Staging Determiner of Hepatocellular Carcinoma Progresivity Dahvia Nursriyanti; Ani Kartini; Mutmainnah Mutmainnah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2044

Abstract

Hepatocellular carcinoma (HCC) is the most common malignant tumor with a poor prognosis and is known as the silent killer. The currently recommended HCC staging system is Barcelona Clinic Liver Cancer (BCLC). The Alpha-fetoprotein (AFP) test is still used to manage HCC patients. The purpose was to find out the AFP comparations and to decide cut-off values for each stage according to BCLC. Cross-sectional retrospective study using secondary data from medical records of Outpatients Clinic and Inpatients from January 2016 to October 2021 at Dr. Wahidin Sudirohusodo Hospital. A total of 432 samples based on BCLC were taken with AFP values and analyzed in this study. The male sample was 72.7%. The highest age is 46-65 years (62.7%). The etiology of HCC mostly is hepatitis B (72.5%). The most BCLC systems were BCLC B (53.7%), followed by BCLC A (25.9%), BCLC D (12.5%), and BCLC C (7.87%). There was a significant difference in AFP values between BCLC stages and the highest significance was BCLC D, followed by BCLC C, B, and A (p=0.05). The cut-off results values at the BCLC stage were BCLC A <21.84 ng/mL, BCLC B: 21.84 ng/mL (sensitivity 90.3%, specificity 85.7%), BCLC C: 478 ng/mL (sensitivity and specificity 100%), BCLC D: 7.693 ng/mL (sensitivity and specificity 100%). There was a significant difference in AFP values between BCLC stages and the highest is BCLC D. Based on the results of calculating the cut-off value, which has good sensitivity and specificity, AFP can be used as a determinant of stage progression of HCC.  
Analysis of the Relationship between Serum Magnesium Levels and Severity of COVID-19 Patients Muyadhil Nurindar; Ruland DN. Pakasi; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2045

Abstract

Magnesium (Mg) plays an important role in the homeostasis functions of the lungs and heart for humankind. However, there is limited information concerning the importance of such an electrolyte mineral to COVID-19 pathogenesis. The Mg level is not primarily considered for the analysis of infectious diseases in the laboratory. The purpose of this study was to analyze the relationship between Mg levels and COVID-19 patient severity at Dr. Wahidin Sudirohusodo Hospital, Makassar. This research was a retrospective study with a cross-sectional design. Samples were prepared from 186 patients. Serum Mg levels were measured using an ABX Pentra 400C analyzer and the patients diagnosed with COVID-19 were then classified into abnormal and normal magnesemia. Based on the severity of COVID-19, patients were then categorized into severe and non-severe. The obtained data were then statistically analyzed using the Kolmogorov-Smirnov test, Mann-Whitney test, Chi-Square, and odd ratio with a significant level of p <0.05. The mean values of serum Mg levels of severe COVID-19 patients (2.53±2.03 mg/dL) were not significantly different compared to those of non-severe COVID-19 patients (2.12±0.83 mg/dL) with p=0.712. Patients with abnormal magnesemia had a 2.625 times higher risk of severe COVID-19 (95% CI = 1.499 – 4.757, p-value=0.001) compared to those with normal magnesemia. There was a significant relationship between serum Mg levels and the severity of COVID-19 patients at Dr. Wahidin Sudirohusodo Hospital. Patients with abnormal Mg levels had a 2.625 times higher risk of severe COVID-19. Magnesium concentration is an important parameter, which must be monitored in the laboratory analyses of COVID-19 patients.  
Analysis of Serum Ghrelin Levels and BMI in Obese and Non-Obese Subjects Patachna Junita; Ruland DN. Pakasi; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2047

Abstract

Obesity is excessive body fat and was associated with the importance of metabolic and endocrine problems in somatotropic secretion in functional obesity. Ghrelin is an acylated peptide hormone produced by the stomach, which is a mediator of the growth hormone secretory receptor. The activity of ghrelin stimulates the release of growth hormone, and appetite and stimulates the metabolism of carbohydrates. Circulating ghrelin levels in healthy people increase during fasting and decrease after meals. This study aims to analyze the difference in ghrelin levels among obese and non-obese subjects. A cross-sectional design research was conducted in August 2022. The samples consisted of obese and non-obese subjects based on Body Mass Index (BMI). Ghrelin levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were statistically analyzed using the Mann-Whitney and Spearman tests. p<0.05 was reported significant. The samples consisted of 80 obese and non-obese subjects, 39 males and 41 females. There was no difference in ghrelin serum levels in the obese group (1.45±2 ng/mL) compared to the non-obese group (0.67±0.25 ng/mL) with p =0.233 (p>0.05). There was a positive correlation between ghrelin levels and BMI (r=0.247). There was no difference in ghrelin levels between the obese group and the non-obese group, and there was a positive correlation between ghrelin levels and BMI. A higher BMI would lead to higher ghrelin levels.
Correlation Analysis of Galectin-3 Serum Level in Obesity with and without Obesity Nurjannah Nurjannah; Nurahmi Nurahmi; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2048

Abstract

There are more than 3.4 million deaths every year in the world due to overweight and obesity. Obesity is a chronic proinflammatory condition marked by increased lipid and adipose tissues, leading to ectopic fat accumulation with increased levels of proinflammatory cytokines. Obesity causes a progressive increase in galectin-3 expression, especially in visceral and subcutaneous adipose tissue in experimental animals. Galectin-3 is upregulated in obesity and is defined as a proinflammatory molecule that can cause insulin resistance. This study aims to analyze differences in galectin-3 levels between obese and non-obese subjects. This was a cross-sectional study, using a total of 80 subjects. The study was conducted throughout August 2022. The samples were grouped into obese and non-obese based on Body Mass Index (BMI). The galectin-3 measurement used the Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical tests used the Mann-Whitney test and Spearmen rho; the test results were significant if the p-value <0.05. The samples were divided into obese and non-obese groups, each group had 40 people. Galectin-3 levels in the obese group were 0.9±0.36 ng/mL significantly higher than the non-obese group’s 0.43±0.11 ng/mL, (p<0.001). There was a strong positive correlation between levels of galectin-3 and BMI, (r=0.866, p<0.001). There is a positive correlation between serum galectin-3 levels and BMI. The greater value of the BMI, the higher levels of galectin-3.

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