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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Ilmiah Akuntansi dan Bisnis JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Abdi Insani JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Keperawatan Ophthalmologica Indonesiana Folia Medica Indonesiana

Laksmi Wulandari

Departement Of Pulmonology, Faculty Of Medicine, Airlangga University

Author-ID : 3289685

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2006.144 KB)

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as âfluâ. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

PENINGKATAN EKSPRESI LAMININ NAMUN TIDAK VE-CADHERIN PADA SAWAR DARAH OTAK SETELAH INFEKSI Mycobacterium tuberculosis INTRAPULMONALIS Widayati, Aris; Wulandari, Laksmi; Riawan, Wibi
Majalah Kesehatan FKUB Vol 5, No 3 (2018): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Tuberkulosis merupakanÂ masalah kesehatan utama di dunia. Pada tahun 2016, WHO menemukan angka kejadian TB kurang lebih 10,4 juta, dan untuk Indonesia dilaporkan sebesar 156.723 kasus. Meskipun penyebaran Mycobacterium tuberculosis di susunan saraf pusat tercatat hanya 1%, namun memiliki tingkat kecacatan dan kematian yang tinggi, sehingga menuntut adanya tatalaksana yang efektif untuk mengatasinya. VE-chaderin dan laminin merupakan protein adhesin yang berfungsi mengendalikan permeabilitas pembuluh darah dan mempertahankan integritas blood brain barrier, sehingga kedua protein adhesin tersebut dapat menjadi salah satu target terapi tuberkulosis otak. Penelitian ini bertujuan untuk mengetahui efek paparan M. tuberculosis secara inhalasi terhadap ekspresi laminin dan VE-chaderin pada sel endotel blood brain barrier. Penelitian ini menggunakan mencit Balb/cÂ (Mus musculus) yang diinfeksi oleh M.tuberculosis strain H37Rv secara inhalasi. Jaringan otak diperiksa menggunakan metode imunohistokimia denganÂ antibodi mt-38, antibodi VE-chaderin dan laminin. Hasil penelitian menunjukkan adanya invasi M. tuberculosis padaÂ mikroglia jaringan otak mencit, diiketahui juga adanya peningkatan ekspresi laminin, sedangkan VE-chaderin tidak menunjukkan adanya perubahan. Proses masuknya M. tuberculosis ke otak diduga terjadi melalui proses diapedesis atau melalui peningkatan ekspresi laminin tanpa perubahan pada VE-chaderin dan reseptor laminin diduga sebagai tempat berikatan yang memungkinkan bakteri tersebut masuk ke jaringan otak.Â

Viral Profile and Clinical Characteristic in Acute Asthma Exacerbation Patients Resti Yudhawati; Erwin Winaya; Laksmi Wulandari; Aldise M Nastri; Retno A Setyoningrum; Kazufumi Shimizu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14872

Background: Asthma is a heterogeneous disease characterized by chronic airway inflammation. Thevirus infection in respiratory tract will activate greater pro-inflammatory cytokines in asthma patients.The enhancement of pro-inflammatory cytokines induces various clinical symptoms. This study aims toinvestigate the respiratory virus and clinical characteristics among patients with acute asthma exacerbation.Methods: In this study, subjects were divided into 3 groups based on acute asthma exacerbation triggers.The first group triggered by virus infection; the second group triggered by non-virus infection with ILI; andthe third group without any infection. Nasopharynx or throat swabs were collected to detect any respiratoryvirus. Virus was detected by Multiplex PCR (xTAG Respiratory Viral Panel Fast V2/ LUMINEX)Results: According to PCR examination, the prevalence of virus infection was 46.2%. Only two types ofviruses identified, which were Influenza A virus and Rhinovirus. All patients in the second groups showeda symptom of cough with purulent sputum, while no patients from the other two groups showed similarsymptoms. PEFR and % PEFR prediction of patients with Influenza A virus infection were higher than inRhinovirus infected-patients (210 L/min and 48.6% vs 195 L/min and 45%).Conclusion: Acute asthma exacerbation is one of the most reasons patients came to emergency ward. Themajority of acute asthma exacerbation was caused by infection, and most of it was viral infection. Clinicalsign differs according to the trigger, therefore the use of antibiotics should be avoided, unless there are signsand symptoms of bacterial infections

Comparison of the Efficacy of Generation 1 and 2 Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Patients with EGFR Positive Mutations Suwandi; Laksmi Wulandari; Gatot Soegiarto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15970

Background: The use of TKI generation 1 (Gefitinib, Erlotinib) and Generation 2 (Afatinib) has become thestandard therapy for JPIC pulmonary adenocarcinoma type with positive EGFR gene mutations.Objective: to analyze the comparison of the efficacy of TKI generation 1 and 2 in NSCLC patients withpositive EGFR mutations.Methods: The design of this study used a retrospective in which the participants who received EGFR therapyfor TKI generations 1 and 2 were compared its efficacy. Data collected included health-related quality of life(HRQOL), body weight, performance status (PS), Response Evaluation Criteria in Solid Tumors (RECIST)of thoracic CT, Common Terminology Criteria for Adverse Events (CTCAE), progression free survival(PFS) and overall survival (OS). The statistical analysis used was the independent t test, Mann Whitney test,or Kruskal Wallis test with p <0.05.Results: Most of the participants’ quality of life scores did not change before and after therapy, where theEQ5D value was 67.5% (group 1 = 60.6%; Group 2 = 94.1%; p = 0.806). The participant’s weight decreasedby 49.5% (group 1 = 45.9%; group 2 = 60.0%; p = 0.658) and the participant’s PS was stable (group 1 =29.4%; group 2 = 50.0%; p = 0.014). The RECIST value of the participant was progressive disease 51.0% (p= 0.338). CTCAE differed in stomatitis (p <0.001), paronychia (p <0.001), and diarrhea (p <0.001). Therewas no significant difference between the first and second groups in the PFS (p = 0.197) and OS (p = 0.740)values.Conclusion: EGFR therapy for TKI generations 1 and 2 have almost the same efficacy, in which there is nosignificant difference in the quality of life of the participants.

ANALISIS PENGARUH GOOD CORPORATE GOVERNANCE DAN MANAJEMEN LABA TERHADAP CORPORATE ENVIRONMENTAL DISCLOSUREPADA PERUSAHAAN PERTAMBANGAN YANG TERDAFTAR DI BURSA EFEK INDONESIA DAN PROPER PERIODE 2012 –2014 Wulandari Laksmi
Jurnal Ilmiah Akuntansi & Bisnis Vol 1 No 1 (2016)
Publisher : Universitas Pendidikan Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38043/jiab.v1i1.20

The trend toward environmental awareness has brought a change in attitude of orientation towards profit orientation of the company environment. Management as agents can not avoid the reality of the impact of the company’s activities were not only generate profits and raise share prices, but also have environmental impacts such as damage to ecosystems, pollution, wastewater and waste all of which are the responsibility of companies that deal with environmental aspects.This study aimed to examine the effect of earnings management and good corporate governance of the Corporate Environmental Disclosure (CED). Earnings management is measured by discretionary accruals.Population of this research are 44 mining companies listed on the Stock Exchange in 2012-2014. The data used in this study comes from the annual report and sustainability report mining companies listed on the Stock Exchange and Corporate Performance Rating Program (PROPER) in 2012 for a total of 5 companies. The sample is obtained by using purposive sampling method. Hypothesis testing method used is multiple regression analysis. The results showed that the number of audit committee meetings significantly influence the Corporate Environmental Disclosure. Meanwhile, earnings management, the proportion of independent board does not significantly influence the Corporate Environmental Disclosure. Simultaneously good corporate governance and earnings management significantly influence the Corporate Environmental Disclosure.

Lung Cancer Patients’ Profile in Dr Soetomo General Hospital Surabaya 2016 - 2017: Newest Report Sita Ro'yul Aini; Laksmi Wulandari; Susilowati Andajani
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 10 No. 1 (2019): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Lung cancer is the leading cause of cancer death in the world, its 5 years survival rate is only 17%, whereas its incidence is the first most in men and third in women.Methods: This research was a descriptive observational study. The samples were 240 patients of lung cancer in Poly Oncology Dr. Soetomo General Hospital Surabaya 2016-2017. Sampling technique was non-random sampling (consecutive sampling). The variables were: age, sex, smoking habits, type of lung cancer, type of mutation, stage, symptoms, Vena Cava Superior syndrome, and therapy. The data analyzed were analyzed descriptively.Results: Patients mostly at age 51-55 and 56-60 years old (18% each). Ratio men and women are 1,7:1. In all type of lung cancer, men are dominant than women and mostly patients is active smoker. Ephidermal Growth Factor Receptor (EGFR) mutation found in adenosquamous (75%) and adenocarcinoma (65%). Most patients diagnosed at advance stage. Most symptoms are cough (70.4%), dyspnoea (50%), and chest pain (49.2%). Vena Cava Superior Syndrome (VCSS) found in adenocarcinoma (75%) and squamous cell carcinoma (25%). In adenocarcinoma and adenosquamous, patients commonly got targeted therapy.Conclusion: Lung cancer patients: 1) Men tend to be exposed to younger than women, 2) ratio men and women is 1.7:1 and most type in lung cancer is adenocarcinoma 3) mostly patients is active smoker, 4) EGFR mutation tent to be in women with adenocarcinoma, 5) most stage is stage IV, 6) most symptoms is cough, 7) Vena Cava Superior Syndrome is in adenocarcinoma (75%) and carcinoma cell squamous (25%), 8) patients’ therapy mostly with targeted therapy followed by chemotherapy.

Profile of Pulmonary Tuberculosis Patients with Type 2 Diabetes Mellitus in Pulmonary Department Dr. Soetomo General Hospital Surabaya Ayu Rahmanita Putri Soetrisno; Rebekah Juniati Setiabudi; Laksmi Wulandari
Jurnal Respirasi Vol. 6 No. 2 (2020): May 2020
Publisher : Faculty of Medicine Universitas Airlangga

Background: Pulmonary tuberculosis (TB) is the most important infectious disease, caused by Mycobacterium tuberculosis (MTB). Indonesia is the third country with the most prevalent TB cases in the world. Not all people who were exposed to MTB will become active TB, because the immune response is the main determinant. Immunocompromised person, such as patients who have type 2 diabetes mellitus (DM) as a comorbid are more prone to develop active TB infection. This study aimed to analyze the profile of pulmonary TB patients with type 2 DM in Pulmonary Department Dr. Soetomo General Hospital Surabaya.Methods: This was an observational descriptive study with a cross-sectional design. The research data were obtained from the medical records of TB patients with type 2 DM in Pulmonary Department Dr. Soetomo General Hospital Surabaya in January - December 2017.Results: Out of a total of 414 hospitalized patients, 74 patients with pulmonary TB were found with type 2 DM. Only 53 patients fulfilled the inclusion criteria. Gene Xpert results were sensitive (66.7%), previous TB treatment history (54.7%), unregulated type 2 DM (88.4%), RBG with the average of 311.83 mg/dl, PPBS with the average of 263.31 mg/dl, FBG with the average of 238 mg/dl, and HbA1C > 10% (68%).Conclusion: The majority of the patients of pulmonary TB with type 2 DM have average high blood glucose and unregulated DM.

Problem Penegakkan Diagnostik Pasien dengan Massa di Paru: [Diagnostic Problems in Lung Mass Management] Laksmi Wulandari; Nikson Eduard Faot
Jurnal Respirasi Vol. 3 No. 2 (2017): Mei 2017
Publisher : Faculty of Medicine Universitas Airlangga

Background: Lung cancer are divided into 2 groups; i.e. Small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). About 30% of NSCLC is squamus cell carcinoma and the other is adeno carcinoma. Late diagnosis makes such a high mortality rate. Early diagnosis plays a very important role in the management of therapy. Case: Patients complain of chronic cough more than 6 months, decreased appetite and weight loss. Chest X-ray and CT scan show a density of round shape mass, with firm border and smooth regular edge, also lympnodes enlargement (T2N2Mx) stage IIb. Appearance of lung mass is benign according to clinically and radiologically. FNAB-CT Guiding results are difference each time examination. The first result is squamous cell carcinoma but the last result is teratoma. Discussion: Based on the multidisciplinary discussion on Tumor Board Meeting, the diagnosis was decide as Squamous cell Carcinoma. The choice management of stage IIb lung cancer is surgery (Lobectomy). Histopathology finding post surgery is a Squamus Cell Carcinoma. Patients were then given adjuvant chemotherapy for 4 cycles with Platinum Base regimen paxuscarboplatin with the aim of clearing micrometastase that may still be left behind. The complete respons of platinum based chemotherapy following surgery in early stage of squamous cell carcinoma. Conclusion: Difficulties of lung cancer diagnostic are still the problem in the management of lung mass. Difference of diagnostic makes difference treatment choice. Multidiscipline discussion is needed to decide the diagnostic and treatment judgment.

Terapi ARV pada Penderita Ko-Infeksi TB-HIV: [Antiretroviral Therapy in TB-HIV Co-Infection Patient] Indana Eva Ajmala; Laksmi Wulandari
Jurnal Respirasi Vol. 1 No. 1 (2015): Januari 2015
Publisher : Faculty of Medicine Universitas Airlangga

TB and HIV have a very close relationship since the development of AIDS. Through a significant reduction in cellular immunity, HIV affects the pathogenesis of tuberculosis, thereby increasing the risk of TB in HIV co-infected individuals. In 2006, there were an estimated 9.2 million new TB cases worldwide, there were 710.00 in patients with HIV and 500,000 cases with MDR-TB. Sensitivity to TB associated with cytokine production by T lymphocytes (IFN gamma and TNF are like alpha). During HIV infection, IFN gamma production declined dramatically in line with the decrease in CD4 T lymphocytes This leads to an increased risk of developing reactivation or reinfection Mycobacterium tuberculosis. Clinical symptoms of pulmonary TB in people living with HIV are often non-specific. Clinical symptoms often found are fever and significant weight loss. The other symptoms usually associated with extrapulmonary TB. Antiretrovirals are drugs that inhibit HIV replication. The main priority in patients co-infected with TB-HIV is a start of TB therapy, followed by cotrimoxazole and ARV. ARV treatment recommendation on co-infection tuberculosis is starting ARV therapy to all people living with HIV with active TB, regardless of CD4 cell count. Antiretroviral therapy start as soon as possible after TB treatment can be tolerated, as soon as 2 weeks and no more than 8 weeks. Regimen set by WHO for first-line regimen containing two nucleoside reverse transcriptase inhibitors (NRTIs) plus one non-nucleoside reverse transcriptase inhibitors (NNRTIs). In the co-infection of TB-HIV nucleoside was elected WHO recommended Zidovudine (AZT) or tenofovir disoproxil fumarate (TDF), in combination with lamivudine (3TC) or emricitabine (FTC). For NNRTI, WHO recommends efavirenz (EFV) or nevirapine (NVP).

Tumor Mediastinum Anterior (Yolk Sac Tumor) pada Seorang Laki-Laki Dewasa Muda: Sebuah Kasus yang Jarang: [Yolk Sac Tumor in a Young Man: A Rare Case] Risnawati Risnawati; Laksmi Wulandari
Jurnal Respirasi Vol. 2 No. 2 (2016): Mei 2016
Publisher : Faculty of Medicine Universitas Airlangga

Background: Primary mediastinal yolk sac tumor is an extremely rare and highly malignant tumors occuring in children and young adult. They are more common in men. The most common symptoms on ptesentation were dyspnea, chest pain, cought, fever, night sweat, or weight loss. Primary mediastinal tumor are considered to have poor prognosis. Case: A 18- year-old man who presented with shorthness of breath, chest pain, fever, night sweat, and generalized weakness. He had no significant surgical, familiy or social history. The chest X-Ray and computed tomographic scan of the chest showed a large anterior mediasti nal mass. The serum level of alpha- fetoprotein and β-HCG was elevated. The histological examination revealed the finding of yolk sac tumor. This supported the diagnosis of yolk sac tumor. The patient received a combination chemotherapy consisting of cisplatin, etoposide and bleomycin every 3 weeks for total of 4 cycles. Conclusions: Primary mediastinal yolk sac tumor is a rare tumor. The diagnosis should be made not only by morphological studies but the also the patients age and the elevation of serum alpha-fetoprotein. In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor.

Co-Authors Agustinus Rizki Aldise M Nastri Aldise Mareta Nastri Aldise Mareta, Aldise Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andreas Infianto Anna Febriani Apriyanto, Yudi Arfiansyah, Mochammad Aris Arif Santoso Arif Santoso Ariobimo, Bonfilio Neltio Aris Widayati Arta Rahman Aryati Aryati Atik, Nurul Ayu Rahmanita Putri Soetrisno Cita Rosita Sigit Prakoeswa Dana Hendrawan Putra Delvac Oceandy Dewajani Purnomosari, Dewajani Dewajani Purnomosari3 Dewi, Gusti Agung Ayu Ira Kencana Djoko Poetranto, Djoko Dominicus Husada Duyen, Natalie Edith Frederika, Edith Elisna Syahruddin Emmanuel Djoko Poetranto Ermayanti, Sabrina Ermayanti, Sabrina Erwin Winaya Evelyn Asaleo Fahmita, Karin Dhia Farahannisaa, Kintan Adelia Febriani, Anna Ferry Dwi Kurniawan Gatot Soegiarto Gemilang Khusnurrokhman Gilang Muhammad Setyo Nugroho Grahana Ade Candra Wolayan Hamidah, Berliana Hanif, Muhammad Alfin Hariputri, Wulan Rahmawati Haryati Haryati Haryati Haryati Hendra Ikhwan Gautama Hidayat, Moulid Husniyah, Barizatul Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Indana Eva Ajmala Infianto, Andreas Jasminarti, Ida Ayu Juwita, Putri Mega Kazufumi Shimizu Khansa Fahira Wisdana Khusnurrokhman, Gemilang Kinanthi, Monica Tiara Arum Kurniawan, Ferry Dwi Kusdiantoro Kusdiantoro Kusdiantoro Kusdiantoro Landia Setiawati Lim, Darren Wan-Teck Linda Dewanti Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Lukisiari Agustini Lusida, Michael AP. Mahdi, Bagus Aulia Maqnun, Lu'lu'il Masaoki Yamaoka Masaoki Yamaoka, Masaoki Muhammad Amin Muhammad Dany Ramadhan Muhammad Fitra Ramadhan Nadira Putri Nastiti Nathaniel Aditya Neni Daniati Nikson Eduard Faot Nina Mauthia Noni Novisari Soeroso Novananda, Donny Ardika Novita Andayani, Novita Pakpahan, Cennikon Paladan, Triadi Putra Pradhevi, Lukita Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Prodjosoewojo, Susantina Pudji Lestari Puteri, Rr. Astrid Aulia Artiono Putra, Andika Chandra Rebekah Setiabudi, Rebekah Resti Yudhawati Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Risnawati Risnawati Riyanto, Shandy Billy Rizki, Agustinus Rusli, Musofa Saefudin, Rendra P. Sahrun Sahrun Sahrun, Sahrun Santoso, Andintia Aisyah Setyawan, Ungky Agus Sita Andarini Sita Ro'yul Aini Sjahjenny Mustokoweni, Sjahjenny soedarto soedarto, soedarto Sopha, May Ira Sri Melati Munir Sri Melati Munir Subagyo, Zaufy Verlieza Oktaviano Sulistiawati Sulistiawati Surya, Prima Ardiansah Susilowati Andajani, Susilowati Suwandi Syamsuri, Ibrahim Thendeyas, Richar Tomy Thirafi, Sacharissa Zerlina Tsarwah Tri Wibawa Utami Meilanie Putri Veda Septian Cahya Budi Vincent, Agustinus Wati, Farah Fatma Wibi Riawan Wiriansya, Edward Pandu Wiwin Is Effendi Yashinta, Yolanda Ayu Zahira Pelangi Rahmadilla Satriadi Zaini, Jamal Zaphiria Loka Pramesthi

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