International Journal of Nasopharyngeal Carcinoma
The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management.
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<![CDATA[CHARACTERISTICS OF RECURRENCE NASOPHARYNGEAL CARCINOMA IN HASAN SADIKIN HOSPITAL PERIOD 2017-2019 ]]>
<![CDATA[Mohammad Adithya Prawiranata]]>;
<![CDATA[Yussy Afriani Dewi]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3843
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is a malignancy that occurs in the squamous epithelium in the nasopharynx region. Recurrent Nasopharyngeal carcinoma is defined as tumor recurrence after the complete remission. Patients with recurrent NPC always experience local, regional, or both failure, with or without distant metastases and can damage surrounding tissue.. Methods: This research method was a retrospective descriptive based on medical record data in patients with recurrent nasopharyngeal carcinoma at ORL-HNS outpatient ward subdivision of Head Neck Surgery, RSHS, Bandung from 2017 to 2019. Result: In RSHS Bandung, there was 1727 patient NPC period 2017-2019. There was 135 recurrent nasopharyngeal carcinoma patients (7,8 %) consist of 96 male and 39 female, aged over 40 years as many as 107 patients. More patients were found in T3-T4 (56%), N2-N3(56%), M0 (91%), stage III-IV (75%). The duration of the patient experienced a relapse after initial therapy for more than 24 months (52%). Conclusion: Characteristics of recurrent nasopharyngeal carcinoma most of them come with stage III-IV, T3-T4 without distant metastases, with a recurrence within less than 24 months. There was 7,8% recurrent nasopharyngeal carcinoma patients Keywords: Charactherisic, Nasopharyngeal Carcinoma, Recurrence]]>
<![CDATA[CHARACTERISTICS OF RECURRENCE NASOPHARYNGEAL CARCINOMA IN HASAN SADIKIN HOSPITAL PERIOD 2017-2019 ]]>
<![CDATA[Adithya Prawiranata, Mohammad]]>;
<![CDATA[Afriani Dewi, Yussy]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3843
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is a malignancy that occurs in the squamous epithelium in the nasopharynx region. Recurrent Nasopharyngeal carcinoma is defined as tumor recurrence after the complete remission. Patients with recurrent NPC always experience local, regional, or both failure, with or without distant metastases and can damage surrounding tissue.. Methods: This research method was a retrospective descriptive based on medical record data in patients with recurrent nasopharyngeal carcinoma at ORL-HNS outpatient ward subdivision of Head Neck Surgery, RSHS, Bandung from 2017 to 2019. Result: In RSHS Bandung, there was 1727 patient NPC period 2017-2019. There was 135 recurrent nasopharyngeal carcinoma patients (7,8 %) consist of 96 male and 39 female, aged over 40 years as many as 107 patients. More patients were found in T3-T4 (56%), N2-N3(56%), M0 (91%), stage III-IV (75%). The duration of the patient experienced a relapse after initial therapy for more than 24 months (52%). Â Conclusion: Characteristics of recurrent nasopharyngeal carcinoma most of them come with stage III-IV, T3-T4 without distant metastases, with a recurrence within less than 24 months. There was 7,8% recurrent nasopharyngeal carcinoma patients Keywords: Charactherisic, Nasopharyngeal Carcinoma, Recurrence]]>
<![CDATA[CORRELATION BETWEEN S100 PROTEIN EXPRESSION WITH CLINICAL STAGING NASOPHARYNGEAL CARCINOMA TYPE III ]]>
<![CDATA[Ismi Cahyadi]]>;
<![CDATA[Yussy Afriani Dewi]]>;
<![CDATA[Nur Akbar Aroeman]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3898
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is the most found head and neck cancer, which originated from a nasopharyngeal epithelial cell, and predilection site commonly at rosen muller fossa. S100 protein inflammatory mediators are involved in the regulation of cellular processes including inflammation and malignancy. S100 protein plays a central role in the proliferation, regulation of cell apoptosis and metastasis causing continuing growth of cancer cells through activation of STAT3 by IL-6, NF-κB, ROS. Objective: This study aimed to determine the correlation between S100 protein expression levels to the clinical stage of NPC WHO type III. Method: This research is a cross-sectional analytic study. This study was held in the Anatomical Pathology Department of Hasan Sadikin Hospital from August until October 2015. The study was conducted using 29 pieces of secondary data, medical records and paraffin blocks anatomical pathology of NPC patients were examined S100 protein immunohistochemistry. Result: This study was performed from 29 subjects (18 males and 9 females). There was a strong positive correlation between histoscore S100 protein expression with clinical staging p<0.05. There is a significant correlation between S100 protein expression with the clinical stage of NPC WHO type III using double regression analysis (F=15.676, p=0.000). Conclusion: There were significant correlation S100 protein expression levels to clinical stage nasopharyngeal carcinoma WHO type III.]]>
<![CDATA[CORRELATION BETWEEN S100 PROTEIN EXPRESSION WITH CLINICAL STAGING NASOPHARYNGEAL CARCINOMA TYPE III ]]>
<![CDATA[Cahyadi, Ismi]]>;
<![CDATA[Dewi, Yussy Afriani]]>;
<![CDATA[Aroeman, Nur Akbar]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3898
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is the most found head and neck cancer, which originated from a nasopharyngeal epithelial cell, and predilection site commonly at rosen muller fossa. S100 protein inflammatory mediators are involved in the regulation of cellular processes including inflammation and malignancy. S100 protein plays a central role in the proliferation, regulation of cell apoptosis and metastasis causing continuing growth of cancer cells through activation of STAT3 by IL-6, NF-κB, ROS. Objective: This study aimed to determine the correlation between S100 protein expression levels to the clinical stage of NPC WHO type III. Method: This research is a cross-sectional analytic study. This study was held in the Anatomical Pathology Department of Hasan Sadikin Hospital from August until October 2015. The study was conducted using 29 pieces of secondary data, medical records and paraffin blocks anatomical pathology of NPC patients were examined S100 protein immunohistochemistry. Result: This study was performed from 29 subjects (18 males and 9 females). There was a strong positive correlation between histoscore S100 protein expression with clinical staging p<0.05. There is a significant correlation between S100 protein expression with the clinical stage of NPC WHO type III using double regression analysis (F=15.676, p=0.000). Conclusion: There were significant correlation S100 protein expression levels to clinical stage nasopharyngeal carcinoma WHO type III.]]>
<![CDATA[EFFECT OF SEA CUCUMBER OIL AND HONEY IN POST RADIOTHERAPY NASOPHARYNGEAL CARCINOMA PATIENTS ]]>
<![CDATA[Wawan Hendrawan]]>;
<![CDATA[Bogi Soeseno]]>;
<![CDATA[Tonny Basriyadi S]]>;
<![CDATA[Yussy Afriani Dewi]]>;
<![CDATA[Ade Burhanuddin]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3899
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is one of the most commonly found cases of head and neck malignancy. The most common side effects of radiotherapy is skin damaged. Until now, there is no standard therapy that has been given to post radiotherapy patient in Hasan Sadikin Hospital. Sea cucumber and honey can accelerate the healing process of the wound caused by radiotherapy. Objective: This study was conducted to compare the effects of the use topical sea cucumber oil and honey in patient with nasopharyngeal carcinoma post radiotherapy. Method: The study was conducted at Radiotherapy Clinic in Hasan Sadikin Hospital from may until September 2015 with patients who experienced skin damaged level two or more based on the criteria of Radiation Therapy Oncology Group (RTOG). This was an experimental study. Subjects were selected consecutively between the two groups: sea cucumber oil group and honey group. The draft analysis was done using Randomized Controlled Trial (RCT). Result: 30 patients were divided equally into two groups, sea cucumber group and honey group. Most of the nasopharyngeal carcinoma patients were >45 years old, the ratio man to woman was 2-3:1, with the BMI was <18.5. All subjects in this study experienced recovery rate up to level 1 (p=1.0), after one week of treatment. In the 2nd week after treatment all patients in the sea cucumber group achieved recovery up to level 0, and in the honey group as much as 2 patients only experienced the recovery rate to level 0, while the remaining 13 subjects remained at level 1 (p=0.0001). It was found that the wound healing process occurs better in sea cucumber oil group than the honey group (p=0.0001). Conclusion: Sea cucumber oil accelerates the healing process of the skin tissue damaged in patients with nasopharyngeal carcinoma after radiotherapy, faster than with honey.]]>
<![CDATA[EFFECT OF SEA CUCUMBER OIL AND HONEY IN POST RADIOTHERAPY NASOPHARYNGEAL CARCINOMA PATIENTS ]]>
<![CDATA[Hendrawan, Wawan]]>;
<![CDATA[Soeseno, Bogi]]>;
<![CDATA[Basriyadi S, Tonny]]>;
<![CDATA[Afriani Dewi, Yussy]]>;
<![CDATA[Burhanuddin, Ade]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
Show Abstract
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Download Original
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Original Source
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DOI: 10.32734/ijnpc.v2i02.3899
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is one of the most commonly found cases of head and neck malignancy. The most common side effects of radiotherapy is skin damaged. Until now, there is no standard therapy that has been given to post radiotherapy patient in Hasan Sadikin Hospital. Sea cucumber and honey can accelerate the healing process of the wound caused by radiotherapy. Objective: This study was conducted to compare the effects of the use topical sea cucumber oil and honey in patient with nasopharyngeal carcinoma post radiotherapy. Method: The study was conducted at Radiotherapy Clinic in Hasan Sadikin Hospital from may until September 2015 with patients who experienced skin damaged level two or more based on the criteria of Radiation Therapy Oncology Group (RTOG). This was an experimental study. Subjects were selected consecutively between the two groups: sea cucumber oil group and honey group. The draft analysis was done using Randomized Controlled Trial (RCT). Result: 30 patients were divided equally into two groups, sea cucumber group and honey group. Most of the nasopharyngeal carcinoma patients were >45 years old, the ratio man to woman was 2-3:1, with the BMI was <18.5. All subjects in this study experienced recovery rate up to level 1 (p=1.0), after one week of treatment. In the 2nd week after treatment all patients in the sea cucumber group achieved recovery up to level 0, and in the honey group as much as 2 patients only experienced the recovery rate to level 0, while the remaining 13 subjects remained at level 1 (p=0.0001). It was found that the wound healing process occurs better in sea cucumber oil group than the honey group (p=0.0001). Conclusion: Sea cucumber oil accelerates the healing process of the skin tissue damaged in patients with nasopharyngeal carcinoma after radiotherapy, faster than with honey.]]>
<![CDATA[NASOPHARYNGEAL CARCINOMA WITH INTRACRANIAL INVOLVED ]]>
<![CDATA[Ervin Yamani Amouzegar]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3900
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive carcinoma come from postnasal space. Histology type of nasopharyngeal cell carcinoma and the staging that affect with management therapy. Nasopharyngeal carcinoma can be controlled by implementing evidence-based strategies of cancer and management of patients. Case report: Reported a case in 47-year-old man, diagnosis squamous cell carcinoma of nasopharynx with intracranial involvement. Conclusion: Histology type of nasopharyngeal carcinoma and the staging determined the modality of therapy and nasopharyngeal carcinoma prognosis]]>
<![CDATA[NASOPHARYNGEAL CARCINOMA WITH INTRACRANIAL INVOLVED ]]>
<![CDATA[Yamani Amouzegar, Ervin]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3900
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive carcinoma come from postnasal space. Histology type of nasopharyngeal cell carcinoma and the staging that affect with management therapy. Nasopharyngeal carcinoma can be controlled by implementing evidence-based strategies of cancer and management of patients. Case report: Reported a case in 47-year-old man, diagnosis squamous cell carcinoma of nasopharynx with intracranial involvement. Conclusion: Histology type of nasopharyngeal carcinoma and the staging determined the modality of therapy and nasopharyngeal carcinoma prognosis]]>
<![CDATA[RECURRENT NASOPHARYNGEAL CARCINOMA: PROBLEM AND MANAGEMENT ]]>
<![CDATA[Rusina Hayati]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3901
<![CDATA[Abstract Introduction: Treatment results for nasopharyngeal carcinoma (NPC) have been improved, but there were still some patients who developed localized persistent or local recurrent. Local recurrence still represents a major cause of mortality and morbidity also management still challenging issues. Case Report: A 27-year-old woman presented with bilateral conductive hearing loss, dysphagia, rhinorrhoea, epistaxis, and cranial nerve palsy after chemo radiation for NPC. The results of nasopharyngoscopy, CT scan, and PET scan were not found a mass in the nasopharynx. The result of nasopharyngeal biopsy result was undifferentiated carcinoma. Patient diagnosed with recurrent NPC and planned for re-radiotherapy. Conclusion: After complete treatment for NPC we must immediately ensure recurrence and choose the next appropriate treatment.]]>
<![CDATA[RECURRENT NASOPHARYNGEAL CARCINOMA: PROBLEM AND MANAGEMENT ]]>
<![CDATA[Hayati, Rusina]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3901
<![CDATA[Abstract Introduction: Treatment results for nasopharyngeal carcinoma (NPC) have been improved, but there were still some patients who developed localized persistent or local recurrent. Local recurrence still represents a major cause of mortality and morbidity also management still challenging issues. Case Report: A 27-year-old woman presented with bilateral conductive hearing loss, dysphagia, rhinorrhoea, epistaxis, and cranial nerve palsy after chemo radiation for NPC. The results of nasopharyngoscopy, CT scan, and PET scan were not found a mass in the nasopharynx. The result of nasopharyngeal biopsy result was undifferentiated carcinoma. Patient diagnosed with recurrent NPC and planned for re-radiotherapy. Conclusion: After complete treatment for NPC we must immediately ensure recurrence and choose the next appropriate treatment.]]>
