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Rachmat Hidayat
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Sriwijaya Journal of Surgery
Published by Universitas Sriwijaya
ISSN : -     EISSN : 27223558     DOI : https://doi.org/10.37275/sjs.v2i2
Core Subject : Health,
Medicine & Pharmacology
SRIWIJAYA JOURNAL OF SURGERY Sriwijaya Journal of Surgery (SJS) is a peer-reviewed journal published twice a year (June and December) by Department of Surgery, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia. SJS is intended to be the journal for publishing articles reporting the results of research on surgery. SJS invites manuscripts in the various topics include: General Surgery, Gastrointestinal Surgery, Neurosurgery, Orthopedics, Oncology Surgery, Thoracovascular Surgery, Reconstruction Surgery, Children Surgery, Urology, all aspect related surgery and medicine.
Arjuna Subject : Kedokteran - Pembedahan
Articles 141 Documents
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Serum Calcium as a Preoperative Surrogate of Tumour Burden in Stage III Breast Carcinoma: A Cross-Sectional Surgical-Oncology Study Feizal Faturahman; Mulawan Umar; Theodorus
Sriwijaya Journal of Surgery Vol. 9 No. 1 (2026): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v9i1.153

Abstract

Introduction: Stage III breast carcinoma dominates surgical-oncology practice in Indonesian referral hospitals. Tumour-secreted PTHrP and dysregulated calcium signalling link tumour mass to systemic calcium, yet routinely available serum calcium is rarely quantified as a preoperative surrogate of tumour burden. Methods: In this cross-sectional study, 35 women with Stage III breast carcinoma at Dr. Mohammad Hoesin General Hospital Palembang underwent preoperative serum calcium measurement. Tumour size was dichotomised (≤5 cm vs >5 cm). Associations were tested by Spearman correlation and the Mann–Whitney U test; serum calcium was assessed as a classifier of large tumours by ROC analysis, with multivariable logistic regression, effect sizes and 95% confidence intervals (CI). Results: Mean serum calcium was 9.34 ± 0.82 mg/dL, and 27 patients (77.1%) had tumours >5 cm. Calcium was higher in tumours >5 cm (9.58 ± 0.76 mg/dL; 95% CI 9.28–9.88) than ≤5 cm (8.54 ± 0.37 mg/dL; 95% CI 8.23–8.85), a difference of 1.04 mg/dL (95% CI 0.66–1.43; Cohen d = 1.50; Mann–Whitney U = 0.000; p < 0.001; r = 0.72). Calcium correlated with size (Spearman rho = 0.731; p < 0.001) and discriminated tumours >5 cm (area under the curve 1.000; cut-off 8.95 mg/dL; sensitivity and specificity 100%). Immunohistochemical subtype was the only independent predictor (adjusted odds ratio 71.37; 95% CI 2.95–1728; p = 0.009). Conclusion: Preoperative serum calcium rose in proportion to tumour size in Stage III breast carcinoma, acting as a low-cost surrogate of tumour burden that may aid risk stratification in resource-limited centres, pending validation.

Page 15 of 15 | Total Record : 141

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