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Journal of Science and Technology Research for Pharmacy
Published by Universitas Negeri Semarang
ISSN : -     EISSN : 27760685     DOI : https://doi.org/10.15294/jstrp.v1i2
Core Subject : Science,
Chemistry
Journal of Science and Technology Research for Pharmacy is open access, peer-reviewed journal published by Pharmaceutical Science Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Indonesia. The journal publishes only papers describing original findings and review articles of all aspects in developing the field of pharmaceutical science and technology.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol 2 No 1 (2022)" : 5 Documents clear
The The Effect Of Uncontrolled Addition Of Gelatin In Paracetamol Tablet Formulation And The Evaluation
Journal of Science and Technology Research for Pharmacy Vol 2 No 1 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i1.57436

Abstract

Acetaminophen is a pain-relieving (analgesic) and fever-treating (antipyretic) medication that can be obtained over-the-counter. Wet granulation evaluation of granule among others flow time, angle of repose, tapped density tableting evaluation tablet among others weight uniformity, friability, disintegration time tablet flow time evaluation test was 0.16 with an angle of repose 51.78 tapped density of 30%. Tablet manufacturing process, tablet was damaged during the initial printing, namely capping. The tablet evaluation test obtained weight uniformity 248mg, friability 3.22%, disintegration time 1 minute, dissolution results at 60th minutes is 2.2817. The formulation of paracetamol tablets made by the researchers did not meet the specifications for marketability, where the discrepancy in tablet specifications occurred in the physical and chemical properties of the tablets.
The Optimization the use of Amylum Manihot in Paracetamol Tablet Formulation Using Wet Granulation Method
Journal of Science and Technology Research for Pharmacy Vol 2 No 1 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The oral route of drug administration is preferred by most of the patients. One of the most preferred oral preparations are tablets. Tablets are solid dosage forms containing active ingredients with or without fillers. One of the additions to the manufacture of tablets is a binder. The manufacture of tablets depends on the nature of the active substance used. Paracetamol is an active substance that has poor flow properties and compressibility, so it requires a binder and a wet granulation method for making tablets in order to increase fluidity and good compressibility. Amylum manihot is one of the starches used as additives in the pharmaceutical industry. This starch is very suitable to be used as a binder in the manufacture of tablets by the wet granulation method. In this review article, we will discuss the general method of making tablets, namely the wet granulation method using amylum manihot as a bonding agent and the evaluation of granules and tablets, namely the flow time test, angle of repose test, determination test, weight uniformity test.
FORMULATION OF VITAMIN C GEL SERUM USING SODIUM ALGINATE FROM BROWN ALGAE (Sargassum polycystum) AS GELLING AGENT
Journal of Science and Technology Research for Pharmacy Vol 2 No 1 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i1.64852

Abstract

Background : Brown algae contains alginate which can be used as a gelling agent on cosmetics product. In this study, alginates from brown algae can be formulated on antioxidant serum gel. Vitamin C was used as a model of active ingredient which are known as potent antioxidants. In order to obtain a serum gel preparation with good physical characteristics, optimization was also carried out in the formula between sodium alginate as a gelling agent and propylene glycol as a humectant. Aim : The purpose of the research is to determine the yield of sodium alginate produced from brown algae extraction, and determine the optimum ratio between sodium alginate and propylenglycol to provide good physical characteristics for vitamin C serum gel. Method : The extraction method used to obtain sodium alginate from brown algae Sargassum polycystum using the acid pathway extraction method. The method used to optimize sodium alginate and propylenglycol is the Simplex Latice Design method with Design Expert software version 10.0.1. Optimization parameters included tests of viscosity, spreadability, adhesion, and pH. Penetration test using franz diffusion cells, and the stability test of the preparation using the cycling test method. Result : The yield of sodium alginate extraction was 20.61%. Results of analysis software Design Expert version 10.0.1 show that sodium alginate could increase the response of viscosity, adhesion, and pH, also reduce the spreadability of vitamin C serum gel. While, propylenglycol could increase all the responses. Conclusion : The yield of brown algae (Sargassum polycystum) obtained was 20.61% with the combined composition with propylene glycol in the preparation of serum gel vitamin C being 7.56% : 10.44%.
VALIDATION OF ANALYTICAL METHOD FOR THE DISSOLUTION TEST OF VITAMIN D3 5000 IU CHEWABLE TABLETS WITH HPLC AND STABILITY TESTING
Journal of Science and Technology Research for Pharmacy Vol 2 No 1 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i1.65801

Abstract

Background: Vitamin D3 is a fat-soluble vitamin. The low solubility of vitamin D3 in water has attracted the researchers to develop a modification of vitamin D3 to be soluble in water, thus increasing bioavailability of vitamin D3 in the body and improving product performance in vitro and in vivo. Aim: This study aims to knowing the dissolution analysis method of vitamin D3 chewable tablets with HPLC and the stability of samples vitamin D3 5000 IU at 6th weeks of shelf life with storage conditions of 30 °C ± 2 ℃ and 40 °C ± 2 °C at Rh 75% ± 5%. Material and Methods: This study refers to USP 43 NF 38 with modifications of mobile phase. Results: The analytical method used shows linear results with a coefficient of correlation (r) equal to 0,9997. LoD and LoQ is 0,0076 ppm and 0,02302 ppm. The Q values of intermediate precision test were 86,431% and 85,2182%. The recovery percentage is 96,8147% - 100,1338%. The specificity test shows the analyte can be clearly distinguished from other components. In testing the stability of the test solution were 100,138% and %RSD equal to 0,12903% for 0 hours and 99,2754% and %RSD equal to 0,33193% for 24 hours. In the accelerated stability test, the results at 0 week were 85,2182%, the results at 6 weeks of 30 °C and 40°C is 86,718639% and 82,80894%. Conclucion: Validation of analytical method has met the acceptance criteria from ICH and USP.
The Bright Side and the Dark Side of Scopolamine (Pharmacology, Toxicology, and Clinical Use Review)
Journal of Science and Technology Research for Pharmacy Vol 2 No 1 (2022)
Publisher : Universitas Negeri Semarang

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Abstract

Scopolamine is one of tropane alkaloids obtained from Solanaceae plants. This compound has been used for a long time by human for both good and bad cause, such as dilating pupil, analgesic, anaesthesia, and even poisoning or other criminal acts. Scopolamine possess many pharmacological activities due to its anticholinergic activity. It binds non-selectively to muscarinic receptors both peripherally and centrally. At therapeutic dose, scopolamine may be beneficial for preventing motion sickness and Post Operative Nausea and Vomiting (PONV), treating sialorrhea in disabled patients, lowering depression, and preventing death rattle. However, its effect on anxiety level is still conflicting. Adverse effects commonly occurred at therapeutic dose is usually tolerable, such as sedation, dry mouth, skin reactions, blurred vision, mydriasis, and confusion. At higher dose, scopolamine may generate harmful effects, such as amnesia, delirium, hallucination, hypertension, tachycardia, and arrythmia. For its effect on memory and sedative effect, scopolamine is frequently used in some countries, such as Columbia and Indonesia recently to incapacitating victims. Treatment for poisoning of scopolamine is usually supportive to treat symptoms. Antidote use, acetylcholinesterase inhibitor, such as physostigmine may be used in certain condition.

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