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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 15 Documents
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Search results for , issue "Vol. 7 No. 1 (2025)" : 15 Documents clear
Pengaruh Beberapa Jenis Praperlakuan Terhadap Peningkatan Rendemen Hidrodistilasi Minyak Atsiri Gaharu Aldrat, Hendri; Khoerunnisa; Wandani, Karina; Supandi; Musdja, M. Yanis
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49005

Abstract

Agarwood essential oil (minyak atsiri gaharu or minyak gaharu) has the potential to be developed as aromatherapy to help reduce stress, but its availability in nature is not abundant, so effective efforts are needed to get optimal results. Although various pretreatments before hydrodistillation are known to enhance the yield of agarwood oil, no comparative study using the same sample has been reported to date. This research aims to compare the yield and profile of agarwood oil compounds obtained from maceration, microwave, ultrasonic and fermentation using ragi tapai and ragi tempe pretreatments. The research was carried out by pretreatment extraction, distillation of agarwood powder, identification of essential oil compounds via Gas Chromatography Mass Spectrometry (GC-MS), and hedonic tests. The distillation results showed that pretreatment yeast tapai fermentation had the highest percentage yield of agarwood oil at 0.050% followed by Fusarium sp fermentation. (0.036%), ultrasonic (0.034%), microwave (0.030%), maceration (0.024%), control (0.018%) and ragi tempe (0.002%). Six compounds were consistently found in each sample, such as α-agarofuran, neoisolongifolene, α-santalol, δ-guaiene, dihydrocolumellarin, and hexadecanoic acid. The most sesquiterpene compounds were obtained from pretreatment using tempeh yeast. Based on the research results, it is known that maceration, microwave, ultrasonic and fermentation pretreatments can increase the yield and influence the compound profile of agarwood oil.
Studi Awal: Identifikasi Keragaman Bakteri Saliva Wanita Usia Lanjut Menggunakan Teknologi 16S rRNA Sequencing Oxford Nanopore Adhiyanto., Ph.D, Chris; Hendarmin, Laifa A.; Harriyati, Zeti; Suwarsono, Erike A.; Suri , Auliyani Andam; Nugraha, Yudhi; Gunarti, Dwirini Retno
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49111

Abstract

The elderly are a population particularly susceptible to diseases resulting from the decline in immune system function. The mouth is one of the areas of the body that is the entry point for microorganisms into the body. It is known that the oral microbiome greatly affects oral and systemic health. The oral bacterial profile is important to understand its role in maintaining health and causing disease. Therefore, maintaining oral health is very important, especially in our study of the elderly. Utilizing advanced sequencing techniques such as Oxford Nanopore Technology (ONT) offers the opportunity to reveal bacterial diversity comprehensively. This study aims to identify the oral microbiome in a group of elderly women. Knowledge of the oral microbiota profile could help spread awareness of the benefits of maintaining good dental hygiene, especially in older adults. Methods: Seven elderly housewives had their unstimulated saliva samples taken in the morning and kept at -80°C. The phenol-chloroform technique was used to isolate the DNA, and a Qubit Fluorometer was used to measure purity and concentration. By employing ONT for 16S rRNA sequencing and Epi2Me software for analysis, taxonomic mapping of the bacterial diversity was accomplished.  Results: According to the taxonomic analysis, Streptococcus and Veillonella were the most common genera in the samples. It was common to find species like Veillonella parvula, Veillonella atypica, Streptococcus mitis, and Streptococcus rubneri. These genera contributed to the dynamics of oral biofilms by exhibiting complex ecological interactions. With advanced sequencing technologies, this work highlights the diversity of oral bacteria in elderly women in Indonesia while providing a new perspective. Notwithstanding a few limitations, these findings provide insight into the ecological dynamics of the oral microbiota, potentially leading to clinical applications in the treatment and prevention of disease.
The Effect of Administration Platycerium bifurcatum (Cav.) C.Chr  Extract on Total Bilirubin Levels and Hepatosomatic Index Values of Ethanol-Induced Rats Saputra, Hendri; Pertiwi, Reza; Sari, Delia Komala; Wulandari, Septi; Rahmawati, Reza
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49112

Abstract

The Liver is a vital metabolic organ. Liver injury is related to an inflammatory process that increases the hepatosomatic index (HSI). One indicator of liver damage is increased total bilirubin levels (hyperbilirubinemia). Currently, hyperbilirubinemia treatment is still limited to irradiation therapy and exchange transfusions, because there is no pharmacological specific treatment. This study aimed to evaluate the hepatoprotective effect of Platycerium bifurcatum (Cav.) C.Chr extract on total bilirubin levels and the hepatosomatic index (HSI) in male white rats. A laboratory-based experimental design was employed using a post-test only control group, involving 35 rats randomly assigned to seven groups: normal control, negative control, positive control (sacatonic active), solvent control (Na CMC), and treatment groups receiving ethanol extract at doses of 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW.The treatment was administered orally for 14 consecutive days. On the final day, all rats (except the normal group) were induced with absolute ethanol at 2 mL/200 gBW. After 12 hours, the animals were euthanized for liver and blood sample collection. Total bilirubin levels were measured, and the hepatosomatic index was calculated. Data were analyzed using one-way ANOVA followed by LSD post hoc test. The results demonstrated that administration of Platycerium bifurcatum (Cav.) C.Chr extract significantly reduced total bilirubin levels and HSI, particularly at doses of 50 mg/kgBW and 100 mg/kgBW, compared to the negative control group (p<0.05). These findings suggest that Platycerium bifurcatum (Cav.) C.Chr ethanol extract exhibits a hepatoprotective effect by reducing total bilirubin levels and HIS.
Comparative Anti-Inflammatory Effect of Aceclofenac-Saccharin in Mice Granuloma Model Usman, Hendrizal; Aldi, Yufri; Umar, Salman; Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49145

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Most Probable Number (MPN) Coliform of Jamu Gendong Beras Kencur in Traditional Markets in Sukoharjo Region Jamilatun, Makhabbah; Lukito, Pradea Indah; Safitri, Eka Nanda
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49174

Abstract

: One of the traditional medicines that is very popular with the public is the jamu gendong beras kencur. The safety of traditional medicine products (herbal medicine) is a demand that has been put forward since the emergence of human health problems due to microorganism contamination, such as coliform. This study aims to determine Coliform bacteria contamination in jamu gendong beras kencur in traditional markets in the Sukoharjo area. The method used in this study is the MPN (Most Probable Number) method, which consists of two stages, namely the Presumptive Test and the Confirmed Test. The study results showed that samples with codes 1, 2, 5, 6, 7, 8, 11, and 12 had an MPN value of 0/100 ml. Furthermore, samples with codes 3, 4, 9, and 10 showed an MPN value >0/100 ml. Based on the research results, samples that meet the quality of good drinking water based on the Regulation of the Minister of Health of the Republic of Indonesia in 2010, are samples with codes 1, 2, 5, 6, 7, 8, 11, 12 while samples with codes 3, 4, 9, 10 do not meet the requirements. There needs to be education on how to make good herbal medicine, environmental sanitation, and clean herbal medicine sales locations so that herbal medicine sellers can improve the quality of the herbal medicine they sell and ensure it is safe to consume

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