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INDONESIA
Jurnal Farmanesia
Published by Universitas Sari Mutiara Indonesia
ISSN : """"     EISSN : 25282484     DOI : https://doi.org/10.51544/jf.v8i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 20 Documents
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Search results for , issue "Vol 7 No 1 (2020): Jurnal Farmanesia" : 20 Documents clear
AKTIVITAS PENGHAMBAT ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2OLEH SENYAWA DARI SPONGE(Filum Porifera) SECARA IN SILICO Kesaktian Manurung; Siti Maimunah; Fitri Yulia Sari
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

The metabolite content in sponge has a unique chemical structure and very interesting pharmacological activity, such as anticancer, antimicrobial, anti-inflammatory, antifouling, antifouling, and inhibiting enzyme activity. The purpose of this study is to find out the value of RMSD in protein validation 6LU7 in silico, to know the ability of Sponge compounds in inhibiting protease enzyme 6LU7 from SARS-CoV-2 Virus in silico, and to know the comparison of the results of docking score of Sponge compounds in the inhibition of protease enzyme 6LU7SARS-CoV-2 virus to visualize docking results to know the amino acids that bond with each other. This research is a descriptive study that is to test the activity of Sponge compounds against inhibition of protease enzyme 6LU7 SARS-CoV-2. The phases in this study include downloading and installation applications needed. And validation of in silico tethering method to protease enzyme 6LU7 SARS-CoV-2 virus, as well as the docking of Sponge compound molecules against protease enzyme 6LU7 SARS-CoV-2 virus in silicon. The results of the study obtained that the process of tethering protease enzyme 6LU7 sars-cov-2 virus is declared valid so that it can be used for molecular tethering of Sponge test compounds in silico. Sponge test compounds can inhibit the protease enzyme 6LU7 Sars-CoV-2 virus. The docking score of Sponge test compounds on protease enzyme 6LU7 SARS-CoV-2 virus is lower than the comparison. As the result of docking visualization, several amino acid residues interact with each other including hydrogen bonds.
FORMULASI SEDIAAN BLUSH ON DARI SARI BUAH STROBERI (Fragaria vesca L) SEBAGAI PERONA PIPI Artha Yuliana Sianipar; Siti Nurbaya; Adiansyah Adiansyah; Eva Priasanti Sitanggang
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Colorisone of the determining factors for the quality of cosmetics. The use of synthetic colors in blus her can cause irritation on facial skin. Because of that, wetried to make a blush preparation using natural dyes, namely strawberries (Fragariavesca L). The purpose of this study was to make blushusing natural dyesfromstrawberries (Fragariavesca L). The juice is obtaineddirectly using a juicer machine, then heated in a waterbath /Waterbath to obtain a thick juice of strawberry fruit (Fragariavesca L) with a concentration of 15; 25; 35%. The resultsshowedthatthepreparationwashomogeneous, remainedstable, did not cause irritation, wassafe for the skin because thep Hofthepreparation was still in the normal skin phrange of 4.5-6.5, and was quiteliked by the respondents. The conclusion of this study shows that strawberry juice (Fragariavesca L) canbeused as a blush (blush), but the resulting colorisless visible.
PENETAPAN ANGKA KAPANG KHAMIR (AKK) PADA REMPAH-REMPAH YANG DIJUAL DI PASAR SRI GUNTING MEDAN Yosy Cinthya Eriwaty Silalahi; Kesaktian Manurung; Putri Niat Salma Halawa
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Spices containing fungal contamination exceed the stipulated limit of 1x104 colonies/g which will affect the stability of the preparation and aflatoxins that are harmful to health such as liver cancer. This study aims to determine the value of the yeast mold number (AKK) in spices at the Sri Gunting market, Medan. The population in this study were spices in the form of wet powder, namely turmeric (Curcuma longa Linn.), ginger (Zingiber officinale Rosc.), and temulawak (Curcuma xanthorhiza Roxb.), and 250 grams of each ingredient was taken from four spice traders. with location criteria such as on the edge of a highway, near a ditch/gully, inside a kiosk, and near a meat seller as a sample. Subjects of research and observations are presented in the form of tables and figures which are then analyzed descriptively. The results of the study found that the AKK of spices sold at the Sri Gunting market in Medan was equal to trader A (turmeric 16.1x10^4, Ginger 7.9x10^4, Temulawak 11.1x10^4cfu/g), trader B (turmeric > 150, Ginger 11.5x10^4Temulawak 18x10^4cfu/g), merchant C (turmeric 12.2x10^4, Ginger 6.1x10^4, Temulawak 4.5x10^4cfu/g), and merchant D (turmeric >150, Ginger 10.9x10^4, Temulawak >150cfu/g) which means that the AKK contained from spices sold at the Sri Gunting market in Medan does not meet the requirements according to the Food and Drug Supervisory Agency (BPOM).
FORMULASI SEDIAAN KRIM DEODORANT EKSTRAK ETANOL DAUN BELUNTAS (Plucea indica Less.) SEBAGAI PENCEGAH BAU BADAN Eka Margaret Sinaga; Supartiningsih Supartiningsih; Siti Maimunah; Nikmat Jayadi
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Beluntas is one of the plants that is often used as traditional medicine. Beluntas leaves have antimicrobial activity against various kinds of bacteria. This study aims to formulate Beluntas leaf extract (Plucea indica Less.) in the form of a deodorant cream that functions as a deterrent to body odor. The research method was carried out experimentally which included extract preparation, formulation using Beluntas leaf extract (Plucea indica Less.) with a concentration of 5%, 7.5%, 10%, preparation quality test, and hedonic test. The results of the formula The deodorant cream preparation can be used properly and can prevent sweating for 8 hours and the deodorant cream does not cause irritation and provides comfort when used, from formulas 1, 2, and 3, all the results are good to prevent sweating in the armpits but, the formula favored by the volunteers was formula 1 because the aroma was just right unlike formula 2, and formula 3 which had a slightly more pungent aroma, and similarly to the color in formula 1, the color was light green, unlike formula 2, and formula 3 which tended to be lighter in color. dark green. Beluntas leaf ethanol extract can be used to prevent body odor, and the extract can be used as a natural deodorant cream to prevent body odor.
ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Panal Sitorus; Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Bernadetta R. Munthe
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux
UJI PENINGKATAN KADAR ASAM AMINO PADA TAPE KETAN HITAM DENGAN PENAMBAHAN SARI BUAH NANAS DENGAN METODE SPEKTROFOTOMETRI SINAR TAMPAK Supartiningsih Supartiningsih; Siti Maimunah; Yosy Cinthya Eriwaty Silalahi
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Amino acid levels in sticky rice tape are still relatively low, while amino acids themselves are food substances for body growth. Pineapple contains the enzyme bromelain. This enzyme is one of the protease enzymes that can hydrolyze protein, therefore it can increase amino acid levels. This study aims to determine the increase in amino acid levels in black sticky rice tape with the addition of pineapple juice and to determine the effect of adding pineapple juice to amino acid levels in black sticky rice tape. In the process of making black sticky rice tape, 25 ml 50 ml of pineapple juice was added per 500 grams each, while one treatment did not add pineapple juice as a control. Black glutinous rice that has been fermented for 2-3 days was tested for increased levels of amino acids by using visible light spectrophotometry. The sample of black glutinous tape without the addition of pineapple juice obtained an average content of 4.73%, on the sample of black glutinous tape with the addition of 25 ml of pineapple juice the average content obtained was 6.50%, and the sample of black sticky rice tape with the addition of 50 ml pineapple juice the average level obtained was 7.76% and gave the effect of increasing amino acid levels on black sticky rice tape.
IDENTIFIKASI MERKURI PADA BEBERAPA KRIM WAJAH YANG TERDAPAT DI PASAR BINJAI Zuhairiah Zuhairiah; Siti Nurbaya; Yosy Cinthya Eriwaty Silalahi; Fitri Margaretta Simarmata
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Cosmetics are used to whiten the skin and also to avoid skin disorders both from inside and outside, such as blemishes, spots, freckles. The addition of mercury to cosmetics causes dark spots, allergies, irritation, and high doses can cause brain and kidney damage. Mercury is a substance that is prohibited by the Regulation of the Head of the Food and Drug Supervisory Agency (BPOM) of the Republic of Indonesia No. HK.00.05.42.1018 concerning cosmetics. The purpose of this study was to determine whether there was a mercury compound in facial whitening cream. The cream was taken at random from a whitening cream vendor in the Binjai market. Mercury identification was carried out at the Medan Regional Health Laboratory and from the results of research on 5 samples of facial whitening cream, it turned out that there was one sample containing mercury compounds, namely sample B, which did not meet the requirements.
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL JERAMI NANGKA (Artocarpus heterophyllus) SECARA SPEKTROFOTOMETRI-Visible Jon Kennedy Marpaung; Zuhairiah Nasution; Cut Masyithah Thaib; Junisan Siringoringo
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Flavonoids are compounds consisting of 15 carbon atoms which are generally distributed in the plant world. Flavonoid compounds are a group of the largest phenolic compounds found in nature, these compounds are red, purple, and blue dyes as well as yellow dyes found in plants. This study aims to determine the total flavonoid content of the jackfruit straw ethanol extract by using the UV-VIS spectrophotometric method, this study includes sample preparation, simplicia phytochemical screening, and extract manufacture, then determine the total flavonoid content of the jackfruit straw ethanol extract which is equivalent to quercetin (Quercetin). Equivalent (QE)) using aluminum chloride reagent with a wavelength of 437 nm by Visible spectrophotometry. Based on the research conducted, the total flavonoid content of jackfruit straw extract determined by Visible spectrophotometry using aluminum chloride reagent was 114.7590± 52.1263 mg QE/g extract.
ANALISIS MIKROBIOLOGI Escherichia coli JAJANAN MINUMAN DI SEKITAR JALAN KAPTEN MUSLIM KOTA MEDAN Siti Maimunah; Artha Yuliana Sianipar; Cut Masyithah Thaib
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Escherichia coli is a gram-negative rod bacteria, not encapsulated and is a normal flora in the digestive tract of animals and humans that easily pollutes water. Escherichia coli can turn into an opportunist pathogen if it lives outside the intestine, for example in urinary tract infections, wound infections and mastitis. Drinks contaminated with microorganisms can cause health problems in the form of disturbances in the digestive tract with symptoms of nausea, heartburn, vomiting and diarrhea. The purpose of this study was to determine the presence of Escherichia coli bacterial contamination in snacks sold around the Kapten Muslimstreet. This descriptive study used 4 samples of iced drinks, namely young coconut ice, sugar cane ice, mixed ice and dawet ice. The sample testing technique uses the Most Probable Number (MPN) method. The media used in this study were lactose Broth, Brilliant Green Lactose Bile Broth, Eosin Methylene Blue Agar. This research was conducted at the Pharmacy Microbiology Laboratory, Sari Mutiara University, Indonesia. After the research, the results showed that 1 of 4 samples of snacks found on Jalan Captain Muslim was detected with Escherichia coli bacteria ranging from 2,800 cells/100 ml so that it was included in the poor criteria, in the category These snacks are not suitable for consumption and do not meet the criteria set out in the Indonesian Ministry of Health No.492/Menkes/Per/IV/2010 (Colifrom and Escherichia coli 0/100 ml).
ANALISIS MINERAL KALSIUM (Ca) DAN ZAT BESI (Fe) DENGAN VARIASI WAKTU PERENDAMAN PADA PEMBUATAN SUSU KEDELAI SECARA SPEKTROFOTOMETRI SERAPAN ATOM Eka Margaret Sinaga; Yosy Cinthya Eriwaty Silalahi; Artha Yuliana Sianipar
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Minerals, calcium, and iron are needed for humans to stay healthy and active and have various roles in the human body. The purpose of this study was to determine the levels of calcium and iron in SK1, SK2, SK3, and SK4 milk. To compare calcium and iron levels in SK1, SK2, SK3, and SK4 milk. The results of the determination of calcium and iron levels by atomic absorption spectrophotometry showed that there was a difference in the content of calcium and iron in SK3 soy milk (12.178 ± 46, 399 mg/100 ml), SK1 milk (5, 3008 ± 8, 798 mg/100). ml), SK2 milk (9, 8821 ± 55, 676 mg/100 ml), SK4 milk (4, 8634 ± 125, 845). The iron content of SK4 milk is (1.3851 ± 82.709 mg/100 ml), SK1 milk is (0.5501 ± 68.924 mg/100 ml), SK2 milk is (0.6450 ± 50.026 mg/100 ml), SK3 milk of (0.7464 ± 64 mg/100 ml). The results showed that SK3 soy milk contained more calcium than SK1, SK2, and SK4. The results of iron levels showed that SK4 soy milk contained greater iron than SK1, SK2, and SK3 soy milk.

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