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INDONESIA
Jurnal Farmanesia
Published by Universitas Sari Mutiara Indonesia
ISSN : """"     EISSN : 25282484     DOI : https://doi.org/10.51544/jf.v8i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 20 Documents
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Search results for , issue "Vol 7 No 2 (2020): Jurnal Farmanesia" : 20 Documents clear
AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2 OLEH SENYAWA ALKALOID DARI ATTARASA (Litsea cubeba (Lour.)Pers.) SECARA IN-SILICO Jon Kenedy Marpaung; Melisa Rekayana Tambuan
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Attarasa (Litsea cubeba (Lour.) Pers.) is a mountain plant known as "Mountain pepper" or "Mountain Pepper". This plant contains alkaloids, such as Oblongine; Actinodaphine; Isoboldine; Cassameridine; Coclaurine; Corydine; Corytuberine; Dicentrine; Laurotetanine; Lindcarpine; Isocorydine; Isodomesticine; Juziphine; N-Methylcoclaurine; N-Methyllaurotetanine; N-Methyllindcarpine; Norcorydine; Norisoboldine; Norisocorydine; Xanthoplanine. Alkaloids in Attarasa (Litsea cubeba (Lour.) Pers.) have properties such as antimicrobials. This study aimed to determine the inhibition of the protease enzyme 6LU7 of the SARS­­-CoV-2 virus by an alkaloid compound from Attarasa (Litsea cubeba (Lour.) Pers.) by using the in silico tethering method. The in silico tethering process is carried out using the PLANTS program and visualized using the MOE2008 program. The protease enzyme was downloaded via the Protein Data Bank (PDB) with the code 6LU7. Two- and three-dimensional models are generated using the Marvin Sketch program. The resulting docking value is evaluated as a result of the docking process. The results of this study indicate that the binding of alkaloid compounds from Attarasa (Litsea cubeba (Lour.) Pers.) to 6LU7 expression gave valid results in silico. The compound N-Methylcoclaurine, Coclaurine, and Laurotetanin inhibited the protease enzyme 6LU7 with the best score close to the comparative value of Lopinavir and Remdesivir and produced 7 amino acid residues that were bound to each other, namely val_114, val_13, leu_115, phe_150, gly_140, val_140, and ser_147.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN LEGUNDI (Vitextrifolia L.) TERHADAP PERTUMBUHAN Staphylococcus epidermidis Jon Kenedy Marpaung; Panal Sitorus; Pandapotan Nasution; Roma Devina Yanti
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Legundi leaves (Vitextrifolia L.) contain flavonoid compounds, alkaloids and saponins, tannins, steroids/triterpenoidsthatact as antiseptic substancesandaid in the wound healing process. Staphylococcusepidermidis (Gram positive) is a mild skin infection-causing bacteria that accompanies the formation of abscesses. As for the purpose of this study To know the absence of antibacterial activity from concentrations of 10%, 15%, 20%, 25% legundileaf extractagainst Staphylococcus epidermid is bacteria and know the effective concentration of legunleaf extract in in hibiting the growth of Staphylococcus epidermidis bacteria. This research methoduses experimental methods and legundileaf extract with concentrations of 10%, 15%, 20%, 25%. The resultsshowedthatconcentrationsof 10%, 15%, 20%, 25% of legundileaf ethanol extract had antibacterial activity against the growth of Staphylococcus epidermidisindicated with a blockable zone diameter of 8 mm, 8.84 mm, 9.84 mm, 10.54 mm, respectively. Base dont here search that has beendone can be concluded that legundileaf extractcan inhibit the growth of bacteria Staphylococcus epidermidis, because around the discpaperthere is a clear zone that indicates the absence of bacterial growth.
ANALISA CEMARAN LOGAM MERKURI PADA IKAN AIR LAUT DAN UDANG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Yosy Cinthya Eriwaty Silalahi; Jon Kenedy Marpaung; Supartiningsih Supartiningsih
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. Mercury metal contamination in food is regulated in SNI number 7387 of 2009 regarding the Maximum Heavy Metal Limit. Some metal waste disposal ends up in rivers, lakes, or sea waters so that metal pollution can occur in the ecosystem. This study aims to determine levels of mercury metal contamination in seawater fish, including shark, mackerel, salmon, tuna, red snapper, and white shrimp. Sample preparation was carried out by wet digestion method using a microwave digestion device. Mercury analysis was carried out using the AAS (Atomic Absorption Spectrophotometry) method. The wavelength used is 253.7 nm. The results showed that mercury in sharks was 0.2045 ± 0.0099 mg/kg, mackerel 0.4184 ± 0.0297 mg/kg, salmon 0.3848 ± 0.0794 mg/kg, tuna fish 0.3706 ± 0.0674 mg/kg, snapper 0.4088 ± 0.0397 mg/kg, and shrimp 0.4289 ± 0.0813 mg/kg. The results of the analysis showed that of the six samples of seawater fish that had been tested, the maximum metal contamination limit determined by SNI 7387 the Year 2009 was 0.5 mg/kg.
UJI AKTIVITAS BUAH OKRA(Abelmoschus esculentus L) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS Dicky Yuswardi Wiratma; Kesaktian Manurung; Soraya Syaviera
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Diabetes mellitus is a metabolic disorder disease characterized by hyperglycemia. Abelmuschus esculentus or known as the okra plant, is often used as a treatment for DM because it has hypoglycemic and antioxidant effects. Okra (Abelmuschus esculentus) is believed by the public as one of the plants that can prevent and treat diabetes. This study aims to test whether the administration of okra fruit extract can reduce blood glucose levels in rats. The research subjects were 25 rats which were divided into 5 groups, which consisted of a negative control group with 1% NaCMC, a positive control group using glibenclamide and ethanol extract of okra fruit at a dose of 200 mg/kgBW, a dose of 250 mg/kgBW, a dose of 300 mg. /kgBB. Glucose levels were measured at T0, T1, T2, T3, T4 AND T5 using a test strip glucometer. This study was experimental.
UJI EFEK EKSTRAK ETANOL DAUN SALAM (Syzygiumpolyanthum) SEBAGAI DIURETIKA PADA TIKUS PUTIH JANTAN Kesaktian Manurung; Novarianti Marbun; Salomo Joseph Empindonta
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Bay leaf is a plant that one of its benefits is as a diuretic. Diuretics are drugs that act directly on the kidneys and increase the excretion of urine and sodium salts. The aim of the study was to determine the diuretic effect of ethanol extract of bay leaf (EEDS) on male white rats. The study used 25 male white rats, divided into 5 treatment groups: negative control group (CMC suspension 0.5%), positive control (furosemide suspension at a dose of 3.6 mg/kg BW), and a test group EEDS suspension at a dose of 100 mg/kg. BW, 200 mg/kg BW and 300 mg/kg BW. The test preparation was given orally to rats and then observed in a modified metabolic cage for 6 hours. The results of simplicia phytochemical screening showed positive for flavonoids, saponins and tannins. The results of EEDS characterization included a total ash content of 3.66%, water-soluble extract content of 3.69%, and ethanol-soluble extract content of 3.65%. The results showed that EEDS at a dose of 300 mg/kg BW showed the best diuretic effect compared to 200 mg/kg BW and 100 mg/kg BW, but the effect was lower than S. Furosemide 3.6 mg/kg BW. The results of the ANOVA EEDS test at doses of 100, 200 and 300 mg/kg BW had significant differences.
PEMANFAATAN LIMBAH CAIR TAHU MENJADI Nata de Soya MENGGUNAKAN BAKTERI Acetobakter xylinum Zuhairiah Zuhairiah; Jon Kenedy Marpaung; Maringan Silitonga
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Nata de Soya merupakan salah satu jenis pangan yang diperoleh dari pengolahan limbah cair tahu yang berbahan dasar kedelai. Penelitian ini bertujuan untuk memanfaatkan limbah cair tahu yang sering terabaikan dan menjadi penyebab rusaknya lingkungan perairan dekat perindustrian pembuatan tahu. Nata de Soya dibentuk oleh bakteri Acetobacter xylinum yang merupakan bakteria erob. Masing-masing perlakuan difermentasi selama 8-14 hari, parameter yang diamati yaitu berat nata, kadar air, kadar serat dan selulosa Nata de Soya selama 8-14 hari. Pada penelitian ini didapat data ketebalan Nata de Soya dengan perlakuan 1, 2, dan 3 dengan kosentrasi 5, 10, dan 20% starter bakteri yaitu, 2,4503 gr, 2,8922 gr, dan 2,9226. Pada berat nata didapat 0,21 cm, 0,82 cm, dan 1,53 cm. Kandungan kadar air pada Nata de Soya pada perlakuan 1,2 dan 3 dengan kosentrasi masing-masing 5, 10, dan 20% yaitu 82,71, 83,71%, dan 84,17%%. Kandungan kadar serat Nata de Soya pada perlakuan 1, 2, dan 3 dengan kosentrasa bakteri 5, 10 dan 20% didapat 49,90%, 50,74% dan 54,02%. Pada uji kadar selulosa menggunakan FTIR dengan sampel 0,4 g nilai tertinggi didapat sebanyak 3361,12 menunjukan adanya gugus aldehid dari selulosa acetat. Pemanfaatan limbah cair tahu menjadi Nata de Soya menggunakan bakteri acetobacter xylinum dapat menjadi alternative pengolahan limbah cair tahu.
PENGARUH VARIASI WAKTU FERMENTASI TERHADAP KADAR ETANOL HASIL FERMENTASI SINGKONG KUNING (Manihotutillissima Pohl) Siti Maimunah; Zuhairiah Zuhairiah; Artha Yuliana Sianipar
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Cassava is an agricultural commodity that is widely grown in Indonesia and is an important source of carbohydrates after rice with a content of 34.7%. Yellow cassava is usually served in the form of tape through a fermentation process. This study aims to determine the effect of variations in fermentation time on ethanol content resulting from yellow cassava fermentation. This study used an experimental method with the distillation method using yellow cassava samples which were fermented for 72 hours, 96 hours, and 120 hours. The results of this study indicate that there is an effect of time variation on the ethanol content of fermented yellow cassava with a value of 0.93% (72 hours), 1.00% (96 hours), 1.27% (120 hours) which has a very significant effect (p < 0.01 >). The yield of this fermentation can be determined using the alcohol BJ table.
UJI EFEKTIVITAS ANTIBAKTERI NANO GEL BAHAN AKTIF EKSTRAK KAYU MANIS (Cinnamomum burmannii) TERHADAP Staphylococcus aureus Vivi Purwandari; Artha Yuliana Sianipar; Yosy Cinthya Eriwaty Silalahi; Dinda Juita Nasution
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Nanogel preparations consist of nanoemulsions and gels, where nanoemulsion is one type of preparation that can increase drug permeability on the membrane surface. The use of cinnamon extract as an antibacterial active substance is because cinnamon (Cinnamomum burmannii) contains saponins, tannins, and flavonoids. This study aims to make nanogel preparations with the active ingredient of cinnamon extract and to determine the antibacterial effectiveness of the nanogel as the active ingredient of the cinnamon extract against Staphylococcus aureus. The manufacture of 2% cinnamon extract nanoemulsion aims to make nanoparticle-sized nanogel preparations and as an antibacterial active substance in nanogel preparations against Staphylococcus aureus bacteria. Nanogel preparations were made by adding cinnamon extract nanoemulsion with varying concentrations of F1(2%), F2(4%), F3(6%), and blank formula (F0) as the basis for nanogels without cinnamon extract nanoemulsion. The results showed that the cinnamon extract nanoemulsion could be made into nanogels to produce a thick, brown-colored gel with a characteristic cinnamon smell. The result of the pH of the preparation is 6 according to the pH of the skin, has good homogeneity, and is not irritating to the skin. The PSA test produces a nanoparticle size of 24.2 nm, and the antibacterial effectiveness test of the nanogel preparation can inhibit Staphylococcus aureus bacteria. Produced a moderate inhibition zone category (6.7-7.1 mm) and the F3 formulation (6%) was the best formulation.
PENENTUAN KADAR PROTEIN PADA SUSU KEDELAI (Glycinemax L. Merril) DENGAN MENGGUNAKAN METODE Kjeldahl Siti Nurbaya; Supartiningsih Supartiningsih
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Soy milk has a combination of nutrients that are almost the same as cow's milk, but soy milk has low cholesterol, gluten, and lactose levels so that soy milk is safe for consumption by people with lactose intolerance, vegetarians, and is also safe for health. Determination of protein content that is most often done is the determination of crude protein which aims to determine the total amount of protein in food ingredients. The most commonly used protein assay method is the Kjeldahlmethod. This study aims to determine the protein content of soy milk packaged in boxes that are made by themselves and sold in traditional markets. The samples used in this study used packaged soy milk, traditional soy milk, and homemade soy milk. The results showed that the protein content of the three samples determined by the Kjeldahlmethod was 3.35±0.0816% traditional soy milk, 2.31±0.3562% box-packed soy milk, and 2.62±0.2495% whole milk. Homemade soybeans. The protein content in box-packed soy milk, homemade soy milk, and traditional soy milk haveeach met the requirements of SNI (1995). The results showed that the protein content of traditional soy milk was greater than that of packaged soy milk and homemade soy milk.
PENENTUAN KADAR KAFEIN DALAM KOPI INSTAN SECARA SPEKTROFOTOMETRI ULTRAVIOLET Supartiningsih Supartiningsih; Zuhairiah Zuhairiah; Cut Masyithah Thaib; Naim Bahagia
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Caffeine in coffee has clinically beneficial pharmacological effects, such as stimulating the central nervous system, relieving fatigue, drowsiness and also increasing concentration. However, excessive use of caffeine can cause heart palpitations and stomach upset. According to SNI 01-7152-2006, the maximum limit of caffeine in food and beverages is 150 mg/day and 50 mg/serving. The purpose of this study was to determine the level of caffeine in instant coffee circulating in supermarkets in Medan City by Ultraviolet Spectrophotometry. Determination of caffeine content was carried out by the UV Spectrophotometry method after extraction using chloroform in an alkaline environment. The caffeine concentration can be calculated from the calibration curve regression equation. The results showed that the three instant coffee samples were determined to have different levels of caffeine, namely instant coffee sample code A 5.2585 mg/gram, code sample B 4.2348 mg/gram, and code C 133564. mg/gram. When viewed from the requirements, the caffeine content in the instant coffee samples coded A and B has exceeded the portion limit of 131.4625 mg and 84,768 mg, respectively, but is still within the limits set by SNI 01-7152-2006 if consumed in one pack. per day, henceforth the code C sample does not exceed the caffeine content limit of serving, which is 26.7128 mg of caffeine.

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