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Reny I’tishom
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ritishom@fk.unair.ac.id
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androgynbiomedical@journal.unair.ac.id
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Department of Medical Biology Faculty of Medicine Universitas Airlangga Jl. Mayjen Prof. Dr. Moestopo No. 47 Surabaya 60131 Telp. 031-5020251, 5030252 ext. 137, Fax 031-5022472
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Kota surabaya,
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INDONESIA
Indonesian Andrology and Biomedical Journal
Published by Universitas Airlangga
ISSN : -     EISSN : 27464474     DOI : 10.20473
Core Subject : Health,
Health Professions
Andrology Sexology Anti-aging and male aesthetics Male physical and mental fitness Assisted reproductive technology Biomedicine
Arjuna Subject : Kedokteran - Kedokteran Reproduksi
Articles 5 Documents
 1 
Search results for , issue "Vol. 1 No. 1 (2020): June" : 5 Documents clear
Hylocereus polyrhizus Peel Extract Increase Testosteron Levels of Balb/C Mice (Mus musculus) Exposed Lead Acetate Reny I’tishom; Evy Wulandari; Sri Agus Sudjarwo
Indonesian Andrology and Biomedical Journal Vol. 1 No. 1 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.941 KB) | DOI: 10.20473/iabj.v1i1.25

Abstract

Lead is a heavy metal, the main polluting material in the environment, which comes from gasoline, batteries, paint, pipes, soil, cosmetics, household appliances, and decorations. Lead is a free radical causing oxidative stress. Lead can accumulate in the body due to its slow elimination process. Lead increases oxidative stress by forming reactive oxygen species (ROS) such as superoxide ion (O2-), hydroxil radical (OH-), and nitric oxide (NO), and direct suppression of antioxidant reserves such as Superoxide Dismutase (SOD), Catalase, and Glutathione Peroxide (GPx). Hylocereus polyrhizus peel is a natural antioxidant that can overcome the toxic effects of lead. The aim of this study was to analyze the treatment of Hylocereus polyrhizus peel extract orally once in a day for 40 days to increase testosteron levels of Balb/C mice (Mus musculus) exposed to lead acetate. The type of this study was true experimental study with Post Test Only Control Group design. Forty mice aged 8-10 weeks and the range of the body weight 30-40 grams were divided into 5 groups (each group of 8 mice). K- group was the control group without lead acetate and Hylocereus polyrhizus peel extract. K+, P1, P2 and P3 group was given 100 mg/kgBW lead acetate orally on the 1st day until day 14th. P1, P2 and P3 group was continued by giving Hylocereus polyrhizus peel extract orally on the 15th day until 39th day. P1 with dose 250 mg/KgBW, P2 with dose 500 mg/KgBW, and P3 with dose 1000 mg/KgBW. The results showed significant differences in testosterone levels between the K+ groups with P1 and P2. The conclusion of this study is Hylocereus polyrhizus peel extract can increase the testosteron levels of mice exposed to acetate lead.
Interpretation of Detection SARS Cov-2 in Semen Cennikon Pakpahan; Agustinus Agustinus; Aucky Hinting
Indonesian Andrology and Biomedical Journal Vol. 1 No. 1 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.485 KB) | DOI: 10.20473/iabj.v1i1.28

Abstract

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus with a high virulence which cause SARS-CoV-2, a disease with potentially dangerous implications for human health and pandemic. The involvement of other organs in the spread of this virus is still being debated. Considering the presence of (Angiotensin Converting Enzyme-2 (ACE-2) and Transmembrane Serine Protease 2 (TMPRSS2) in the reproductive organs including male reproduction,the male reproductive system possiblity for spreading SARS-CoV-2 should be studied. Reviews: Five studies were reveal the presence of SARS-CoV2 in semen. The reported results are inconsistent. Some of these studies also used unclear methods and procedures, which led to bias in the final results. Ongoing studies are needed to confirm the definite findings before specific recommendations can be made for further management. Summary: There is no definite interpretation of whether SARS-CoV-2 spreads through semen, but protection is still needed when it comes into contact with the semen.
The Effectiveness of LenshookeTM Semen Quality Analyzer X1 Pro for Human Semen Agustinus Agustinus; Supardi Supardi; Pety Narulita; Budiono Budiono
Indonesian Andrology and Biomedical Journal Vol. 1 No. 1 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (936.071 KB) | DOI: 10.20473/iabj.v1i1.26

Abstract

Background: LenshookeTM Semen Quality Analyzer (SQA) X1 Pro is an automated semen analysis. The accuracy of LenshookeTM SQA X1 Pro has never been analyzed with World Health Organization (WHO) standard method. Aim: This study aims to examine whether the LenshookeTM SQA X1 Pro method provides reliable results according to the WHO standard method. Methods: This study was a laboratory analytic observational study using 60 patients in Andrology clinic of Dr. Soetomo Hospital. The concentration, progressive motility (PR), total motile sperm count (TMSC), and morphology results of the LenshookeTM SQA X1 Pro and standard method were analyzed statistically using correlation, Bland Altman, and diagnostic test. Results: Significant correlation between two methods were found in all parameters (concentration: r = 0,970; PR: r = 0,781; TMSC: r = 0,952; morphology: r = 0,568). The mean difference for concentration, PR, TMSC, and morphology between the two examination methods were 1,165 million/ml, 7,05%, 7,584 million/ejaculate, and 2,25%. However, it found that the correlation and agreement were weaker in sample with low number of spermatozoa per high power field. The results revealed a sensitivity of 100%, 81%, and 59% for oligozoospermia, astenozoospermia, and teratozoospermia, respectively. The specificities were shown to be 100%, 74%, and 100% for oligozoospermia, astenozoospermia, and teratozoospermia, respectively. Conclusion: The LenshookeTM SQA X1 Pro gives a reliable result for determining oligozoospermia and asthenozoospermia, but in the situation that the clinicians need the accurate data, standard method should be used.
The Potential of Soy Isoflavones (Glycine max) and Magnetic Hydroxyapatite Nanoparticles as Osteoporosis Therapy for Menopausal Women Ayik Rochyatul Jannah; Faiza Rahma Ebnudesita; Savira Butsainah Dienanta; Reny I’tishom
Indonesian Andrology and Biomedical Journal Vol. 1 No. 1 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (601.908 KB) | DOI: 10.20473/iabj.v1i1.29

Abstract

Background: Menopausal women experience amenorrhea for 12 consecutive months. In Indonesia, one of four women aged 50 – 80 years has a risk of osteoporosis. This age range is related to the menopause phase. Low estrogen levels in menopausal women cause decreased bone mineral density resulting in osteoporosis. Osteoporosis is a degenerative disease characterized by decreased bone density and bone strength that causes fractures. This literature review aims to determine the potential of soy isoflavones (Glycine max) and magnetic hydroxyapatite nanoparticles as alternative therapies for osteoporosis in menopausal women.Reviews: Soy isoflavones are phytoestrogens because they have estrogen-like structures and functions. Some studies explain that phytoestrogens have benefits in osteoporosis therapy by maintaining bone density through decreasing osteoclast resorption and stimulating osteoblasts. Consuming enough soy supplements everyday has been shown to increase bone mineral density. This effect is strengthened by coating the soy isoflavones with magnetic hydroxyapatite nanoparticles through two mechanisms, as a therapeutic agent and drug carrier. The magnetic field of the magnetic nanoparticles produces force and torque to increase the temperature until 42°C  and trigger organelles movement, causing apoptosis of osteoclasts. Hydroxyapatite is a major component of bone mineral that replaces bone tissue deformity and has an osteoblastic effect in bone regeneration. Nano-sized hydroxyapatite will increase material properties and stability in high temperatures. However, hydroxyapatite has less magnetic activity so this function is completed by magnetic nanoparticles.Summary: Therefore, the combination of soy isoflavones and magnetic hydroxyapatite nanoparticles works synergistically as an alternative therapy for osteoporosis in menopausal women. 
Primary Testicular Failure with Unilateral Cryptorchidism Ahmad Ricardo Silalahi; Tjahjo Djojo Tanojo; Reny I'tishom
Indonesian Andrology and Biomedical Journal Vol. 1 No. 1 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.953 KB) | DOI: 10.20473/iabj.v1i1.27

Abstract

Background: Primary Testicular Failure (PTF) in men with unilateral cryptorchidism is a rare case, which might be the first time reported. Case: A 34-year-old man came with infertility and azoospermia. Signs of secondary sex found. FSH levels: 60.68 mIU / ml, LH levels: 15.96 mIU / ml, T levels: 336.14 ng / dl, E2 levels: 27.81 ng / dl. Ultrasound showed the left testis in the left inguinal +/- 2,4x1,1x3,6 cm in size, with decrease vascularization; +/- 4.1 cm from the base of the penis. The right testis size +/- 2,8x1,1x2,2 cm in the right scrotum accompanied by spermatocele. The patient was referred to the Urology department for orchidopexy of the left testis in the inguinal. Discussion: Primary testicular failure, in this case, may occur due to idiopathic but does not rule out the mosaic type of Klinefelter syndrome. The patient has unilateral cryptorchidism for 20 years, there will be a risk of testicular cancer. Management of cryptorchidism must be performed orchidopexy the first year after birth. After orchidopexy, monitoring is needed every year until at least 5 years. Conclusion: PTF occurs when the parenchymal tissue contained in the testes is no longer able to produce sperm or testosterone. PTF diagnosis is only possible through pathology and testicular cytology, but the combination of FSH and Inhibin B examination remains the best recommendation as a biomarker for patients with PTF.

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