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Jurnal Ilmiah Sains
Published by Universitas Sam Ratulangi
ISSN : 14123770     EISSN : 25409840     DOI : https://doi.org/10.35799/jis.v22i2.40961
Core Subject : Science, Education, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Mathematics Physics
Jurnal Ilmiah Sains (Journal of Scientific Sciences) is the Journals Published by Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. Jurnal Ilmiah Sains Published Twice a Year, i.e April and October. Jurnal Ilmiah Sains  welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Mathematics Statistics Computer Science Physics Chemistry Biology
Arjuna Subject : Umum - Umum
Articles 8 Documents
 1 
Search results for , issue "Volume 25 Issue 1, April 2025" : 8 Documents clear
Antioxidant Activity of Ethanol Extract of Breadfruit Peel (Artocarpus altilis (Park.) Fosberg) and Determination of Total Phenolic and Flavonoid Levels Febriana Wahyuningtyas; Ibrahim Arifin; Khoirul Anwar
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.57255

Abstract

Breadfruit peel (Artocarpus altilis (Park.) Fosberg) contains phenolic compounds and flavonoids. These compounds have benefits as antioxidants. This study aims to determine the antioxidant activity of ethanol extract of breadfruit peel by using the ABTS (2,2- Azinobis (3- Ethylbenzothaizoline-6- Sulfonic Acid)  method and determining the total phenolic and flavonoid levels.  The skin of breadfruit is extracted using a method with a 96% ethanol solvent. The results of the extract were tested for antioxidant activity by ABTS and trolox methods as a comparison, and the total phenolic and flavonoid levels were determined by comparing gallic acid and quercetin using UV-VIS spectrophotometry. The results of the absorbance data were analyzed by linear regression to obtain IC₅₀ values. Total phenolic and flavonoid levels were expressed by mgGAE/gram extract and mgQE/gram extract.  The results showed that the extract ethanol of breadfruit peel extracted by maceration method obtained IC₅₀ 47.86±0.07 ppm, trolox IC₅₀ 20.17±0.06 ppm. The determination of the total phenolic and flavonoid levels was obtained as 280.70±2.54 mg GAE/gram and 5,51±0.02 mgQE/gram extract. Antioxidant activity of ethanol extract of breadfruit peel is categorized as a very powerful antioxidant. Keywords: antioxidants; breadfruit peel; flavonoids; phenolics
Antioxidant, Antibacterial, Cytotoxic, and Anticancer Potential of Belulang Grass (Eleusine indica) Vanda Selvana Kamu; Max Revolta John Runtuwene; Jetlee Merentek; Harry Steven Julius Koleangan; Maureen Kumaunang
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.58431

Abstract

A study was conducted to determine the antioxidant, antibacterial, cytotoxic, and anticancer activities of the belulang grass plant (Eleusine indica). Antioxidant activity was assessed using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity method. Antibacterial activity was determined using the disk diffusion method, cytotoxicity was determined using the Brine Shrimp Lethality Test (BSLT), and anticancer activity was evaluated using the MTS assay. The results showed that the antioxidant activity of the extracts and solvent fractions of Eleusine indica had the highest average value for the n-hexane fraction (FNH) at 35.0%, ethyl acetate fraction (FEA) at 56.4%, aqueous fraction (FA) at 30.3%, and methanol extract (EM) at 32.5%. Among these, the highest value was obtained in FEA, while the lowest was obtained in FA. Based on the cytotoxicity test with the BSLT method, the ethyl acetate fraction had an LC50 value of 7.384 ppm, categorizing it as highly toxic. However, in cytotoxicity testing with HeLa cells, the IC50 value for the ethyl acetate fraction was 223.70 ppm, indicating that the ethyl acetate fraction was less active against HeLa cervical cancer cells. Keywords: Eleusine indica; belulang grass; cytotoxic; HeLa cells
Analisis Fitokimia Hasil GC-MS Parmelia sulcata (Ascomycota : Parmeliaceae) Sebagai Pewarna Alami Muzzazinah Muzzazinah; Awanda Elrita Putri; Nurmiyati Nurmiyati; Alanindra Saputra
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.56404

Abstract

A Parmelia sulcata is the largest family of lichen fungi, consisting of around 2,700 species spread across 80 countries. Lichen is an organism resulting from symbiosis between fungi and algae. This research aims to analyze the phytochemical results and find out whether Parmelia sulcata has potential as a natural dye to be applied to natural fiber fabrics. The research location is Tanen Village, Kemuning, Ngargoyoso, Central Java. Sample exploration was carried out using the exploration method, the samples were analyzed using GC-MS, where from the GC-MS results there were various compounds, therefore the researchers wanted to provide laboratory test data regarding the chemical content of the Parmelia sulcata species. Phytochemical and GC-MS test results are as follows: 3,5-Dihydroxytoluene 33.77%; 2-[3' Hydroxypropyl]-1,4-Benzenediol 3.32%; 1,3-Benzenediol, 2-Methyl 3.75%; Resorcyclic Beta Acid, 6-Methyl, Methyl Ester 1.43%; Resorcyclic Beta Acid, 6-Methyl, Methyl Ester 8.56%; 3-Cyclohexene-1-Methanol,6-1(1-Hydroxycyclopentyl)-, Cis 1.91%; Resorcyclic Beta Acid, 6-Methyl, Methyl Ester 37.15%; Acetonitrile, 9h-Pyrolo[1,2-A] Indole-9-Ylidene 1.00%; Fluoranthene-2-Carboxaldehyde 3.62%, this shows that Parmelia sulcata has less potential to be used as a natural dyes. Keywords: Phytochemistry; Compound Content; Parmelia sulcata; Natural Dyes
Flavonoid Levels in Beluntas Leaves (Pluchea indica (L.) Less) in Lamongan Regency Using a Spectrophotometer UV-Vis Faizatul Fitria; Farida Noor Arifah; Prima Agusti Lukis; Sofira Dwi Meylinda Sari
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.56217

Abstract

The beluntas plant (Pluchea indica (L.) Less) is one of the Indonesian medicinal plants that is rich in secondary metabolite compounds, one of which is flavonoids. The level of flavonoid compounds in beluntas leaves (Pluchea indica (L.) Less) is quite large, around 2.79%. Flavonoids in beluntas leaves provide the greatest biological activity at 63.1%, and can be used for health. The purpose of this study is to determine the total flavonoid levels of beluntas leaf extract from Lamongan regency using Spektrophotometer UV-Vis with quersetin as standart. The extraction method used is maceration with 70% ethanol solvent and the ratio of simplicia and solvent is (1:5). The presence of flavonoid compounds was determined by qualitative tests using concentrated HCl reagents and Mg powder. Total flavonoid levels were analyzed using a UV-Vis spectrophotometer with a quercetin standard measured at a wavelength of 408 nm for 2 minutes. Positive results are shown from qualitative tests by a change in orange color. The beluntas leaf extract obtained was 56.024 grams with a yield of 14.006%. The total flavonoid content from measurements using a UV-Vis spectrophotometer was 6.522%. Keywords: Beluntas leaves; flavonoids; maceration; secondary metabolites; Spectrophotometer UV-Vis
Antioxidant and Sunscreen Activities of Ethanol Extract Body Lotion Preparation of Dewandaru Leaves (Eugenia Uniflora L.) Khoirul Anwar; Gharsina Ghaisani Yumni; Aulia Septiani Putri; Melani Putri Britama
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.58632

Abstract

Dewandaru (Eugenia uniflora L.) is one of the plants that has antioxidant properties and activity as a sunscreen, so to facilitate its use it must be formulated in the form of body lotion. This study aims to test the antioxidant and sunscreen activity of a body lotion preparation from dewandaru leaf extract. Ethanol extract of dewandaru leaves is obtained by maceration using 96% ethanol. The ethanol extract of dewadaru leaves was identified as an active compound using phytochemical screening and FTIR. The body lotion formulation uses an extract with a concentration of 5% (F1); 10% (F2) and 15% (F3). Body lotion was tested for antioxidant and sunscreen activity using the ABTS method and the Mansur equation. The results of the absorbance data were analyzed using linear regression to obtain the IC₅₀ value and SPF value.   The results of phytochemical screening showed that dewandaru leaf extract contained phenolic compounds and flavonoids. It was proven by the FTIR test results that the ethanol extract of dewandaru leaves contains flavonoid compounds such as dihydroflavonol which have the functional groups OH, aliphatic CH, C=O and C–O. Evaluation of the physical characteristics of body lotion preparations, all formulas meet the requirements. Dewandaru leaf ethanol extract body lotion has strong antioxidant activity in all formulas and the best antioxidant activity results were obtained at F3 with an IC50 value of 59.85 ppm. Dewandaru leaf ethanol extract body lotion has the potential as a sunscreen with an SPF value of F1, namely 7.5675 in the extra protection category, F2, namely 16.1866 in the ultra protection category, and F3, namely 17.003 in the ultra protection category. So based on the results above, the greater the concentration, the stronger the antioxidant activity and sunscreen activity obtained. Keywords: Antioxidants; body lotion; dewandaru leaves; sunscreen
Identification of Parasitoid Insects in the Coastal Area of Temboan Village in the Biological Control of the Coconut Pest Beetle Plesispa reichei Chapuis Tartius Timpal; Meitha J.W Lepar; Conny M Mandagi
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.59507

Abstract

This study aims to discover and identify types of parasitoid insects found in the coastal area of Temboan Village and examine their potential in biological population control of the pest Plesispa reichei. The research methodology consisted of four stages. 1) A preliminary survey, which included field observations of the physical characteristics of the study area, 2) Data collection for species identification, recording the number of species, and determining population size, 3) Data processing and analysis related to diversity and dominance, 4) The final stage involved drawing conclusions. This research reveals the presence of several species of parasitoid insects from the Chalcidoidea and Ichneumonoidea families, which exhibit high parasitism rates against this pest. The existence of these parasitoid insects suggests that biological control could be an effective strategy for managing the coconut plant ecosystem in the coastal area of Temboan Village. Apparently, this study identified only one type of pupal parasitoid, Tetrastichus brontispae  on the coconut pest Plesispa reichei in the coastal area of Temboan and its surroundings. The high parasitism rate (50.5%) indicates that T. brontispae is highly effective as a biological control agent. This supports the use of parasitoids as a sustainable alternative for controlling Plesispa reichei populations. Keywords: Parasitoid Identification; Biological Control; Coconut Pest Beetle
A Aktivitas Antikanker Sel Murine Leukimia P-388 dan Analisis ADMET Senyawa Bioaktif Ekstrak Metanol Kayu Lawang secara In Silico Jonathan Cavin Ezra Sinaga; Hartanto Bisma; Dewa Gede Katja; Lidya Irma Momuat; Max Revolta John Runtuwene
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.59759

Abstract

Lawang wood (Cinnamomum culilaban L. Presl.) is often used by the public as a traditional medicine. It has been studied to have inhibitory activity on one type of murine leukemia cell protein P-388, namely cyclin-dependent kinase 2, this protein is important in the process of blood cell malignancy. This research aims to determine the potential of the bioactive compounds contained in lawang wood in inhibiting the action of the cyclin-ependent kinase 2 protein (PDB ID: 5D1J) by molecular docking as well as evaluating the physicochemical and pharmacokinetic properties of lawang wood bioactive compounds. lawang wood bioactive compounds were extracted using methanol solvent and identified using Gas Chromatography-Mass Spectrometer (GC-MS). Molecular docking was carried out using PyRx software by docking at the active site of the cyclin-ependent kinase 2 protein receptor followed by Lipinski's rule of five testing, and ADMET screening using SwissADME and admetSAR. The GC-MS results of lawang wood methanol extract contained 9 bioactive compound components. The molecular docking results were compared with the molecular docking results of the native ligand which was used as a control in this study. Based on the results obtained, the compound 4-Phenylpyrazolidine-3,5-dione has the lowest binding affinity value (-7,7 kcal/mol). The five best compounds, namely 4-Phenylpyrazolidine-3,5-dione, 2H-1-Benzopyran-2-one, 5,7-dimethoxy-, 2H-1-Benzopyran-2-one, 4,7-dimethoxy-, Camphore, and Safrole fulfilled Lipinski's rules and showed good results in ADMET analysis. Keywords: Cinnamomum culilaban L Presl.; mololecular docking; cyclin-dependent kinase 2; ADMET predictions
Pengaruh ENSO Terhadap Kejadian Upwelling di Perairan Kota Bengkulu (Studi Kasus : El Nino 2023) Angeli silaban; Septi Johan; Lizalidiawati Lizalidiawati
Jurnal Ilmiah Sains Volume 25 Issue 1, April 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v25i1.60370

Abstract

One of the areas affected by the ENSO phenomenon is the waters of Kota Bengkulu. The 2023 El Nino event was categorized as strong, making it essential to understand its impact on upwelling in the waters of Kota Bengkulu. The objective of this study is to examine the influence of the 2023 El Nino on the upwelling phenomenon in the waters of Kota Bengkulu. The data used in this study were obtained from Marine Copernicus and NOAA, consisting of monthly averages over a two-year period (2022–2024). The research method applied is descriptive and quantitative. The descriptive method illustrates the 2D distribution of Sea Surface Temperature (SST), Sea Surface Height (SSH), and Chlorophyll-a during the 2023 El Nino event. Meanwhile, the quantitative method analyzes the values of SST, SSH, and Chlorophyll-a corresponding to the period of the El Nino event. The results indicate that the strong El Nino of 2023 caused a significant decrease in sea surface temperature, reaching 26.9°C in September 2023. This decline in SST was attributed to upwelling in the waters of Kota Bengkulu, driven by the Southeast Monsoon coinciding with the strong El Nino event, which had an ONI value of 1.8°C. The occurrence of upwelling was also indicated by a lower SSH in October 2023, recorded at 0.2 m. Additionally, Chlorophyll-a concentration increased in October 2023, reaching 16.2 mg m⁻³, following the decrease in SST in September 2023. The peak of the 2023 El Nino in October further intensified the upwelling event that year. Keywords: chlorophyll-a; ENSO; sea surface height; sea surface temperature; upwelling

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