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UPT Publikasi Ilmiah, Universitas Islam Bandung. Jl. Tamansari No. 20, Bandung 40116, Indonesia, Tlp +62 22 420 3368, +62 22 426 3895 ext. 6891
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Bandung Conference Series: Pharmacy
Published by Universitas Islam Bandung
ISSN : -     EISSN : 28282116     DOI : https://doi.org/10.29313/bcsp.v2i2
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Bandung Conference Series: Pharmacy (BCSP) menerbitkan artikel penelitian akademik tentang kajian teoritis dan terapan serta berfokus pada Farmasi dengan ruang lingkup Airlock system Kanker, Alcohol, Antelmintik, Antigastritis drugs, Antioksidan, Artemia franciscana, Ascaris suum, Cacing babi (Ascaris suum Goeze), Contact Bioautography TLC, Daun cincau hijau (Cyclea barbata Miers), Daun kelor (Moringa oleifera Lam), Diabetes mellitus, DPPH Flavonoid, Fenilpropanolamin, Fermentasi, Flavonoid, Flavonol,Iles-iles, Isolasi, Lichen, Malassezia furfur, Metode Brine Shrimp Lethality Test (BSLT), Obat antidiabetes (OAD) Propionibacterium acnes, Obat tradisional, Parkia Speciosa Antibakteri, Pektin, Propionibacterium Acnes, Pseudoefedrin, Saccharomyces Cerevisiae, Spektrofotometri uv sinar tampak, Staphylococcus epidermidis, uji aktivitas antibakteri, Uji sitotoksik, Usnea baileyi. Prosiding ini diterbitkan oleh UPT Publikasi Ilmiah Unisba. Artikel yang dikirimkan ke prosiding ini akan diproses secara online dan menggunakan double blind review minimal oleh dua orang mitra bebestari.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 1 Documents
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Search results for , issue "501 - 508" : 1 Documents clear
Kajian Metode Top Down dalam Pembuatan Nanokristal Obat Antidiabetika Oral Nina Renata; Fitrianti Darusman; Hanifa Rahma
Bandung Conference Series: Pharmacy 501 - 508
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25145

Abstract

Abstract. Type 2 diabetes mellitus remains one of the most prevalent non-communicable diseases in Indonesia, and most first-line oral antidiabetic agents such as glibenclamide, glimepiride, and gliclazide belong to Biopharmaceutics Classification System (BCS) class II, characterized by poor aqueous solubility and consequently limited and variable oral bioavailability. Nanocrystal technology has emerged as a practical formulation strategy to overcome this limitation by reducing drug particle size to the nanometer range, thereby increasing the surface area available for dissolution. This article aims to review top-down methods used to produce nanocrystals of oral antidiabetic drugs through a literature review approach. Sources were obtained from international scientific databases, including PubMed, ScienceDirect, and MDPI, focusing on publications from the last ten years. The review shows that wet media milling and high-pressure homogenization are the most widely applied top-down techniques, either alone or combined with cocrystallization to form nano-cocrystals. Each method has distinct mechanisms, critical process parameters, and stabilizer requirements that determine the final particle size and dissolution performance. Overall, top-down nanocrystallization offers a scalable and solvent-minimal approach for improving the solubility, dissolution rate, and potential bioavailability of poorly soluble oral antidiabetic drugs. Abstract. Type 2 diabetes mellitus remains one of the most prevalent non-communicable diseases in Indonesia, and most first-line oral antidiabetic agents such as glibenclamide, glimepiride, and gliclazide belong to Biopharmaceutics Classification System (BCS) class II, characterized by poor aqueous solubility and consequently limited and variable oral bioavailability. Nanocrystal technology has emerged as a practical formulation strategy to overcome this limitation by reducing drug particle size to the nanometer range, thereby increasing the surface area available for dissolution. This article aims to review top-down methods used to produce nanocrystals of oral antidiabetic drugs through a literature review approach. Sources were obtained from international scientific databases, including PubMed, ScienceDirect, and MDPI, focusing on publications from the last ten years. The review shows that wet media milling and high-pressure homogenization are the most widely applied top-down techniques, either alone or combined with cocrystallization to form nano-cocrystals. Each method has distinct mechanisms, critical process parameters, and stabilizer requirements that determine the final particle size and dissolution performance. Overall, top-down nanocrystallization offers a scalable and solvent-minimal approach for improving the solubility, dissolution rate, and potential bioavailability of poorly soluble oral antidiabetic drugs. Abstrak. . Diabetes melitus tipe 2 masih menjadi salah satu penyakit tidak menular dengan prevalensi tertinggi di Indonesia, dan sebagian besar obat antidiabetika oral lini pertama seperti glibenklamid, glimepirid, dan gliklazid termasuk ke dalam Biopharmaceutics Classification System (BCS) kelas II yang memiliki kelarutan dalam air rendah sehingga bioavailabilitas oralnya terbatas dan bervariasi. Teknologi nanokristal menjadi salah satu strategi formulasi yang banyak dikembangkan untuk mengatasi keterbatasan tersebut dengan mengecilkan ukuran partikel obat hingga skala nanometer sehingga luas permukaan yang tersedia untuk disolusi meningkat. Artikel ini bertujuan untuk mengkaji metode-metode top-down yang digunakan dalam pembuatan nanokristal obat antidiabetika oral melalui pendekatan studi literatur. Sumber pustaka diperoleh dari basis data ilmiah internasional seperti PubMed, ScienceDirect, dan MDPI dengan fokus pada publikasi sepuluh tahun terakhir. Hasil kajian menunjukkan bahwa wet media milling dan high pressure homogenization merupakan teknik top-down yang paling banyak diterapkan, baik secara tunggal maupun dikombinasikan dengan pendekatan kokristalisasi untuk membentuk nano-kokristal. Setiap metode memiliki mekanisme, parameter proses kritis, dan kebutuhan stabilizer yang berbeda, yang menentukan ukuran partikel akhir serta kinerja disolusinya. Secara keseluruhan, nanokristalisasi top-down menawarkan pendekatan yang scalable dan minim pelarut untuk meningkatkan kelarutan, laju disolusi, dan potensi bioavailabilitas obat antidiabetika oral yang sukar larut.

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