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TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY Suryawati Suryawati; Safrida Safrida; Firdausa Sarah; Azizah Vonna; Vera Dewi Mulia
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.

TEST OF ANTI-INFLAMATION ACTIVITIES OF PEPAYA LEAF (Carica papaya L.) EXTRACT ON MALE WISTAR RATS INDUCED BY CARAGENAN 1% Fenny Hasanah; Nurul Hidayah
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Inflammation is a normal protective response to tissue injuries caused by physical trauma, destructive chemicals, or microbiological substances. The purpose of this study was to determine the anti-inflammatory activity of papaya leaf water extract (Carica papaya L.) on the feet of male Wistar rats which were induced by carrageenan 1%. The research method used is experimental. The stages of this study include plant identification, making dry simplicia powder, simplicia characteristics, extracting papaya leaves using water, simplicia phytochemical screening and papaya leaf water extract (EADP), as well as testing for anti-inflammatory activity. Anti-inflammatory testing was carried out on 20 male Wistar rats induced with 1% carrageenan sub plantar. The test group was divided into five groups for the induction, comparison, EADP 50, 100, 200 mg/kg BW groups. The parameters observed were the volume of mouse leg udema measured by a pletismometer every 30 min for 5 h. Data obtained then calculated percent inflammation and percent inflammation inhibition. Furthermore, it was analysed by ANOVA with a confidence level of 95%. The results of the simplicia characteristics showed that the water content, water content of the sea water and soluble extracts of ethanol were 8.9%, 51.4% and 10.2% respectively. The results of simplicia and EADP phytochemical screening showed the content of flavonoids, tannins, triterpenoids, glycosides, and alkaloids. Observations of the percentage of inflammation in the induction group had the highest percentage of inflammation compared with the other test groups at time of 300 min (p 0.05). Whereas the percentage of inflammatory inhibition of all groups of test extracts has effectiveness comparable to the comparison group. EADP group 200 mg/kg BW is the best dose of extract as anti-inflammatory, where flavonoid compounds are thought to be responsible for decreasing the volume of inflammation in the legs of test animals.

ANTIOXIDANT ACTIVITY OF ETHYL ACETATE EXTRACT OF NUTMEG (Myristica fragrans Houtt) STEM BARK Ilham Maulana; Binawati Ginting; Nurdin Nurdin; Saiful Fakri
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Antioxidant activity test for the extract of ethyl acetate nutmeg stem bark (Myristica fragrans Houtt) was carried out using 2,2-diphenyl-1picrylhydrazil (DPPH). The test results of antioxidant activity of ethyl acetate nutmeg stem bark extract with DPPH method at a concentration of 25 ppm, 50 ppm and 100 ppm obtained IC50 value = 68.14 ppm with IC50 value of vitamin C (as positive control) 3.657 ppm. The results of column chromatographic separation of ethyl acetate nutmeg stem bark extract obtained 5 combined fractions namely MFEK 1, MFEK 2, MFEK 3, MFEK 4 and MFEK 5. The test results of the fraction antioxidant activity in a good category were the MFEK 1 fraction. The MFEK 2 fraction to MFEK 5 showed an antioxidant activity lower than compared to the ethyl acetate extract. This shows that the ethyl acetate nutmeg stem bark extract has a better inhibitory activity, because there are several active compounds contained in the extract which can inhibit free radicals, so the IC50 value of the extract is better than the fractions.

GOOGLE MAPS AND MAPBOX API PERFORMANCE ANALYSIS ON ANDROID-BASED LECTURE ATTENDANCE APPLICATION Kurnia Saputra; Muhammad Furqan; Taufik Fuadi Abidin; Dalila Husna Yunadi
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Attendance is an inseparable component from lectures. The current manual attendance process still has its weaknesses, such as the loss or broken attendance sheets, the easiness to conduct fraud on the attendance sheets, and other cases. The attendance system using fingerprint devices are also not available in other locations yet, such as lectures that are done on the field or outdoor, where fingerprint devices are not available. Because of that, an online lecture attendance system that makes use of Android-based smartphones is developed in order to tackle the problem. This online lecture attendance system has the main feature of recording students’ attendances in a radius of 300 metres from the lecturer. This application is named Lecture Attendance System is developed using Rapid Application Development (RAD) model, because it is an effective method to minimise errors in the application. There are two testing performed to the application. The first testing was functional testing of the application. This testing was carried out in order to make sure that all functionalities and features are performing well. The second testing carried out is the distance accuracy testing, to compare between the Google Maps and MapBox API distances. From this testing, it was found that the error percentage using Google Maps is 9.250% and 12.128% for MapBox. From these results, they show that in calculating the distance, using Google Maps API has higher accuracy compared to the MapBox API.

PSIDIUM GUAJAVA LEAVES COMPOUND AS ANTI-INFLAMMATION: SYSTEMATIC REVIEW Angela Librianty Thome; I Ketut Sudiana; Abu Bakar
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Psidium guajava leaves are plants that have been widely used to treat health problems, such as inflammation. Guava leaves are one of the parts used in this plant. People use guava leaves because it can be reached and has minimal side effects. The aim of this study was to identify the content available in guava leaves and their bioactivity as anti-inflammatory. The design of this study uses systematic reviews. Article are taken from electronic databases such as Scopus, Pubmed, ProQuest, and Science Direct. Articles are taken from 2013 to 2019 with the keywords “phytochemical” OR “chemical” OR “compounds” AND “psidium guajava leaves” AND “anti-inflammation”. The review results of 3 articles explained that guava leaves contain ingredients that can be useful as anti-inflammatory. Guava leaves provide a great effect or benefit to inflammation.

GOOGLE MAPS AND MAPBOX API PERFORMANCE ANALYSIS ON ANDROID-BASED LECTURE ATTENDANCE APPLICATION Kurnia Saputra; Muhammad Furqan; Taufik Fuadi Abidin; Dalila Husna Yunadi
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.14459

Attendance is an inseparable component from lectures. The current manual attendance process still has its weaknesses, such as the loss or broken attendance sheets, the easiness to conduct fraud on the attendance sheets, and other cases. The attendance system using fingerprint devices are also not available in other locations yet, such as lectures that are done on the field or outdoor, where fingerprint devices are not available. Because of that, an online lecture attendance system that makes use of Android-based smartphones is developed in order to tackle the problem. This online lecture attendance system has the main feature of recording students’ attendances in a radius of 300 metres from the lecturer. This application is named Lecture Attendance System is developed using Rapid Application Development (RAD) model, because it is an effective method to minimise errors in the application. There are two testing performed to the application. The first testing was functional testing of the application. This testing was carried out in order to make sure that all functionalities and features are performing well. The second testing carried out is the distance accuracy testing, to compare between the Google Maps and MapBox API distances. From this testing, it was found that the error percentage using Google Maps is 9.250% and 12.128% for MapBox. From these results, they show that in calculating the distance, using Google Maps API has higher accuracy compared to the MapBox API.

TEST OF ANTI-INFLAMATION ACTIVITIES OF PEPAYA LEAF (Carica papaya L.) EXTRACT ON MALE WISTAR RATS INDUCED BY CARAGENAN 1% Fenny Hasanah; Nurul Hidayah
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.12498

Inflammation is a normal protective response to tissue injuries caused by physical trauma, destructive chemicals, or microbiological substances. The purpose of this study was to determine the anti-inflammatory activity of papaya leaf water extract (Carica papaya L.) on the feet of male Wistar rats which were induced by carrageenan 1%. The research method used is experimental. The stages of this study include plant identification, making dry simplicia powder, simplicia characteristics, extracting papaya leaves using water, simplicia phytochemical screening and papaya leaf water extract (EADP), as well as testing for anti-inflammatory activity. Anti-inflammatory testing was carried out on 20 male Wistar rats induced with 1% carrageenan sub plantar. The test group was divided into five groups for the induction, comparison, EADP 50, 100, 200 mg/kg BW groups. The parameters observed were the volume of mouse leg udema measured by a pletismometer every 30 min for 5 h. Data obtained then calculated percent inflammation and percent inflammation inhibition. Furthermore, it was analysed by ANOVA with a confidence level of 95%. The results of the simplicia characteristics showed that the water content, water content of the sea water and soluble extracts of ethanol were 8.9%, 51.4% and 10.2% respectively. The results of simplicia and EADP phytochemical screening showed the content of flavonoids, tannins, triterpenoids, glycosides, and alkaloids. Observations of the percentage of inflammation in the induction group had the highest percentage of inflammation compared with the other test groups at time of 300 min (p 0.05). Whereas the percentage of inflammatory inhibition of all groups of test extracts has effectiveness comparable to the comparison group. EADP group 200 mg/kg BW is the best dose of extract as anti-inflammatory, where flavonoid compounds are thought to be responsible for decreasing the volume of inflammation in the legs of test animals.

PSIDIUM GUAJAVA LEAVES COMPOUND AS ANTI-INFLAMMATION: SYSTEMATIC REVIEW Angela Librianty Thome; I Ketut Sudiana; Abu Bakar
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.13829

Psidium guajava leaves are plants that have been widely used to treat health problems, such as inflammation. Guava leaves are one of the parts used in this plant. People use guava leaves because it can be reached and has minimal side effects. The aim of this study was to identify the content available in guava leaves and their bioactivity as anti-inflammatory. The design of this study uses systematic reviews. Article are taken from electronic databases such as Scopus, Pubmed, ProQuest, and Science Direct. Articles are taken from 2013 to 2019 with the keywords “phytochemical” OR “chemical” OR “compounds” AND “psidium guajava leaves” AND “anti-inflammation”. The review results of 3 articles explained that guava leaves contain ingredients that can be useful as anti-inflammatory. Guava leaves provide a great effect or benefit to inflammation.

ANTIOXIDANT ACTIVITY OF ETHYL ACETATE EXTRACT OF NUTMEG (Myristica fragrans Houtt) STEM BARK Ilham Maulana; Binawati Ginting; Nurdin Nurdin; Saiful Fakri
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.12618

Antioxidant activity test for the extract of ethyl acetate nutmeg stem bark (Myristica fragrans Houtt) was carried out using 2,2-diphenyl-1picrylhydrazil (DPPH). The test results of antioxidant activity of ethyl acetate nutmeg stem bark extract with DPPH method at a concentration of 25 ppm, 50 ppm and 100 ppm obtained IC50 value = 68.14 ppm with IC50 value of vitamin C (as positive control) 3.657 ppm. The results of column chromatographic separation of ethyl acetate nutmeg stem bark extract obtained 5 combined fractions namely MFEK 1, MFEK 2, MFEK 3, MFEK 4 and MFEK 5. The test results of the fraction antioxidant activity in a good category were the MFEK 1 fraction. The MFEK 2 fraction to MFEK 5 showed an antioxidant activity lower than compared to the ethyl acetate extract. This shows that the ethyl acetate nutmeg stem bark extract has a better inhibitory activity, because there are several active compounds contained in the extract which can inhibit free radicals, so the IC50 value of the extract is better than the fractions.

TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY Suryawati Suryawati; Safrida Safrida; Firdausa Sarah; Azizah Vonna; Vera Dewi Mulia
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.13405

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.

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Suhartono

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suhartono@usk.ac.id

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Journal Mail Official
jurnal.natural@fmipa.unsyiah.ac.id

Editorial Address
Block A 2nd Floor FMIPA USK Jl. Tegk. Syech Abdurrauf No. 3, Banda Aceh, 23111, Indonesia

Location
Kab. aceh besar,

Aceh

INDONESIA

Abstract

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Abstract

Abstract

Abstract

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Suhartono

Contact Email suhartono@usk.ac.id

Phone -

Journal Mail Official jurnal.natural@fmipa.unsyiah.ac.id

Editorial Address Block A 2nd Floor FMIPA USK Jl. Tegk. Syech Abdurrauf No. 3, Banda Aceh, 23111, Indonesia

Location Kab. aceh besar, Aceh INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Suhartono

Contact Email
suhartono@usk.ac.id

Phone
-

Journal Mail Official
jurnal.natural@fmipa.unsyiah.ac.id

Editorial Address
Block A 2nd Floor FMIPA USK Jl. Tegk. Syech Abdurrauf No. 3, Banda Aceh, 23111, Indonesia

Location
Kab. aceh besar,

Aceh

INDONESIA