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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis , Identification and Evaluation Antimicrobial activity of some novel N-substituted Azetidinone, Imidazolidinone and Tetrazole incorporating 2- phenyl- 3- (ethyl acetate)-quinazolin-4(3H)-one Maryam M. Sahib
Journal of Global Pharma Technology .
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Abstract

A novel series of azetidinone, imidazolidinone and tetrazole incorporating quinazolin-4(3H)-ones were synthesized and evaluated their antimicrobial activity in this research.  Anthranilic acid as a simple molecule under acylation with benzoyl chloride yielded 2-benzamidobenzoic acid [1] followed by cyclization reaction of compound [1] with acetic anhydride yielded 2-phenyl-4H-benzo[3,1]oxazin-4-one [2] that treatment with ethyl glycinate yielded 2-phenyl-3-(ethyl acetate)-quinazolin-4(3H)-one [3] as a starting compound. Compound [3] was reacted with hydrazine hydrate to gave 2-phenyl-3-acetohydrazide-quinazolin-4(3H)-one [4]. aroyl hydrazone derivatives [5-9] prepared by reacted of compound [4] with different substitution aromatic aldehydes. Then compounds [5-9] was cyclization under three pathways with chloro acetyl chloride, 2-amino acetic acid and sodium azide to gave azetidinone derivatives [10-14], imidazolidinone derivatives [15-19] and tetrazole derivatives [20-24] respectively. Moreover the chemical structure of synthesized compounds were identified via different techniques such as FTIR,1H-NMR,and13C-NMR and some of its physical properties were measured. Also we have evaluated the effect of some prepared compounds against four types of bacterial and fungal strain. The result showed significant actions for this compound as antimicrobial agents.Keywords: Quinazolin-4(3H)-one, Schiff base, Azetidine, Imidazolidine, tetrazole, Anti-microbial.
Association between obesity and depression among women in Indonesia: A questionnaire based study Susi Ari Kristina; Nur Aini Mardea; Suci Hanifah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Obesity is a global public health issue and the prevalence of obesity is growing worldwide every year. Studies have been performed since the early 1970s on the association between obesity and depression or other psychological disorders. In Indonesia, however, only a small number of studies have been carried out. The aim of this study was to examine whether obesity was associated with depression in a sample of women with overweight and obesity based on their BMI, anti-obesity treatment experience, and age among women in one province in Indonesia. Women aged 18 years and older who were selected from fitness centers in urban area of Yogyakarta province and self-reported BMI categorized as overweight and obese were eligible to participate. Voluntary participation in study survey was consented. A set of questionnaire consisting demographic characteristics and depression symptoms was developed and validated. Depression was assessed by the Patient Health Questionnaire-9 (PHQ-9), with a score of ≥10 used to indicate severe depression. Respondents who classified as overweight mostly had minimal depression level (33.58%) and none had severe depression level, whereas respondents who classified as obese mostly had moderate depression level (44.74%) and 3.95% had severe depression level. This study found that BMI, experience of using anti-obesity drugs, and age of respondents were significantly affected PHQ-9 score. Thus, these factors determined the level of depression among women surveyed. The study reported significant association between obesity and depression among women. This association depends on BMI, anti-obesity treatment experience, and age variables. Approaches to public health to reduce the burden of obesity or depression have to consider the strong link between these two common conditions.
The Study of Electrical Activity of the Triceps Brachia Muscle according to the Chemical Changes of Water Loss during Spike in Volleyball Haythem Ali Alsayigh
Journal of Global Pharma Technology .
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Abstract

The aim of this study is to study muscle activity of triceps according to what happens from chemical changes due to loss of water in a volleyball game, especially in spike skill, since this skill requires the performance of high accuracy and speed of a big reaction. Was selected sample of players who suffer from potassium deficiency (Hypokalemia) as a result of incorrect nutrition and not to drink fluids regularly as well as the performance of the game in hot weather, which led to an imbalance in the ionic balance of the cell as a result lost a little amount of potassium ion is essential for the occurrence of muscle contraction. The results showed that continued positive performance without compensation potassium element led to an imbalance in muscular activity of the triceps muscle.Keywords: Electrical activity, Muscle triceps brachial, Chemical changes, Water loss, Spike and volleyball.
Molecular Detection of Multi-drug Resistant Acinetobacter baumannii from Patients Wounds Amina N. Al-Thwani
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

150 swabs were collected from patient's wounds and hospital units, population of this study included both genders with different ages in AL-Imamein AL-Kadhimein Medical City in Baghdad. The collected swabs were cultured using appropriate media and tested biochemically in order to find out the profile of bacteria that colonize patient's wounds and hospital units. The results of culture revealed that, the most common isolated bacteria were, Staphylococcus aureus followed by Pseudomonas aeruginosa and A.baumannii. The isolates of A. baumannii was tested for antibiotic susceptibility, the results showed that, clinical and environmental isolates were (100%) resist to Ceftriaxone, Ceftazidime Ampicillin–Sulbactam, and Cefepime. Metallo Beta Lactamase (MBL) genes as bla IMP gene and bla VIM were detected by Molecular method (PCR) in 12 clinical and environmental isolates of A.baumannii. The result revealed that among all isolates (12) only bla IMP gene was detected in 4 isolates while the reminder isolates (8) of A.baumannii have no amplified bands for neither bla VIM nor bla IMP. It was concluded that, A.baumannii responsible for many nosocomial infections, and these bacteria were high resistant to different types of antibiotics.
Polymorphism of ITS4 Gene of Candida guilliermondii Wafaa K. Al-mansour
Journal of Global Pharma Technology .
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Abstract

The aim of this study is investigate the polymorphisms of Candida guilliermondii based on ITS4 gene sequencing. To achieve this goal, samples were collected from  patients with dermal infection symptoms, were applied for microbiological analysis using SDA media DNA was isolated from Candida guilliermondii and the ITS4 gene were amplified by using specific primer, then sequencing of nucleic acid of genes was performed by machine is AB13730XL, Applied Biosystem, Macro gen company, the DNA sequencing results of flank sense of ITS4 gene from 5 strains of Candida guilliermondii was found to be compatible 99%  and score 1517 and expect 0.0 of the ITS4 gene of  Candida guilliermondii strain BO418 from the Gene Bank, The expected substitution  were found after the analysis of the sequences there were 5 Transversion  and one transition in the 5 Candida guilliermondii with  Sequence ID emb|AJ3tf10144.1| location at range of nucleotide from 5128 to 5408, compared with data obtained from Gene Bank, these finding lead to conclusion, our assay allows rapid detection of Polymorphism in Candida guilliermondii.Key words: Candida guilliermondii, ITS4 gene, Polymorphism, and Sequencing.
Photographical Assessment of Face Pleasantness using Facial Analysis for a Sample of Iraqi Adults Females (Retrospective Study) Shahbaa A. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Aims: The aim of this study was to assess facial attractiveness and to check if the numeric facial analysis can determine this attractiveness for a sample of Iraqi adults' females and characterize the studied sample according to subjective concepts of facial esthetics in esthetically pleasant, esthetically acceptable and esthetically unpleasant, considering frontal photographs.  Subjects and Methods: Forty frontal standardized photograph of females aged between 20 and 22 years old. The frontal photograph and lateral photograph were obtained by asking each female to look to the center of the lens and at a distant mirror respectively which is placed in front of her face. All the frontal photographs were evaluated by using our own esthetics criteria (orthodontist evaluation) as graduation in: pleasant, acceptable and not pleasant. The numeric facial analysis was then performed. Linear, proportional and angular measurements were compared among groups. Results: The sample was consisted of 25% of unpleasant, 55% of acceptable and 20% of pleasant according to subjective analysis.  In most measurements there were no differences among groups. Just in one linear measurement (sn-U1 FILS) significant statistical difference was observed. Group III has higher right and a left symmetry angel despite it has lower facial symmetry Conclusions: In the evaluation of facial measurements, it was observed that there were statistically non-significant except for the sn-U1 FILS, which is statistically significant. The photographic evaluations require more than one evaluator in different specialties to give more reliable judgment. The facial analysis influenced by, age, gender, cultural and racial factors.Keywords: Attractiveness, Facial esthetics, Facial analysis.
A Review on Novel Biochemical Mediator Triggered on Demand Drug Delivery System Mithila Sawalwade; Anup Naha; Shubham Zende
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Unavailability of drug in appropriate amounts on apt time at the desired site of action can lead to further complications in the diseases which can turn into more deadly condition. Timely delivery of right amount of drug is very crucial in proper therapy, thereby avoiding the adverse effects of the drug. Feedback regulated closed loop delivery system can controllably deliver the drug on demand which means the release rates can be increased, decreased or totally stopped, as a response towards physiochemical response produced by the body. The system can be designed in such a way that the concentration of the drug released from the system is proportional to the degree of stimuli produced by the body. Various diseases and disorders progress by feedback loop mechanisms, owing to which biochemical signal triggered delivery of drug can be achieved in such conditions. The system is also advantageous in case of some drugs whose fluctuation in plasma concentrations is unenviable. In the current work, self-regulated drug delivery devices designed for various conditions like diabetes mellitus, hypercoagulation, cancer, microbial infections and opioid poisoning are reviewed. Various combinations of smart polymers are employed to design such devices that work by responding to the feedback produced by the body.
The Impact of a Training Program Using Brain-based Learning Theory in the Development of Creative Thinking and Skills of Passing and Scoring of Young Player's Handball Nabeel. Kazem Heribd
Journal of Global Pharma Technology .
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Abstract

Through field work and handball experience it was noted that there are weaknesses in the performance of basic skills (passing and scoring) and correct behavior and lack of appropriate solutions for players to perform basic skills and this negatively affects the performance of the player and thus the results of the team believes one of these reasons weakness in the creative thinking of players Therefore, the researcher sought to use the theory of learning based on the brain in the development of creative thinking and skills of passing and scoring of young players handball.This experiment is the first step in the sport in general and in the field of handball in particular, and the objectives of the research:Preparation of a training program using the theory of learning based on the brain to develop creative thinking and skills of passing and scoring of youth handball in the club Alqasim Sports.To identify creative thinking and skills of passing and scoring of youth handball in the club Alqasim Sports.Knowledge of the impact of the training program using the theory of learning based on the brain to develop creative thinking and skills of passing and scoring of youth handball in the club Alqasim Sports.The researcher used the experimental method and determined the research society of the players of the club Alqasim youth of handball, the number of (19) players were drawn random sample of the number (12) and were divided into two groups (control and experimental) The most important conclusions are:The training program using brain-based learning theory has a positive impact on the development of creative thinking of young players in handball.The approach adopted by the coach has a positive impact in the development of skills of passing and scoring of young player's handball.The training program using brain-based learning theory has a better effect on the development of the skills of passing and scoring of young player's in handball.Keywords: Training program, Brain, Learning theory, Creative thinking and handball.
Association of Mannan Binding Lectin to Liver Fibrosis in Chronic HCV Patients Wafaa Ezzat
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

The interaction between viral and host immune factors plays an important role in natural history of chronic HCV infection .We aimed to determine serum level of MBL and its relation to grades of liver fibrosis in chronic HCV patients.we studied the impact of serum level of MBL on early virological responsein chronic HCV patients.subjects and methods: included 70 HCV patients (40 HCV patients with liver fibrosis grades <F3 (group Ι) &30 HCV patients with liver. fibrosis ≥F3 (groupΙΙ) according to METAVIR score), who fulfilled inclusion & exclusion criteria of the National Egyptian treatment protocol of treatment of CHC, in addition to 16 control subjects. All studied cases were subjected to history taking, thorough clinical examination, routine investigation(fasting blood sugar, serum creatinine, alkaline phosphatase, ALT, AST, total bilirubin, albumin ,complete blood picture ,prothrombin activity, alpha feto-protein, TSH) ,  abdominal ultrasonography and liver biopsy in addition to ELISA for MBL. Results: mean values of MBL was significantly increased among group 2 patients more than that of group 1(P=0.001). After 12wk of combined therapy, it was found that 61 patients (87.14%) were responders to antiviral therapy, while9 patients (12.85%) were non responders.  The mean value of MBL among responders was 64.44± 26.75 while it was 90.41± 82.41 without any statistically significant differences. So it can be concluded that MBL plays an important role in the pathogenesis of liver fibrosis in HCV liver disease. MBL has no impact on early virological response among patients with chronic HCV infection.
Nasal Carriage of Methicillin Resistant Staphylococcus Aureus among Medical Personnel of Salah Al-Din Hospitals using Classical Method and PCR Technique Nihad Abdul-Hussain Jafar
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objectives: To screen medical personnel of four hospitals at Salah Al-Din governorate for MRSA, and to compare between the classical method and PCR method for detection of Staphylococcus aureus and MRSA. Materials and Methods: A total of 279 nasal swabs were taken from medical personnel of four hospitals in Salah al-Din (Salah Al-Din General Hospital, Tikrit Teaching Hospital, Samarra General Hospital and Baiji General Hospital). Staphylococcus aureus isolates diagnosed by both classical methods based on morphology, coagulase test, DNase test and mannitol salt agar fermentation, and by PCR by detection of femA gene .The isolates diagnosed as MRSA using classical method by its sensitivity to Cefoxitin in disc diffusion method and by detection of mecA gene with PCR. Results: The results showed that out of the 279 swabs taken from the medical staff of four hospitals in Salah al-Din, 88 were isolated as S. aureus (31.5%) using the classical method used in the hospitals of the governorate under study, and 58 (65.9 %) of them were methicillin resistant S. aureus using the Cefoxitin antibiotic method. However, the PCR results showed that only 57 isolates (20.4%) were diagnosed as S. aureus and that the number of isolates of S. aureus that possessed the mecA gene was only 24 isolates (42.1%) from the total isolates. Conclusion: The classical methods used in most Iraqi hospitals are not accurate in diagnosing S. aureus isolates and MRSA isolates, since 31 (35.2 %) isolates of the 88 isolates were misdiagnosed as S. aureus by the classical method. Furthermore, 34 (58.6 %) isolates of S. aureus were misdiagnosed as MRSA by the classical disc diffusion method.Keywords: MSRA, Nasal carriage, Meca.

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