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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Correlation of LIF and Glycodeline an in Prediction of Embryo Implantation of Infertile Women with and without PCOS Zena F. Hussien
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Implantation of the blastocysts into the maternal uterus is a crucial step in mammalian reproduction, which is controlled by a number of complex molecules like hormones, cytokines, and growth factors and their cross talk. A network of these molecules plays a crucial role in preparing receptive endometrial and blastocysts. This study aimed to found out the role of Glycodeline A,LIF gene expression, concentration,  in the endometrial that may interfere with implantation process of polycystic ovary syndrome (PCOS) and non-PCOS women, A convenient blood sample of 80 infertile women undergoing in vitro fertilization (IVF) program were intentionally divided according to the cause of infertility into 40 healthy women their husbands complaining from male infertility factors, and 40 infertile women with polycystic ovary syndrome. Glycodeline A, LIF were measured on ovulatory and  luteal phase of cycle (CD14-CD16,17) at the day of ovarian pickup and embryo transfer by using quantitive polymerase  chain reaction (qPCR ) and Elisa technique , Results of the present study   showed that The gene expression of PAEP ,LIF in addition to levels of  serum(Glycodeline A, LIF)  were  more valuable in  predicting  the  pregnancy out come in infertile PCOS women than in  non-PCOS women  This result  can be utilized to be used as predictors  of  implantation window for successful implantation and pregnancy.Keywords: Implantation, Glycodeline A, PCOS, IVF program, LIF.
Determain Kind and Concentration of Allium sativum L.Plant Ingredients and its Effect on Isolated Bacteria Causing Urinary Tract Infections Ayyub J. Abdl-Rahmaan Al-Baytay
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Atotal of  (190)  samples urinary were collected patients with Urinary Tract Infections(UTIs) from the period 2017/11/18 to 2018/2/17 ,for determain kind and concentration of Allium sativum L.ingredients and its effect on growth of the Gram-negative bacteria isolated from urinary tract infections in Al-Alam city/Tikrit Governoratr/Iraq,The study was carried out in the laboratories of Al-Alam Hospital and the laboratories of the College of Education for Women , Department of life Science,chemical analysis by HPLC apparatua showed the plant contain severel active ingrdients: S-ally cysteine,Y-glutomycysteine, Vinyl-{4H}1,2dithlin(agoene),di-allyldisulfide and Diallytrisulfide with concentrate,5.72% 9.75%, 53.09%,9.72%,12..85% and 10.60% respectively,also appeared many bacteria genus on In the samples taken from patients patients: E.coli, Klebsiella, Pseudomonus,Proteus,Serratia and Chromobacterium with isolates concentration reached for each genus reached, 44.2%, 23.5%, 17.6%, 5.5%, 5.8% and 2.9% respectively,and the current study for aquoues and alcoholic for  extracts appeared a clear contrast on inhibition of studied bacteria kinds, as it was alcoholic extract of Allium sativum more inhibiton than aquoues extract on the concentration 100% throught observation inhibition diameter on the concentration 25,50 and 100%.Keywords: Allium sativum+plant extract+bacteria.
Nosocomial Infection in Al-Hilla City Hospital Amean A. Yasir
Journal of Global Pharma Technology .
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Abstract

Some of the problems are reviewed. Methods suggested for dealing with them are probably not the ideals that should ultimately be attained but minimum standards to serve as immediate objectives for the search about Nosocomial infection. They concern indications for and methods of isolation control of infection from staff, environmental contamination, and a few technical procedures. A new type of dressing towel for wounds is described.Keywords: Nosocomial Infection, Control of infection, Healthcare-associated infection, Mechanism of infection control.
Microencapsulation of Lactobacillus plantarum in Lactic Acid Fermentation of Winter Melon (Benincasa hispida) Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Winter melon (Benincasa hispida) is a popular vegetable that were grown primarily for its use as a vegetable and usually recognized for its nutritional and medicinal properties. Consumers tend to prefer the food and beverages that are fresh, highly nutritional, health promoting and ready to consume. Objective of this study focused on different technical parameters such as the initial soluble solid content (6.0, 6.5, 7.0, 7.5, 8.0 oBrix), loading ratio of Lactobacillus plantarum encapsulated in calcium alginate bead (2.0, 4.0, 6.0, 8.0 10.0 g/100mL), fructo-oligosacharide (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) as prebiotic affecting to the lactic acid fermentation of winter melon juice. Results showed that the best quality of the fermented winter melon juice would be achieved by the initial soluble solid content of juice 7.5 oBrix, Lactobacillus plantarum bead loading 8.0 g/100mL, fructo-oligosacharide 2.0%. Through fermentation, winter melon juice was preserved and maintained, while improving the nutritive and sensory properties. Lactobacillus plantarum was stable under acidic condition by the microencapsulation. The probiotic winter melon juice is very beneficial for health as health it plays an important role in immune system improvement.Keywords: Benincasa hispida, Lactobacillus plantarum, Microencapsulation, Fermentation, Fructo-oligosacharide, Juice.
Antibacterial Evaluation of Gradient Extracts of Stenochlaena palustris (Burm.f) Bedd. Towards Bacteria Involved in Skin Diseases Toji Thomas
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
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Abstract

Objective: The work attempted to analyse the antibacterial character of gradient distillate of Stenochlaena palustris, a healing fern used to treat burn. The plant was evaluated for its antibacterial capability towards bacteria occupied in skin infections. Methods: Whole plant of S. palustris was examined for its antibacterial potential and phytochemical constituents in different solvents extracts of incrementing polarity. The typical disc diffusion method was done to inspect antibacterial activity. Basic phytochemcal assessment was accomplished by various standard spraying reagents and used to detect the same. Minimum inhibitory concentration and minimum bactericidal concentration were established towards Pseudomonas aeruginosa. Results: The plant could basically demonstrate antibacterial activity in acetone extract. P. aeruginosa was the most sensitive organism observed out of the tested bacteria. Water extracts did not provide antibacterial activity to the analysed bacteria. Phenols, flavonoids, polyphenols and sterols were track down in various extracts. Flavonoids, phenols, polyphenols and sterols found in acetone extract of the plant could be responsible for its antibacterial activity. Acetone extract of the plant yielded minimum inhibitory concentration as 12.5 mg/ml and minimum bactericidal concentration as 25.0 mg/ml towards P. aeruginosa. Conclusion: S. palustris manifested antibacterial activity in acetone extract notably towards   P. aeruginosa, a bacterium frequently associated with nosocomial infection. Keywords: Stenochlaena palustris, Antibacterial activity, Pteridophytes, Disc diffusion, Phytochemicals.
Role of Vitamin B12, Folic Acid and Oxidative Damages, in Serum of Patients with Vitiligo Sherief Mahdy Hussein
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Vitiligo is a chronic common disease which may cause as a result of oxidative stress which is proposed to implicate in its etiopathogenesis. Vitiligo is an autoimmune disease affecting skin, hair and oral mucosa. This disease is characterized by a loss of melanin. Disturbance of thyroid hormones has been known as a key trigger of this pathology. Objective: The aim of this study is to determine the levels of vitamin B12, folic acid , oxidative stress (lipid peroxidation ;MDA),total antioxidant capacity (TAC), Paraoxanase (PON1)in serum of patients with  vitiligo  compared to matches control group. Materials and subjects:  The study included 42 patients from Egyptian population suffering from generalized vitiligo (29 male patients and 13 female patients; mean age 35.1 years; ranging from 28-45 years and 36 healthy volunteers as control group (22 male patients and 14 female patients; mean age 36.2 years; ranging from 25–47years). Vitiligo patients were recruited from Medical research center of excellence of National Research Centre, Egypt, during interval of 6 months (1 October, 2018 to 31 March , 2019). Vitiligo diagnosis is based on if areas of patient's skin, hair or eyes lose coloring and confirmation is done by using Wood’s lamp. Blood samples were obtained from the patients and controls. PON1, MDA, TAC vitamin B12 (vit.B12) and folic acid biomarkers were analyzed in serum samples of both control and vitiligo patients. Results :  The present results declared  significant elevation of  oxidative stress ; MDA  (+159.26), which is associated with significant decrease in PON(-34.10) ,TAC (-35.89),vitamin B12(-53.41)  and folic acid (-89.23) in vitiligo patients compared to  control group. Conclusion: Oxidative stress and antioxidant balance are strongly implicated in the vitiligo patients .Vitiligo disease should be examined for multifactorial such as homocysteine levels for a possible implication due to the  postulation  in the pathogenesis of vitiligo based on the previous  findings . Moreover, the therapeutic role of supplementation with Vitamin B12/folic acid in vitiligo needs to be studied further.Keywords: Autoimmune disease, Melanin loss, Oxidative stress, Vitiligo, Vit. B12, Folic acid, TAC,PON.
Distribution of Both Fungi and Bacteria Detected from the Nasal and Oral Cavity (Statistical Survey in Kirkuk) Sanaa H. Mohammad
Journal of Global Pharma Technology .
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Abstract

The study was carried out at the period from 1st march 2018 to 31st june 2018 in order to determine the relationship of the allergic fungi with the worker in services and restaurant also university student and study the occurrence of fungi and bacteria detected from nasal  and oral cavity among University  Students , Restaurant workers and  services workers with mean age (47.40±22.14) subjects from different areas of Kirkuk City(107) isolates of bacteria and fungi isolated from the nasal cavity in the same time( 45) isolates of bacteria and fungi isolated from the oral cavity the isolates represented by :  A.  niger,  A.  flavus,  A. fumigatus,  A.  nidulans,  A. terreus, A.  japonicas, A.  japonicas, Alternaria spp, C. albicans, C. parapsilosis,  Penicillium spp, Rhizopus spp,  S.pyogen, S.aureus .The statistical analysis, existence of significant differences at the level of probability (P< 0.05) between the type of isolates the high frequency isolation represented by, A.niger, and S.aureus in the oral and nasal cavity which appeared with high occurrence  .  The subjects in this study were divided into five age groups.  On the other hand the statistical analysis of the existence significant differences (P< 0.05) between the fungal and bacterial isolation infection and age for all age groups, it had been found that the age group 26-35 years was the most influential of these infections, compared with the other age groups.Keywords: Fungi, Bacteria, Nasal and oral cavity
Estimation of Alpha-L-Fucose and Vitamin D3 Levels in Beta Thalassemia Patients in Al-Najaf Province Mohammed Abdulrazzaq Assi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present study deals with the prominent inherited disease that is thalassemia. Β-thalassemia is an extreme hereditary blood disorder resulted after a change in the gene encoding for the hemoglobin β chains. Hemoglobin is made up of a genetic defect in the synthesis of a globin chain, or more, which results in a reduced rate of these chains. The creation of atypical hemoglobin molecules is a result of the reduction in the synthesis of one chain of the globin, and thus, leads to the most specific symptom of the thalassemia; anemia. This study was conducted with 40 subjects, whose age ranges from 4-20 years, divided among (males 30 and females10), who has visited the Thalassemia Center at Al-Zahraa Teaching Hospital in Najaf province, Iraq, for managing the disease, and 40 voluntary healthy as a control group. The study has been done between September and February 2019. This study was performed to evaluate the levels of serum of Vitamin D3 and L-Fucose in major and intermediate beta-thalassemia patients. It also estimates protein-bound fucose (PBF), hemoglobin (Hb), hematocrit (HCT), liver function tests, calcium, TIBC and Ferritin. The results showed a significant increase in the levels of alpha -L- fucose and protein-bound fucose in thalassemia patients as compared with control. The results showed a very important reduction (P<0.001) in Vitamin D3,Hb, HCT, TIBC and calcium in thalassemia patients in both males and females in comparison with the healthy control, except ferritin, AST,and ALT which is increased significantly(p<0.001) in those patients in comparison with control. Keywords: Thalassemia, Vitamin D, L-Fucose.
Thickness Effect on Some Physical Properties of the Ag Thin Films Prepared by Thermal Evaporation Technique Mohammed Ahmed Mohammed
Journal of Global Pharma Technology .
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Silver (Ag) "thin films were successfully deposited by thermal evaporation using Edward’s Auto 306 Magnetron Sputtering System"(homemade). Theirstructural, optical and electrical properties were investigatedby using XRD, AFM, SEM, UV-Vis, electrical conductivity and the Hall effect, respectively. The average grain size increased from 20.03nm to 51.86 nm with increasing thin film thickness. The deposited Ag thin films had an absorbance ranging between 0.21-0.1, the values of energy gap were obtained in the range of 3.2-2.0 eV.Keywords Thermal evaporation, Thickness of thin film, Ag films, Hall effect, X-ray diffraction.
Various Factors Affected the Production of Pickled Chinese Jiaotou (Allium Chinense) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Chinese jiaotou is fresh during the harvesting season but perishable under the prevailing conditions of temperature and humidity as well as lack of adequate storage facilities. An alternative approach of preserving surplus Chinese jiaotou could be fermented to pickle products. Preservation of the Chinese jiaotou by lactic fermentation can eliminate the undesired taste and improve flavor of the vegetable. Therefore we explored a lactic fermentation from Chinese jiaotou by focusing on the effect of different parameters such as salt soaking concentration, sun drying time and CaCl2 soaking as pre-treatment; sugar concentration and fermentation time to physicochemical, microbial and sensory characteristics of pickled Chinese jiaotou. Experimental results revealed that 15% salt is soaking, sun drying in 6 hours, 0.4% CaCl2 soaking as pre-treatment for raw Chinese jiaotou; then 6% sugar in 21 days of fermentation was appropropriated to get a pleasant pickled Chinese jiaotou quality. Chinese jiaotou pickles are considered as one of the health supplements.Keywords: Chinese jiaotou, Pickle, Lactic fermentation, Soaking, Drying, Sugar, Salt.

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