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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Assessment of Patients with Coronary Artery Diseases Need to Discharge Plan regarding to Living and Home Arrangement at Babylon Teaching Hospitals Kareem Waheed Mohamed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Coronary artery disease is one of the most serious diseases affecting human health, leading to more disability, economic cost and death (Hussein. 2014). Implementing the discharge plan from the health personals in the hospital correctly is to reduce the patient's long stay in the hospital also to improve the coordination of services after the discharge to home and reduce the frequency of admission to the hospital (Shepperd, ET .al. 2013). Objective: To assess the needs of patients with coronary artery disease for discharge plan related to living arrangement and home activities. Method and Results: Descriptive- cross sectional design selected to carry out this study, two Babylon Teaching Hospitals used to collect the study from the period between 1 Sep. 2016 to 1 Sep. 2017.Non- probability purposive sample of (100) patients who admitted to the Coronary Care units or medical ward were selected to participated in the study. Special questionnaire prepared after comprehensive literature review, face-to-face interview used as a method to collect the data. The statistical results shows that the majority (65%) of the study sample were male, (64%)were 60 or above 60 years old, (41%) were illiterate, most of the sample (34%) were retired, related to the living arrangement and home activities they recorded poor responses regarding most items. Conclusion: Significant need poor related to home and living arrangement discharge plan for patients with coronary artery disease. Which need health team intervention? Poor responses recorded by the patients with coronary artery disease, significant need to structured discharge plan related to living arrangement and home activities clearly appears. Significant need, poor responses recorded by the patient with coronary artery disease related living and home arrangement. Recommendation: Special discharge plan may take place to cover the patients need and increase their knowledge related to the home activities and living arrangement, which enhance life style and reduce expected complication.Keywords: Discharge plan, Coronary artery disease, Living and home arrangement.
Regression on cause-specific hazard in Competing Risks for Survival analysis sujatha vishnumoorthy
Journal of Global Pharma Technology .
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Abstract

In the study of  survival analysis, Kaplan–Meier (KM) estimates of survival curves and Cox proportional hazard models were widely used to describe survival trends and identify significant prognostic factors. All these statistical analyses deal with only one type of event like death, independently of its cause. Most part of the analysis are all  based on the hazards. In a competing risks setting, There are two types of hazard namely, the cause-specific hazard and the sub distribution hazard. The cause-specific hazard is the instantaneous risk of progression to a specific type of event, conditionally on being at risk for experiencing that event, generally hazards are not the probabilities, they are the rates., and used to quantify the probability of the crude risk or cause-specific cumulative incidence to progress to a specific cause by time t, When estimating the cause-specific hazard, the individuals experienced a competing event leaving behind the risk set. The cause-specific regression model was applied on to the real data sets and  try to shed light on causal mechanisms and prediction at the population level.
Synthesis and Characterization of Silica-Thioamide Hybrid Compounds Derived from Rice Husk Ash with Expected Biological and Catalytic Activity Hayder Hamied Mihsen
Journal of Global Pharma Technology .
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Abstract

The thiosemicarbazide (TSC) and thionicotinamide (TNA) were immobilized onto silica extracted from RH (rice husk) using 3-chloropropyltriethoxysilane (CPTES) forming solid organic-inorganic hybrid compounds labeled as RHACTSC and RHACTNA, respectively. The   BET data of the new compounds reported that the surface area for RHACTSC and RHACTNA to be 240 m2g-1 and 153 m2g-1 with an average pore diameter of 4.63 nm and 5.25 nm, respectively. The analysis of CHNS and FT-IR spectra revealed that the thiosemicarbazide and thionicotinamide have successfully incorporated on RHACI. The amorphous nature of RHACTSC and RHATN was investigated using X-ray diffraction technique, while the scanning electron microscope (SEM) technique showed that the surface was smooth with white rocky shape particles. Thermogravimetric analysis (TGA) of RHACTSC and RHACTNA indicate that the disappearance of  physical adsorb water between 25- 217 °C, while at 588°C the residual parts of materials were decomposed.Keywords   Rice husk ash; thiosemicarbazide ; thionicotinamide; organic-inorganic hybrid ; surface area.
Preformulation Parameters Characterization towards Design, Development and Formulation of Etodolac Loaded Nanoparticles Saminathan C
Journal of Global Pharma Technology Volume 13 Issue 01 (2021) Jan. 2021
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Abstract

The purpose of the present study was to systematically investigate some of the important physicochemical properties of Etodolac loaded nanoparticles. Etodolac is a non-steroidal anti-inflammatory drug, is used to manage rheumatoid arthritis associated symptoms. Almost all drugs are marketed as tablets, capsules or both. Prior to the development of these major dosage forms, it is essential that pertain fundamental physical and chemical properties of the drug molecule and other divided properties of the drug powder are determined. This information decides many of the subsequent events and approaches in formation development. A modified release nanoparticle of Etodolac was prepared by solvent evaporation method using EUTRAGIT RS 100 as coating material. Hence along with selection of excipients, the preformulation study of drug Etodolac is completed for successful formulation of modified release nanoparticles. Preformulation studies included solubility, pKa, dissolution, melting point, assay development, stability in Solution, stability in solid state; microscopy, bulk density, flow properties, excipients compatibility, entrapment efficiency and release profile of nanoparticles were investigated. The experimental values and results of this study will be presented. Keywords: Nanoparticles, Entrapment efficiency, Etodolac, EUTRAGIT RS 100, Preformulation.
Sustainable Exploitation from Aquifer of Shahrekord Plain Using the Various Scenarios Rahim Alimohammadi Nafchi
Journal of Global Pharma Technology .
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Abstract

Human's insufficient information of its role that naturally played for the water cycle in nature (hydrologic cycle) and the set of these treats and performances are as main factors to divulge source of economic, environmental and social challenges at the different communities. Lack of appropriate use and comprehensive management of water resources in the catchments were caused that was made imbalance at the water balance in catchments and aquifers. In this regard, for implementing the integrated water resources management in the Jahanb in catchment and to avoid the negative performance and balance of Shahrekord plain, to protect and continuing of aquifer life and sustainable exploitation from it, this project was implemented at the Jahanbin catchment for two years. To analyze the situation of water resources in the future by predicting five scenarios from the method of water balance equation and using software Modflow, behavior and reaction of Shahrekord plain aquifer were used. The results indicate that the water balance of aquifer is always negative. Negative performance and reaction of aquifers has caused to be having a subsidence from 1976-1977to2013-2014that is 14.9 m. According to the conditions of 2013-2014, the results show that a subsidence in groundwater level will be in the short term (5-year in 2018) and the medium term (12-year in 2025) 17.8 and 43.4 m, respectively and the most of area tube wells will be dryin long-term (20-year in 2033). It should be noted that if a specific program was not carried out to manage water resources, it caused that catchment subsidence and finished the stored water of aquifer off.To prevent events as the subsidence, drying up wells, and unemployment of people and prevent the migration of residents, it needs to adhere to optimize water use and integrated water resources management in catchment by executive ruling and precise and intelligent control of water extractions in the Jahanbin catchment.Keywords: Jahanbin catchment and Shahrekord plain, Various scenarios, Sustainable and integrated water resources management, Water balance. 
Cosmeticology: Disorders and its Advanced Treatment Gita Chaurasia
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
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Abstract

COSMETICOLOGY: DISORDERS AND ITS ADVANCED TREAT-MENT
The Dominance of the ACE Gene Shapes According to Anaerobic Threshold for Players in Handball Donnie Sabah Ali
Journal of Global Pharma Technology .
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Abstract

The current study aimed at identifying the shape s of the ACE gene and the laconic threshold. The researchers used descriptive research in a survey method to identify the majority of players who had a delay in reaching the genetic threshold according to the gene, as were identified shape s of dominant gene in the research sample which (DD, ID, II) has been the research sample and selected determine purposively they handball players for the team Muthanna province's 12 players have been divided according to shape s to (DD) and the number (5 ) players and (II) and the number (4) players, and finally (ID) and the number (3) players have been conducting a blood test for the withdrawal of a sample corresponding to the date on Monday, a brief summary (14 \ 2 \ 2018). The gene was detected in the sample, after which the gene shape s were detected to identify the differences between the groups through any group that was delayed to reach fatigue and the group with the genetic makeup (DD) was the most delayed to reach the anaerobic threshold where researchers attribute the genetic makeup (DD) is what distinguishes this group from others.Keywords: ACE gene and anaerobic threshold.
Influence of Erythropoietin and Platelet-Rich Plasma on Cyclophosphamide-Induced Hepatotoxicity in Male Albino Rats Ahmed Hafidh
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present study was conducted to investigate the protective effects of erythropoietin (EPO) and platelet-rich plasma (PRP) against cyclophosphamide (CP)-induced hepatotoxicity. Thirty six male albino rats were divided into six equal groups. The first group (control).The 2nd group was injected with a single dose of EPO (3000 IU/Kg, i.p.). The 3rd group was injected with PRP extract (150 µl/Rat, s.c.) on days (0,5 and 10). The 4th group was injected with a single dose of CP (150 mg/Kg, i.p.). The 5th group was injected with (EPO+CP) and the 6th group was injected with (PRP+CP). At the end of the experiment (day 15) sera were collected for assessment of liver function enzymes (AST, ALT and ALP) and protein levels (total protein, albumin and globulin). The CP-induced hepatotoxicity was evidenced by increased serum AST, ALT, and ALP accompanied by reduction in the levels of total protein, albumin and globulin in the serum. Administration of EPO or PRP significantly reduced the liver toxicity. The results revealed that EPO and PRP have ameliorative effect against CP-induced hepatotoxicity in male albino rats. Keywords:  Cyclophosphamide, Erythropoietin, Platelet-Rich Plasma, Hepatotoxicity
Expression of Endoglin in Bladder Carcinoma of Iraqi Patients Rawaa Al-Chalabi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Angiogenesis is an important process for tumor growth in almost all malignancies. Endoglin (CD105) is a membrane glycoprotein, part of the TGF beta receptor complex, which strongly expressed on the surfaces of cancerous cells. It has a vital role in angiogenesis, tumor growth, survival and metastasis of cancer cells to other locations in the body. Methods: This study designed to evaluate the role of endoglin immune expression in the development of bladder carcinoma by using monoclonal antibody, 137 biopsies of bladder carcinoma were collected from patients and 42 normal bladder tissues were collected from forensic autopsy. Results: 118 (86.13%) out of 137 tumors and 27 (64.26%) of normal tissues gave positivity with different scores while other biopsies expressed negative staining pattern. Score +3 showed the highest frequency among the tumor tissues while normal bladder tissues expressed score+1 as the highest one. Conclusion: endoglin is a marker of angiogenesis closely associated with malignant potential and bladder carcinoma development.Keywords: Endoglin, Angiogenesis, Urinary bladder Carcinoma (UBC)
Comparison of Proventriculus and Ventriculus Histology in Gallus Gallous Domestic us According to Food Composition Fatemeh Soltani S arvestani
Journal of Global Pharma Technology .
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Abstract

The most important part of alimentary tract in digestion is proventriculus and ventriculus in poultry. Histology of these organs increasingly is affected by food composition. This study was carried out to investigate Histology of proventriculus and ventriculus with two different food compositions. One group was fed with natural food such as chopped vegetables and fruit and the other group fed with artificial food diet was provided from commercial company, for 8 weeks. Sections of proventriculus and ventriculus was provided and stained with hematoxilin and eosin routine method, histometric studies showed, there was significant increase in thickness of mucosa layer and number of adenomers in sub mucosa layer in proventriculus in group with natural food composition in compare to the other group. Moreover Thickness of mucosa layer and number of secretional crypts in sub mucosa layer and diameter of muscular layers in ventriculus showed remarkable increase in compare to the group with artificial food composition.Keywords: histology, Poultry, Diet

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