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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Path Analysis of the Influence of Nurses Role on Family Caregiver Diabetes Self-Management Capabilities with Empowerment as Intervening Variables in Indonesia Rondhianto Rondhianto
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction:  Nurses have a responsibility to empower the family that is a preventive promotion effort to improve the ability of the family caregiver to manage diabetes. The purpose of this study was to analyze the role of nurses on the ability of family caregivers through family caregiver empowerment. Methods: This study was an analytic observational study with a cross-sectional design. This study was conducted in the Jember Regency, East Java Province of Indonesia, with a sample size of 150 respondents using a multi-stage random sampling technique. The instrument were namely the Role of the Nurse Perception Questionnaire, Psychological Empowerment Scale, and Diabetes Management Self Efficacy Scale. The data analysis used descriptive analysis and inferential analysis with Structural Equation Modeling-Partial Least Square (SEM-PLS). Results: The results showed that nurse's role had a direct effect on family caregiver empowerment by 93.80% (t = 89.558; p = 0.000 <0.005), but did not have a direct effect on the diabetes self-management capabilities (t = 0.508; p = 0,600> 0,005). However, nurse's role has an indirect effect on the diabetes self-management capabilities through family caregiver empowerment of 64.50% (t = 4.036; p = 0,000 <0.005). This path analysis model is fit model and  has an accurate predictive relevance to the existing constructor has a relevant ability to predict (SRMR Value = 0.053 <0.8; Q2=0.331 >0). Conclusion: The nurse's role has a direct influence on family caregiver empowerment and has an indirect effect on the diabetes self-management capabilities through family caregiver empowerment. The efforts to empower family caregivers by nurses through enabling, reinforcing, and supporting as a preventive-promotion intervention need to be improved to enhance the ability of family caregivers in type 2 diabetes management.Keywords: Diabetes Self-Management Capabilities; Family Caregiver Empowerment; Nurse's Role; Type 2 diabetes.
Estimation Level of IL-12 in Blood of Patients with Tuberculosis Eklass N. Ali
Journal of Global Pharma Technology .
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Abstract

Background: Tuberculosis (TB) is caused by mycobacterium tuberculosis; which is considered as one of the most common infectious diseases and major cause of morbidity and mortality worldwide. Methodology: The study included 45 patients with TB (38 males and 7 females) with age range between (10-69) years, and 16 apparently healthy subjects (as control) (14males and 2 females) who have been collected from the Specialized Center for Chest and Respiratory Disease in Baghdad. Specimens from TB patients were divided into three subgroups: 21 specimens from new diagnosis, 13 specimens from old patients (under treatment) and 11 specimens from Multi Drug Resistance (MDR). This study included bacteriological tests such as smear microscopy by ziehl-Neelsen stain for sputum samples and immunological diagnosis by estimation the concentration of cytokine (IL-12) and control by Enzyme Linked Immune sorbent Assay ELISA technique has been applied for patients and healthy groups (control), all TB patients sample were positive by smear microscopy. Results: This study showed a significant increase in the serum level rate of IL-12 in the patients (82.1)pg/ml comparing with the control group (48.9) pg/ml whereas The serum level of IL-12 in new cases & MDR TB was elevated than in old cases (p<0.05) and the concentration  of IL-12 was significantly increased  among  young age (10-19) compared to other age group and was non-significant increased among females. The prevalence of fever, positive chest-X-ray finding, weight loss were    more among the newly diagnosed patients (p<0.05) while the prevalence of positive DM patients was more among old cases (p<0.05). This study verified the correlation between the serum levels of IL-12 with different clinical forms of tuberculosis. It was reduced in patients with positive DM (71.8) pg/ml in comparison with patients with Negative DM (95.89) pg / ml with statistically significant differences between two groups (p<0.05). Conclusion: the high  serum level of IL-12 in TB patients indicate an important role of these cytokine in the pathogenesis of tuberculosis, so they could be considered as good biomarker for diagnosis and considered as a target for future therapy. Keywords: TB, MDR, IL-12, chest-X-ray.
Synthesis and Characterization of Some New Benzothiazine, Dihydroquinazolinone and Oxazepine Derivatives from 1, 8-Naphthalic Anhydride and Evaluation of Their Antimicrobial Activity Mohammed G. A Al-Khuzaie
Journal of Global Pharma Technology .
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Abstract

New benzothiazine, hydroquinazolinone, and oxazepine derivatives had been synthesized from the reaction of 1, 8-naphthalic anhydride with p-phenylenediamine to give 1,8-naphthalimide derivative (1), which in turn react with a number of aromatic aldehydes to give Schiff  bases derivatives (2-7) that reacted with three different reagents (2-mercaptobenzoic acid, anthranilic acid and phthalic anhydride) respectively to form benzothiazine (8-13), dihydroquinazolinone (14-19) and oxazepine (20-25) derivatives, respectively. The structures of synthesized derivatives were characterized by [13C-NMR, 1H-NMR, and FTIR] and measuring of characteristic physical properties and specific reactions. Moreover, the biological effect of some of preparing compounds was tested on fungicidal and some of bacteria.Keywords: 1, 8-naphthalic anhydride, benzothiazine, hydroquinazolinone, oxazepine, anti-microbial activity.
Radiation and Hygiene Assessment of the Consequences of Nuclear Tests at the Semipalatinsk Test Site Nikolay Meshkov
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The analysis of the spatial and intra-profile distribution of cesium-137 (137Cs) reserves in the soils of the Altai Mountains, as well as the dynamics of the specific activity of this radionuclide in food products produced in the territory of the Republic of Altai and the Altai territory, in 1966-1985, was performed. Individual annual effective doses of internal radiation of the adult population of the Republic of Altai and the Altai territory due to the receipt of 137Cs with food were calculated and a forecast of long-term radiological consequences for the population of the Republic of Altai was made. Keywords: Radioactivity; Radio nuclides; Cesium-137; Semipalatinsk.
Nurses Knowledge toward Heparin Intake for Patient’s in Intensive Care Unit at AL- Imam AL-Hussain Medical City in Holy Kerbala Fatma Makee Mahmood
Journal of Global Pharma Technology .
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Abstract

Heparin is used to prevent or treat certain blood vessel, heart, and lung conditions. It is used in low doses to prevent the formation of blood clots in certain patients, especially those who must have certain types of surgery or who must remain in bed for a long time. Objective This Study aims to assess nurses’ knowledge toward Heparin Intake for Patient’s in Respiratory care and to find out the association of Respiratory care unit s nurses knowledge with some of socio demographical characteristic (level of education, and years of experience in Respiratory care unit (.Methodology A descriptive study was carried out at respiratory care unit of Baghdad teaching hospitals started from December 25th, 2015 through   through end of May, 2016. Non-probability (purposive sample) of (30) nurses, who were working in respiratory care unit, were selected from AL- Imam AL-Hussain Medical City. The data were collected through the use of constructed questionnaire, which consist of two parts (1) Demographic data form that consist 6-items and (2) Nurses’ knowledge form that consist of 27 items, by means of direct interview technique of the nurses. Reliability of the questionnaire was determined through a pilot study and the validity through a panel of (15) experts. Descriptive statistical analysis procedures (frequency, percentage, mean of score) and (person correlation coefficient, contingency coefficient) were used for the data analysis.  Were used for the data analysis. Results The findings of the study indicated that there was an adequate knowledge about heparin intake in respiratory care unit. A significant relationship was found between nurses’ knowledge and their level of education and years of experience in respiratory care unit .Recommendations The study recommended that the importance of employing Academic nurse in respiratory care unit, a booklet should be designated and distributed to all nurses who were working in respiratory care unit including the standard actions that should be applied and followed to care for patients in respiratory care unit, and an educational program should be designated to the nurses who were working in respiratory care unit including the standard actions that should be applied to care for patients in respiratory care unit Keywords: Anticoagulant, Heparin, Respiratory care unit Critical Care Nurses.
Urease Activity Level in Crude Extract From Peels of Some Legumes and Cucurbits Zainab M. Dahham
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Ureases are an important group of enzymes with various applications in the analysis of food and water, chemicals, clinical, agricultural and pharmaceutical industry, besides having great interest for the treatment the industrial waste. The main objective of the present project is to extract urease enzyme from economical sources which can be utilized in biotechnology, medicine and industrial fields, as well as clean the environment from the plant wastes and recycle it. In this study urease was extracted from peels of some legumes and cucurbits: (bean, pea, water melon and melon), as well as bean seeds were also used as a known main source of urease for comparison. The enzyme was extracted from peels by electrical blender homogenization with phosphate buffer (0.2 M, pH 7), then protein concentration, urease activity, pH stability, thermal stability and storage stability were determined in crude extract. Urease activity and specific activity extracted from pea peels was the highest among the other extracted wastes, which showed stability at neutral pH 7 at room temperature, also it was very stable when incubated at (40-50 °C) for 20 min, and during storage at -18 °C at pH 7 for 3 months indicating that this enzyme was very stable. No significant differences were found between urease activity using pea peels with that measured by standard kit for the blood urea determination in serum of normal and patients. So, pea peels considered as an important economic source of urease enzyme.Keywords: Urease activity, Pea peels, PH stability, Thermal stability.
Antimicrobial Activity of Olive Leaf Extract and Dental Gel against Some Pathogenic Fungi and Bacteria Ghadeer H. Al-Jader
Journal of Global Pharma Technology .
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Abstract

The results of chemical  detesters for some active substances in Olive leaf extract  Revealed that contains Glycosides, Flavones, Saponine, Alkaloids and Turbines The statistical analysis of the results showed of the inhibitory effect of olive leaf extract on the growth of some pathogenic fungi, there are significant differences below the level of probability (P<0.05) between the inhibitory effectiveness of olive leaf extract of the studied  species, compared with the standard antifungal (Itraconazole) used as control in the present study, table  (2). The  alcoholic extract of the olive leaf plant gave higher inhibition  impact compared with the inhibitory effect of Itraconazole at the concentration 100% (Figure 1), the inhibitory effect of the extract at concentration of 100 % was (32, 35, 33, 36, 31, 35) mm to species (T. mentagrophytes, T. verrucosum, M. gypseum, M. audouinii, T. schoenleinii, M. canis) respectively, while was the inhibitory effect of Itraconazole  (30, 31, 30, 34, 30, 30) mm respectively.Keywords: Denta gel, Olive leaves extravt, Antimicrobial Activity, Pathogenic bacteria. 
Synthesis, Characterization and Biological Effect Study of Some New Azo and Azo–Chalcone Compounds Derived from 2, 6-Diaminopyridine Nihad I. Taha
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The objective of this work was to prepare azo and azo-chalcones derivatives out of 2, 6- diaminopyridine (2, 6-DAP) which has extensive use in the synthesis of pharmaceutical compounds. The azo-diamine (S1-S6) was prepared from the coupling reaction of diazonium salt prepared from various substituted aromatic amines with 2, 6-diaminopyridine. The product (S1) was reacted in basic condition with one equivalent of different substituted aromatic aldehydes in methanol to give ten new azo-chalcones (S2-S11) in good yields. The final products were identified by their physical properties besides their UV-visible, FTIR and 1H NMR spectra. Biological activity of the compounds (S1-S6) was investigated and compounds (S1 and S2) showed high activity against B. subtilis and E. coli.Keywords: Azo- Chalcone, 2, 6-Diaminopyridine, diazonium salt, Pyridine.
Potency of Phitofert in Improvement of Reproductive Efficacy in Sulpiride-Treated Rats Nahla J. M. S. Al-Shahery
Journal of Global Pharma Technology .
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The current study was designed to investigate the persisting of hyperprolactinaemic (Hprl) symptoms because the impact longstanding of sulpiride injection (the 2nd model of Hprl), to prove these symptoms when they compared with these in 1st model of Hprl. Also we investigated whether Hprl had ablility to induce altering in the activity of ovarian hydroxy steroid dehydrogenase (HSD) enzymes and oxidative status in the ovarian tissue. The goal of this study was to evaluate the potentiality of phitofert product in adjustment of Hprl status for each 2nd model of Hprl. Therefore, female rats were divided as follows: G1: female rats were injected with normal saline (0.9% NaCl) for 28 successive days (control1). G2: female rats were injected with 40 mg/kg b.w. of sulpiride for 28 successive days (as a first model). G3: female rats were injected with normal saline (0.9% NaCl) for 28 successive days, and they were orally administrated with d.w. for another 28 successive days (control2). G4: female rats were injected with 40 mg/kg b.w. of sulpiride for 28 successive days, and they were orally administrated for another 28 successive days with d.w. (as a second model). G5: female rats were injected with 40 mg/kg b.w. of sulpiride for 28 successive days, and they were orally administrated with 7 mg/kg b.w. of phitofert for another 28 successive days. The hyperprolactinaemia signs primarily a significant (P≤ 0.05) elevation in the serum prolactin (Prl) and progesterone (P) levels were found, while the serum FHS, LH and estrgen levels were found to be significantly (P≤ 0.05, P≤ 0.001) decreased in G2 and G4 than controls (G1and G3). The hyperprolactinaemic rats (G2 and G4) also, showed a significant (P≤ 0.05) decreased in the activity of an ovarian 20α-HSD enzyme, compared to G1 and G3. The oxidative stress (OS) as evidenced by significantly (P≤ 0.05) increased in the activity of lipid peroxidation (MDA) and decreased in the ovarian activity of GSH and CAT levels were found in these groups.  Also the estrus cycles and ovulation process were ceased in hyperprolactinemic groups (G2 and G4). Whereas the results of G5 showed that, the phitofert had a positive role in the reverse of all above assessed parameters in sulpiride-induced hyperprolactinemia groups. The phitofert treatment resulted regular estrus cycle and the restoration of ovulation, ditto the ovulated oocytes were able to fertilize in vitro. These fertilized oocytes of G5 were succeeded in the development in vitro to blastocyst stages. So the transferred blastocysts into recipient females were able to implantation compared to those in control (G3). Thus, our findings proved the ability of phitofert product in therapy of HPRL.
Use of Integrative Medicine Approaches for Treating Adults with Sleep Disturbances Raad Issa Taqi Al-Shammaa
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: This learning recognized the occurrence then effectiveness of perceived, influencing elements or assessment about data sources as much well as like boundaries then facilitators for the usage regarding IMA between the past 12 months in accordance with treat adults together with sleep disorders. Background: There are no researches evaluating the use concerning complementary remedy strategies among adults together with couch disorders. Method: Perform a sectional scan. Adults along intentional lie issues had been elected beside a lie center in a sanatorium into Taiwan. Binary logistic regression used to be back after analyze yet examine variations into use corporations then non-use of. Results: The response rate was 94.5% (n = 515). The occurrence over the uses of complementary medication techniques was 53.4% (n = 275). The almost frequent IMA is music. However, the near fine integrative medicine techniques were acupressure, accompanied via tune and meditation. Independent explanatory variables had been academic attainment, quantity regarding persistent diseases / symptoms, or wholesome lifestyles because IMA use. The near common source concerning statistics is television / radio. Was the top facilitator and obstruction in imitation of the uses on complementary medicinal drug techniques beyond the facet results of slumbering drugs yet confined access? Conclusions: IMA is ancient through a big share over adults in conformity with deal with lie problems between Taiwan. The results concerning that lesson recognized important explanatory variables because of IMA utilizes and furnished a primary perception regarding the elements over IMA utilizes into adults along couch problems so much are of precise value to health ponderabil vendors among the work related with their patients.

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