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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis and Antibacterial Activities of New β-Lactam and Imidazole Derivatives Hind J. Shawkat
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

New β-lactam, imidazole, oxazole and amide derivatives were synthesized with good yields using simple methodology. Thiosemicarbazide derivatives 2(a-f) were treatment with ethyl chloro acetate to give compounds 1-((arylidene) amino) 2-thioxoimidazolidin-4-one 3(a-f), then3 (a-f) were converted to oxazole derivatives have β-lactam moiety by reaction with chloro acetyl chloride. Amide derivatives were synthesized by convertion 3(a-f) with acid chloride (acetyl chloride and benzoyl chloride).Structural of all derivatives have been confirmed with IR, H1 NMR and some of them with mass spectroscopy .These derivatives were tested for invetro antibacterial against Staphylococcus aureus, Pseudomonasaeruginosa Kelebsiella pneumonia and Escherichia Coli.Large number of compounds showed high inhibition zone (mm) against different bacterial species.Keywords: Imidazole, Oxazole,β-lactam, Amide, Antibacterial activity.
Genotyping of Helicobacter Pylori Isolated From Iraqi Patient with Upper Gastrointestinal Disease Aseel H. Al-Sabary
Journal of Global Pharma Technology .
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Abstract

H. pyloriis one of the most frequent pathogen infected about half of the world population, despite that most infections are asymptomatic; some infections can develop chronic gastritis, peptic ulcer and gastric cancer. The aims of the study are the molecular detection of H. pylori and the main virulence factors association with clinical outcome of H. pylori infection. This study was start from February to September 2016, ninety two cases of H. pylori infections were detect in patients admitted to Medical Marjan City in Babylon -Iraq. The study display the high frequencies of H. pylori were observed for chronic gastritis, which h constituted 88% while low frequencies were 3.3% for gastric cancer whereas 8.7% for duodenal ulcer. Moreover, identification of H. pylori by PCR technique was performed on all gastric biopsy and ure C as well as ure genes were used as markers for confirmatory diagnosis of H. pylori through using specific primers of PCR technique. The result showed that, 84.8% and 73.9% of H. pylori were positive respectively for both genes. In additions, cag A gene was investigated in all H. pylori isolates. The result showed that65 (70.6%) was positive for PCR amplification of cag A gene whereas 56 (60.8%) was positive for PCR amplification of cag E gene. The frequency of the vac a gene found in the present study was 68.5% (63/92).It was concluded that the molecular detection of H. pylori genotype is important tool to determine pathogen city of H. pylori.Keywords: Helicobacter pylori, Gastric biopsy, Gastric diseases, Ure A gene, Ure C gene, Virulence genes. 
Giant Cell Tumor of the Right Distal Radius Campanacci Iii Treated with Wide Excision and Space Filler Using Prefabricated Polymethyl Methacrylate (Pmma) Bone Cement: A Case Report Magetsari R
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

ABSTRACT Background: Giant cell tumor of bone (GCT) is the most common benign aggressive primary bone tumor (metastatic rate less than 5% of cases). The hallmark appearance of GCT is an expansile lesion which is centrally radiolucent with formation of a thin neocortex at the border of the lesion (epiphysis and metaphysis). Campanacci grade is the classification system for giant cell tumors. Grade I tumors are confined within the cortex, grade II expand to cortex, and grade III perforating cortex with higher incidence of recurrence and transformation into malignancy. Functional outcome of the wrist joint was evaluated using Mayo wrist score (pain intensity, functional status, range of movement, and grip strength).Case Report: A 39 years old male presented lump in his right wrist joint since 6 months ago. The patient complained of decreasing range of motions and palpable mass that increase progressively over time. Slight pain was also felt around the wrist joint. He sought traditional (masseuse) therapy for the last 6 months, but the complaint persisted. He then underwent operation (tumor excision and augmented graft) in our institution. The graft was made from PMMA bone cement and designed identically similar to distal part of the patient’s radius. Histopathologic analysis was consistent with Giant cell tumor. We evaluated patient’s functional outcome using Mayo wrist score, with satisfactory result.Discussion : Most common method of replacing distal part of radius after excision of GCT was grafting using proximal fibula or ceramic prosthesis. There has never been a published clinical trial of using PMMA as a space filler. Nonetheless we used prefabricated PMMA bone cement based graft to mimic the bone in order to prevent the risk of recurrence and to achieve good functional outcome. We took the measurement of the patient’s left radius using X-ray as a model, then fabricate the PMMA bone cement in the Anatomy laboratory according to the model’s measurement. Although it’s not a popular method, but after 6 months of follow up satisfactory functional outcome was achieved (Mayo wrist score) and without sign of recurrence or metastatic.Conclusion: After excision of the GCT, prefabricated PMMA bone cement could be considered as one alternative of space-filling material to achieve good functional outcome.Keywords : Giant cell tumor, Radius, Excision, Bone Cement, Polymethyl Methacrylate, Graft
An Integrated Approach to the Treatment of Severe Psoriasis: A Clinical Case Lyudmila Smirnova
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Psoriasis is a disease of autoimmune origin, affecting not only the skin, but also the internal organs of a person. Currently, many methods of treating psoriasis are in use, which vary in effectiveness. The aim of this work is to analyze the results of complex physiotherapeutic and pharmacological treatment of a patient with severe psoriasis in comparison with the initial failed treatment with traditional pharmacological methods. The therapy was carried out in 2018-2019 (observation by a rheumatologist at the place of residence), after treatment that was unsuccessfully carried out in 2016 at the Institute of Rheumatology (Federal State Budget Scientific Institution "Scientific Research Institute of Rheumatology named after VA Nasonova") with an incorrect diagnosis of rheumatoid arthritis. In the secondary complex therapy, the following treatment methods were used: a) antihistamines (Chloropyramine 1.0 IM in the evening for 22 days, Chloropyramine 1 tablet 2 times a day in the morning, 18 days for the day); b) Methotrexate 15 mg IM once a week; c) hepatoprotector (heptor 400 mg 1 tablet 1 time per day-22 days); d) Folic acid 0.1 mg 2t 2 pd -6 days; e) Desensitizing therapy (200 ml of 0.9% Sodium Chloride-20 days); f) Local therapy (Komfoderm; Salicyl-dermatol ointment-22 days); g) Physiotherapeutic methods. With complex treatment, the trunk skin showed rashes regression, up to residual hyperpigmentation. The rash regression was 50% in the form of a decrease in the brightness of erythema in the palms, a decrease in peeling and the number of papular elements. Similar processes occurred on the skin of the feet, but with the preservation of large-plate peeling. A detailed literature analysis of known methods of treatment of psoriasis, with a comparison of new and traditional methods was performed. In recent years, the treatment of psoriasis has become more focused on targeted biological drugs. New methods of treatment not only demonstrate optimistic results, but also lead to a deeper understanding of the immunopathogenetic pathways of psoriasis, identifying new potential targets for therapeutic intervention and diagnosis. Our comprehensive approach has allowed us to establish one of the ways to achieve effective treatment.Key words: Psoriasis, Pharmacology, Symmetry, Paradoxical reaction, Physiotherapy, Papules, Rashes, peeling of the skin.
Different Parameters Influencing to Extraction and Drying of Anthocyanin Powder from Magenta (Peristrophe Roxburghiana) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Leaves of magenta (Peristrophe roxburghiana) have a good source of anthocyanin. They have potential health benefits for human consumption. Objective of the present study to examine various aspects affecting to anthocyanin extraction including blanching, solvent, solvent: solid, extraction time and temperature under ultrasound, carrier and temperature for drying. Optimal results were clearly shown that the panda leaves should be blanched under 95oC in 10 seconds; extraction should be conducted by ethanol 90%, ethanol: solid (2.0:1.0), 60oC, 8 minutes; vaccum drying should be executed at 60oC with the support of carrier (0.5 maltodextrin: 0.5 gelatin: 1.0 magenta fluid). Ultrasonic had positive effect on anthocyanin extraction and this method could be utilized to optain the most anthocyanin powder.Keywords: Magenta, Anthocyanin, Ultrasonic, Blanching, Solvent, Extraction, Carrier, Drying.
Bioequivalence Study of Morphine Hydrochloride Oral Solution versus Immediate Release Tablets Geliya Gildeeva; Andrey Belostotsky; Ekaterina Ezhova; Vladimir Yurkov
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Objective: Comparative study of bioequivalence and safety of Morphine Hydrochloride 2 mg/ml oral solution (T) and Morphine Hydrochloride 10 mg immediate release film-coated tablets (R) after single dose administration (1 ampoule 5 ml, 2 mg/ml / 1 tablet 10 mg) by healthy subjects under fasting conditions. Methods: Open-label, single dose, 2-period crossover, randomized design study in 42 healthy subjects under fasting conditions. Test product: Morphine Hydrochloride 2 mg/ml oral solution (FSUE «Moscow Endocrine Plant», Russia) was compared with the reference product Morphine Hydrochloride 10 mg Immediate Release Tablets (FSUE «Moscow Endocrine Plant», Russia) under fasting conditions. The statistical method is testing for Cmax, AUC0-t and AUC0-∞. Bioequivalence study was based upon the 90% confidence interval (90% CI) for the test and reference geometric mean ratio. Bioequivalence was to be assumed if 90% CI fell within the recommended acceptance interval 80%; 125%.Results:Forty-two subjects completed the study. Both Morphine T and Morphine R exhibited peak plasma Morphine concentrations of ~13 ng/ml. 90% CIs of the ln-transformed values of Morphine AUC0-t and Cmax were within 80% to 125% range for bioequivalence. The most common adverse events were anemia and headache. These data show that, in these subjects, Morphine T was bioequivalent to Morphine R, a treatment for pain with well-established efficacy and safety profiles.
Description of Personal Factors, Information and Attitudes of Young Women in Early Marriage Dwi Purwanti
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Early marriages are marriages conducted by 18 year olds, who physically, physiologically and psychologically are not yet prepared to take on the responsibilities of marriage, if they are done it can disturb reproductive health. Adolescent problems are a very complex problem ranging from a large number to problems surrounding adolescent reproductive health. Methods: This research is a descriptive quantitative research. The population of this research is all female adolescent of 60 people. The sampling technique was simple random sampling, with a sample size of 30 adolescent female. The variables of this research are personal, information and attitudes. The data collection tool uses a questionnaire, to measure the personal dimension and the dimension of information. Data analysis using descriptive statistics in the form of frequency distribution and central tendency. Presentation of research data in the form of table and textual data. Results: The results of the research on personal factors in adolescent female were 23 (76.7%) women with good personalities, 30 (100%) women with good life values, 23 (76.7%) women with sufficient emotions, and 23 (76.7%) women with good intelligence as much as 21 (70%). Personal factors consisting of dimensions of personality, life values, emotions and intelligence in adolescent female, are 23 (76.7%) women with good personalities, 30 (100%) women with good life values, young women with good emotions. enough as much as 23 (76.7%) and the group of women with good intelligence as much as 21 (70%). The Attitude Toward The Behavioral (Attitude) factor of 28 (93.3%) young women with good beliefs about early marriage and 28 (93.3%) women who have good consequences. Discussion and Conclusion: Three factors in the survey to examine the background of early marriage in ramaja are the personal dimension, the information dimension and the attitude dimension. The description of the results of the three-factor study shows that the numbers need to be taken into account and need to be used as a basis for follow-up in reducing the rate of early marriage among adolescent female.The recommendations offered based on this research are necessary Health care providers should consider a multidimensional approach to supporting and empowering these vulnerable girls. Keywords: Early Marriage, Personal, Information, Attitude.
Study of Medical and Biological Properties of Zinc Lysinate-Riboflavinate Qasim Shakir Kadhim
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Biomedical houses about the Zinc-lysinitroboflavinate a new colloidal chelate structure over zinc address microelement are investigated within the case on the work. Intragastric ruler of a hundred mg/kg regarding zinc lysinate-riboflavinate in imitation of experimental animals does no longer cause signs regarding toxicological effects. Toxicological tests on zinc lysinate-riboflavinate have been conducted outdoors over the basis concerning the department about remedy and pharmacology regarding the Faculty regarding Veterinary Medicine on StSAU. The give phase arrangement about zinc lysinate-riboflavinate aqueous solutions was once investigated with the aid of the method over photon-correlation spectroscopy within the laboratories about the branch on technological know-how over Nanomaterials (NCFU, Engineering Institute).Keyword: Zinc-lysinitroboflavinate, biomedical properties, toxicological effects.
Dermatoglyphics and Type 2 Diabetes Mellitus: Review Falah S. Al-Fartusie
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Study of epidermal ridges on the skin covers the palmar and plantar surface of hands and soles, and is known as Dermatoglyphics (also known as fingerprints). Dermatoglyphics patterns are genetically determined and are affected by environmental factors in the uterus. After their formation, they remain stable, unchanged, and are not affected by postnatal environment or age. Dermatoglyphics can serve as a reliable marker of individual identification, as they can be a morphological trait, and a mirror to explain genetic and environmental factors in the first trimester of pregnancy. Diabetes is a chronic disease with serious complications if not managed well. In fact, 90% of diabetics are type 2 diabetes mellitus, multifactorial metabolic syndrome. T2DM will not be diagnosed until the long-term complications. Early diagnosis and treatment are very important to prevent long-term complications of the disease (such as retinopathy, neuropathy, nephropathy), and predicting people with high risk of T2DM can be useful in preventing disease and complications. In this review, we will discuss dermatoglyphics, and the main results of researchers who studied Dermatoglyphics for T2DM patients.Keywords: Dermatoglyphics, T2DM, Arch, Loop, Whorl, Ridge count.
The Physical Exercise Program during Post-Surgery Rehabilitation of Elderly Patients Diagnosed with Thrombophlebitis of the Lower Limbs in Jordanian Hospitals Mutasem Abdel Wahhab Khalaf Al-Soub
Journal of Global Pharma Technology .
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Abstract

Deep vein thrombosis (DVT) or thrombophlebitis is frequently found in human limb veins and it is is a manifestation of venous thromboembolism (VTE). Thrombosis is a process of intravital blood clot formation inside blood vessels. This may be lethal. The mortality rate associated with this disease is higher than that of many extremely dangerous disorders. In most countries, statistical figures provided by healthcare systems regarding thrombosis patients are high. Aim of the study is checking the physical exercise program efficiency designed for post-surgery rehabilitation of elderly patients diagnosed with lower-limb thrombophlebitis in Jordanian hospitals. Research methodology was based on theoretical analysis and scientific and methodical literature, pedagogical observation, medical and biological research methods, as well as on statistical methods. The studied group was formed by elderly patients diagnosed with lower-limb thrombophlebitis. They underwent surgery and were sent to restore with a one-year (2014-2015) rehabilitation program in the Physiotherapy Department of the AL-Karak State Hospital (Jordan). The patients were in the age of 55-60 years. Before doing exercises, patients have not been feeling pain or distress. The rehabilitation program was applied for 30 minutes three times per week. Each session was attended by four patients. Results were processed by means of mathematical statistics and by calculating significant differences with the Student’s t-test. We have substantiated the use of a physical exercise program designed for post-surgery rehabilitation of elderly patients with thrombophlebitis of the lower limbs. This paper provides a research on bodily exercise program efficiency during one-year rehabilitation period of elderly patients, who underwent surgical management of lower-limb thrombophlebitis. The program has improved a number of patient characteristics: body weight, blood pressure, heart rate, physical condition index, the adaptive capacity of cardiovascular system.Keywords: Diagnosis, Thrombophlebitis, Physical Rehabilitation, Exercise, Elderly Patients.

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