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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Comparison between Low Flow and High Flow Sevoflurane Isocapnic Technique to Achieve Early Recovery after Surgery (ERAS) Adinda Putra Pradhana
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective. The purpose of this study was to compare recovery time between low flow and high flow sevoflurane isocapnic anesthesia techniques, as well as the total consumption of sevoflurane.Design. This study was an observational single-blind randomized trialSetting. Operating room.Patients. Total 40 patients from both gender, 18 to 60 years old, BMI 18.5-29.99 kg/m2 with physical status ASA I or II, that scheduled for elective surgery under general anesthesia approximately between 3-5 hours were selected for this study.Intervention. Selected patients divided randomly into two groups (n=20 each). First group was given low flow sevoflurane, delivered with initial flow 6 L/min until MAC 0.9 or expiration level of sevoflurane 2.2 vol% then reduced flow to 0.5 L/min; second group with high flow technique  4L/min after induction.Measurement. The duration of operation, duration of anesthesia, time reaching of BIS 75, eye-opening with command, extubation, moving into the recovery room and when reaching Modified Aldrete score 10.Main Results: Based on statistics, sample characteristics, hemodynamic conditions, length of anesthesia and number of fentanyl were not significantly different. There was a significant difference on post anesthesia recovery time between low flow and high flow anesthesia time BIS 75: 1.7 (± 0.801) vs 7.05 (± 3.956), p<0.001, eye-opening time: 5.45 (± 3.82) vs. 14.86 (± 7.945 ), p<0.001, extubation time: 5.8 (± 2.783) vs. 15.29 (± 8.776), p<0.001, moving into recovery room: 15.35 (± 5.133) vs. 23.52 (± 12.213), p=0.021, time reaching modified aldrete 10: 8.95 (± 4.211) vs. 29 (± 18,091), p<0.001).Conclusion: Recovery time after general anesthesia using low flow sevoflurane isocapnic anesthesia technique is faster than the high flow anesthesia technique with less sevoflurane consumption.
The Ratio of Runx-2 and Osterix in Tension Area of Orthodontic Tooth Movements on Days 7 and 14 after Giving Mangostin I Ketut Sudiana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Orthodontic relapse is the return of the tooth to the first position after being treated with an orthodontic appliance. Bone density in tension area of orthodontic in new bone formation (apposition) is critical in orthodontic treatment to prevent relapse so that orthodontic treatment can be achieved optimally through runt-related transcription factor 2 (Runx-2) and Osterix evaluation. This study aims to determine the role of Runx-2 and Osterix ratio in the tension area of orthodontic tooth movement after Mangostin administration. Material and Methods: An experimental laboratory study was conducted among 30 male Wistar rats were divided into several groups. The K1 was a negative control group (K-) without treatment, K2 was a positive control group (K +) given orthodontic mechanical strength and observed for 7 days, and K3 was a positive control group, given orthodontic mechanical strength and was observed for 14 days. In addition, K4 was a treatment group (P) given orthodontic mechanical strength and were observed for 7 days, and K5 was the treatment group (P) given orthodontic mechanical strength and were observed for 14 days. Data were tabulated and analyzed using SPSS version 17 for Windows. Results: Mangostin administration is significantly increasing the expression of Runx-2 (8.3±0.4 ng/mL), Osterix (4.7 ± 1.8 ng/mL), and bone formation (1:3.23 vs. 1:1.23) in the tension area of the treatment group (P<0.05) after 14 days. The Osterix levels were also suggest a significantly higher among groups from K1 (0.2 ± 0.2 ng/mL), K2 (1.1 ± 0.2 ng/mL), K3 (1.4 ± 0.3 ng/mL), K4 (1.3 ± 0.6 ng/mL), and K5 (4.7 ± 1.8 ng/mL) (P<0.05). The ratio of Osterix (1:3.23) seemed to be higher in treatment groups, whereas Runk2 ratio was slightly lower compared with control groups (1:1.23).Conclusion: The administration of Mangostin can increase the expression of Runx-2 and Osterix in the area tension of orthodontic tooth movement on day 14.Keywords: Mangostin, Runx-2, Osterix, Tension area, Tooth movement.
Synthesis, Spectral and Antibacterial Studies of New 1-(4-Antipyrine azo)-2-hydroxy-3, 6-Disulphonic Acid Sodium Salt with Group IIB Metal ions Alyaa Khider Abba
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

A series of IIB group metal complexes have been synthesized from new azo ligand derived from 4-amino-antipyrine and 2-hydroxy-3, 6-disulphonic acid sodium salt. The structural features have been done on the basis of metal content C.H.N analysis, molar conductance measurement, FT-IR, UV-Vis and HNMR spectral studies. The natures of the prepared complexes were studied according to the Jobs method and Mole ratio method after fixing the optimum condition of pH and concentration. Beers low obeyed over a concentration range (1×10-4 -3×10-4) M .The stability constant of the complexes and Gibbs free energy have been conformed. The antibacterial studies were also studies.Keywords: azo dye, 4-aminoantipyrine, Spectral studies, Antibacterial studies.
Stunting Determinants Among Indonesian Children Aged 0-59 Month: Evidence From Indonesian Family Life Survey (IFLS) 2014/2015 Eka Mishbahatul Marah Has
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This study aimed to analyze the determinants of stunting among children aged 0-59 months old in Indonesia. A cross-sectional survey by using data from the Indonesian Family Life Survey period 2014/2015 (IFLS-5) was conducted, which focused on the household with children aged 0-59 months old (n=3623). Ordinal regression test showed that determinants of stunting among children aged 0-59 months old, consist of children aged <6 and 6-23 months old; male; low birth weight; underweight mother; normal height mother; poor household; and ever had antenatal care. Integrated intervention address children, mother, and health service factors associated with stunting is needed.Keywords: Children, Indonesian family life survey, Stunting.
Vitamin D Status and its Association with Homocysteine, Insulin and Insulin Resistance among Type II Diabetes Mellitus in Iraqi Patients Luay Qasim Abdulhameed
Journal of Global Pharma Technology .
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Abstract

The study aimed to assess vitamin D level and its impact on homocysteine, fasting blood glucose,Glycated hemoglobin, insulin and insulin resistance. The study conducted in Baqubah city, Diyala province, Iraq. Study period from September 2017 to June2018. Totally123samples, (78) samples of patients type II with mean age (54.75±1.11), and (45) samples with mean age (37.24±0.79) as control group. Vitamin D, homocysteine, fasting blood glucose (FBG), Glycated hemoglobin (HbA1C), insulin and insulin resistance (HOMO-IR) were measured. Results indicated presence of significant higher (p ≤ 0.001) in fasting blood glucose, glycated hemoglobin, insulin, insulin resistance and homocysteine among diabetic patients type II compared to control. Whereas, vitamin D was significant lower (P<0.001) in diabetic patients type II compared to control. In addition vitamin D level was inversely correlation (P<0.01) with fasting blood glucose, glycated hemoglobin. Moreover, it was inversely correlation (P<0.001) with insulin, insulin resistance and homocysteine.The study concluded thatvitamin D was inversely correlation with all variables in current study and it has important effect on these variables through several mechanisms at level gene expression in diabetic patients.  Keywords: Diabetes mellitus,Vitamin D, Homocysteine,Insulin, Insulin resistance.
Differences in the Effectiveness of SRQ (Self Reporting Questionnaire) and HRQLQ (Health-Related Quality of Life Questionnaire) with Malamoi Dialect for Early Detection of Mental Disorders Symptoms in Aimas District Residents of Sorong District in 2019 Butet Agustarika; Panel Situmorang
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Early detection tools for mental disorders can be one of the tools to overcome mental health problems in Indonesia, where there are still many patients with mental disorders who gets an incorrect diagnosis. This study aims to obtain the results of the analysis of differences in the effectiveness of the SRQ and HRQLQ questionnaires in the Aimas District residents of Sorong regency, with the characteristics of the respondents for each questionnaire respectively most are lazy (57.5% and 70%), with elementary school education (50% and 40%) and have jobs as laborers/farmers/fishermen (62.5%). Based on the result of data analysis correlation of Detection of Mental Disorders Symptoms with Question Type, it was concluded that there was a significant difference between the detection of mental disorders using the SRQ and HRQLQ questionnaires, with SRQ effectiveness levels higher than HRQLQ (SRQ's mean rank is 47.50 and HRQLQ at 33.50). Keywords: Self-reporting Questionnaire, Health-related Quality of Life Questionnaire, Mental Health, Malamoi Dialect.
Assessing the Rate of Social Phobia among Infertile Women Mohsen Hojat
Journal of Global Pharma Technology .
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Abstract

Introduction although social phobia is considered mainly as behavioral disorder in the field of clinical psychology, it entails by social factors and in consequences that can be followed in the fields of social sciences and social psychology. Infertile women implicate in social phobia disorder; therefore, this study is designed to put into effect the rate of social phobia among infertile women. Materials and Methods The present study is a descriptive-analytical. It is carried out on 210 infertile women in Jahrom and Yazd. Utilized tool is SPIN questionnaire that its validity and reliability are confirmed. Data collection is inquired by educated group, and it is analyzed by software SPSS: 16. Findings Results indicate that infertile women implicate a high rate of social phobia, and there is significant relationship between social phobia and education, religiosity, and social support (p<0.05).  Conclusion Due to high rate of social phobia among infertile women, it is recommended to consider social phobia and its increasing and decreasing variables, along with mental advisory and physical examination in fertility treatment clinics.Keywords: Social phobia, Religiosity, Social support, Socio-economic status, Infertility, Women.
A Case Report on Diabetic Ketoacidosis in Children Keerthana Chandrasekar; Diya C; Vignesh Kumar K
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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Abstract

Abstract:Introduction: Diabetic Ketoacidosis (DKA) is a complex metabolic state characterized by hyperglycaemia, ketonemia and acidosis. It oocurs as a complication of diabetes that results in accumulation of ketone bodies and acidosis in large quantities in the blood. It occurs as a result of a complication of Type 1 Diabetes Mellitus (T1DM) and rarely in Type 2 Diabetes Mellitus (T2DM) in children and adult.Presentation of the case: A 10 year old female child had the complaint of polyuria and polydipsia and within 2 weeks her weight has reduced to 10 kg; she also had itching, burning sensation during micturition and history of vomiting 2 episodes. She was diagnosed as T1DM with DKA and was treated with Intravenous Fluids, cefotaxime, ranitidine and insulin. She was re-admitted with complaints of fever, cough, headache and vomiting for which she was managed symptomatically and discharged.Conclusion: DKA is found to be common; hence early diagnosis and proper education and public awareness should be initiated.Key Words: Diabetic Ketoacidosis, Children, Polydipsia, Polyuria, Type 1 Diabetes Mellitus 
Preparation a New SHE-Medium Replacement of RPMI1640-Medium using Oral Rehydration Solution Ekhlass N. Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The study showed that the use of the new  culture medium which called (SHE-medium) prepared by using oral rehydration salts, led to increase  the  ratio of cell viability of PMNs and lymphocytes compare with RPMI 1640-medium on 24,48,72 h. The results shows that ratio of cell viability of PMNs in SHE-medium were 89%,91% ,93% respectively, while in RPMI 1640-medium were 80%,90%,93% respectively while the  ratio of cell viability of lymphocyte in SHE-medium were 88%,90% ,91% respectively, compare with RPMI 1640-medium which are 80%,85%,90% respectively. But when tested the effect of SHE-medium on THP-1 cell line and REF cells and comparison with RPMI 1640-medium, the results shows that the ratio of cell viability on SHE-medium were 84.33% and 74.33% respectively, while in RPMI 1640-medium were 86.67% and 80.67% respectively.Keywords: 1640-medium, SHE-medium, Oral rehydration solution.
The Effect of Teaching Exercises by Means of Aids in Some of Biomechanical Variables and the Achievement of Shot Put for Girls Students Mayassa Abd Ali Kahdim Sebti
Journal of Global Pharma Technology .
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Abstract

The study aimed to identify the effect of educational exercises related to the aids in the development of some biomechanical variables and the achievement of the weight-effectiveness of the students. The study also hypothesis that there are statistically significant differences between the results of the tribal and remote tests of the experimental and control groups. The researcher used the experimental method (and the design of the two equal groups) for the suitability and the nature of the research on the research community of the first stage students (40) students in the Department of Physical Education and Sports Sciences / Faculty of Education for Girls / University of Kufa for the academic year (2016 - 2017) Randomization The sample was randomly divided and distributed by lottery method to two groups of 15 students for both experimental and control groups. After conducting the pre and posttests, the data were collected and processed statistically to extract the results through which the most important conclusions were reached:There are statistically significant differences between the results of the pretest and the posttest of the achievement of the shot put and the experimental and control groups, as well as when comparing the results of the tests of the control and experimental groups and for the benefit of the experimental group.The use of educational aids to teach the activity of the shot put and greatly develop the skill mentioned.The results showed that there were differences between the results of the post and pretests of the experimental research group, except for variable high aviation point, since there were no differences between the results of the pre and posttests.There were significant differences between the results of the pre- and post-test tests of the control group in the investigated biomechanical variables, while there were no significant differences in high aviation point.There were no significant differences between the two post-experimental tests of the experimental and control groups in variable high aviation point, while the biomechanical variables detected showed significant differences in favor of the experimental group.Keywords: Teaching exercises, Means of aids, Biomechanics and Shot put.

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