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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Effect of an Innovative Device to Perform the Sitting Test from Lying Down to Students Applying for Admission to the College of Physical Education and Sports Science Mohamed Abdulrahman Mohamed
Journal of Global Pharma Technology .
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Abstract

The main purpose of any test must contain and include all the specifications of the good test, relying on the scientific basis for the test itself. As you know, scientific progress has a clear effect on the consideration of the requirements of the good test, including the provision of effort, time and cost, it is one of the tests for acceptance of applicants to accept Physical Education and Physical Sciences Test the sitting of the bowel as one of the fitness tests. Through the follow-up of the researchers for this test it was found that it takes a lot of time and effort as well as the cadre of the work. Each group of testers comprises at least (10) elements which require (10) of the faculty members for the purpose of keeping and fixing the feet of the laboratory and also to calculate the number of the gift for each laboratory and this requires a large number of teachers and teachers who are also in the original also have other tests are done as if all skills (plane - basket - foot ... etc). The sit-down test of students applying for admission to the Faculty of Physical Education and Sports Science takes a lot of effort, time and cost through the number of staff required to conduct the test to hold the testers and calculate the number of times the test is conducted. The aim of the research is to design an innovative device and know its effect in conducting the sit-down test. It is assumed that the innovative device has the effect of conducting and achieving the sit-down test, taking into account the saving of effort, time and accuracy in performance.Keywords: Innovative device, Sitting test, Admission, Physical Education and Sports Science.
Explanation of the Effective Components in Entrepreneurial Orientation among Students: A Case Study of the Faculty of Agriculture, Razi University Shahbazi Somayeh
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Abstract

In spite of the increasing unemployment level and the entrepreneurship need of the agricultural graduates, they do not considerably pay attention to entrepreneurship. Regarding the significance of this issue, the major objective of this study was to explain the effective components in entrepreneurial orientation among Razi University students. The population included 1392 student, of whom 310 people were selected based on simple random sampling. A questionnaire was used as the data collection instrument. The validity of the questionnaire was confirmed by the members of the Faculty of Agriculture, Razi University; the reliability of which was also confirmed as 0.86 by means of SPSS 20. Data were analyzed and 10 effective factors in entrepreneurial orientation were identified, the most important of which was the university structural change with a mean of 3.94. Furthermore, the most important factor of the lack of entrepreneurial orientation was the need for capital and lack of support with the mean of 4.01. The investigation of Razi University students’ entrepreneurial status indicated that most of whom are willing to get employed by the government. Moreover, there was not a difference between the urban and rural students as well as the male and female students in terms of entrepreneurial orientation. However, the single students were more interested in entrepreneurship than the married ones. The results of Chi-square test indicated that major and educational level, age, parents’ jobs, parents’ educational level, gender, marital status, and the living place have a significant relationship with the lack of entrepreneurial orientation at the level of 0.05 percent. According to the results, in addition to governmental support, the goals, methods, and the approaches of the agricultural higher education system are needed to be revised so as to improve the agriculture students’ entrepreneurial orientation.Keywords:  Entrepreneurial orientation, Unemployment, Agriculture students, Razi University.
Correlation of Radiographic Parameter with Functional Outcomes in Pediatric Supracondylar Humerus Fractures (SCHF) Treated with Close Reduction and Percutaneus Pinning (CRPP) Irsan Kesuma
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background Humerus supracondylar fracture is one of the most common elbow injuries and this injury approximately includes 16.6 % of all fractures in children(1). Until now, one of the current treatment for a displaced supracondylar humeral fracture is closed reduction of  the fracture is using the percutaneous skeletal fixation(4). The Baumann angle and Carrying angle  of the humerus has been a commonly used as an outcome measure for supracondylar fractures in children(6,7). The aim of this study was to evaluate the radiographic parameter with functional outcomes in pediatric Supracondylar Humerus Fractures (SCHF) treated with CRPP. Materials and Method This was a cross sectional observational study conducted on a consecutive series of supracondylar humerus fracture patients. It involved patients in Sardjito General hospital that were diagnosed as supracondylar humerus fracture treated with close reduction percutaneous pinning. Several parameters were reviewed, including Bowmann angle, Carrying angle, age at injury, sex, right or left extremity, Gartland fracture type, mechanism of injury, operative or nonoperative treat­ment intervention. Then, the functional outcome of the subjects in this study was measured using QuickDASH score which is the short form of  DASH score. Chi Square test and Independent T Test was using as the statistical analysis for this study. Result This study included 78 out of 104 supracondylar humeral fractures. 26 patients were excluded from this study. Out of 78 patients, 25 (32%) were in girls and 53 (68%) were in boys. The mean duration of follow-up all patients was 35 months. During the first data-collection, the mean Baumann angle of the humerus was found to be 72.76 ° (range 55.00 ° to 87.00 °, SD 6.17 °) . This was not significantly different from the data obtained during the second data-collection (mean 72.98 °, range 65° to 80 °, SD 6.21 °). Carrying angle pre operatively was found (mean 10.80 °, range 2 ° to 17°, SD 3.12 °). And not significantly different from post operatively (mean 10.94 °, range 2° to 18 °, SD 3.23 °). There was  no functional interference with normal social activities, sports performing, and a activities of daily living, and no functionally limiting symptoms Conclusion This study showed that good functional outcome with better carrying angle was achieved in patient with SCHF patients treated with CRPP.
Factors Influencing Social Interactions among Nursing Home Residents (Case Study: Golabchi Nursing Home, Kashan, Iran) Shabnam Baghban Kashani
Journal of Global Pharma Technology .
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Abstract

The present study aimed to find effective factors in promoting social interactions among elderly people as a factor influencing participation of the elderly population. The factors promoting social interactions between Golabchi nursing home residents were identified and classified using questionnaires, interviews and field observations. Then, the factors required to suitable design housing for them were identified. Afterwards, the data was analyzed and finally the most important factors promoting social interactions among nursing home residents were presented. Descriptive-analytical survey was used to conduct this research and data were imported into SPSS to be analyzed. The results showed that among the 27 identified factors related to residential satisfaction, learn ability, communicability, ease of access, walk ability, exercisability, and space standardization, had the maximum impact on increasing happiness, hope and safety in elderly people. These factors will ultimately lead to promote interactions among the elderly population.Keywords: Design for elderly, Social interaction, Personal satisfaction, Physical space.
Purification and Characterization of TRACP from Sera of Patients with Chronic Renal Failure Sura A. Abdul Sattar
Journal of Global Pharma Technology .
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Abstract

Background and Objective Tartrate Resistant Acid Phosphatase (TRACP) also known as type 5 acid phosphatase is a glycoprotein with basic pI , and occurring as two similar isoforms 5a and 5b with different carbohydrate content. This study aims to characterize both TRACP isoforms physico-chemically and spectrophotometrically Materials and Methods: Ion exchange chromatography was applied in order to purify TRACP isoforms (5a and 5b) from sera of control and patients with End Stage Renal Disease (ESRD). Results: The results indicated different specific activities of TRACP 5a and 5b and their proportional amounts in sera of patients with ESRD were different from that of the control group, they had approximate molecular weight of (36.8-39.3 KDa) and a basic isoelectric point equal to9.6 incontrol and patients with ESRD. The optimal pH for 5b is relatively higher than for 5a,the heparin (23 KU/L) had an inhibitory effect only on the activity of TRACP 5a ,the iron content of isoform 5b was found to be one mole  per one mole of enzyme, and UV spectrum of TRACP 5a was found to be  different from that of TRACP 5b in both control and patients with ESRD. Conclusion: We conclude that there are differences in the characterization of both isoform TRACP 5a and 5b in sera of end stage renal disease.Keywords: TRACP, Purification, Isoform, Characterization.
The Impact of Training Pattern According to the Function Exercises of Play to Develop the Some of Physical Capabilities and the Performance Accuracy of the Fundamental Skills in Soccer Adnan Fadous Omar
Journal of Global Pharma Technology .
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Abstract

The research problem indicates a weakness and a decrease in the level of some special physical abilities as well as a decrease in the accuracy of the performance of some basic skills of the research sample and this is clearly evidenced by the slow movement and frequent maneuvers or cases and the failure of most cases scoring. The main objective of the research was to develop training pattern according to the training exercises in the training curriculum and to identify the effect of these training pattern on the research variables under consideration. The research hypotheses were statistically significant differences in the results of pre and posttests between the control and experimental research groups, statistical significance between the posttests between the control and experimental research groups and for the benefit of the experimental group. The researchers were used the experimental method, the sample of research consisted of (20) players representing the club (Ararat) the experimental group and (20) players representing the Club (Shaklawa) total control, the most important conclusions reached by researchers that the training models according to the exercise exercises used in The research has developed in some special physical abilities and accuracy of the performance of the basic skills used in the research. The recommendations are the adoption of training models according to the training exercises in the preparation stage and the two repetitive training methods in the training curricula of trainers.Keywords: Training pattern, Exercises, Physical capabilities, Fundamental skills and soccer.
Effect of Anticoagulant on Acetylsalicylic Acid and Salicylic Acid Analysis in Plasma In Vitro with High Performance Liquid Chromatography Yahdiana Harahap
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background: Evaluation of the anticoagulant effect and analysis of acetylsalicylic acid (ASA) and salicylic acid (SA) is important. Full validation of in vitro methods using citrate anticoagulant in the form of CPD-A has previously been done, whereas in the implementation of in vivo studies, EDTA and heparin were used as anticoagulants. Based on EMEA 2011, if there are anticoagulant changes in validated analysis methods then partial validation should be performed. Objective: This study aims to evaluate the effect of different types of anticoagulants on the analysis of ASA and SA in plasma after being preceded by partial validation. Materials and Method: Analysis was performed using high pressure liquid chromatography column C18 (Waters, ReliantTM 5μm; 250 x 4.6 mm); mobile phase acetonitrile - phosphate buffer 20 mM (35:65) with pH 2.5; 1.0 mL/min flow rate; column temperature 35˚C; 14 minutes of time analysis with furosemide as internal standard. Results: Accuracy and precision in plasma citrate, heparin, and EDTA analysis fulfilled linear calibration curves in ASA and SA. Stability and recovery of ASA and SA in plasma with different anticoagulants showed no significant difference, however the peak area response ratio for the three types of anticoagulants between plasma with anticoagulant heparin-citrate and EDTA-citrate showed significant difference and plasma with heparin anticoagulant provides a larger area than plasma with EDTA anticoagulants. Conclusion: From this experiment, the analytical methods obtained were considered to meet the validation requirements for use of citrate, heparin, or EDTA anticoagulants based on EMEA 2011.
Evaluation of the Bacterial Contamination of Well Waters and the Effects of Leaf Plant Extract of Melia Azedarach on Such Contamination Saba Riad Khudhaier Al-Taei
Journal of Global Pharma Technology Volume 11 Issue 04.
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This work has been conducted to examine bioactivity of certain species of bacteria in well water samples collected from eight wells in Yusufiyah area southern Baghdad and to assess the effects of plant leaf extraction of Melia azedarach on these bacteria. Bacteriological properties such as total plate count cfu/ml, MPN/1.ml, Fecal Coliform, Fecal Streptococci, E. coli and Pseudomonas aeruginosa of well water samples have been evaluated in July and January 2017. Total numbers of bacteria in July was varied from 210 to 6070 CFU / ml while the total numbers of bacteria in January was ranged from 115 to 1300 CFU / ml. The local and international specifications MPN reached the upper limit for the preparation of the total coliform count in a manner most likely CFU / ml> 1600 (MPN) and have a minimum CFU / 900ml in July but in January, it has reached the upper limit of the number of total coliform manner that count the most likely CFU / 100 ml> 1550 (MPN) and minimum CFU / 100 ml 100 hence conclude that 87.5% of water wells in July and January. Well waters indicators fecal coliform bacteria and E. coli and fecal Streptococci contamination. However, the contamination with fecal coliform bacteria was considered as an acceptable because they are not exposed to any type of chlorination before consumption by users. The dried plant leaves of the Melia azedarach were extracted by using methanol alcohol and the bioactivity of this extract was evaluated with isolated bacteria. The results have showed that the effects of the extract depend on bacteria species and the extraction concentration used. However, it was found that the extract had significant bioactivity on bacterial contaminated water and such ability of methanol alcoholic extract may be due to the content of steroidal, phenols and tannins compounds in the examined plant leaves being very effective against microbes.Keywords: Bioactivity,   Melia azedarach, Extraction, Bacterial contamination, Well water.
Effect of Ozone on Antagonistic Activity of Lactobacilli Anzor A. Ismailov
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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This article describes study results that confirm the effect of ozone on the antagonistic effect of Lactobacillus plantarum 8P-A3 against Bacillus subtilis, Escherichia coli and Candida albicans test cultures. A stable (within 48 hours) dose-dependent effect on lactobacilli antagonistic activity was proven; it was maintained in all used ozone concentrations (from ˂0.29 mg/L, 0.29 mg/L, 0.38 mg/L). It was found that the intensity of lactic acid formation which is the most important criterion for lactobacilli antagonistic activity is significantly higher at the ozone concentration of ˂0.29 mg/L than in control samples; herewith the bacterium retains the properties of a strong antagonist. Level of lactic acid at the doses of 0.29 mg/L and 0.38 mg/L is reduced in comparison to control samples, and lactobacilli can be characterized as weak antagonists.Keywords: Antagonistic activity of lactobacilli, Antagonistic factors, Ozone, Effect of ozone on microorganisms, Lactic acid.
Synthesis and Biological Activity Evaluation of New Imidazo and Bis Imidazo (1, 2-A) Pyridine Derivatives Naeemah Al-Lami
Journal of Global Pharma Technology .
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A series of imidazo [1, 2-a] pyridine derivatives were obtained from the work that was conducted in this research. Firstly; reaction of 2-amino pyridine with (4-phenyl phenacyl bromide) or (4-bromo phenyl phenacyl bromide) to give 2-substituted imidazo [1, 2-a] pyridine as a starting compound (1a, 1b).Then reactions of compounds (1a, 1b) were carried out through two pathways: the first pathway involved condensation of two analogous of compounds (1a, 1b) with different aryl aldehyde to give bis imidazo [1, 2-a] pyridine (2a, 3a, 4a, 2b, 3b, 4b). While; the second pathway was introduced Carbaldehyde group at position-3 of prepared 2-substituted imidazo pyridine rings by Vilsmeier-Haack reaction, the produced was reacted with different aromatic amines to give Schiff bases of these derivatives. Then Schiff bases reacted with α-amino acid, monochloro acetic acid and phenyl isocyanate to give compounds (10a-15b). The new prepared compounds were identified by [FTIR, 1H-NMR and 13C-NMR] and their physical properties were measured. Furthermore, we have evaluated the effect of some prepared compounds on some bacterial and fungal strains. Keywords: Imidazo/pyridine, Bis imidazo, Aza-β-lactam, oxazolidin, imidazolinone.

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