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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Scalp Nerve Block in Combination to General Anesthesia Lower the Increase of Inflammatory Markers Compared to General Anesthesia alone in Craniotomy Surgeries Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Background: Regional anesthesia reduces the inflammatory response and surgery-related immunosuppressive response. The scalp nerve block technique is a relatively simple and safe technique. The goal of this study was to compare the inflammatory response between a combination of general anesthesia and scalp nerve block compared with general anesthesia in craniotomy surgery. Methods: This was a double-blind, randomized controlled trial with pre and post-test study in 50 subjects carried out at Sanglah General Hospital (Bali, Indonesia). Group A treated with scalp nerve block using 0.25% levobupivacaine solution, and group B treated with scalp nerve block using 0.9% NaCl solution. Blood tests were carried out before and after the surgery to measure platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP) as inflammatory markers. Results: The mean difference of PLR, NLR, and CRP between the two groups were significantly different (p <0.001) at 72 hours after the surgery. The tests found no significant difference at before and right after the surgery (p >0.05). Conclusion: The application of scalp nerve block in combination to general anesthesia lower the increase of PLR, NLR, and CRP compared to general anesthesia alone in craniotomy surgeries.Keywords: PLR, NLR, CRP, Inflammation, Regional anesthesia.
Nurses’ Perception of The Implementation of Patient Safety in the Inpatient Ward of a Teaching Hospital Setiawan Setiawan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Patient safety is a complex system to prevent injuries caused by mistakes and it allows the nurse to consider taking action or not to deal with the problem of patient safety. The purpose of this study was to explore the nurses’ perceptions of the implementation of patient safety in the inpatient ward of a teaching hospital. A qualitative study was used. The sample consisted of 20 nurses who were involved in a focus group discussion for 70 minutes. The data was analyzed using content analysis as guided by Collaizi. This research found 5 themes that included events almost causing harm to the patients during shifts, obstacles related to reporting events, information about events that should be reported, primary concerns regarding patient safety and habits done to reduce the risk of making mistakes. The implementation of patient safety still needs to be improved due to the lack of perception among the nurses. Patient safety occupies an important position in the health services provided and it plays an important role in the perception of the nurse.Keywords: Inpatient ward, Nurse perception, Patient safety.
Association of IL-1α (-889) and TNF-α (-309) Gene Polymorphisms with Chronic Periodontitis in Hilla City Doaa H. Hassan
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Background: Periodontitis is a infectious disease leading to the destruction of periodontium including periodontal ligament and adjacent alveolar bone induced by periodontal pathogens biofilm. Materials and Methods: A total of 90 patients, 50 with chronic periodontitis (CP) and 40 normal subjects0referring to the clinic of collage of Dentistry, Babylon University, Hilla City, Iraq, were evaluated, TNF-α and IL-1α genotyping was performed by PCR)and analyzed by polyacrylamide gel. Results: polymorphism of  IL­1α (-889) and TNFα(-308), The results showed that there was no (significant) allele frequency) difference between(patients and)control groups. Conclusion: The current study suggest that there is no association between IL­1α (-889) and TNF-α 308 polymorphism and chronic periodontitis in this population.Keywords: Periodontitis, IL­1α (-889), TNF-α 308, Genetic Polymorphism, PCR.
Reduce the Pollution of Some Heavy Elements in Agricultural Soil by Biological Treatment of Certain types of Algae Ibtisam Fareed Ali Karm
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Many researches on soil contamination had been done but few solutions were offered. This research focused on the use of some microorganisms as an alternative ways for remediation environmental pollution to reduce the concentration of five heavy elements that were tested Pb, Cd, Cr, Ni and Cu. Therefore, this research was conducted in order to find out the effect of mixed algae culture from two important microalgae (Oscillatoria sp. and Chlorella sp. ) that were locally isolate and cultivated easily under lablotary conditions to give a biomass production , a laboratory experiment was done for 12  samples of contaminated soil with heavy metals. Testing the bioactivity of remediation take three weeks, a significant difference were recorded in some data treatments, others show no significant, in general all concentrations of heavy metals were degreased after using the mixed algae culture that chosen for its wide ability for cleaning or removing the pollutants from agriculture soils. Keywords:  Mixed algae culture, Agriculture soils, Heavy metals, Bioremediation. 
The Modern State and Historical Aspects of Homeopathy as a Scientific and Educational Discipline in Ukraine Olena Olexandrivna Gaidukova; Svitlana Valentynivna Oliinyk; Evgen Yakovych Nikolenko; Kira Vitaliivna Vovk; Olha Olexandrivna Vlasenko
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The problem-targeted analysis of the modern homeopathy structure is carried out. The state of the modern regulatory and legal framework concerning regulation of the homeopathic method of treatment as the basis of the legal mechanism in state management of this branch is analyzed. The historical aspects of homeopathy are generalized, the analysis of homeopathic doctors’ activity legal regulation in Ukraine is carried out, and also issues of their education are covered. The results of scientific achievements are presented and their role in the formation of the evidence base for the homeopathic method of treatment is outlined. The problems of homeopathic medicine, pharmacy and science are covered. Key words: homeopathy, data of scientific literature, legal regulation, homeopaths, pharmacological studies.
Relationship between Vitamin C and Parathyroid Hormone and Insulin Resistance Associated with Obesity Ali Mojed Al-Dhmoshy
Journal of Global Pharma Technology .
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Abstract

Objective: To show the association between parathyroid hormone and obesity and to determine the relationship between vitamin C and insulin resistance with obesity. Background Obesity is representing a global epidemic that affecting more than 1.9 billion adults in 2014, 18 years and older, were overweight. Of these over 600 million were obese. Many causes have been implicated for developing obesity such as: environmental, hereditary, medical disease like endocrine disorders furthermore, some medication like antipsychotic drugs and steroids. Obese people are at high risk to develop much complication such as diabetes, hypertension, atherosclerosis, joints problems, cancers especially hormone dependent, respiratory problems and others. Material and methods: Eighty-eight people were in cladding this study visiting Merman medical city from December 2015 to June 2016.A 40 normal non-obese , and 48 obese, The overall mean age of patients and controls was 34.48±9.83 and 28.78±6.96  years old, respectively. They were classified according to body mass index after measuring their weight, height, The be line Questionnaire was done for all patients and control for diagnosis excluded disease and any treatment that effect on obesity. The investigation was done and include fasting blood glucose, Calcium , Phosphate, HOMA IR, Vitamin C, Then hormonal testing : parathyroid hormone, insulin hormone, c-peptide . Results: There is a significantly higher difference (p value ≤ 0.05) between case and control groups concerning education, gender. Regarding investigation there is significantly higher difference (p value ≤ 0.05) between case and control groups in parameters of fasting blood glucose, HOMA IR, but all the investigations were within normal acceptable clinical range. Whereas, in regard to the hormonal parameters:- parathyroid hormone : There is significant difference between case and control (p value ≤ 0.05) , While no significant difference (p value ˃ 0.05) in percentage between case and control for insulin hormone . While significant difference  in C-peptide. Conclusion: The results of this study support the evidence that obesity associated with parathyroid hormone. Furthermore obese patients have a tendency toward higher serum PTH, there does not appear to bea resistance to PTH in the obese based on the similar serum calcium-PTH curve between obese and no obese. Hyperparathyroidism also can cause obesity. Vitamin C has   responsible effect in preventing of obesity by antioxidant role.Keywords: Obesity, Vitamin C, Ascorbic acid, Parathyroid hormone, Hyperparathyroidism, Insulin resistance. 
Structural, Spectral and Thermal Studies of Novel Tridentate Schiff Base Ligand Type (NOO) as Donor Atoms Derived from Nalidixic Acid and 4-Aminoantipyrine and Metal Complexes and Evaluation of their Biological Activity Hawraa K. Salloom
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this study, a novel Schiff base (E)-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)-1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid [HL] was synthesized from nalidixic acid 4-Aminoantipyrine and its metal complexes for metal ions M=VO, Mn, Co, Ni, Cu, Zn, Pd and Pt in ethanol and acetic acid  with mole ratio (M:L) (1:2). All complexes have general composition [VO (L)(SO4)] H2O, [Mn(L)2], [Co(L)2] H2O, [Ni(L)2] H2O, [Cu(L)2] H2O, [Zn(L)2].H2O, [Pd(KL)2] and [Pt(KL)Cl2] Cl2 where L- =C23H22N5O3. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UV Vis, 1HNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against one type of bacterial and one type fungus. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry accept [[VO (L)(SO4)] H2O] square pyramidel geometry and [Pd (KL) 2] Square planer geometry. The value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligand and starting material.Keywords: Nalidixic Acid, 4-Aminoantipyrine, Metal complexes, Biological activity.Introduction
Radon Concentration Measurements and Physiochemical Parameters of Sawa Lake Water-Samawa City, South of Iraq Ahmed Augab Sharrad
Journal of Global Pharma Technology Volume 11 Issue 05.
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Radon concentration measurements were carried out for 85 water samples collected from Sawa Lake in Samawa city, Southern part of Iraq, in order to obtain the levels of radon concentration in this area and for enhancing the national radon survey. For the measurements, a continuous radon monitoring detector (RAD7) was used. The period of assessment was two months (from December, 1st  2018 to February, 1st  2019) during the winter season. Radon activity concentrations were ranged from (0.111 Bq/l) to (0.965 Bq/l), while the average value was (0.396 Bq/l), the annual effective dose (AED) of inhalation was estimated from the measured radon concentrations and is found to be ranged from (0.080784 µSvy-1) to (0.917136 µSvy-1) with a mean value of (0.325764 µSv/y). Physiochemical parameters such as pH, EC, TDS, resistivity, and turbidity were determined samples and the correlation between these parameters and radon concentrations was conducted. The results have revealed that the radon concentration and the associated annual effective dose does not pose any kind of health hazard to the population and tourists, and were found to be well within the reference levels as reported in the ICRP 2000.Keywords: Radon, Sawa Lake, Samawa City, Physiochemical Parameters, RAD7Detector.
Assessment of Fungal Filtrates Efficiency against Escherichia coli in Comparison with Common Artificial Antibiotics Nihad Habeeb Mutlag
Journal of Global Pharma Technology .
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The study aim to isolate ,  identify and characterize the Escherichia coli and look for their antibiotics resistance in children with diarrhea in najaf , the study includes 60 samples of stools gathered from patients children visiting Educational AL_Zahraa hospital for the period  beginning of November 2016 to mid-January of the same year,  the age of these children were less than ten years , specimens were phenotypic assays , microscopically examined and diagnosed by biochemical tests , the highest bacterial pathogens isolated  were Escherichia coli. The sensitivity of isolates of E.coli were examined for 11 types of antibiotics, E. coli exhibite different pattern of resistance to different antibiotics ,it is have highest resistance to penicillin (ampicillin and carbenicillin), and it is have higher resistance for ceftazidime and cefepime , while have  moderate resistance for aztreonam.it is have lowest resistant rate to imipenem ,meropenem and ertapenem.Also the same  isolates of E.coli  were examined by the Pleurotus ostreatus fungi filterates which appeare a significant values in the inhibition of growth of  E.coli in petri dish which reach  8 cm in compare with antibiotics that  used  in the study .
Post-Spinal Anesthesia Hypotension during Cesarean Delivery, A Review Ghalib J Al-asadi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Maternal hypotension is a common complication after spinal anesthesia for cesarean delivery. Prevention and treatment of post-spinal hypotension (PSH) in cesarean delivery has been frequently investigated. Fluid loading is superior to no-fluid regimen; however, the incidence of PSH is still high with all fluid loading protocols; thus, the use of fluid loading as a sole method for prophylaxis might be not satisfactory for many anesthetists. Phenylephrine is the preferred vasopressor for prevention and management of PSH in most cases. Ephedrine may be more beneficial in patients with bradycardia, patients with uteroplacental insufficiency and pre-eclamptic patients. Norepinephrine infusion was recently investigated as an alternative for prophylaxis of PSH with minimal cardiac side effects. The high incidence of PSH with most of the pharmacological and non-pharmacological methods suggests the need for multimodal protocols for prevention and management of this problem. PSH in cesarean delivery is a common daily situation facing all anesthetists; thus, future research should focus on simple and rapid protocols that can be easily applied by anesthetists with moderate and low experience with minimal need to complex devices or costly drugs.Keyword: Hypotension, Spinal anesthesia, Cesarean delivery.

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