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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Characterization of Carotenoid Extract and Bioactivity Membrane of the Seeds of Annato (Bixaorellana) Lia Kusmita
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Bixa Orellana has a typical compound in the form of carotenoids. The types of carotenoids found in these compounds are bixin and norbixin. Both of these compounds have many benefits, one of which is as an antioxidant. Its nature as an antioxidant can also be used as a sunscreen. The purpose of this study was to determine the characteristics of carotenoid pigment in extract of the B.orellana sees membrane. Besides that, it is also to determine its biological activity in the form of antioxidants and sunscreen protectors. The TLC results showed 4 spot of carotenoids in the extract. Spot 1 identified as a bixin compound, because it has the same Rf as the bixin standard. HPLC result showed there were 5 peaks. The peak in tR of 9.046 was identified as norbixin and the peak in tR of 9.819 was identified as bixin. Carotenoid extract on the membrane of the seeds of B. orellana has antioxidant activity 16 times greater than standard bixin. Carotenoid extract at a concentration of 3.10 ppm had an SPF value of 6.27, including the extra protection category, and had a %TE value of 21.71% and Tp of 18.24% in the sunblock category. Keywords: Carotenoid, Antioxidant, Sunscreen, Bixin.
The Patho-Histological Change of Fetus Amniotic Sac as a Result of Bacterial Infection Sura I. A. Jabuk
Journal of Global Pharma Technology .
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Abstract

Amniotic fluid is defined as a transparent liquid that is present in the uterus during pregnancy. In this study obtain 100 sample of vaginal swaps(50from normal birth and 50 from caesarean), 100 samples of amniotic fluid (50 samples from normal birth and 50 samples from caesarean) from pregnant women revision born lounge  in Hilla teaching hospital, and 50 samples of amniotic sac from the caesarean women to made histological section. The result showed the number of positive swaps of bacteria  was 81 (81%) , while positive samples from amniotic fluid was 76 (74%) from the total 100 sample and present relationships between vaginal  infection and the present of bacteria in the amniotic fluid .The  type of  aerobic bacteria isolated was Escherichia coli ,Pseudomonas aeruginosa, Bacillus subtilis, Klebsiella pneumonia, Staphylococcus epider midis, Staphylococcus aureus,  Streptococcus  mutans, Proteus mirabilis and anaerobic bacteria was Peptp streptococcus sp. Neisseria gonorrhoeae, Lactobacillus sp. and Actinomyces sp. were isolated from amniotic fluids and vaginal swabs. then injection the same bacteria isolated in mice and made histological section from mice amniotic sac. Cross section of amniotic tissues in both of women and mice showed infiltration of lymphocyte, hemorrhage and elongation of epithelial cell as a result of bacterial infection.Keywords: Amniotic fluid, Amniotic sac, Caesarean, Vaginal infection. In vitro, In vivo.
High Spectrum of PTEN Gene Mutations in Iraqi Breast Cancer Patients Wafaa Sabri Mahood
Journal of Global Pharma Technology .
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Abstract

Breast cancer conceder the higher tumor rate among Iraqi women.  New potential and prognostic markers are required to identify those women. PTEN gene (phosphatase and tensin homolog deleted from chromosome 10) is tumor suppressor; its mutations in breast cancer are well reported in many populations but not in the Iraqi people. The main purpose of this research was to identify the PTEN mutation spectrum as predictive marker in Iraqi patients with breast cancer and benign lesion. The mutations in the 7th exon of PTEN gene was analyzed on thirty tow Iraqi females with breast disease, twenty women were diagnosed breast cancer and six women with precursor lesions of the breast (benign) in addition to six healthy women served as reference (controls). Results showed several mutations including thirty different mutations in malignant samples, the most five were characterized by high alteration  rates75% (15/20), at position 115833 and 115950  these are T>G and T>A  followed  by  65%(13/20)  and 50 % (10 /20)  at positions 115921 and 115843 respectively  this is G>C, other more mutations frequency 45% (9/ 22)   at position 115912 this is G>T .We also detected an insertion G and T between (115833-115834) in 20%(4/20) and 10 % (2/20) respectively .Comparison of mutations between malignant and benign patients showed the frequency of several mutations in three sits (115833, 115843 and 115912) were appear in both benign and malignant patients may indicating to important role of the three sits in initiation and progression of breast cancer. Other two positions (115832, 115949) also have high mutations rate were found only in malignant patients indicating that these positions may have a role in progression of breast cancer.  In conclusion we believe that PTEN gene is a promising biomarker that could be useful in detection of breast cancer patients and predicting the prognostic state of those women.Keywords: Iraq, PETN gene, Breast cancer.
Production of Lemongrass (Cymbopogon Citratus) Powder Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Lemongrass (Cymbopogon citratus) is a perennial grass belonging to genus Cymbopogon. The lemongrass has a very wide demand in nutritional, medicinal and flavoring industry. Cymbopogon citratus contains various phytoconstituents such as flavonoids and phenolic compounds, terpenoids and essential oils, which may be responsible for the different biological activities. The demand for lemongrass (Cymbopogon citratus) is for its high citral content. But it is not stored as fresh for long time at ambient condition because it turns brown and rotten quickly. Even processing or preservation, its volatility and susceptibility to degradation are the major drawbacks for the use of Cymbopogon citratus oil. This research studied the feasibility of lemongrass dried powder production by treatment of vapor steaming (140oC in 10s; 130oC in 15s, 120oC in 20s, 110oC in 25s), drying temperature (40oC, 45oC, 50oC, 55oC) in 6 hours to 6.5% moisture content, grinding and coating materials (β-cyclodextrin, sodium alginate, carrageenan, cacboxymethyl cellulose) in different concentration (1.0%, 1.5%, 2.0%, 2.5%). The total chlorophyll content (mg/100g), citral content (%) were estimated. Results revealed that vapor steaming at 130oC in 15s, drying at 50oC in 6 hours to 6.5% moisture content, grinding and coating with 2.0% of β-cyclodextrin were appropriated for lemongrass dried powder production.Keywords: Lemongrass, Dried powder, Chlorophyll, Citral, β‐cyclodextrin, Sodium alginate, Carrageenan, Cacboxymethyl cellulose
Introducing Optosonographic Surgical Monitoring Into Clinical Practice Olga V. Surnina
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Materials and methods: In the period from 2010 to 2017 quite a few people were examined, i.e. a ‘comparison’ group of 200 people and an observation group, i.e. 1667 people. The results were as follows. Optosonographic monitoring in 935 patients (56%) revealed surgical thyroid disease, in 732 patients (44%) revealed a surgical pathology of the mammary glands. Among the identified neoplasms, 741 (79%) were benign ones, and 194 (21%) were malignant ones. The number of patients with mammary neoplasms was 732 patients. Of these, 634 were benign ones (87%) and 95 were malignant ones (13%). Results: The sensitivity in the differential diagnosis by optosonographic method of benign thyroid neoplasms is increased from 63% to 95%, malignant neoplasms from 66% to 96%. Reliability increase from 60% to 98% for the diagnosis of benign breast neoplasms, for malignant ones from 37% to 98%. This allows the use of non-invasive optosonographic monitoring to verify the diagnosis.Keywords: Optosonographic method, Implantation, Mammary gland, Thyroid gland.
Effect of Ballistic Exercises in Explosive Capacity, Accuracy of Service and Spike of the Volleyball of the Physically Disabled-Sitting Ammar Khaleel Ebrahim Al-Ezzi
Journal of Global Pharma Technology .
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Abstract

The study aimed to: Identify the effect of ballistic exercises in the explosive ability, accuracy of service and the spike of the volleyball of the physically disabled - sitting. The researcher used the experimental method in the style of the two equal groups. The research society was determined by the players of the national team in the 12-player volleyball team. They were divided into two equal groups (control and experimental). Ballistic exercises included moderate and moderate exercises similar to the skill performance, the course lasted for (8) weeks by (3) training units per week and the main findings of the researcher after the extraction of the results of Posttests the following conclusion:Ballistic training used has a positive effect on the development of exploding explosive capability, accuracy of service and spike of the ball off the disabled for movement-sitting.Keywords: Ballistic exercises, Explosive capacity, Accuracy and physically disabled.
Clinical Use of Ultrasound in Obstetrics Saba Kamal Mahmood
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

During the past three years, ultrasound diagnostic procedures have been important and useful means in clinical practice of obstetrics and gynecology. Ultrasound images of the flow, whether color flow or spectral Doppler, are obtained from motion measurements. In ultrasound scanners, a series of pulses are transmitted to detect blood movement. Echoes of fixed tissues are the same from pulse to pulse. The echoes of the transition from scatter to slight differences appear at the time of signal return to the receiver. These differences can be measured as a direct time difference, or usually, in terms of the phase shift from which the Doppler frequency is obtained. It is then processed to produce either a color flow display or Doppler ultrasonography.
Estimation of Anti CMV Antibodies in Iraqi Pregnant Women Infected with Chronic Cytomegalovirus Safa A. Khudhair
Journal of Global Pharma Technology .
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Abstract

Cytomegalovirus (CMV) is a double-stranded DNA virus that belongs to the Herpesviridae (Herpesvirus) family, and it is the largest herpes virus in size. It affects all age groups and spreads worldwide. Human cytomegalovirus (HCMV) can cause fatal diseases to humans, and it is the most common cause of congenital birth and maternal infections. The study was conducted on 122 Iraqi pregnant women who had chronic CMV infection (with positive IgG antibodies), and 10 healthy women (with negative IgG and IgM antibodies) as control group for comparison purposes at Al-Elwiya hospital from May to August 2017. Venous blood samples were collected from the studied women to evaluate the levels of serum anti CMV IgG and IgM antibodies.  The results of the study showed that the highest antibody titers was within the age group (< 25 years) and women without previous abortion showed the highest CMV infection (55%), while no significant difference was shown between the IgG and IgM values within the categories of number of pregnancies.Keywords: CMV IgM & IgG antibodies-Pregnancy.
Synthesis, Antibacterial Evaluation and Docking Study of Some New Fused Pyrido-Pyrimidine and Naphthyridine Cycles Hamid H. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

New fused pyrido-pyrimidine and naphthyridine cycles were synthesized and characterized using spectral analysis. Initially, 2-cyano-N-(1-phenylethylidene) acetohydrazide (2) was prepared from the reaction of cyanoacetic acid hydrazide (1) with acetophenone then cyclized to 4,6-diamino-2-oxo-1-((1-phenylethylidene)amino)-1,2-dihy-dropyridine-3-carbonitrile (3) by the action of malononitrile and triethyl amine in dioxin. Fused pyridopyrimidine cycles (4-6) were obtained from the reaction of compound 3 with formic acid, glacial acetic acid and propionic acid, respectively in the presence of POCl3 as a catalyst. The novel cycles (7-9) were synthesized from the cyclization reaction of compound 3 with benzoyl chloride, phenylisocyanate and phenylisothiocyanate in presence of pyridine. Naphthyridine cycles (10-13) were obtained by cyclization of compound 3 with some of aliphatic ketones namely; acetone, cyclohexanone, 2-butanone and 4-methyl-2-pentanone, respectively in presence of FeCl3 as catalyst. The antimicrobial activity of the synthesized derivatives was evaluated against several bacterial species as well as candida albicans. Docking study was also achieved to explore the binding affinity of the potent discovered hit (9) inside the binding pocket of glucosamine-6-phosphate synthase, a target enzyme for the antimicrobial agents.Keywords: Naphthyridine Cycles; Fused Pyrido-Pyrimidine; Antibacterial.
Synthesis and Biological Evaluation of New Boron Compound with Cephalexin and some of Its Transition Metal Complexes Asmaa Mohammed
Journal of Global Pharma Technology .
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Abstract

Synthesis of the ligand [ 7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic boric anhydride] by the  reaction of cephalexin monohydrate with boric acid  in a mole ratio (1:1).  The metal complexes of this ligand with Cr(III),Co(II),Ni(II)and Cu(II) have been also synthesized .The ligand and its metal complexes were characterized by UV-Vis, FTIR, 1HNMR, 13CNMR  , atomic absorption spectra, CHNS analysis, melting point ,magnetic susceptibility and molar conductivity measurements  . The antimicrobial activity for the ligand and its metal complexes were evaluated against Pseudomonas auroginosa (G-), Staphylococcus aurus (G+), Klebsiella pneumonis (G+) and Staohylococcus epidermidis (G+) and Asporgillus as fungi.                                                                                   Keywords: Boron compound, Cephalexin.

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