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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Some Technical Parameters Influenced to Production of Baked Purple Sweet Potato (Ipomoea Batatas) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Purple sweet potato possesses a high content of anthocyanins and has an abundant amount of phytochemicals beneficial to human health. The high perishability of sweet potato roots during storage remains a major constraint. This study was carried out to assess value addition of purple sweet potato (Ipomoea batatas) processed in forms of baked strip. This present research aimed to optimize the production parameters as well as come out with an acceptable product. Different parameters affecting to the production of baked purple sweet potato were examined. The results revealed that blanching the purple sweet potato strip in 1.4 cm thickness in 0.15% CaCl2 solution, coating 0.2% xanthan gum, baking at 155oC in 2 minutes, and packing in PET/AL/PE bag were appropriated to maintain the physicochemical properties of baked strips as well as extend product shelf life. From this approach, the biological value of purple sweet potato tubers could be accelerated.Keywords: Purple sweet potato, Blanching, Coating, Baking, Shelf life, Anthocyanin, Xanthan gum.
Analysis of Lethal Outcomes in the Cases of Sefere Acute Pneumonia Associated with Influenza A (H1N1) Pdm09 Sergeeva IV
Journal of Global Pharma Technology .
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Abstract

The article analyzes 9 pathology records of deaths from severe complicated influenza A (H1N1) pdm09.It was found that among the deceased were predominantly young women aged 25 to 40 years with a burdened premorbid background, 77.8% of cases. Risk factors were: metabolic syndrome in 77.8% of cases and cardiovascular diseases, chronic viral hepatitis, chronic pyelonephritis was diagnosed in 11.1% of cases, respectively. Lethal outcome follows as a result of ARF and acute respiratory distress syndrome. Severe total injury of the trachea, lungs, and bronchi associated with internal organs plethora was detected morphologically. Clinical manifestations of ARF and ARDS were combined morphologically with alveolar damage. In all cases of lethal outcome, diffuse alveolar damage and polyorganism changes were diagnosed.Keywords: Influenza A (H1N1) pdm09, Community-acquired pneumonia, Lethal outcome.
Isolation and Identify the Antibiotic from the Local Isolates of the Streptomyces antibiotics and Test their Antifungal Activity against Plant Pathogens Safaa Ismail Rashid Al-Obaidi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

A bacterial isolates of (80) from (17) soil samples has been collected from the rhizosphere of different plants of many regions Mosul city; the isolates were initially identified as a Streptomyces genus according to the chalky appearance and the odor of the moist earth. Antagonistic activity against fungi isolated from the soil rhizosphere of plantshas been tested. Only (49) isolates (i.e. 57.64%) proved their antagonized ability against one or more of the tested fungi. The best isolation  that gave antifungal efficacy against all fungi, and was the largest diameter of the inhibition area against A. flavus (48 mm) followed by M. Phaseolina (27 mm), the least inhibition zonewas (12 mm)  of Sclerotiumcepivorum (12 mm). The isolation elected to the level of the species was identified by the morphological, physiological and hematological tests and was found to belong to the species of Streptomyces lydicus. The identification of the antibiotic extracted by ethyl acetate was done using three solutions that are butanol: pyridine: water (6:3:4), methanol: dichloromethyne: water (1:1:1) and butanol: acetic acid: water (6:4:3). A single spot appeared on a thin-layer chromatography plate (TLC) indicating the production of one type of antibiotic. It was noticed that Rf for the spot in the 3 solvents was 0.82, 0.47, and 0.80 respectively. The solvent with Rf 0.86 was the best hence it gave the highest inhibition for the growth of at least 2 fungi. Ultra violet absorption for the antibiotic was (286) and appeared that this compound was a Macrolides. Also Infra red (IR) was measured suggesting that the expected structure of the antibiotic is Oleandomyein.Key words: Streptomyces antibiotics, Bacteria, Antifungal, TCL plate.
Physicochemical, Antibacterial Studies of Some New Transition Metal Complexes of Chelating Active Compound Mahasin. F. Alias
Journal of Global Pharma Technology .
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Abstract

Metal (II) complexes of Co, Ni, and Cu with Amoxicillin derivative [Methyl-6-[2-(benzyl ideneamino) 2-(4-hydroxy phenyl) actamido]-2,2-dimethyl-5-oxo-L-thio-4-azabicyclo[3.2.0] heptan-3-carboxylate], (L) were synthesized and identification by phesio. Chemical procedures i.e (elemental analysis CHNS, metal analysis AA, Uv-Vis, FTIR, TGA, magnetic susceptibility and conduct metric measurement. From analysis the ligand behaves as a bidentate through oxygen carbonyl group of amide and nitrogen atom of imine group. Tetrahedral geometry was suggested for the cobalt ion and a six coordination octahedral geometry for nickel and copper complexes has been proposed. The ligand and its metal complexes were also tested for the Candida albicans .c., and as antibacterial activity to assess their inhibiting potential against two selected microorganism, staphylococcus aureus and Escherichia Coli using two different concentration (10 and 5 mm) in nutrient agar medium.Keywords: Schiff base, Metal complexes, Physico-chemical, Microorganism, Amoxicillin.
Immunohistochemical Protein Tracing of p15 INK4B Gene Expression in Latent Membrane Protein-1-Epetein Barr Virus Oncoprotein Infected Tissues from Ovarian Tumors Patients Ruqaya M.J. Awadh
Journal of Global Pharma Technology .
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Abstract

This study was designed as a retrospective case-control study research. A total number of (150) formalin-fixed, paraffin embedded ovarian tissues was included. These tissues  were including 45 malignant ovarian tumors (which including Serous epithelial  (32 cases : 71.11%), Mucinous (9 cases :20%) and Endometrium (4 cases :8.89 %)  ,  45 benign ovarian tumors), 20 borderline tumors and 40 of apparently healthy ovarian sections which were included as baseline control .The mean age of the patients with ovarian carcinoma was higher (42.58±8.083years) than the mean age of the borderline ovarian tumor (41.90±10.126 ) and benign tumors group (39.82± 7.646 years), followed by mean age of those females in the group of apparently healthy control  (35.64± 10.183). The results of immunohistochemistry staining of LMP1-EBV gene expression  showed that  57.8% ( 26 out of 45 tissues) was positive in malignant ovarian tumors .While, in benign ovarian tumors the positive results was 40 % (18 out of 45 tissues) of LMP1-EBV. Whereas, the positive results in borderline ovarian tumor group was 40% (8 out of 20 tissues), followed by the apparently healthy ovarian control tissues was 15% (6 out of 40 tissues).
Theoretical Justification of Structure and Development of Capsule Technology with Cerebroprotective Activity Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Treatment of brain remains an urgent problem in the health system in Ukraine, due to the wide prevalence of the most common as a result of this disease causes cerebrovascular diseases, including atherosclerosis and hypertension, leading to a narrowing of the blood vessels of the brain and decreased cerebral blood flow. An alternative method of treatment of cerebrovascular diseases (CVD) it is expected pharmacological effect, which is achieved through use in medicines herbal drug that exhibits antyarytmichal, sedative, tranquilizing, antispasmodic, antiseptic hypotensive effects. According to literature data types such therapeutic activity black horehound grass, the grass dead-nettle herb wormwood and compatible whose presence leads to a potentiation of pharmacological action due to the fact that the components of the content biologically active substances (BAS) show a complex impact on different parts of body systems and increase reliability and predictable therapeutic effect. This complex of action reduces the possibility of side effects of display. The aim of this work is the theoretical basis structure and development of technology for rational drug cerebroprotective action in the form of hard gelatin capsules based on dry extracts medical plant material (MPM), namely black horehound grass, herb nettle deaf, sage herb. On the basis of experimental studies, we have proved the composition of masses for encapsulation of drug in the form of hard gelatin capsules number 0. Composition per capsule: a mixture of dry extracts MPM-400 mg; aerosol-50 mg; lactose monohydrate -50 mg. The weight of the contents of the capsule-500 mg. Keywords: Dry extracts, Development composition and technology, Gelatin capsules, Cerebroprotective activity.
Comparison of the Changes of D-Dimer and FDP Serum Levels in Ischemic Brain stroke Patients with and without Malignancy Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Introduction: Cerebral artery diseases are the third cause of death in the U.S. proceeded only by the heart diseases and cancer. It is the most prevalent neurological disorder leading to illness and death. Stroke is a syndrome characterized by the initiation of acute neurological disorders lasting at least for 24 hours. It reflects the focal involvement of central nervous system induced by blood circulation disorders in brain. This study was designed to study D-Dimer and FDP serum levels in ischemic brain stroke patients with and without malignancy. Method of study: This is a randomized clinical trial in the form of a case-control study. The population of study consists of all cases admitted in the neurology department of Imam-Khomeini Hospital in Urmia who included in the study via randomized allocation after obtaining their consent. Cases with underlying malignancy were grouped in case group and those with no malignancy were grouped in control group. Results: In this study, 60 and 120 cases were studied in the case and control groups, respectively. There was a significant difference in mean D-Dimer (P=0.01), mean FDP (P=0.02), mean ESR (P=0.01) and mean CRP (P=0.01) between case and control groups. Lung cancer was the most prevalent cancer (31.7%) in the case group. In addition, diabetes mellitus, hyperlipidemia and hypertension risk factors were reported in the case group with a frequency of 28.3%, 33.3% and 30%, respectively. Conclusion: In patients with ischemic stroke and malignancy, the serum levels of D-dimer and ESR was elevated and risk factors such as DM, HLP, and HTN had a high rate in these patients, so in patients with cancer, occurrence of cerebral ischemia is higher compared to patients without malignancy. So knowing mechanisms, type and stage of cancer is critical for survival of these patients.Keywords: Diabetes mellitus, D-Dimer, ESR, Hyperlipidemia, Hypertension, Ischemic stroke.
Arterial Pedal Arch Revascularization Impact on the Clinical Results in Critical Lower Limb Ischemia Igor I. Katelnitskiy
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: There are still many unresolved problems that reduce frequency of clinical and technical success of angioplasty of lower limb arteries. One of such problems is impact of the arterial pedal arch revascularization on the clinical result of angioplasty in patients with IV class critical lower limb ischemia according to Pokrovsky-Fontaine classification. Material and methods: The results of treatment of 98 patients with peripheral arterial disease (PAD), complicated by critical lower limb ischemia of IV class according to Pokrovsky-Fontaine classification were analyzed in the early postoperative period and 1 year later after the completed angioplasty. Patients were divided into two comparable groups: the first group-the patients with the arterial pedal arch revascularization, the second group – the patients whom it had been impossible to revascularize the arterial arch. Results: “Good result” in patients of the first group in the early postoperative period and one year later was 23.1% and 22.7% respectively. In the patients of the second group-9.2% and 5.6%. The both group patients avoided amputations in the early postoperative period, but one year later 53.3% of the second group patients with the “unsatisfactory result” underwent amputation. Conclusions: According to the results, the arterial pedal arch revascularization influences on the clinical results and decreases the quantity of amputations in patients with purulent-necrotic changes in the lower limb. Keywords: Critical low limb ischemia; Arterial pedal arch; Revascularization; Transluminal balloon angioplasty.
Administrative Possibilities of Academic Institutions and Their Correlation with Sports Tendencies of Students and Attitudes towards Practicing Sports Salam Hantosh Rashed
Journal of Global Pharma Technology .
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Abstract

The research aims to identify the availability of the administrative possibilities of academic institutions, sports and their correlation with the wishes and preferences of students, the sample included current research (367) students were chosen randomly stratified where they were taking the sample from the Department of Physical Education and Sports Science for the academic year (2017/2018), where the researchers developed a questionnaire consisting of (3) areas and (20) is distributed when the sample data analysis was used arithmetic averages and standard deviations using the bag statistical (SPSS). The most important results of the research, most sports establishments in the department of physical education and sports sciences neglected, as well as there is no supervisor for every sport activity of the programs of sports in the department of physical education and Sports sciences. There is no fitness related to health because of the lack of sports activities in the department of physical education and sports sciences, and the most important recommendations: The head of the department of Physical Education and Sports Sciences must provide all possibilities for students to exercise sports activities, and must provide supervisors of various activities for students in all disciplines and sports activities, and provide effective administrative possibilities through interest in the institutions of the department of physical education and mathematical sciences.Keywords: Administrative possibilities, Sports tendencies and practicing sports.
Different Technical Variables Affecting Noni (Morinda Citrifolia L.) Wine Fermentation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Noni (Morinda citrifolia L.) is one of the most important fruit which was widely used for its health restorative properties. It has been used an herbal medicine in various ailments. This fruit is considered a natural antioxidant. It can prevent cancer, heart disease, diabetes, cognitive dysfunction, hypertension etc., and maintain overall good health. Over the years, its popularity has been diminished due to unpleasant smell from the ripened fruit. There is limited study mentioning to processing of this functional fruit. Therefore we explored a wine fermentation from noni fruit by focusing on the effect of different variables such as sugar supplementation, yeast ratio inculation, fermentation time and temperature in the primary fermentation, and fermentation time and temperature in the secondary fermentation to noni wine quality (%v/v alcohol; g/l acidity; oBrix residual sugar; sensory score). Our results proved that the primary fermentation should be conducted with 15% sugar supplementation, 0.15% Sacchromyces cerevisiae at temperature 29.0oC in 10 days. The secondary fermentation was adequate in 9.5oC for 3 weeks to get a pleasant flavor and aroma. Noni wine also evaluated the antioxidant capacity and total phenolic content. Noni wine could be considered as a good source of antioxidants and phenolics ideal for daily healthy consumption.Keywords: Noni, Wine, Fermentation, Sacchromyces cerevisiae, Antioxidant, Phenolic.

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