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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Synthesis, Characterization and Study Some Thermal Properties of New Maleimide Polymers from Sulfadiazine Ehab Kareem Obaid
Journal of Global Pharma Technology .
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Abstract

Series homo  and  copolymers  of  N-substitution  maleimides  by convert Sulfadiazine to chloroacetyl sulfadiazine (compound G) by mixture  Sulfadiazine  and  chloroacetyl chloride in presence triethylamine in DMF as solvent, and then substitution of chloro group in compound G by hydrazine to prepare hydrazinyl chloroacetyl sulfadiazine (compound H), then amic acid derivative (I)  were prepared by reaction malic anhydride with (compound H). This compound convert to N-substitution maleimide by closed the ring to preparation the (monomer) compound (J) by use access of acetic anhydride and sodium acetate. Finally preparation of homopolymers (K) by reaction the monomer carried out with Azobisisobutyronitrile (AIBN) as a free radical initiator in DMF as a solvent, and preparation of two different copolymers by reaction (I) compound with (acrylamide and maleic anhydride) carried out with AIBN as initiator and DMF as a solvent, and then study thermal properties of prepared polymers by TGA and DSC. All synthesized compounds were identified by many spectroscopy methods including   FT-IR, 1H-NMR, 13C-NMR, and Mass spectroscopy.Keywords: Sulfadiazine, Amic acid, Maleimide, AIBN, homopolymaleimide, copolymaleimide.
Phytosterol Composition in Various Kinds of Red Beans Processing (Vigna angularis) Sugijanto Kartosentono
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The high level of blood cholesterol can be overcome by consuming phytosterols obtained from plants, especially nuts. One of the leading beancommodity in the society is red beans (Vignaangularis). This study aims to identify the content of phytosterols in red beans and the processing effect of phytosterols. Red beans sample which has been processed, was extracted with n-hexane, acetone, and hydrolyzed. The results of sample extraction were analyzed using the 6890 Series Agilent Gas Chromatography instrument with a Flame Ionization Detector (FID) and HP-5 column (5% Phenyl, 95% Methyl Siloxane). Phytosterol content in the form of campesterol, stigmasterol, and sitosterol was found in red bean samples. The most composition of stigmasterol was found in baked samples and significantly different from boiled samples (p
The Effect of Cognitive Interventions with Drug Control on Emotional-Behavioral Problems in Adolescents Mohsen Saeid Manesh
Journal of Global Pharma Technology .
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Abstract

The purpose of this study was to investigate the effect of cognitive intervention with drug control on emotional-behavioral problems in Adolescents. Being a quasi-experimental study, the research employed a pretest, posttest and follow-up (one month) design. The statistical population included bereaved Adolescents in yazd city in 2016. Of them, 30 students were selected via access sampling method, and were then randomly assigned into experimental and control groups. The measurement instrument was Goodman Strengths and Difficulties Questionnaire (Goodman, 1997). Experimental group received 8 sessions of cognitive intervention (each a 90-minute session). The results of analysis of covariance (with SPSS21) showed that cognitive intervention had significantly reduced emotional-behavioral problems in both in posttest and follow-up (P ≤ 0.05). Results also showed a significant difference between groups in all subscales including emotional problems, conduct problems, hyperactivity and peer problem in posttest and follow-up (P ≤ 0.05).Keywords: Cognitive interventions, Drug control, Emotional-behavioral problems, Adolescents.
Assessment the Aurora a Kinas Overexpression among Colorectal Adenocarcinoma in Iraqi Patients Ali A. Majeed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In the worldwide the colorectal carcinoma is  represented the most common gastrointestinal malignancy The cancer represent one of major causes of death after cardiovascular diseases in Iraq. Aurora Kinase a (AURKA) is a member of the serine/threonine kinas family as well refers as (STK15) or (BTAK) regulates the function of centrosome, spindles, kinetochores in mitotic and chromosomal instability. AURKA overexpression is observed in various cancers including colon cancer and depended on our knowledge there is no in our country about the expression of AURKA colorectal carcinoma patients. This study included fifty five blocks embedded in paraffin was 31 (56.36%) males and 24 (43.63%) females which were obtained from colorectal adenocarcinoma patients and all samples composed of 25 (45.45%), 20 (36.36%) had moderate differentiated and (18.19%) had poorly differentiated colorectal carcinoma. The ages of patients had ranged from 20 to 80 years, with a mean of (7.44±50.6  SE).In this study, Iraqi patients showed that the protein overexpression of AURKA by immunohistochemical technique was significantly difference among these grades (p=0.0001,r=552) with high expression in well-moderate than poor differentiated while the AURKA protein overexpression was non- significant difference among different stage tumor sizes (P value =0.1746, r=0.254) as well as, the results showed there were no significant differences between AURKA protein overexpression with the gender, age and lymph-vascular and perinural invasions (P value =0.613,r=0.078), (P value 0.812, r=0.356), (p=0.711,r=0.192) respectively. Conclusion: The AURKA biomarker may be used as prognostic factor of tumor initiation in Iraqi patients with colorectal adenocarcinoma.  Keywords: Iraqi patients, Colorectal Adenocarcinoma, AURKA.
Cultural-psychological Alienation and its Effect in Teaching the Ability to Stand on the Head in the Gymnastics for Students in College of Physical Education and Sports Sciences AWS Yousif Khelfa
Journal of Global Pharma Technology .
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Abstract

The basic ground-based movements in learning skills on all other devices, not without these skills difficulties. The problem of research is that there is a weakness in the orientation towards learning skills. The problem of research is summarized by the following question: Is psycho-cultural alienation the reason for the weak tendency towards learning skills or other reasons? What is the relationship between psycho-cultural alienation in the performance of this skill? To achieve the objectives of research will conclude the researcher to the actions achieved, including the identification of psychological alienation levels - cultural at the College of Physical Education and Sports Science students, and to know the relationship between psychological alienation - cultural and learn the skill of standing on the head. Is there a relationship of statistical significance between psychological and cultural alienation and the ability to stand on the head and the researcher used the descriptive method to suit the nature of the problem. The study sample was randomized to 30 students from the second stage of the Faculty of Physical Education and Sports Sciences, Thi-Qar University. It was found that there is a significant correlation between psychological and cultural alienation and learning the ability to stand on the head. So as not to attract second-stage students to practice skill. The teacher's failure to use the principle of reinforcement and correction of errors that may occur during performance leads to a poor approach to learning skills. The researcher recommended the use of a good method in the gymnastics to clarify and absorb the skill technique. And the need to use the principle of reinforcement. And the need to provide the appropriate educational environment.Keywords: Cultural-psychological alienation, gymnastics and Sports Sciences.
Van A Gene for Intestinal Bacteria Enterococcus faecium (E. faecium) Resistant to Vancomycin Venus H. Al-Saffar
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Out of 100 enterococcal strains clinical samples, a total of 59 (59%) Enterococcus faecium (E. faecium), 32 (32%) E. faecalis, 3 (3%) each of  E. casseliflavus, and E. avium, and 1 (1%) each of E. gallinarum, E. flavescens, and E. raffinosus  isolates were recovered, from burn, wound, and urine samples in Al-Hilla teaching hospital were identified to species level with a VITEK-2 system. For detection vancomycin resistance, all of enterococcus spp. isolates were tested by using multiplex PCR for (VanA, VanB, and Van C) genes. Results showed that only 5 isolates were resistant to vancomycin; 2 (VanA) genes were from E. faecium, 2 (VanB) genes were from E. faecalis, 1 (VanC) gene was from E. gallinarum.Keywords: VITEK-2, PCR.
Using of Whey Proteins as Antioxidant in Some Food Products Nahla Tariq Khalid
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Oxidation of foodstuffs has become an issue concerning with food quality and consumer health, specifically in dairy products which contain a percentage of fat. The present study aimed to use whey proteins concentration (WPC) as additive to some samples of dairy products selected from local market. Adding WPC to these products with different concentration demonstrated a good activity of whey proteins concentration as antioxidant. Lipid oxidation measured on the basis of malondialdehyde by determining thiobarbaturic acid (TBA). Results obtained show differences in TBA value before and after adding WPC. Adding WPC reduced the TBA value about half in collected samples, and that led us that the period of lipid oxidation with adding WPC will be longer than these samples used without adding WPC. Using this method to protect food products from lipid oxidation by adding WPC has been proved the activity of whey proteins as antioxidant in this research.Keywords: Whey proteins, Antioxidant activity, Foods products. 
Improving the Efficiency of Cloud Computing Services Using Cuckoo Search and Bee Colony Algorithms Mojtaba Aliabadian
Journal of Global Pharma Technology .
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Abstract

Nowadays, the tendency of organizations to use service-orientation instead of using applications is being increased day by day. Existence of port for the organizations and providing organizational services in frame of web services has enables users to use organizational services rapidly and easily via internet. The basic and initial services of the organization are provided for the users in frame of web services and through the organizational port. Cloud computing as a common computing model for the organizations and firms and even individuals is based on two types of servicing: the deployment location and the type of service provided. In order to meet needs of applicants in best way and to adjust the services rapidly with changed requirements, the services are combined to utilize capability of several available services within the organization or other organizations. In the issues of combining cloud services, one of the most important challenges is the issue of implementation time. As various services are existed in the cloud distributed space, the pace of the problem is large and selecting the optimal option is complicated and time-consuming in most cases. In this study, a new approach is presented for combination of services in cloud computing. The main objective of the proposed method is improvement of efficiency and reduction of implementation time for optimal selection of services available in cloud and consequently, combination of these services. Combination of the services in proposed method is done using combination of Cuckoo Search and Bee Colony Algorithms as the most important meta-heuristic in field of optimization. The way of using these algorithms in frame of proposed method to combine the services in cloud computing is presented in details and practical evaluation is also presented. The simulation results show that the proposed method could provide considerable improvement in field of efficiency criteria compared to similar algorithms.Keywords: Cloud computing, Cloud services combination, Cuckoo Search Algorithm, Bee Colony Algorithm.
Effect of Various Anticoagulants on Ethinyl Estradiol and Levonorgestrel Analysis in Human Plasma in Vitro by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry Yahdiana Harahap
Journal of Global Pharma Technology Volume 10 Issue 12.
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Objective: This research objective is to evaluate the different types of anticoagulant to ethinyl estradiol and levonorgestrel analysis in plasma using ultra performance liquid chromatography tandem mass spectrometry. Method: Chromatography condition was obtained with Acquity® UPLC BEH C18 column (1.7 µm; 50 x 2.1 mm); mobile phase consisting 0.1% formic acid in water – acetonitrile under gradient elution ; flow rate of 0.3 mL/minute; column temperature of 40ºC; injection volume of 10.0 µL; 5-minute analysis time and prednisone as internal standard. Sample preparation used protein precipitation followed by liquid-liquid extraction. Results: There was a linear result ranging from 5-500 pg/mL concentration of ethinyl estradiol and 100-10,000 pg/ml concentration of levonorgestrel. There was no significant difference for stability and recovery of ethinyl estradiol and levonorgestrel in citrate, heparin, and EDTA plasma (p > 0.05; ANOVA). However, significant difference for peak area ratio (p < 0.05; Kruskal Wallis), between citrate, EDTA, and heparin plasma was observed. Conclusion: Citrate and heparin plasma analysis had better result than EDTA plasma analysis.Keywords: Ethinyl estradiol, Levonorgestrel, Prednisone, EDTA, Heparin, Citrate.
Serum Levels of Zinc, Selenium and Homocystine among Iraqi Patients with Type-2 Diabetes Mellitus Aqeel Abbas Noaman
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background  and Objectives: ( The disease of  Diabetes  Mellitus ) is  a  main  medical,  economic and social   big problem,  because  the  high  pervasion  and increment incidence (of this depilating disease with )subsequent cascading of (several disabling complications) and it needs for special medical care. High prevalence of this disease) occur in Middle East.Its prevalence in Iraq increased from 5% in 1978 to19.7%in 2012). The current study initially focuses on the investigation of serum micronutrients [zinc (Zn), selenium (Se)] and homocystin (Hcy)] levels as well as their relatedness with (type 2 Diabetes Mellitus) in Iraqi patients. Subjects and Methods: This study was designed as a case - control investigation and conducted at diabetic center in Baquba General Hospital in Diayla, Iraq. This study involves 50 patients with type 2 DM and 25 apperently healthy, age and sex matched subjects for that represent as control group. The patients were classified into two sub-groups including, type 2 DM with nephropathy (33 patients) and type 2 DM without nephropathy (17 patients). (Fasting blood sugar, creatinine as well as some selected serum levels including two important micronutrients (Se, Zn) with addition and all of them were measured in each group. Results: The prevalence of DM Type2 was at age of 60 to ≥ 70 years. (Diabetes was more prevalent) in males than in females (58 % ,  42 % consecutively)  .The mean level of blood glucose  and creatinine (were  typically higher in  both diabetic groups) as compared to the control group (p = .000). Selenium level was lower in diabetic patients with a significant difference when it compared with healthy control. Study groups according to zinc level (p-value= 0.149) did not indicate a significant difference. In this study homocysteine levels was)higher in DM patients with nephropathy than diabetes without nephropathy (17.09±1.942 vs 16.72±2.323)  with statistically significant differences comparing  with the control group (6.74±0.946) No significant correlation  was  found among Zn , Se and Hcy with plasma glucose and creatinine. Conclusion: (The findings of the current research show obvious decreased in the serum Se among Type2 DM patients with and without nephropathy comparing with control. Additionally, serum homocystine levels were elevated regarding to the occurrence of diabetic nephropathy so it could be an indicator for observed DM and progression of DM nephropathy.Keywords: Type 2 Diabetes, Zinc, Selenium, Homocysteine.

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