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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis and Spectral Study of mono-ligand Complexes for Acriflavine with Some Metalions and Evaluation Their Antibacterial Activity Haya H. Abdul. Hameed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

In this study, a new seven complexes have been prepared from acriflavine (LCl) with metal ions VO (II),Co (II),Ni (II),Cu (II) ,Cd (II), Zn (II) and Hg (II) with mole ratio (M:L) (2:2) all complexes have general composition [M2(L1)Cl4(H2O)4]Cl2, [(VO)2(L1)2(SO4)2(H2O)2]Cl2in ethanol. The ligand and all complexes were characterized by modern spectroscopic(IR, UV_Vis , Mass, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements and molar conductance. In addition to evaluated their antibacterial activity against two type of bacterial. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry, the value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligandKeywords: Acriflavine, Acridine, Acriflavine metal complexes, Biological activity.
Antibiotic Susceptibility Patterns of Uropathogens Isolated From Catheterized Patients in Al-Imam Hussein Medical City in Holy Karbala Zahra M. Al-Hakak
Journal of Global Pharma Technology .
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Abstract

Objective: Indwelling urinary catheters (IUCs) are commonly used in hospitalized patients. Catheter-associated urinary tract infections (CAUTIs) are a major source of nosocomial infections in the worldwide. The present study was conducted to the etiological Bacterial pathogens of the UTI and to determine the antibiotic sensitivity pattern of pathogens isolated.  Methods: This study was carried out in AL- Imam Hussein Medical in holly Karbala city from (1st March, 2017) to (30st June, 2017).Total (300) urine samples were tested bacteriologically and for antibiotic susceptibility using standard procedures. Results: A total (300) patients,(111) by(37%) were female and (189) by (63%) were male with indwelling urinary catheters were studied divided into four groups according to hospital ward. The highest percentage of age group was seen in (36-45) years group. Uropathogens were isolated from (244) patients sample only. The bacterial isolates included E. coli (53), Pseudomonas aeruginosa (99), Klebseillapneumonia  (22), Staphylococcus aureus (20), Coagulase negative Staphylococcus (16), Candida albicans (14), Enterococcus faecalis (8), B hemolytic  Streptococci (6) and Serratiamarcesens (6). All isolated bacteria display variation in sensitivity and resistance pattern. Conclusions: This study observed that Pseudomonas aeruginosais the main organism which isolated from Catheterized patients caused UTI. In addition, the study showed that E. coli isolates were the predominant pathogens and showed increasing resistance pattern to the commonly drugs which used in present study.Keywords: Urinary Catheter, Urinary Tract, Infection, Antibiotic, Patterns, Holy Karbala.
Inhibitory Effect of Silver Nano Particles (AgNPs) Against Biofilm Formation in Multidrug Resistance P. aeruginosa Isolated from Burn infections Huda H. Al-Hasnawy
Journal of Global Pharma Technology .
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Abstract

P. aeruginosa is an opportunistic pathogen that display uncommon phenomena of antimicrobial resistance. It is important to reminder that more than (80 %) of bacterial infections are caused by biofilms. Disruption and inhibition of preformed biofilms can be accomplished using silver nanoparticles. Out of 40, 22 (55%)  P. aeuroginosa isolates were recovered isolated pathogen was subjected to antibiotic susceptibility test using disc diffusion test. Screening of silver resistance using silver nitrate also done by agar dilution method using different concentrations (100µglml-400µglm). Formation of biofilm was detected. Silver nano particles were prepared and tested for anti-biofilm activity using different concentrations ranging from (2.5µg/ml-20µg/ml) employing tissue culture plate method. P. aeruginosa isolates were recovered from burn unit at a percent (55%), those isolates were found to be multidrug resistance and silver resistance as following: (100%) for each of piperacillin, imipenem and Cefotaxime. While (88%), (65%), (62%) for amikacin, ceftriaxone and gentamicin respectively. Biofilm production was detected quantitatively by microtiter plate method (100%), qualitatively via congo red agar method (44%) in multidrug resistant P. aeruginosa isolates. The inhibitory effect of silver nano particles in formation of biofilm was estimated using tissue culture plate method using different concentrations ranging from (2.5µg/ml -20µg/ml) and show high inhibition rate at 20µg/ml. This study concluded that silver nano particles have good antibiofilm activity with small concentration that could be used as an alternative therapy in those opportunistic pathogen.Keywords: Silvernanoparticles, P.aeruginosa, Biofilm Inhibition, Biofilm Formation.
Studies on Anti-Inflammatory, Antioxidant and Free Radical Scavenging of Cu (Ii)-N-Acetyl-Para-Aminophenol (APAP) Based Complex Ouiza HAMRANI
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

N-acetyl-para-aminophenol (APAP) or paracetamol–copper based complex with [Cu(APAP)2(OH)2.H2O] formula and noted Cu-APAP has been synthesized and characterized on the basis of elemental analysis, conductivity, IR and thermal (TG/DTG), NMR and electronic spectral studies. The value of molar conductance of the complex indicates a non-electrolyte nature.The antimicrobial activity of the complex was evaluated against several pathogenic microorganisms to assess its potential. The copper complex was found to be more active against Gram-positive than Gram-negative bacteria. The pharmacological and toxicological ability of the complex were equally explored. The results are compared to those obtained with the unbound drug molecule.The metal complex has been tested for antioxidant and catalase-like activity in order to assess its catalytic properties. The results are encouraging.
A Thermodynamic Study of Adsorption 2-(4-Antipyriyl azo) Orcinol [APAO] on Zincoxide as Adsorbent Nuha Abdul-Saheb Ridha
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

We can remove Organic materials contaminated from their solutions in several methods, for examples the Adsorption. In this research was studies adsorption APAO which dissolved in 2.5% ethanol/water by the Zinc Oxide as adsorbent. The adsorption isotherms it was found similar to L4-shape according to Gilles classification. Also it studied the influence of adsorbent weight and adsorption time on removal% of APAO; it was 0.35gm best weight and 35 min. best time. The impact of changing the function of the acidic PH on removal% of APAO was found as follows (PH=4> PH=10> PH=7). The thermodynamic values were calculated (∆H, ∆G, ∆S) depending on changing temperature with concentration were (+24.74002KJ/mol, +9.4256KJ/mol, +51.390J/mol.K).
Synthesis, Structure and Antibacterial Activity of 1, 4-bis (1-benzimidazolyl) butane Complexes with some Transition Metal Salts Abbas Washeel Salman
Journal of Global Pharma Technology .
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Abstract

This study presents the synthesis, characterization and antibacterial activity of Mn2+, Co2+, Ni2+, Cu2+, Zn2+ and Ag+ complexes derived from the ligand 1,4-bis(1-benzimidazolyl) butane (Dbz). The ligand and its complexes were characterized by using different techniques including IR, Uv-Vis, 1H and 13C NMR and elemental analysis CHN. According to the abovementioned techniques, a polymeric structure was proposed to the prepared complexes. Further, the structure of Ag(I) complex was confirmed by single crystal X-ray diffraction technique which reveals the polymeric structure trigonal geometry around the Ag+ center. The in vitro antibacterial activity of the prepared ligand and complexes were tested against the standard Escherichia coli (E. coli ATCC 25922), environmental Bacillus sp. and 16 clinical bacterial isolates (both Gram-positive and Gram-negative bacteria) by using amikacin as a standard antibiotic. All the tested compounds except the Zn(II) complex showed antibacterial activities at minimum inhibition concentration (MIC) level, particularly, the silver complex which shows a significant activity with MIC = 15- 250 µg/ml.Keywords: Benzimidazole; Synthesis; Crystal structure; Metal complexes; Antibacterial; Silver.
Antioxidant Activity Assay of Combination of Purified Extract of Banana Peel (Musa Paradisiaca Sapientum) and Andrographis Paniculata Leaves Jastria Pusmarani M.Sc., Apt.
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Antioxidant is a compound that able to postpone, slowdown and prevent free radical reaction which able to postpone degenerative disease. Banana peel (Musa Paradisiaca Sapientum) and Andrographis paniculata contain flavonoid compound which have antioxidant activity. The aim of this study is to measure antioxidant activity of the combination of banana peel extract and Andrographis paniculata to DPPH free radical (2,2-difenil-1-pikrilhidrazil). Extraction process of banana peel using methanol, meanwhile Andrographis paniculata using ethanol 70%. Extract purification conducted using n-hexan and ethyl acetate. This study using combination of the purified extract of banana peel and Andrographis paniculata with the following comparison consecutively (1:10) (1:1) (2:1) (1:2) (0:1) concentration of  20,40, 60, 80 and 100 ppm, measured their antioxidant activity with DPPH method using visible spectrophotometry, thus resulted in IC50value. IC50value for the combination of purified extract of banana peel and Andrographis paniculata (0:1) as many as 256.76 ppm, the combination of purified extract of banana peel and Andrographis paniculata (1:1) as many as 140.33 ppm, the combination of purified extract of banana peel and Andrographis paniculata leaves (1:2) as many as 110.05 ppm, the combination of purified extract of banana peel and Andrographis paniculata (2:1) as many as ppm, the combination of purified extract of banana peel and Andrographis paniculata (1:0) as many as 184.13 ppm. The result can be concluded that combination of purified extract of banana peel and Andrographis paniculata have an antioxidant activity even though in moderate category included purified extract of combination of of banana peel and Andrographis paniculata with comparison (0:1) (1:2), (2:1), (1:1) and (1:0) have medium antioxidant activity.
Study the HLA Genotyping in Pulmonary Tuberculosis Patients in Babylon Province-Iraq Mohammed A. K. Al-Saadi
Journal of Global Pharma Technology .
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Abstract

This study aimed to investigate the role of Human Leucocyte Antigen (HLA-DRB1) alleles in susceptibility to pulmonary tuberculosis in Babylon/ Iraq population. Whole blood samples collected from 50 pulmonary tuberculosis patients who are admitting to consultant clinic for respiratory diseases in Hilla – Babylon province during the period from February 2016 to February 2017. Out of the pTB patients, there were 27 males and 23 females, the patients age range was 12-80 years. Sequence specific oligonucleotide (SSO) was used to genotyping HLA-DRB1.The distribution of HLA-DRB1 genotypes in 50 patients with pulmonary tuberculosis and 50 healthy controls studied. HLA-DRB1*13 was a significantly increased in pulmonary tuberculosis patients 48% as compared with healthy controls 16% while HLA-DRB1*15 was a significantly increased in healthy controls 24% as compared with pulmonary tuberculosis patients 6%.The genotyping of all HLA-DRB1alleles found more common in females 77% than males 23% from total number of patients. Also, HLA-DRB1*13 was more common in females 75% than males 25% with pulmonary tuberculosis patients while HLA-DRB1*15 was common in females 100% and no appeared in males.Keywords: Pulmonary Tuberculosis, HLA-DRB1, SSO.
Effect of Sonication to Protein Extraction from Jackfruit Seed (Artocarpus Heterophyllus) Flour Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Ultrasound technology is growing rapidly in the field of research and development of non-thermal food processing methods. Jackfruit seeds are not only nutritive, but also tasty. The flour from seeds is a fruit residue featuring alternative protein, carbohydrate and fiber source. A wide range of ultrasound power, treatment temperature, treatment time, ratio of liquid: solid have been investigated. Optimum conditions for the extraction of protein were found to be: sonication power of 30 W/g, sonication time 3 min, sonication temperature 45oC and solid-liquid ratio of 2.0: 1.0, and the extraction time of 30 min. Ultrasound is one of the emerging technologies that were developed to reduce the cost and time of processing. It ensures the quality and safety of food products. The use of ultrasound can enhance the extraction process by increasing the mass transfer between the solvent and plant material. Ultrasound in the use of plant extraction has benefits in increased mass transfer, better solvent penetration, less dependence on solvent used, extraction at lower temperatures, faster extraction rates and greater yields of product.Keywords: Jackfruit, Protein, Extraction, Sonication.
Study of Some Optical Properties of Poly Methylmethacrylate Copper Nanocomposites Films Nahida B. Hasan
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The addition effect of nano Cu on some optical properties for poly methyl-methacrylate has been investigated. Poly methyl-methacrylate with different weight percentages of nano Cu content and different thickness have been prepared. The wavelength range for which absorption spectra have been recorded is (200-800) nm. For indirect allowed and forbidden transition the absorption coefficient, extinction coefficient and energy gap have been determined. Results show an increasing in absorption coefficient and extinction coefficient and decreasing in the energy gap with the Wt.% concentration of nano Copper. Scanning Electron Microscope (SEM) Measurements certificates the compatibility between various components of the polymers and nano materials through the detection of phase separations and interfaces. All figures show the very detailed three-dimensional images at very high magnifications for all films.Keywords: Polymethyl-methacrylate, Nanoparticles, Nano-composites.

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