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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Fabrication of PS/PMMA/MgO Nano Composites: Structural and Optical Properties as Coating Materials for Antibacterial Applications Ahmed A. Auda
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Optical properties of P.S.P.M.M.A. polymer composite with doped MgO nanoparticles have been studied. The composite study was prepared by the solution of casting. Various concentrations were used for polymer material P.S- P.M.M.A/ (75 %-25 %). The weight ratios for Nano material (MgO) were 0 %, 2 %, 4% and 6 % of the total weight for the 1g sample. The optical spectrometers were measured at a wavelength of 220 nm-890 nm using a FTIR device optical properties of PS such  as  absorbance,  transmittance, absorption  coefficient, refractive  index,  extinction  coefficient,  real   and  imaginary  parts  of dielectric constant have been investigated. The results of the test on the refractive index, the attenuation coefficient and the insulation constant in its real and imaginary parts give good results with increasing the concentration of nanoparticles. The composite materials of polymer and nanoparticles were applied as antibacterial to Pseudomonas bacteria and they give the concentration (0.02 and 0.04 MgO) a good effectiveness to those bacteria.Keywords: Optical properties, Polystyrene, PMMA, Pseudomonas Bacteria.
Synthesis and Characterization of Some New 1,3-Oxazepine and 1,3-Diazepine Derivatives Combined with Azetidine-2-one Ruaa Wisam Adam
Journal of Global Pharma Technology .
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This work involved prepared of some new series of chemical compounds of 1, 3-oxazepineand 1, 3-Diazepine derivatives. First step reaction of sulfadiazine with 4-amino acetophenone product of Schiff base (A) 4-((1-(4-aminophenyl) ethylidene) amino)-N-(pyrimidin-2-yl)benzenesulfonamide. Then, Schiff base [A] enter reactions with chloro acetyl chloride to product four-membrane ring  (B) 4-(2-(4-aminophenyl)-2-methyl-3-oxoazetidin-1-yl)-N-(pyrimidin-2-yl)benzene sulfonamide (B) were condensed with different aromatic aldehydes such as (p-hydroxybenzeldehyde, N,N-dimethylaminobenzeldehyde] in ethanol absolute   to give new Schiff  bases derivatives [B1-B2] respectively, Then the  resulting  imines  derivatives [B1-B2] were reacted  with  malic  anhydride  in toluene  to give new 1,3-oxazepine-4,7-dione ring derivatives [B1a-B2a] ,reaction 1,3-oxazepine[B2a] with Naphthyl amine to give 1,3-diazepine-4,7-dione ring derivatives[C].All compounds were characterized by M.P and FT-IR spectroscopy, some of them were characterized by 1H-NMR and C13NMR spectroscopy analysis.Keywords: Sulfadiazine, 4-aminoacetophenone, Azetidine-2-one, 1, 3-Oxazepine, 1, 3-Diazepine.
Study and Analysis of Raw Water and Drinking Water in Garma District, Anbar Province, Iraq Bashar Abdulazeez Mahmood
Journal of Global Pharma Technology .
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Abstract

The study included physical, chemical and biological laboratory measurements of raw water and potable water in Garma district in Anbar province in several areas (Central Garma, New Garma, Sabihat, Sabihat 1, Sabihat 2, Al-Sager, Al-Habib, AlBukhlifa, Al Busheihan, Abautai, Karagul, Dwaya, Buakakul). A comparison was made between the values of the laboratory-measured variables and their measured values in the Directorate of the Central Garma Water Project as well as their comparison with the Iraqi and international standards for drinking water. The modeling process began in September 2017 until March 2018. The study includes physical measurements (temperature, electrical conductivity, turbidity, suspended solids and dissolved solids) and chemical measurements of (pH and positive ions calcium, magnesium, sodium, potassium and Negative ions sulphates, chlorides, and total hardened bases) and biological measurements (M\Plate count1). The study showed variation in values from the Iraqi and international standard limits where there was an increase in the values of electrical conductivity and concentration of magnesium and sulphate. The rest of the values did not exceed the standard values. Linear and back linking and correlations between chemical and physical measurements of different water models were also found for all study areas using SPSS.
Prevention of Oral Health in Persons with Tobacco Smoking of Steam Cocktails Elena Emelina
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Recently, tobacco smoking has an epidemiological character. The largest number of smokers, according to many studies, was found between the ages of 30 and 35. Studies conducted by the World Health Organization (WHO) indicated that if a young man smoked at least two cigarettes, 70 out of 100 would continue to smoke for life. Due to the increasing prevalence of tobacco smoking, WHO began to consider smoking not only as a bad habit, but also included tobacco dependence in the International Statistical Classification of Diseases and Health Problems (10th revision); Class V: Mental and behavioural disorders; group: Mental and substance use behavioural disorders; heading: Mental and behavioural disorders caused by tobacco use (code F 17). Keywords: Oral hygiene, Tobacco smoking, Hookah smoking, Health, Safety, Smoker.
Frequency of Hepatitis B and C Sero Markers Among Hemophiliacs and Von Willebrand's Disease in Alkut, Iraq. (2017) Safaa A
Journal of Global Pharma Technology .
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Abstract

Objective: Blood-borne infections, such as the hepatitis B and C, are major problems in patients receiving blood products. The aim of this study was to determine the frequency of occurrence  of hepatitis B and C viruses among hemophiliacs in AlKut city, Iraq. Methods: A cross sectional study of 50 patient having hemophilia and VWD  registered in hematology center in Al Karama hospital in AlKut city, Was it state, Iraq , in 2017. And evaluated for the presence of hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV-Ab). Demographic data of patient's age at time of diagnosis, sex, ABO blood group and type of treatment were also recorded and analysed .Results: 50 patients presented with bleeding disorder, 41  patients diagnosed as hemophilia [ 100% in male] and 9 patients diagnosed as von wille brand's disease [33.3% are male and 66.7 % was female] . 66% of them have proved to have +ve family history, and 16% have –ve family history, and 18% not yet proved. 42.9% (15 patients) of all investigated patients (35 patients) was sero positive for hepatitis B& C. 8.6% (3 patients) and 31.4% (11 patients) had hepatitis B and C respectively. 2.9% (1 patient) had both of them. 53.3% (8 patients) of patient with +ve hepatitis infection had diagnosed to be having coagulopathy (hemophilia & von will e brand's disease when they was below 10 years, 26.7% (4 patients) between 10 – 20 years and 20% (3 patients) was above 20 years. 4 VWD patients underwent viral screen , 50% of them were +ve for hepatitis C and 50% were ve for all hepatitis types. 31 hemophiliac patients underwent viral screen, 41.9% were +ve { 9.7 % (3 patients) had hepatitis B, 29% (9 patients) had hepatitis C, and 3.2% (1 patient) had both of them} .patients with coagulopathy receive treatment as cryoprecipitate and factor VIII and IX . 66.7% of hepatitis B sero positive patients had received cryoprecipitate, 90.9% (10 of all 11 patients) of hepatitis C sero positive patients had received cryoprecipitate, and the patient who had both types of hepatitis also receive cryoprecipitate.  Conclusion: Management of transfusion of blood and blood products should account for the underlying prevalence of infectious agents, And the risk of getting these infections increased with increasing the period and frequency of exposure to them.
Proapoptotic Effect Annona muricata Leaf Extract on HT29 Colon Cancer Cell Abdullah Kshidan M
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

The occurrence of colon cancer has rapidly increased across the globe and currently ranks among the third highest disease difficult to treat with drugs. Therefore, there is need for the use of natural compound in its treatment. Graviola (Annona muricata) leaf has several anti-apoptosis and proliferation active compoundswhich make the colon cancer induced by constitutive activation of NF-KB. This experiment therefore, utilized leaves of Annona muricataextracts obtained from Materia Medica in Batu. The leaves were found to inhibit cell proliferation by MTT assay and also induced apoptosis by Annexin V and Flowcytometry with the ability to inhibit NF-KB expression present in nucleus cells. The crude extract of Graviola leaves inhibits cell proliferation and increases apoptosis and through the inhibition of NF-KB pathway. It also increases the apoptosis of HT29 cell.
Evaluation the protective impact of Cape gooseberry (Physalis peruviana L.) extract against benzo(a)pyrene induced DNA damage and gene expression change in male rats Lamiaa M. Salem
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Natural bioactive compounds have been increasingly investigated against carcinogenic agents to prevent tumour progression. Thus, several active ingredients exist in different herbs and medicinal plants exhibited preventive impact against benzo(a)pyrene (BaP) induced carcinogenesis. In the present study, the efficacy of Cape gooseberry fruit (CGF) extract was investigated against BaP induced genetic toxicity in Swiss albino male rats. Male rats (n=90) were allocated in several groups exposed to BaP and/or several doses of CGF extract (100, 150 and 200 mg/kg b.w.). Assessment of DNA damage, generation of DNA adducts and expression alteration of stress (Hsp70a, CYP450) and antioxidant (GST) related genes were conducted. The results showed that treatment of BaP-exposed rats with different doses of CGF extract was able to prevent the genetic toxicity in the forms of DNA damage and DNA adducts as well as gene expression alteration induced by BaP. The results suggested that CGF extract-BaP interaction may reflect the extract efficacy against genotoxicity induced by chemotherapeutic drugs that are metabolized by antioxidant enzymes.
The Impact of the Training Programme using Water environment Exercises with Laser in Partial Rupture of the Connective Muscles and the Kinetic Performance of the Football Players Ahmed Redah Mohamed
Journal of Global Pharma Technology .
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The introduction to the research has shown that the incidence of sporting activities is a phenomenon that does not correspond to the health goals of the athlete, and the injuries are not limited to higher levels but are at all levels. football is one of the most aesthetic and vulnerable games and its various forms, both for the competitor and for the player itself, the limited use of modern methods and techniques used in rehabilitation that do not result from the use of any negative side effects and can be used for all ages, different stages and all parts of the body in order to increase the impact on the maximum level of rehabilitation of the injured and return to the practice Sports activities. Hence the importance of research in the establishment of exercises within and outside the aquatic environment and through the laser in rehabilitating those with connective muscle rupture and solving the problem as soon as possible, and the problem of research is that there is a lack of rehabilitative curricula that take practice within and outside the aquatic environment for the rehabilitation of infected players and that most Rehabilitation programmes related to the treatment of the connective muscles lack the use and disregard of modern methods and techniques during the rehabilitation of the injured in such type of infection (the rupture of the connective muscles) and the return of the athlete to the exercise of athletic activity before reaching full recovery.The Research objectives to:Preparation of rehabilitation exercises within the water environment in order to rehabilitate and improve the partial rupture of the connective muscles and the kinetic performance of football players who represent the clubs of the governorate of Baghdad.Identification of the effect of the rehabilitation programme using in-house exercises with the laser in the partial rupture of the connective muscles and the kinetic performance of the football players.Recognition of the preference for the impact of tests (Pretests and posttests) on the members of the experimental search sample.The research hypotheses are as follows:Exercises prepared within the water environment have a positive effect in the rehabilitation and improvement of the partial rupture of the muscles of the plug and the performance of motor for football players. There is a positive effect in the members of the group that used exercises within the water environment accompanied by the laser in the rehabilitation and improves the partial rupture of the muscles of the plug and the performance of motor for football players.There is a preference for the effect between tests (Pretests and posttests) and in to post-test.The search sample (10) included players with partial rupture of the connective muscles, and the researcher used the experimental method to fit the nature of the research as the researcher carried out the pretests tests, after which the qualifying program was applied for 8 weeks, in the case of (3) weekly units, and after the completion of the application Qualifying program the researcher performed the following tests to extract the results after presenting, analyzing and discussing them and to see the significance of the differences between the tests and the extent to which the program contributed to the development of the variables.A number of conclusions were reached:Exercise within the water environment and the laser device helped to improve the motor performance and strength of the macrophages of the injured players.Was the best development for the tests of fitness and strength of the connective muscle and the degree of pain in favor of the post-test?Keywords: Training programme, Water environment, Partial rupture and connective muscles.
The effect of Saccharomyces cerevisiae on the serum creatinine levels of chronic kidney disease mice model besut daryanto
Journal of Global Pharma Technology Volume 11 Issue 6.
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Title: The Effect of Saccharomyces Cerevisiae On The Serum Creatinine Levels of Chronic Kidney Disease Mice Model Besut Daryanto, M.D, Ph.D *, Givary Dymar Lazuardi, Dewi Mustika, M.DDepartment of Urology, Faculty of Medicine, Universitas Brawijaya, Indonesia*Author: Email: besut.daryanto@yahoo.co.idTel.: +628123104879; Fax: +62341333030 AbstractIntroductionChronic kidney disease is pathological condition with various causes, resulting in a progressive loss in kidney function and then ended in end-stage kidney disease. Chronic Kidney Disease become a health problem in the world with increasing number of patients, high progressivity, and bad prognosis. Saccharomyces cerevisiae which has high beta glucan content can increase the level of granulocyte-colony stimulating factor (G-CSF) in the body. The increase of G-CSF level will elevate the excess of hematopoietic stem cell (HSC) in the circulation. The excess HSC can regenerate damaged tubular cells. The study used serum creatinine levels as a marker of improved kidney function. The objective of this research is to determine the effect of S. cerevisae to the serum creatinine levels of mice model with chronic kidney disease and to determine the correlation between dose of S. cerevisae extract and serum creatinin levels of chronic kidney disease mice model.Materials & MethodsThis in vivo experimental study used a randomized post test only controlled group design. The samples were divided into five groups, each group consists of 5 mice, that were negative control group, positive control group, Treatment Group 1 (Aristolochic Acid + S. cerevisae extract 50 mg/kg), Treatment Group 2 (Aristolochic Acid + S. cerevisae extract 100 mg/kg), Treatment Group 3 (Aristolochic Acid + S. cerevisae extract 200 mg/kg). The induction of chronic kidney disease were using aristolochic acid 2,5 mg/KgBW 5 times a week for 2 weeks. The variables measured in this research is the serum creatinine levels.ResultsStatistical data obtained shows that the average number of serum creatinine levels at negative control group was 0,3788 mg/dl in the positive control was 0,6425 mg/dl; in the treatment 1 was 0,4575 mg/dl; in the treatment 2 was 0,3850 mg/dl; in the treatment 3 was 0,3263 mg/dl. ANOVA test results showed significant difference between groups (p < 0.05)Conclusions S. cerevisae was able to decrease the serum creatinine levels of chronic kidney disease mice model and there were correlation between increased dose of S. cerevisae and decreased in serum creatinine levels. Keywords Beta Glucan, Saccharomyces cerevisae, serum creatinine levels, Chronic Kidney Disease
Comparison of Age-Related Hearing Loss in Diabetics and Non-Diabetics Patients Nader Saki
Journal of Global Pharma Technology .
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Background and Objectives Presbycusis refers to symmetrical and bilateral hearing loss which occurs with aging. Diabetes mellitus affects multiple systems of the body and causes conditions that are often irreversible. The aim of this study was to compare age-related hearing loss in diabetic patients and non-diabetics. Methods & Materials In this study, 42 diabetic patients who visited the Diabetes Center of Ahvaz were randomly selected. Forty-two non-diabetics who visited the otolaryngology center not complaining of hearing problems were randomly selected as the control group. Audiometry (AZ26 interacoustic Co. Denmark)  is done for all subjects. Independent t-test was used to compare the two groups. The Mann-Whitney test was used for ordinal variables, while the chi-square test was used for qualitative variables. The analyses were conducted using SPSS version 20 Results The findings showed an increased prevalence of hearing loss in patients with diabetes.  The bilateral hearing loss was observed in both diabetics and non-diabetics but its prevalence was significantly higher in the diabetic group (P value<0.05). Conclusion Hearing loss was more prevalent in diabetics than non-diabetics, while hearing thresholds were affected in all frequencies of audiometry.Keywords: Diabetes; Age-related hearing loss; Presbycusis; Audiometry.

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