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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Prevalence of Osteoporosis and Osteopenia in Iraqi Premenopausal and Postmenopausal Subjects among a Sample of Patients Attending Baghdad Teaching Hospital Ali Hussein Al-Hafidh
Journal of Global Pharma Technology .
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Abstract

Back ground: Osteoporosis is a major public health problem and more common in women and older people Objective: to determine the prevalence of osteoporosis and osteopenia in premenopausal and postmenopausal subjects attending Baghdad teaching hospital  Methods: A cross sectional study was carried out for a period of one year in Baghdad teaching hospital Results:   A total of 240 subjects were included in this study, they were divided into 2 groups: the first group included 120 postmenopausal women with a mean age (59.93±6.88) and the second group included 120 premenopausal women with a mean age (46.36±4.07).Significant differences of bone mineral density of lumbar spine and both femurs between postmenopausal and premenopausal subjects. The percentage of osteoporosis and osteopenia in premenopausal was (26.7%) and (3.3%) respectively and in postmenopausal subjects was (34.17%) and (52.5%).T-score was used for postmenopausal subjects and Z-score for premenopausal subjects. The percentage of osteoporosis and osteopenia was higher in lumbar spine in both postmenopausal and premenopausal subjects than femurs. Normal BMD of right femur was higher than left femur in both postmenopausal and premenopausal subjects. Conclusion: The prevalence of osteoporosis and osteopenia in premenopausal was (26.7%) and (3.3%) and in postmenopausal subjects was (34.17%) and (52.5%) respectively. The percentage of osteoporosis and osteopenia was higher in lumbar spine in both postmenopausal and premenopausal subjects than femurs. Recommendations: Essential measures are needed for public education particularly dietary habit, lifestyle modification and widespread distribution of information about osteoporosis and its prevention.Keywords: Osteoporosis, Osteopenia, Postmenopausal, Premenopausal.
Nanocrystal Technology as a Tool for Improving Dissolution of Poorly Soluble Drugs Manar Adnan Tamer
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Many approaches have been developed over time to counter the bioavailability limitations of poorly soluble drugs. With advances in nanotechnology in recent decades, this issue has been approached through the formulation of drugs as nanocrystals. Nanocrystals consist of pure drug(s) and a minimum of surface active agent(s) required for stabilization. They are carrier-free submicron colloidal drug delivery systems with a mean particle size typically in the range of 200 - 500 nm. By reducing particle size to nanoscale, the surface area available for dissolution is increased, and thus bioavailability is enhanced. Drug nanocrystals constitute a versatile formulation approach to enhance the pharmacokinetic and pharmacodynamic properties of poorly soluble drugs. This enhancement is achieved by increasing the dissolution velocity, saturation solubility and mucoadhesion. However, stabilization of nanocrystals remains a major challenge in the development of nanocrystals. Main stability issues include increase in particle size, agglomeration, crystal transformation, and chemical instabilities. as such, combination of steric and ionic stabilizers are required for optimal stabilization. Nanocrystals can be administered by various routes including oral, parenteral, ocular, pulmonary and dermal routes with enhanced pharmacodynamic activity and safety. Functionalization of nanocrystals with radionuclide, imaging moieties and ligands further increases the versatility of nanocrystals. Nanocrystals has been proven successful, as demonstrated by the number of marketed drug products utilizing this technology. The present work provides an overview of the more recent achievements in improving the bioavailability of poorly soluble drugs according to their administration route, and describes the methods developed to overcome physicochemical and stability related problems.Keywords: Nanocrystals, Poorly soluble drug, Nanotechnology.
The Effect of Cu-doping on the Optical Properties of ZnFe2O4 Films Prepared by Chemical Spray Pyrolysis Method Salim Azara Hussain
Journal of Global Pharma Technology .
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Abstract

In this work, the effect of the copper doping on Optical properties of zinc Ferrite precipitated on the glass Substrate of quartz, with  ratios of Cu (x= 0,0.1,0.3,0.5,0.7,0.9) using the method of chemical spray Pyrolysis of thickness(300 ± 15nm) at a temperature (400 ± 10 oC) and annealing (520 oC) for range of (4h) the Optical properties have been identified of films wavelengths of (300-900) nm , it has been found that the energy gap before doping(2.86 eV) the energy gap increased to increase the proportion of doping the ratios (x=  0.1,0.3, 0.5) the energy gap at ratios (x= 0.7 ,0.9) also found that the highest value of the coefficient of absorption at the ratio (x=0 .9) and the value of(3x104).Keywords: Absorption factor, Optical conductivity, Energy gap, Deflection.
Investigation of Star Gooseberry (Phyllanthus Acidus) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

The star gooseberry fruit is pendulous, bear in small clusters from the branches, round or slightly flattened at the poles. Gooseberry fruit is rich in antioxidants including ascorbic acid and phenolic compounds. It is an important herbal medicine due to its effective antiviral activities. Effect of primary fermentation temperature (26oC, 28oC, 30oC, 32oC), sugar to pulp ratio (4, 8, 12, 16% w/w), Saccharomyces cerevisiae inoculation (1.0 x 108,1.5 x 108, 2.0 x 108, 2.5 x 108 cfu/g) on ascorbic acid (mg/ 100 mL), total phenolic content (mg GAE/ 100 mL) and total flavonoid (mg CE/ 100 mL) content of Phyllanthus acidus wine were thoroughly investigated. The aging (1, 2, 3, 4 weeks) was also examined to improve the turbidity (mJ/cm2) and sensory score of wine. The optimal conditions for fermentation of Phyllanthus acidus juice should be conducted at 12 days of primary fermentation with 12% of sugar supplementation inoculated with 2.0 x 108 cfu/ml of Saccharomyces cerevisiae and 4 weeks of aging to get pleasant physico-chemical characteristics of Phyllanthus acidus wine. Phyllanthus acidus wine was red-pink, clear and transparent. This present study revealed that horticulture farmers would get more added values from Phyllanthus acidus fruits not only by local commerce but also processing. It could be processed by fermentation and conversion into high valued wine.Keywords: Phyllanthus acidus, Wine, Fermentation, Sacchromyces cerevisiae, Ascorbic acid, Phenolic, flavonoid.
Antirheumatoid Artritis Effect of Purslane Herb Extract (portulaca oleracea l.) to Rat (rattus norvegicus) Induced by Complete Freuds Adjuvant Rizqi Nur Azizah
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the joints of hands and feet. The research on antirheumatoid arthritis of ethanol extracts from Purslane (Portulaca oleracea L.) and effective doses of antirheumatoid arthritis. The research used 15 rats divided into 5 groups. Group 1 (1% Na-CMC); group 2 (prednisone) with the dose of 0.511 mg / kgBW; group III, IV and V were given ethanol extract of purslane doses of 100 mg / KgBW, 200 mg / KgBW and 400 mg / kgWW. The animal model of rheumatoid arthritis was made with intraplant injection of 0.1 mL Complete Freund's Adjuvant. The parameters observed were leg volume measurements and arthritis index. The leg volumes of data were analyzed by One Way Anova test followed by the L test while the arthritis index used the Kruskal-Wallis test followed by the Mann-Whitney test. In leg volume measurements, ethanol extract from the red root dose of 400 mg / kg reduced leg volume by 52.49% (p <0.05). Whereas in the arthritis index parameter, the ethanol extract from purslane dose of 400 mg / kg is significantly reduced the arthritis index (p <0.05) with arthritis index reduction by 50%. In conclusion, the ethanol extract from the purslane (Portulaca oleracea L.) with a dose of 400 mg/kg has better activity in treating rheumatoid arthritis in rats.Keywords: Antirheumatoid arthritis, Portulaca oleracea L., complete freund’s adjuvant.
Toxicopaphological Effects of Intravenous Injection of Layer Double Hydroxide (LDH) Nanoparticles in Male Rats Samia Kh. Mahmood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The rapid growth of using nanoparticles in different field of science, lead to the urgent necessity to study the toxicpathology of this submicron particle. Layer Double Hydroxide NPs have qualified features such as bio-compatibility, ion exchange and pH effect which make LDH NPs potential candidate for various biological applications such as drug delivery. Hence, in this study Mg-Al LDH NPs have been prepared by co precipitation method and injected intravenously. Twenty rats were divided into two groups as follows: Group I: Rats served as control and injected 1ml of distilled water intravenously for one month. Group II: Rats served as experimental and received by I/V injected in the tail vein 1ml of 0.00276 of Mg-Al LDH NPs g/ml. daily for one month. The sizes of LDH NPs have been measured by SEM which resulted size ranging between 50- 80nm in diameter. The liver, kidney, heart, lung, spleen and testes were examined histologically. The toxicopathological results were very severe in kidneys, lung, spleen and heart, while being moderate in liver and testes. In general, all organs showed necrotic changes with inflammatory cell infiltration, congestion and thrombosis in blood vessels.Keywords: LDH, Toxicopathological study, Nanoparticles, Rat.
The Effect of Continuous Feedback on High Service Learning According to Wrist Joint Modeling for Junior Squash Players Nouman Hadi Alkhazraji
Journal of Global Pharma Technology .
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Abstract

The research problem concentrated on lack of effectiveness learning for high serve skill of squash players. Plenty of technical mistakes in skill performing, lack of use of feedback and not specifying the appropriate time by the coach commensurate with stages of skill learning. Therefore, the researchers sought to emerged the ongoing feedback through the unites to learning the high serve skill of squash to increase the effectiveness of learning and accelerate it, and the continuous correction of mistakes in order to the learner can master the skill with the least numbers of mistakes. However, the aims of the research were to identify the effect of continuous feedback on learning the high serve skill of squash junior players and to identifying the superiority of the differences between the effects of continuous feedback in learning the two skills of high serve among squash junior players. However, the researchers used the experimental approach (Equal groups design) with pre and post-tests. The research population involved (22) squash junior players in the Babylon university. The researchers have been equalization a number of variables in the experimental and control groups which may impact on the results later. Nevertheless, the research results showed A positive effect of the using of continuous feedback units on learning and developing skillful performance for the high serve skill of squash junior players. In addition, the experimental group has improved as a result of the use effect of continuous feedback in learning the two skills of high serve among squash junior players comparing to the control group.Keywords: Continuous feedback, High serves wrist joint, Modeling and squash.
SPECTROGRAPHIC ANALYSIS OF TITANIUM ALLOYS IN PROSTHETIC DENTISTRY A.S. Utyuzh
Journal of Global Pharma Technology .
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This paper considers changes in the chemical composition of titanium alloys according to the method of their treatment. It investigates the chemical composition of three original samples of titanium alloys, three samples after their casting and three samples after their milling. It is revealed that different methods of alloy handling lead to dissimilar changes in its chemical composition.Keywords: Spectrographic analysis, Titanium, Casting, Milling, Billet.
Adsorption Effect of the Modified Chitosan-Methionine Beads on Human Serum Lipids Profile and Total Protein Ahmed Saleh
Journal of Global Pharma Technology .
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This research is concerned with one of the most important applications of surface chemistry which used in medical, physical and biochemistry.Place of conducting the research University, Faculty and Department. The research is based on the adsorption of lipid profile and total protein from human serum on the surface of  modified chitosan- methionine which are associated with two different types of cross linkers substances: glutaraldehyde with two different concentration (3.13,6.25%) to prepared beads type (A,B) respectively, and ethylene glycol diglycidylether (EGDE) to prepared beads type (C). The formed beads were characterized by using Infrared (IR) spectroscopy to confirm the cross linking reaction and using Scanning Electron Microscopy (SEM) to describe the surface of the beads that used in this research. UV-Vis spectrophotometer was used to determine the concentration of the adsorbents before and after the treatment. As for adsorption of lipid profile (total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and total protein (TP)), it was observed that the adsorption of adsorbents on prepared beads type(A,B and C) followed the order (type C > type A > type B), while in case of  (high density lipoprotein (HDL-C)) , it does not adsorbed or adsorbed very little in some cases on the surface of prepared beads. Keywords: Adsorption, Adsorbent, Chitosan, Methionine, Glutaraldehyde, Ethylene glycol diglycidyl ether, Lipid profile and total protein.
In Vitro Determination of Antioxidant activity, total phenolics, total flavonoids, anti-cholesterol of extracts Saffron (Crocus sativus) Muhammad Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Background: In Indonesia, saffron (Crocus sativus) drinks are now the latest healthy lifestyle trend. Saffron is used as a natural antioxidant, where antioxidants are related to cholesterol inhibition. The antioxidant activity of saffron is closely related to the content of flavonoids and phenolic compounds. This study aimed to determine Saffron 50% ethanol extract's effect on antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC), and anti-cholesterol. Methods: Inhibition of antioxidant activity with 2-diphenyl-1-picrylhydrazyl DPPH, determining TPC using Folin-Ciocalteu and TFC reagent using AlCl3 reagent, and anti-cholesterol with Cholesterol Standard. Results: TFC 19.14 ± 0.9 mg QE / g, TPC 4.8 ± 0.9 mg GAE / g, antioxidant activity with extract IC 50 6939.02, Quercetin 9.57, Rutin 41.70, and decreased the greatest cholesterol occurred at a concentration of 400 ppm with a decrease of 13.22%. Conclusion: The 50% saffron ethanol extract can be an antioxidant and anti-cholesterol in vitro, but it needs further testing in vivo with the same extract.

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