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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Environmental Impact of Pharmaceuticals and Personal Care Products Amean A. Yasir
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Medical waste is considered to be a hazardous waste of a special nature due to its high toxicity and its toxic and radioactive chemicals and its ability to develop diseases. The extent of the presence of germs and viruses in the medical waste and the amount of dose and exposure method and the extent of resistance of the body to these microbes. Medical waste includes the waste of isolation rooms for patients with infectious diseases, residues of bacteria, infectious and biological agents, waste of sterilization, disinfection, blood, serums and plasma, and pharmaceutical residues. This guide provides an overview of hospital waste generating processes and presents options for minimizing waste generation through source reduction and recycling. Reducing the generation of these materials at the source, or recycling the wastes on or off site, will benefit hospitals by reducing disposal costs and lowering the liabilities associated with hazardous waste disposal. The hazardous wastes generated by general medical and surgical hospitals are small in volume relative to those of industrial facilities; however, the wastes are of a wide variety. Some of the hazardous materials used by hospitals that become part of their waste streams include chemotherapy and antineoplastic chemicals; solvents; formaldehyde; photographic chemicals; radionuclide’s; mercury; waste aesthetic gases; and other toxic, corrosive and miscellaneous chemicals. Additional wastes such as infectious waste, incinerator exhaust, laundry-related waste, utility wastes, and trash are not addressed in this guide. The results showed that most hospitals in Basra lack systematic application of the concept of solid waste management and lack of awareness among medical waste workers. All waste incinerators in hospitals are old, operate under temperatures of less than 400 ° C and are therefore a source of toxic gas emissions Dioxin Intermediates. Ashes of incinerators, which contain a percentage of toxic heavy metals and pathogens, are put into domestic waste in landfills and thus make its impact the environment is highly negative in terms of pollution and disease transfer. Misuse of residues with chemical drugs they are used to treat cancer patients and treat them as other medical waste, as exposure to such waste are very dangerous to workers because of their ability to kill human cells or cause malformation.Keywords:Medical waste, Hospital waste, Environmental pollution, Hazardous materials.
Treatment Strategy for Pediatric Patients with Kawasaki Disease in Tertiary Referral Hospitals East Java Indonesia: A Retrospective Study Yulistiani .
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objectives : Giving therapy to pediatric patients with Kawasaki syndrome is crucial in terms of healing and prevention of potential complications. This study aim to analyzed the treatment of pediatric patients with Kawasaki Syndrome at the Tertiary Referral Hospital in East Java, Indonesia. Methodology : This retrospective study involved 16 patients aged ≤ 18 years with a diagnosis of Kawasaki Syndrome in the 2013-2016 time series. Sampling uses a non random sampling technique. Medical record data related to the history of the disease, treatment, and the resulting outcome were analyzed descriptively. Results: Child patients receive treatment therapy in different amounts, types and doses based on the status of the patient and clinical manifestations that appear. The main therapy was given to patients namely acetosal  (94%) and IVIG  (50%), and corticosteroids ; methylprednisolone, prednisone (44%). Oral acetosal use is 80-100 mg / kg body weight as anti-inflammatory until the fever falls and 3-5 mg / kg body weight as platelet anti-aggregation as long as the patient does not show coronary artery abnormalities within 6 to 8 weeks, the IVIG dose is 2 g / kg weigth, and the dose of methylprednisolone is 10-30 mg / kg for 3 to 10 days. Conclusion: Giving treatment adapts to the patient's needs and is in accordance with the recommended standards.Keywords: Treatment strategy, Pediatric, Kawasaki syndrome, Referral hospital.
Degradation of Erythromycin in Seafood Products by Different Thermal Treatments Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Prawn (Macrobrachium rosenbergii) and tilapia (Oreochromis niloticus) are two important seafood farming species cultivated in Mekong river delta, Vietnam. Intensive aquaculture of these species has high risk of disease outbreaks caused by virus, bacteria, fungi, and other pathogens. Erythromycin is the most widely used antibiotic in the macrolide. Erythromycin has a low cytotoxicity for aquaculture. Prawn and tilapia intended for export have to meet the antibiotic residue standards of the importing countries. In the present research, different factors affecting erythromycin residue on prawn and tilapia muscles after thermal treatments were carefully investigated. The present results proved that among frozen, cooked, oil-fried and baked methods; the oil-frying treatment strongly degraded erythromycin at 86.88% in prawn and 87.02% in tilapia samples. Thermal processing by oil heating medium at high temperature caused a significant degradation in the concentration of erythromycin residue.Keywords: Prawn, Tilapia, Erythromycin, Thermal, Degradation, Antibiotic residue.
The Influence of Witley's Constructivist Model in Learning a Rapid Attack Collective for Students in Handball Huda Majid Rashid
Journal of Global Pharma Technology .
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Abstract

The current study aims to identify the effect of Witley's constructivist model in learning the rapid collective-handball attack of students. The researchers used the experimental approach, while the research society included the fourth phase students (76) students. The research sample reached (60) students. Through the findings, the researchers reached several conclusions, the most important of which are:There is a positive development of the two groups in the study of learning rapid attack individual and collective handball.The experimental group that used the Witley's model is superior to the control group in the post tests.The educational units prepared by the researchers had a positive role in learning the rapid attack collective handball students of the experimental group and superior to the control group.Keywords: Witley's constructivist, Model, Rapid attack and handball.
Targeted Systems in Cancer Treatment Yuliya Tikhonova
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The World Health Organization (WHO) estimates that in 2015 cancer was the first or second leading death cause before the age of 70 in 91 out of 172 countries, and ranked third or fourth in the other 22.  This study analyzes three main types of targeted cancer therapies: low molecular weight inhibitors; monoclonal antibodies; and immunotoxins. The low molecular weight inhibitors analyzed in the paper are Gleevec, Sprycel, VEGF targeting, Nexavar, Tykerb, Iressa, EGFR and HER2 Targeting, Torisel. The monoclonal antibodies include VEGF, EGFR and HER2, Herceptin, Avastin, CD20, Rituxan, Zevalin, Campath. The DAB389IL-2 (or Ontak - FDA Approved Medication for the Treatment of Acute T Cell Lymphoma) represents immunotoxins. It proves that depending on the location of the unregulated protein, different approaches are implemented. Monoclonal antibodies can block interactions and functions of unregulated proteins within the extracellular compartment, while low molecular weight inhibitors can reach proteins that are within the cell compartment. Currently, many of these drugs are used in combination with traditional cancer treatments to increase patient survival. As it was found, VEGF inhibitors, for example, Avastin, increased in low concentrations the survival time of patients with metastatic colorectal cancer from 13.8 to 21.5 months.Keywords:  Low molecular weight inhibitors, Gleevec, Pro-angiogenic molecules, Monoclonal antibodies.
Formulation and Evaluation of Oral Disintegrating Film Containing Lisinopril for the Effective Management of Hypertension and Cardiac Diseases Velayutham Pazhanivel
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

This study was aimed to develop oral disintegrating film (ODF) containing an anti-hypertensive drug Lisinopril. Five trial formulations (F1-F5) of Lisinopril ODF were prepared using Hydroxypropyl methylcellulose E15 (HPMCE15), Polyvinyl pyrrolidone (PVPK30), Polyethyleneglycol400, Polyplasdonexl, Mannitol, Peppermint oil, Propylparaben, Citric acid, and Allura red. The prepared formulations were evaluated for their Physico-chemical characters like weight, thickness, surface pH, folding endurance, and disintegration time. They were also evaluated for the content of Lisinopril. The above studies revealed that formulations trial F4 was better than other Formulations. Because, it has exhibited faster disintegration time (21.32 sec) when compared to the other formulation. So, F4 was selected for stability study (40ᵒC,75% RH) for six months and Scanning Electron Microscopy (SEM). The results of the above studies have shown that F4 was stable and has a uniform distribution of Lisinopril.
The Salient Features of Twin Language Development Peyman Rajabi
Journal of Global Pharma Technology .
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Abstract

Multifarious studies indicated that twin language has some prominent features, evinced from the onset of life, as compared closely with single-born children.The current paper intends to illustrate the characteristics of twin language by taking account the following key issues:The effect of genetic or environmental factors on language acquisition (naturevs. nurture).Mother and other older siblings’ interaction to promote the extent of twin language (nurture).The rate of understanding and misunderstanding of twins’ speech.The phonology quality of twins.The language problems which school-age twins more likely encounter in elementary school.This paper arrives at the conclusion that the growth of language acquisition, within twin children, in some suffers from lack of features of language aspects but in some other areas, the percentage of flaw is rare. This typically requires running some further research to expound the momentous issues of twin language due to generalizingwithout any problem.On genetic factors, linguistic discordant takes place but not in a way that leads to raze the construction of communication .In this respect, postnatal factors play crucial role to hamper to imping later language disorders. This lies on the roles of older siblings or parents, particularly mother, who are cognizant of their duties to pave the way for twins to procure language development with ease. Ascribing phonology deficit solely to twins but not on singletons is unfair and a sheer bias approach.Decoding of twin language sounds baffling in the rudimentary steps of interaction among children even the parents but this problem will be resolved by establishing situations to have more engagement with them. Determining commensurate plans by principles in schools, like social-action games and other cooperative activities pave the ground for the twins not to see merely one sibling on their side but variety of imitations, vocabularies of different social class, use of jargons and all aspects of expressive language.Keywords: Genetic, Environment, Maternal speech, Phonology, Misunderstanding, School-age.
The Effect of Capital Gain Tax on Capital Formation, Financial Development and Economic Growth, “Case Study of Selected Europe Union Countries” Majid Sameti
Journal of Global Pharma Technology .
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Abstract

The effect of tax on economic activities is an important issue in public finance. The fact that the existing system may decrease the investment motivation and consequently decrease the future life style is a great crisis. In addition to, the effects of tax system on capital formation, it can affect financial development and economic growth.  In this paper, by simultaneous equations system in GMM method, the impact of capital gain tax on the capital formation and financial development in selected Europe Union countries (Austria, Belgium, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Irelands, Italy, Netherlands, Spain and Sweden), will be studied in panel form. The results indicate that the capital gain tax growth rate, with one lag, increases the physical capital formation growth rate. Also, capital gain tax growth rate, with one lag, decreases the financial development growth and increases the economic growth rate. Keywords: Capital gain tax, Capital formation, Economic growth, Simultaneous equations system, GMM.
Extraction of Poly Phenols from Cladium Mariscus Seeds and studying its Antifungal Activity with Isolation and Identification of one Compound of Flavone Glycosides Husam M. Kredy
Journal of Global Pharma Technology .
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Abstract

Cladium mariscus is one of the plants belonging Cyperaceae family. It is a common plant in AL- Hammar marshes, eastern - south of Iraq. The aim of the present study was extraction poly phenols from C. mariscus seeds by using an ultrasonic-assisted extraction method. The yield of poly phenols extracted by this method was (0.43% w/w). One compound was isolated from the methanolic extract of the plant seeds. The structure of the new compound was identified via the basis of extensive spectroscopic analyses (UV-Vis, IR, 1H NMR, and Mass),  and some chemical test. Acacetin glycosides were expected compound, and the methods of spectroscopy showed that there are three molecules of hexagonal sugars linked with aglycone. The antifungi activity of methanolic extract was examined against fungus: A.flavus, A.fumigatus and C.albicans, by using the well disk diffusion method. The extract showed a clear inhibition effect against fungal at (50 %, 75 % and 100 % w/v) concentrations.  Key words: Ultrasound-assisted extraction, Cladium mariscus, Acacetin glycosides, Antifungal.
Nicotine and Amino Acids Binding, A Theoretical Studies Huda N. Al-Ani
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The binding of twenty Amino Acids to Nicotine, has been studied theoretically by using (DFT) Density Functional Theory of (HF) type, as well as the semi-empirical method (PM3) calculations are carried out by (MOPAC) computational packages, to calculate the molecular orbital's energies and some molecules properties. The studied system was: Cysteine (Cys), Methionine (Met.) and Valine (Val.) with Nicotine. The optimized geometry of the complexes showed interaction  between Nicotine  and  three Amino Acids molecules, Cysteine (Cys), Methionine (Met.) and  Valine (Val.), the binding energies for these interaction were calculated, the binding energies for these interaction varies from -5.188 to -7.223 Kcal.mol-1. Which attributed to the formation of hydrogen bonding   between the studied molecules as it agrees with IR- experimental data .Binding to proteins is an important determinant of the kinetics .Which restricts the unbound concentration and effects the distribution and diminution of it.Key words: Nicotine, Amino Acids, binding, Density Functional Theory (DFT).

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