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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Evaluation of some Virulence Factors, Hemagglutination and Agglutination of Antigens of Acinetobacter baumannii Isolated From Clinical Samples Fatima Rammadan Abdul
Journal of Global Pharma Technology .
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Abstract

A total of 50 clinical samples, isolated from various sources include blood septicemia, urine (UTI), wound and burn swabs and swabs of ear (otitis media). The isolates were identified according to the microscopical , morphological ,cultural, and biochemical tests, in addition to using VITEK-2 compact system. Results showed that (12) isolates were characterized as A. baumannii.  Frequency of positive A. baumannii clinical isolates was higher in blood (50%), followed urine (25%).  The sensitivity of isolates to eight antibiotics, the result showed highly level of resistance for most antibiotics and multi-resistance antibiotics. It was found that all (100%) of bacteria isolates were resistant to Ampicillin and Cefazolin, while Imipenem and Tobramycin were the most effective antibiotics. The isolates showed the ability of biofilm production by Congo red agar method (CRA), 7 (58.3%) isolates positive biofilm production, while 5(41.7%) isolates are non-biofilm production. Consequences of phenotype were demonstrated 4 (33.3% %) of the detaches were protease production, while (8) isolates (%66.7) were not producers of this enzyme, while Sera proteins of patients’ infected by A.  baumannii showed reactivity with A.  baumannii antigens (whole cells ) as :two A. baumannii antigens agglutinated in titer  1:64  of patients sera ( antibodies ) while  6, 3 , 2 ,5 of A. baumannii antigens agglutinated in the patients sera in titer (1: 8 ,1:16,1:128,1:256) respectively. Thee hemagglutinin of A. baumannii may be a virulence factor in the pathogenesis of infection; However, results founded a good correlation between ability of biofilm formed and the hemagglutination. Keywords: Acinetobacter baumannii, Virulence factors, Biofilm, Hemagglutination.                 
Effect of Oct3 Genetic Polymorphism on the Response of Metformin in Type 2 Diabetes Mellitus: Narrative Review Swathi Swaroopa Borra; Bhavya Chebrolu; Poojitha T; Sujin Bright F J; Sadagoban GK; Arun Kanniyappan Parthasarathy
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
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Context: Metformin, the first line therapy of Type 2 Diabetes Mellitus is known to be transported by OCT3 (Organic Cation Transporter 3). Polymorphisms in this gene may lead to interindividual differences in the response to metformin. Objective: This study aims to compile and summarise the effect of OCT3 polymorphism on effect of metformin. Methods: PubMed/MEDLINE, ResearchGate, Google Scholar, Cochrane Library and Scopus were used for literature review. Cmax (Maximum concentration), Tmax (Time to reach maximum concentration), AUC (Area under the curve) and Kel (Elimination rate constant) were used to assess pharmacokinetics and HbA1c (Hemoglobin A1c), blood glucose levels for pharmacodynamics. Results: Data extraction showed that 19 OCT3 polymorphisms were analyzed in various ethnic communities with the plurality of Asians. The results of these genotype alleles were found to be favorable (9), negative (3) and have no impact (7) on the response of metformin. A positive effect on metformin response was expressed as higher Cmax (Maximum concentration), AUC (Area under the curve), lower Kel (Elimination rate constant) or reduced HbA1c (Hemoglobin A1c), FBG (Fasting blood glucose). Conclusion: Influence of OCT3 polymorphisms on metformin responses were unique to the population. This recommends new research requirement on association between OCT3 polymorphism and Metformin.
Feasibility of Bitterness Reduction in Bitter Gourd (Momordica Charantia) Dried Powder By Blanching, Enzyme, and Wall Material N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Momordica charantia, commonly known as bitter gourd has been traditionally used to treat diabetes and its complications. Several medicinal properties of the bitter gourd have been studied such as anti-diabetic, anti-ulcerogenic, antimutagenic, antioxidant, anti-tumour, anti lipolytic, analgesic, abortifacient, anti-viral, hypoglycemic and immunomodulatory. Medicinal value of bitter melon has been attributed to its high antioxidant properties due in part to phenols, flavonoids, isoflavones, terpenes, anthroquinones, and glucosinolates, all of which confer a bitter taste.  However, oral consumption of bitter gourd products could be a problem due to the bitter taste. Bitter taste should be eliminated. β-cyclodextrin is one of the most common materials used in microencapsulation process. β-cyclodextrin comprises seven units of glucopyranose. An attempt studied the feasibility of bitterness reduction in bitter gourd dried powder by treatment of blanching (100oC in 10s; 95oC in 15s, 90oC in 20s, 85oC in 25s), enzyme (florosil 2g/100ml and naringinase 8 mg/100ml), and wall material (β-cyclodextrin, sodium alginate, carrageenan, pectin). Reduction of bitterness and enhancing palatability are obviously observed by treatment of Momordica charantia dried powder by blanching 100oC in 10s, enzymatic treatment with florosil (2g/100ml) + naringinase (8 mg/100ml) and spray drying at inlet temperature 155oC, out let temperature 85oC, feed rate 15 ml/min with β-cyclodextrin 0.5% as wall material. Keywords: Momordica charantia, Dried powder, Bitterness, β‐cyclodextrin.
Quality efficiency indicators of pharmacy management: characteristics, current features, opportunities and threats of the development Iryna Volodimirivna Pestun
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The purpose of this work is a comprehensive research, analytical study and systematization of the pharmacies` management (networks) feature and trends in Ukraine in accordance with qualitative criteria. The objective is to determine the features and possibilities of improving the quality of pharmacies' management (networks), existing threats (risks) of their achievement, which allowed to highlight the topical issues and directions of the decision in the management of pharmacies and their networks. On the bases of scientific literature, regulatory documents, statistical data, information sites of the Internet and structural-logical, analytical methods, generalization, comparison, grouping, and formalization of reasoning were identified problems and trends in this area. The main groups of qualitative criteria for the pharmacies’ (networks) management effectiveness are: provision of pharmacy (network) management process; managerial decisions making; customer service; social management efficiency; the personality of the head; work with personnel. According to the results of the research, individual differences in ensuring the effective management of pharmacies and their associations (networks) are highlighted. It is shown that qualitative indicators of effective management of pharmacies (networks) are characterized by their dependence on the social and economic processes in society, changes in legislation, state and change of health protection, implementation of government social programmes, market and pharmacies informatization, consumer attitudes to treatment and their solvency, etc.Keywords: Pharmacies, Qualitative criteria of management efficiency, Possibilities of strengthening the management efficiency qualitative criteria, Threats.
Kinetic Games and Their Impact on the Development of Some Adaptive Abilities and Behavioral Psychological Compatibility of Students with Slow Learning Ammar Khaleel Ebrahim Al-Ezzi
Journal of Global Pharma Technology .
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The interest in childhood and caring for the important trends in the present time because of the great impact in building their physical, dynamic and emotional as it is the basis on which to build the rest of his future life, the more well prepared by satisfying his needs in a suitable way to achieve psychological balance and social helped to build a personality from Where the strengths and weaknesses, and the researchers' observation of this class of students slow learning separated from their peers in one row and integrated only in the study of physical education and sports sciences and hence the importance of research by helping this group to become people The aim of the study was to identify the effect of motor games on the development of some adaptive abilities and the behavioral psychological compatibility of students of slow learning. The researchers hypothesized that kinetic games had an effect on the development of some compatibility abilities and behavioral psychological compatibility of learning slow learners. (10) Learning slow learners. After performing Pretests of some compatibility abilities and behavioral psychological compatibility, exercise exercises were performed for 9 weeks with two teaching units per week. The researchers found that there are significant differences for some compatibility abilities and behavioral psychological compatibility of the Pre and post-test and for the benefit of the post-test. The researchers attributed the reason for this to the effectiveness of motor games within the educational units as they were the age and abilities of the students, which helped satisfy their desires as a result of emptying their negative emotions and towards good performance The researchers recommend the need to use motor games, competitions and ball games that develop muscular compatibility as well as the establishment of courses for teachers of special education to develop the mental abilities of students slow.Keywords: Motor games, Harmonic abilities, Behavioral psychological compatibility and learning disabilities.
Contribution of Equilibrium Variables with the High Spike Accuracy of the Position Diagonal Center (4) in the National Volleyball Team Players Ban Faisal Al-Azzawi
Journal of Global Pharma Technology Volume 11 Issue 6.
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What is important about this study is whether there is a relationship between the ability to balance and beating overwhelming for the Iraqi national team volleyball? The study aims to identify the percentage of the equilibrium contribution and its variables with the accuracy of the skill of beating the high spike Diagonal center (4) in the players. In the national volleyball team season (2016-2017), the researchers used the descriptive approach in the style of associative relationships to suit the problem of research. The research community included all the players specialized in the high beating of the Iraqi national team applicants in the ball The researchers concluded that the equilibrium variables contributed accurately and quickly to the high landslide of the region (4), and the researchers recommended the emphasis on the stability exercises, which showed a significant contribution and impact in the accuracy And the speed of beating the Diagonal high ground, and the adoption of tests of accuracy and speed in the assessment of the level of the ballots in the national team because it gives greater realism to the level of training.Keywords: High spike, Accuracy and diagonal center.
CRUSADE Bleeding Score as a Predictor for the Risk of Bleeding Events in Patients with Acute Coronary Syndrome: A Prospective Study from Tamil Nadu Aneena Suresh
Journal of Global Pharma Technology Volume 12 Issue 10 (2020) Oct. 2020
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Background: The CRUSADE bleeding risk score is an accurate and robust risk-stratification tool for predicting hemorrhagic complications in patients with Acute Coronary Syndrome (ACS). However, studies assessing and validating this score especially within Indian population are scarce to almost non-existent. Objective: To evaluate the Crusade Bleeding Score in predicting the risk of bleeding events in patients with acute coronary syndrome. Methods: This cross-sectional study was conducted at a secondary care hospital in Tamil Nadu, India. A total of 72 patients with ACS on treatment with anti-thrombotics that fulfilled the inclusion criteria of the study were prospectively recruited. The patient’s demographic data along with their past medical history pertinent to the study was collected and the scores for each patient was calculated. Results: Significant major bleeding was found among considerably older, female patients, diabetic and hypertensive patients, as also among patients having lower GFR values. Five patients classified under the Very High-Risk Category of the CRUSADE bleeding score further went on to develop hemorrhagic complications thereby validating the score among the study population. Conclusion: The CRUSADE bleeding score was found to be an accurate predictor of bleeding events within our study population with good validity. We further recommend the suitable use of the CRUSADE bleeding risk score in clinical practice as there is a need for stronger evidence to support the use of risk stratification systems to optimize therapy and improve patient outcomes in India.
Work’s Environment Effect on Metal and Male Reproductive Hormones Levels: Circulating Testosterone, LH, and FSH are Positively Associated with Cadmium, Lead, and Molybdenum Farha A.Ali Shafi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Objectives: The present study was carried out to investigate the concentration cadmium (Cd.), lead (Pb.), and molybdenum (Mol.) in blood samples of petrol stations workers and its relationships with the male reproductive hormones levels such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and Testosterone. Methods: This study included 31 workers in 4 petrol station in different sites of Thi-Qar city/Iraq, who were working since more than 5 year in the petrol station and spend more than 12h work time, and ten healthy in different sites of a same city. Both groups age were ranged from 23 to 45 years old. Heavy material (Pb, Mo, and Cd) were determined by atomic absorption method using Shimadzu AA-7000 Dual Atomizer system. Hormones level (FSH, LH, and testosterone) were determined by enzyme linked fluorescent assay (ELFA) using the Bio Mérieux VIDAS Automated Immunoassay System. Results: Our results found significantly higher Cd, Mo, and Pb levels in Petrol workers compared to control (p<0.05). While no significantly differences were detected between FSH levels in control and Petrol workers groups, significantly higher testosterone level was found in Petrol workers compared to control (p<0.05). Conversely, significantly lower LH level in Petrol workers group than it in control group (p<0.05). Conclusion: the petrol station workers exposure to Cd, Pb, and Mol which lead to increase its levels in their blood due to neglect the occupational safety instructions. Thus associated positively with the testosterone level and negatively with the LH level in their blood.
Association of Tumor Necrosis Factor-α-308 gene Polymorphism with Psoriasis in Babylon Province Mona N. Aterehi
Journal of Global Pharma Technology .
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Psoriasis is an immune mediated skin disease with wide-world prevalence involves both genders and different age, it a multifactorial disease influenced by genetic and environmental factors. The current study objectives to evaluate the association of Tumor Necrosis Factor-αgenes polymorphism (SNPs) with psoriasis by PCR-RFLP while there serum levels determined by ELISA. Methods case-control study (64) patients with psoriasis and (38) apparently healthy people as control matched with disease group. All samples collected in Marian Medical City in Babylon Province. Polymorphism (SNPs) determined by Polymerase Chain Reaction (PCR), restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing techniques, while there serum levels determined by ELISA .Results this study revealed a significant increasing of TNF-α in patients compare with controls (P<0.01). Also, there a significantly regression between severity of disease and TNF-α serum level (-r=0.49, p=0.0001). Genetically, analysis of the Single Nucleotide Polymorphisms PCR-RFLP genotyping for TNF-α -308 SNP, Genotype distribution in patient were AA 5 (7.81%) ,AG 24 (37.50%) and GG 35 (54.69%) while in control 10 (26.31%), 16 (42.11%) and 12 (31.58%) respectively. Conclusion: The massive majority of single nucleotide polymorphism in the TNF-α gene have a clinical importance concerning psoriasis. There is an interaction among the single nucleotide polymorphism of TNF-α gene and it is serum level.Keyword: Psoriasis, Tumor Necrosis Factor-α polymorphism, PCR-RFLP Polymorphism.
Synthesis New Polymeric Composite Materials Derivatives from thiosemicarbazide Maha T. Sultan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this work tow monomers were prepared by using Thiosemicarbazide free-radical polymerization was used to polymerize monomers one with itself to produce tow polymers (P1, P2) and the second with Nano silica grafted meth acrylic acid to produce tow Nano composite (C1,C2) All the prepared compounds were characterized by FT-IR Spectroscopy. The structures of standard Nano silica and Nano composite were studied by Atomic Forces Microscopy (AFM).The X-ray diffraction offer information on molecular structure configuration of the Nano composite after modification which showed different in intensity between Nano silica and their Nano composite.Keywords: Triazole polymer, Nano composite, Modification.

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