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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Biological Control of Fungal Brown Spot Disease in Rice Plants by Streptomyces spp. Farqad Fathi Hasan
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

This study used thirty isolates of streptomycetes were isolated from different locations of soil. All these isolates were subjected for antagonistic test (as biological control agents) against Brown spot fungus Bipolaris oryzae. About 43% of  tested  streptomycetes  isolates  gave  antifungal  activity  against Brown spot fungus but 57% of  tested  organisms  did  not  reveal  any  antifungal  activity. The highest antifungal activity were obtained from two isolates (42 mm and 45 mm), both streptomycetes isolates were identified according to International Streptomyces Project (ISP) based on morphological (macroscopic and microscopic) and physiological characterization as Streptomyces orientalis and Streptomyces exfoliatus.Keywords: Biological control, Streptomyces orientalis, Streptomyces exfoliatus, Bipolaris oryzae, Brown spot disease.
Extracellular Biosynthesis of Silver Nanoparticles using Fusarium Graminearum and their Antimicrobial Activity Hamzia Ali Ajah
Journal of Global Pharma Technology .
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Abstract

Synthesis of silver nanoparticles (AgNPs) has become a needful field of used science. Biological production silver nanoparticles have been more benefit in the formulation of new pharmaceutical products. In this study we report extracellular of silver nanoparticles by Fusarium graminaerum. The fungal aqueous mycelial extract when added aqueous silver nitrate solution (1Mm) leads to the manufacture of silver nanoparticles extracellular. The silver nanoparticles were characterized by Atomic force microscopy. In visual analysis color change of silver nitrate solution into brown signifies the development of silver nanoparticles. and the antibacterial activity of Ag NPs produced was evaluated against some local pathogenic microorganism isolates, Staphylococcus aureus , Pseudomonas aeruginosa , Streptococcus spp ,  Klebsiella spp , E. Coli and Candida albicans, using the well diffusion method. Our results showed that the Ag NPs were produced by Fusarium graminaerum and their sizes 94 nm. Moreover Ag NPs proved excellent antimicrobial activity with zone of inhibition ranged between 15 to 35 mm.Keywords: Silver nanoparticles, Fusarium graminaerum, Antimicrobial activity, Atomic Force Microscopy.
Investigation of Pineapple (Ananas Comosus) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Pineapple is a wonderful tropical fruit having exceptional juiciness, vibrant tropical flavor and immense health benefits. Pineapples are consumed as fresh, cooked, juiced, and fermented in a wide array of food stuffs. This fruit is highly perishable and seasonal.  Therefore we explored a wine fermentation from pineapple by focusing on the effect of different parameters such as Pectinex Ultra SP-L concentration and time of treatment for juice extraction, yeast inculate for wine fermentation, and secondary fermentation to wine quality. Our results proved that 0.4% Pectinex Ultra SP-L was used for juice extraction, 0.75% sacchromyces cerevisiae was used for the main fermentation at 11.5oC, and 3 weeks of sencondary fermentation in dark bottle at 9.5oC was applied to get a pleasant pineapple quality.Keywords: Pineapple, Wine, Fermentation, Sacchromyces cerevisiae, Pectinex Ultra SP-L.
PHYTOCHEMICAL SCREENING AND ANTICANCER ACTIVITY OF HYDROALCOHOLIC EXTRACT OF NAREGAMIA ALATA W&A abi raami
Journal of Global Pharma Technology .
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Abstract

Objective:The objective of the study was to evaluate the phytochemical and anti-cancer activity of hydroalcoholic extract of Naregamia alata.Naregamia alata (family Meliaceae) is used by various tribal communities and forest inhabitants for the treatment of a variety of diseases. The leaves and stems, combined with bitters and aromatics, are given in decoction for the treatment of biliousness.  Naregamia alata has been used in traditional medicines in India and in the treatment of rheumatism, itch, malarial and chronic fevers, wounds, anaemia, enlarged spleen, ulcers, vitiated conditions of pitta and vata, halitosis, splenomegaly, scabies, pruritis, dysentery, dyspepsia and catarrh. Methods The hydro alcoholic extracts of Naregamia alata was analysed for the presence of flavonoids, alkaloids, glycosides, steroids, phenols, saponins, terpenoid, cardiac glycosides and tannins according to standard method. Cell lines of  Dalton’s Lymphoma Ascites (DLA), Ehrlich Ascites Carcinoma (EAC)  methods have been used in experimental studies of anticancer activity. In the present study, cell lines induced cancer in mice was used to evaluate the anticancer activity. Results: The results of the present findings were the potential of the selected plant as a resource for the discovery of novel anticancer, agents. Conclusion: In this investigation the various parameters proven that the antitumor activity of hydroalcoholic extracts of Naregamia alata, in DLA and EAC tumor bearing mice.Key words: Naregamia alata, phytochemical screening, anti-cancer.
Synthesis of Polymers Containing 5, 5-Dimethylhydantoin and Study of its Optical Properties Ali J. Al-Zuhairi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this research work, four aromatic polymers, known as 5,5-Dimethylhydantoin  derivatives. 5, 5-dimethylimidazolidine-2,4-dione have been condensed with different dihalolkanes (1,2-dichloroethan and dichloromethane respectively) to give  two different poly hetero aromatic polymers. Also 5,5-dimethylimidazolidine-2,4-dione have been treated with chloroacetic acid and polymerized with ethylene glycol and hydroquinone respectively to give two different polyester polymers. The prepared polymers have been identified using FTIR and 1HNMR instruments. All the prepared polymers have shown a high number average molecular weight (Mn) using Gel Permission Chromatography (GPC) technique. Where absorbance was measured by using a device (UV-Spectroscope).The optical properties of the prepared polymers have been studied. The transmittance, absorption coefficient, had been measured. Transmittance values of the four prepared polymers increases with increasing wavelength due to the decrease in absorption values because the transmittance is inversely proportional with absorbance. The absorbance values of the prepared polymers have been decreased with increasing the wavelength. The absorbance spectra of the polymer solution of the concentration (0.3 g/mL %) for polymer N2 and the concentration (0.2 g/ml %) for polymer N3 within the range (200-1100 nm).The highest absorbance value (310 nm) for polymer N2 and (330 nm) for polymer N3. the absorbance spectra of the polymer solution of the concentration (0.3 g/mL %) for polymer N4 and the concentration (0.2 g/ml %) for polymer N5 within the range (200-1100 nm).The highest absorbance value (310 nm) for polymer N4 and (330 nm) for polymer N5.Keywords: Absorption coefficient 5, 5-Dimethylhydantoin, Optical properties, Polymers.
Synthesis, Characterization, Antimicrobial of Studies New 2,2'-{(1Z,2Z)-ethane-1,2-Diylidenebis[(2Z) Hydrazin-1-yl-2-ylidene-1,3,4-oxadiazole-5,2-diyl]}Diphenol and their Transition Metal Complexes Azhar Hameed Gatea
Journal of Global Pharma Technology .
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Abstract

A new ligand 2,2'-{(1Z,2Z)-ethane-1,2-diylidenebis[(2Z)hydrazin-1-yl-2-ylidene-1,3,4-oxadiazole-5,2-diyl]}diphenol and its Cr(III) , Co(lll) and Ni(ll) complexes were synthesized . The ligand and its complexes were characterized by elemental analysis, conductance measurements, as well as spectroscopy (H1NMR, IR, mass), magnetic susceptibility. A new ligand and its complexes were screened for their antibacterial activity against two kinds of strains Escherichia coli (gram negative bacterial strains) and staphylococcus aureus (gram positive bacteria strains) using the agar disk diffusion method.
Purification and Characterization of Karadi Sheep Milk Proteins Jasim M. S. Al-Saadi
Journal of Global Pharma Technology .
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Abstract

The distribution of nitrogen in Karadi sheep milk showed protein nitrogen to be 94.6% of the total nitrogen, non-protein nitrogen 5.4%, casein nitrogen 72.9% and whey nitrogen protein 21.7%. β-Lacto globulin (β-Lg), α-lactalbumin (α-La), κ-casein (CN), αs-CN and β-CN were purified from sheep milk using gel filtration and ion-exchange chromatography. The molecular weights of the purified α-La, β-La, κ-CN, β-CN and αs-CN were 14.01, 18.05, 21.3, 24.8 and 24.95 kDa, respectively. Phosphorus levels in κ-CN, β-CN and αs-CN were 3.14, 7.84 and 11.75 mg/g protein respectively. Κ-CN contained 49.1 mg carbohydrates/g protein.Keywords: Sheep milk, Protein purification, Chromatography, Caseins, Whey proteins.
A review of mobile applications for diabetes: could it replace the role of professional health care? Lusy Noviani; Ajeng Diantini; Anas Subarnas
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background: The prevalence of diabetes is increasing year to year, despite various attempts to reduce prevalence have been made. The role of professional health teams (PHTs) is critical to manage diabetes progression. Advances in technology such as Mobile Applications (MA) have provided new opportunities to support the success of diabetes treatment. This article aims to provide a critical analysis of the challenges that are not fully fulfilled and highlights directives for future research that can enhance the implementation of MA in diabetes management. Methods: A systematic review has been conducted. A number of articles related to mobile applications and diabetes mellitus published between 2011-2020 have been taken from Google Scholar, PubMed, and Medical ProQuest, and 15 articles were selected based on criteria set. Results: Each study appears to have different features in design MA, affecting the results varied in the 15 studies reviewed. Mobile technology-based applications demonstrated their role in improving communication, being accessible, facilitating self-management processes, improving compliance with treatment, and ultimately improving blood sugar control. Conclusion: The role of PHTs is important for the successful implementation of the fast-developing sensor and transfer app in the medical sector. It is the role of a PHTs to select adequate devices, apply them, and earnestly analyse their effectiveness and economic feasibility.
Investigating the Prevalence of Hepatitis B and C among Thalassemia Patients in Jahrom: A Cross-Sectional Descriptive Study Vahid Mogharab
Journal of Global Pharma Technology .
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Abstract

Introduction: Thalassemia is a hereditary anemia which is inherited by the child from the parents. The prevalence of this disease is not equal in Iran. Blood products are used in order to treat thalassemia, especially thalassemia major, exposing the patients to the risk of infections including hepatitis B and C. Due to the vaccination against hepatitis B in thalassemia patients, its prevalence has been significantly decreased. However, hepatitis C is considered a prevalent disease, such that the hepatitis C virus can be claimed to be the most prevalent cause of chronic hepatitis in specific thalassemia groups. Therefore, the present study was conducted to investigate the prevalence of Hepatitis B and C among Thalassemia Patients in Jahrom. Method: This research was a cross-sectional descriptive study. In the present study, 167 patients with thalassemia in the Cooley's Ward of Shahid Motahhari Hospital were examined. Collected data included age, sex, duration of receiving the product, type of received product, type of thalassemia (major, intermedia), type of hepatitis (B, C), number of individuals with hepatitis, examination of the liver enzymes of individuals infected with hepatitis, and number of individuals who had undergone splenectomy. Data were analyzed in SPSS 11 using the chi-squared statistical test. Results: From among 167 thalassemia patients in the present study, 164 patients (98.2%) had thalassemia major and 3 patients (1.8%) had thalassemia intermedia.  Most cases of thalassemia (50 men and women, 60.24%) were found in the age group of 14-26 years. The prevalence of hepatitis B was 0% among thalassemia patients. The prevalence of hepatitis C was 7.93% (13 men and women) only among thalassemia major patients. The level of liver enzymes (AST, ALT) was higher among patients with hepatitis C compared with others. No significant relationship was observed between the number of cases with hepatitis C and age, sex, and times of blood transfusion (p>0.05).Conclusion: According to this study, the prevalence of hepatitis B and C was low among thalassemia patients in Jahrom.Keywords: Hepatitis B, Hepatitis C, Thalassemi.
Evaluation of Red Beet Root Activity Physiologically and Histologically in Males Rats Ibrahem Hasan Al-Kraie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This research design to study the effect of cadmium chloride (Cdcl2) and red beet root juice on heart and kidney by measured the physiological parameters in the experimental male’s rats for 30days.  Twenty males rats were assigned to 4 groups each group contain 5 rats. First group was the control group (G1), the second group was cadmium chloride group (G2), third group was cadmium chloride &red beet juice (G3), than last group was red beet juice (G4). The Cd-exposure group (G2) obtained drinking a water daily containing cadmium chloride (CdCl2) in concentration of 2.0 mg Cd/L, while the G3 group treatment with red beet juice 2ml with 2ml of Cdcl2, while the last group G4 treatment with 2ml of red beet juice only.  At the end of the experimental period, blood samples were collected to determine the changes of serum Total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), Total protein (TP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST).  The results of the present study  indicated  that  a significantly increased  in serum  levels of TC, TG, LDL_C, VLDL_C, ALT, AST, & significant decreased  in the levels of HDL_C & TP in G2 group, while there are no significant changes of all parameters in G3&G4 group comparing with control group at Significant level (p≤0.05). Results registors also that are significantly decreased in some parameters contain T.C ,Triglycerides ,LDL_C,VLDL_C, ALT &AST concentration in G3 & G4 group ,while the results showed a significantly increased in parameters HDL_C & Total proteins comparing with G2 group that trated with cadmium chloride at Significant level (p≤0.05).  In the end of this study we find that exposure to low Cd concentration can effected on the lipid profile & lipoprotein &liver enzymes by increased this parameters, while red beet root juice treatmenting decreased that parameters.Keywords: Cadmium chloride (Cdcl2), Total cholesterol(TC), Triglycerides(TG), High density lipoprotein cholesterol (HDL_C), Low-density lipoprotein cholesterol (LDL-C), Very low density lipoprotein cholesterol (VLDL-C), Total protein(TP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST). 

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