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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Determination of Valproic Acid without Derivatization in Human Plasma using High Performance Liquid Chromatography-Photodiode Array Yahdiana Harahap
Journal of Global Pharma Technology .
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Objective: To develop and validate a simple and sensitive HPLC method without derivatization for determination of valproic acid in human plasma. Methods: Nonanoic acid as internal standard was added to 500 mL of plasma sample prior to liquid-liquid extraction using n-hexane and 0.5% triethylamine. Chromatographic separation was achieved on C-8 Symmetry® column (5µm; 150 x 3.9mm) in isocratic mode at 45°C. The mobile phase was 40 mM sodium dihydrogen phosphate pH 3.5 – acetonitrile (56:44 %v/v) with flow rate of 1.00 mL/min and was detected at 210 nm. Method validation referred to EMA Guideline 2011 for bioanalytical method validation in term of parameters lower limit of quantification (LLOQ), selectivity, calibration curve and linearity, carry over, recovery and stability. The valid method was applied in pharmacokinetic study of one healthy subject after administration of 500mg extended release caplet of valproic acid. The blood was collected as much as 7mL for twelve spots, which are predose, 1, 2, 3, 4, 5, 8, 10, 24, 36, 48, and 72 hours after drug administration. Results: The calibration curve valproic acid was linear over the concentration range of 2.0 – 200.0 µg/mL (r = 0.9992). Within-run and between-run precision and accuracy were studied at four concentrations and RSDs were less than 1.8 % and 5.4 %, while the bias (accuracy values) were less than 17.9 % and 13.1 %, respectively. Conclusion: The developed method provides sensitivity, linearity, precision, accuracy and is suitable for analysis of valproic acid in plasma samples for pharmacokinetic studies.Keywords: Valproic acid, Nonanoic acid, HPLC, Validation, Liquid-liquid extraction.
Effectiveness of Intravenous Subanesthetic Dose of Ketamine on the Subarachnoid Block to Attenuate Inflammation Response in Transurethral Resection of the Prostate Surgeries Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background: Perioperative anesthesia and surgery can induce a stress response in the body. Regional anesthesia with local anesthetic drugs in the transurethral Resection of the Prostate (TUR-P), has been proven to minimize inflammation. Patients and Methods: Forty-eight patients of ASA I-II, scheduled for TUR-P with spinal subarachnoid anesthesia were randomly divided into two groups, group A with ketamine and group B without ketamine. The blood level of interleukin (IL)-10, IL-8, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and IL-10/IL-8 ratio were measured in both groups at 1 hour before operation, also at 1 and 24 hours after operation. Results: Blood level of IL-10 (p<0.001) and IL-10/IL-8 Ratio (p<0.05) were significantly different with higher values on group A. Other parameters were not found to be different. Conclusion: Subanesthetic dose of ketamine on spinal subarachnoid anesthesia technique done for TUR-P operation was found able to control inflammation and prevent the deterioration of immune system perioperatively.Keywords: IL-10, IL-8, CRP, NLR, Benign prostatic hyperplasia.
Pharmacokinetic Modification of Controlled Release Matrix Tablets of Balsalazide Palanisamy Vishnu
Journal of Global Pharma Technology Volume 10 Issue 12.
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Balsalazide is used to treat a certain bowel disease (ulcerative colitis) and it also helps to reduce symptoms of ulcerative colitis such as diarrheal, rectal bleeding and stomach pain.  It has a short half life and under goes extensive first pass metabolism. In the present study, balsalazide  600mg controlled release matrices were prepared by wet granulation method and in vitro drug dissolution studies were performed to find out the drug release rate and patterns. Eudragit L-100, Eudragit RSpo, lactose and their combination were used as rate controlling polymer. Tablets were formulated using different polymers ratios. As In vitro drug releaser was carried out using USP type II (paddle method ) at 50 rpm in 900ml of acetic dissolution medium(pH 1.2) for 2 hrs, followed by 900ml alkaline dissolution medium (Ph7.4) upto 12 hrs. Mean dissolution time is used to characterize drug release rate from a dosage form and indicates the drug retarding efficiency of polymer. When Eudragit L 100 and Eudragit RSpo were used alone as the only retarding polymer, a sustained drug release pattern were not absorbed while, combination in the matrix almost doubled the time required for releasing the drug. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics.
Molecular Detection of Some Virulence Factors Genes of Proteus Mirabilis That Isolated From Urinary Tract Infection Afraa Naji Jamel
Journal of Global Pharma Technology Volume 11 Issue 05.
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A total of (160) clinical specimen of urine collected from patients suffering from urinary tract infections at different ages and from both sex in different hospitals in Baghdad during the period from September 2017 to February 2018.were cultured on selective media MacConkey agar. Bacterial isolates were identified by a microscopic examination and diagnosed by using biochemical tests. A further identification by vitak 2system.The results showed that (103) samples were positive for bacteriological culture (64.6%), the percentage of Proteus spp were (54) urine sample (52.4%) and percentage of Proteus mirabilis isolates were (40) isolates (74%) while Proteus vulgaris were (14) isolates (25.9%) while the results indicated the isolation rate of Proteus mirablis from females was (67%) which was higher than that of males (33%).Selection ten isolates of P. mirabilis which show highest urease activity and adhesion to uroepithelia cell. Aderence capability of the isolates was also tested in accordance to epithelial cells isolated from female urine all isolates were capable of adhering to epithelial cells. The genetic study included an extraction of genomic DNA from (10) p. mirablis, then detection of virulence genes ure C that responsible for urease ,  mrpA for fimbrial and ability to adherence to uroepithelial cell for these isolated by using convential PCR all isolated give positive result. Selection five from ure c and mrp A gene amplicons of P. mirabilis sent to Korea for direct sequencing. The nucleotide sequences of ure c, and mrp A genes were compared with the sequences of the mrp A and  ure c gene using BLAST option of NCBI (Basic Local Alignment Search Tool, BLAST v. 2.2.15, www.ncbi.nlm.nih.gov. The result was 100% matching with the registrar globally.
Synthesis, Characterization and Biological Activities of 5,5,-(ethane-1,2-diyl)bis(4-(4-nitrobenzylideneamino)-4H-1,2,4-triazole-3-thio) and its Complexes with Cu(II), Cd(II), Hg(II) and Ag(I) ions Nada A. Rasheed
Journal of Global Pharma Technology .
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A series of coordination compounds of Cu(II), Cd(II) , Hg(II)  and Ag(I) ions with 5,5, -(ethane-1,2-diyl)bis(4-(4-nitrobenzylideneamino)-4H-1,2,4-triazole-3-thio) , as a ligand has been successfully prepared in alcoholic medium. The synthesized complexes were characterized quantitatively and qualitatively by using: elemental analysis CHNS, FT-IR spectroscopy, UV-visible spectroscopy, 1H and 13CNMR, atomic absorption measurements, magnetic susceptibility, thermal analysis)TG and DTG) and conductivity measurements . This ligand coordinates as a bidentate that to the metal ions through sulphur and nitrogen of (azomethine group) atoms. According to the spectral data, Cu(II)- complex has coordination of 6 with octahedral geometry while the Cd(II)-complex and Hg(II) have coordination of 4 with exhibited tetrahedral ,and the Ag(I)-complex has coordination of 3 with exhibited trigonal planer ,  The Schiff base and its metal complexes have been screened for antimicrobial activity against four  bacteria, namely :(Staphylococcus aureus, , Streptococcus sp. , Klebsilla Pneumonia  Escherichia coli )and the  fungi, namely ( Aspergillus flavus ) .Keywords: Triazole complexes; Schiff base-triazole; Biological activity.
New Indazole Compounds Derived from Ethyl-4-Hydroxy-4'-Substituted-Cyclohexen- 6- One- Carboxylate: Synthesis and Biological Activity Jumbad H. Tomma
Journal of Global Pharma Technology .
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The work involves synthesis of new compounds: Schiff bases [VIII] a-c, pyrazoles[V]a-c, starting with chalcones [I]a-c. 4- Hydroxyacetophenone was reacted with benzaldehyde , anysaldehyde and  tolyaldehyde  in basic medium to give three chalcones[I]a-c compounds by Claisen-Schemidt reaction, the chalcones[I]a-c were reacted with ethylacetoacetate in basic medium to get new compounds[II]a-c, which were reacted with ethylchloroacetate in basic medium to obtained ester compounds  [III]a-c.  The condensation of esters[III]a-c with hydrazine hydrate led to produce accurse pounding  acid hydrazides [IV]a-c , the reaction of acid hydrazides [IV]a-c with ethyl aceto acetate led to formation  pyrazoles[V]a-c , which were reacted with acetyl chloride in basic medium  to get compounds [VI]a-c the later compound  reacted  with phenyl hydrazine or 2,4 di nitrophenyl hydrazine to led compounds [VII] a-f .  On the other hand, acid hydrazides [IV] a-c reacted with 4- substituted benzaldehyde to form Schiff bases [VIII] a-I. The synthesized compounds were characterized by FTIR, 1HNMR and Mass spectroscopy (of some of them).Keywords: Chalcones, Acid hydrazide, Pyrazole, Indazoles, Schiff bases.
Preparation and Characterization of Nanoparticles TiO2 and Its Application for Methylene Blue Dye Degradation under Solar Light Ahmed Hassan Ali
Journal of Global Pharma Technology .
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This research paper study, the treatment of m ethylene blue dye was investigated in a photo catalyticsystem under solar irradiation in heterogeneous solution with multi concentrations like (0.3 , 0.8 , 1.3 ,and 2) g/l of commercial TiO2 as a photo catalyst. The optimum value of photo catalyst concentration (0.8mg/l) the nano particles TiO2 was prepared by using sol-gel technique. The properties of the preparedTiO2 were checked with X-ray and transmission electron microscopy technique. Then the treatment ofthe m ethylene blue dye was checked by using synthesis TiO2with same previous conditions. We havecompared the treatment efficiency of solution between the prepared nanoparticles and commercial TiO2.The results shows that the prepared TiO2hasa more efficiency. The practical work also includes therecycled ofTiO2 nano particles.Keywords: Photo catalytic Degradation; Titanium dioxide; Wastewater treatment; Preparation andcharacterization of nano particles.
The Effect Of Extra Virgin Olive Oil To Increase Endogeneous Antioxidant And PlGF In Preeclampsia Rat Model Yulia Silvani
Journal of Global Pharma Technology Volume 11 Issue 04.
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Background: Preeclampsia is a special disease in pregnancy with oxidative stress as one of its pathogenesis pathways, suspected that it can interfere the process of angiogenesis and negatively impacts the fetus and maternal wellbeing. Objective: This study aimed to determine effect of EVOO as a strong exogenous antioxidant to increase SOD activity and GSH level in accordance with improvement on PlGF level as an angiogenesis factor in preeclampsia rat model. Method: This research consisted of five groups; negative control, positive control (preeclampsia rat model), doses 1, 2, and 3 that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). Blood pressure measurements were carried out at the 12th, 15th, and 19th day of pregnancy. After sacrificed, placentas were collected to determine SOD activity and GSH level either maternal plasma to determine PlGF level. Results: Result of this study showed that there was a reduction of GSH (p=0.02) and PlGF (p=0.233) level between negative and positive control group meanwhile SOD activity seem increased (p=0.049). There were significant differences among positive control and dose 1 in SOD activity (p=0.008), dose 3 in GSH level (p=0.000), both dose 1 (p=0.017) and 2 (p=0.000) in PlGF level. Conclussion: Administration of EVOO increased SOD and GSH in all three doses groups, while there was a decrease in PlGF at dose 3. EVOO had been shown to be a potential antioxidant in preeclampsia through increased SOD activity and GSH level, at once modulate angiogenesis through increased PlGF level.Keywords: Preeclampsia, EVOO, SOD, GSH, PlGF, Antioxidant, Oxidative stress, Angiogenesis
Effect of Topical Artemisinin from Artemisia Annua in Comparison with Tacrolimus on Induced Atopic Dermatitis in Mice Mohammed Fareed Hameed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: To evaluate the effectiveness of artemisinin isolated from Artemisia annua terpenes fraction in atopic dermatitis mice model. Methods: This research is a randomized, prospective, placebo and controlled animal study. Thirty two male, albino mice included in this study. The mice were randomly divided into four groups (Each group eight). Group I without treatment (Healthy). Group II only the inducer Phthalic anhydride given. Groups II, III, and IV subjected to 5% phthalic anhydride solution and after three hours of phthalic anhydride application, treatment is used for group III (Tacrolimus 0.03% ointment) , and group IV (Artemisinin 175mg/kg). Artemisinin was extracted from Artemisia annua and isolated by preparative high pressure liquid chromatography. Measurement of serum interleukin 13, interleukin 4, and immunoglobulin E and histopathology were done. Results: When healthy group is compared to atopic dermatitis induced non-treated group, a significant increase (P value ≤ 0.05) in serum IL-13 and IL-4 were found, while high significant increase (P value ≤ 0.001) in serum IgE was recorded. Regarding Histopathology score, high significant decrease in epidermal thickness, hyperkeratosis, parakeratosis, erosion, inflammation and edema after 4 weeks of starting treatment between Tacrolimus and atopic dermatitis induced non-treated groups. When artemisinin and atopic dermatitis induced non-treated groups were compared, a significant decrease was found in serum IgE. Conclusion: Artemisia annua artemisinin has an effect on phthalic anhydride induced atopic dermatitis albino mice like model.Keywords: Atopic dermatitis, Artemisia annua, Artemisinin.
A Retrospective Study of Erythema Nodosum Leprosum in Dermatology and Venereology Outpatient Clinic of Sanglah General Hospital, Bali-Indonesia I Gusti Nyoman Darmaputra
Journal of Global Pharma Technology Volume 10 Issue 12.
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Introduction: Erythema nodosum leprosum (ENL) or type II reaction in leprosy is acute inflammation in the chronic disease of multibacillary leprosy. Clinical manifestation of ENL on the skin such as painful cutaneous nodule, commonly found on the face and extremities accompanied by nerve inflammation, systemic involvement, and other extracutaneous symptoms which possibly caused disability if it is not treated appropriately. Aim: To find out the ENL pattern in the Department of Skin and Venereology, Sanglah General Hospital for three years. Methods: This study was a retrospective study from the medical record of ENL new cases treated in the Skin and Venereology Outpatient Clinic, within period January 2013-December 2015 classified by the number of patients, age, sex, and type of leprosy. Result: Starting from January 2013-December 2015 there were about 39 new leprosy patients with ENL (36% of all new patients in the leprosy division), 64% are male, 82% aged 17-45 years, and 69% of patients suffer from borderline lepromatous (BL) leprosy. Conclusion: Most leprosy patients with ENL are male, aged 17-45 years with BL type leprosy. Complications that arise due to ENL or the side effects of corticosteroids could cause a large socio-economic impact.Keywords: Erythema nodosum leprosum, Leprosy reaction, Sanglah General Hospital.

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